LeishMANIAdb
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CRAL-TRIO domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL-TRIO domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HX46_LEIIN
TriTrypDb:
LINF_160020900
Length:
640

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HX46
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX46

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008483 transaminase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016769 transferase activity, transferring nitrogenous groups 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 117 121 PF00656 0.706
CLV_MEL_PAP_1 629 635 PF00089 0.414
CLV_NRD_NRD_1 241 243 PF00675 0.655
CLV_NRD_NRD_1 269 271 PF00675 0.444
CLV_NRD_NRD_1 292 294 PF00675 0.700
CLV_PCSK_FUR_1 267 271 PF00082 0.509
CLV_PCSK_FUR_1 559 563 PF00082 0.463
CLV_PCSK_KEX2_1 160 162 PF00082 0.448
CLV_PCSK_KEX2_1 241 243 PF00082 0.652
CLV_PCSK_KEX2_1 269 271 PF00082 0.434
CLV_PCSK_KEX2_1 292 294 PF00082 0.709
CLV_PCSK_KEX2_1 50 52 PF00082 0.579
CLV_PCSK_KEX2_1 561 563 PF00082 0.489
CLV_PCSK_PC1ET2_1 160 162 PF00082 0.448
CLV_PCSK_PC1ET2_1 292 294 PF00082 0.694
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.555
CLV_PCSK_PC1ET2_1 561 563 PF00082 0.489
CLV_PCSK_SKI1_1 201 205 PF00082 0.672
CLV_PCSK_SKI1_1 277 281 PF00082 0.793
CLV_PCSK_SKI1_1 294 298 PF00082 0.555
CLV_PCSK_SKI1_1 410 414 PF00082 0.469
CLV_PCSK_SKI1_1 480 484 PF00082 0.509
CLV_PCSK_SKI1_1 520 524 PF00082 0.488
CLV_PCSK_SKI1_1 574 578 PF00082 0.323
DEG_APCC_DBOX_1 200 208 PF00400 0.616
DEG_APCC_KENBOX_2 444 448 PF00400 0.369
DEG_Nend_UBRbox_4 1 3 PF02207 0.539
DEG_SPOP_SBC_1 64 68 PF00917 0.537
DOC_CYCLIN_RxL_1 550 560 PF00134 0.383
DOC_CYCLIN_RxL_1 9 19 PF00134 0.456
DOC_MAPK_DCC_7 445 454 PF00069 0.423
DOC_MAPK_DCC_7 469 479 PF00069 0.325
DOC_MAPK_gen_1 292 299 PF00069 0.627
DOC_MAPK_MEF2A_6 160 167 PF00069 0.491
DOC_MAPK_MEF2A_6 249 257 PF00069 0.394
DOC_MAPK_MEF2A_6 292 299 PF00069 0.628
DOC_MAPK_MEF2A_6 445 454 PF00069 0.539
DOC_MAPK_MEF2A_6 520 529 PF00069 0.411
DOC_PP2B_LxvP_1 14 17 PF13499 0.458
DOC_USP7_MATH_1 275 279 PF00917 0.724
DOC_USP7_MATH_1 352 356 PF00917 0.718
DOC_USP7_MATH_1 357 361 PF00917 0.696
DOC_USP7_MATH_1 450 454 PF00917 0.362
DOC_USP7_MATH_1 615 619 PF00917 0.530
DOC_USP7_UBL2_3 480 484 PF12436 0.435
DOC_USP7_UBL2_3 601 605 PF12436 0.477
DOC_WW_Pin1_4 16 21 PF00397 0.460
DOC_WW_Pin1_4 320 325 PF00397 0.680
DOC_WW_Pin1_4 96 101 PF00397 0.694
LIG_14-3-3_CanoR_1 134 140 PF00244 0.705
LIG_14-3-3_CanoR_1 354 360 PF00244 0.746
LIG_14-3-3_CanoR_1 401 407 PF00244 0.490
LIG_14-3-3_CanoR_1 513 517 PF00244 0.383
LIG_14-3-3_CanoR_1 520 526 PF00244 0.452
LIG_Actin_WH2_2 226 243 PF00022 0.557
LIG_Actin_WH2_2 464 482 PF00022 0.409
LIG_BRCT_BRCA1_1 66 70 PF00533 0.503
LIG_FAT_LD_1 250 258 PF03623 0.411
LIG_FHA_1 127 133 PF00498 0.690
LIG_FHA_1 344 350 PF00498 0.539
LIG_FHA_1 39 45 PF00498 0.517
LIG_FHA_1 425 431 PF00498 0.457
LIG_FHA_1 481 487 PF00498 0.436
LIG_FHA_1 509 515 PF00498 0.455
LIG_FHA_1 56 62 PF00498 0.648
LIG_FHA_1 568 574 PF00498 0.369
LIG_FHA_1 590 596 PF00498 0.341
LIG_FHA_1 614 620 PF00498 0.458
LIG_FHA_2 115 121 PF00498 0.553
LIG_FHA_2 123 129 PF00498 0.465
LIG_FHA_2 179 185 PF00498 0.554
LIG_FHA_2 223 229 PF00498 0.552
LIG_FHA_2 373 379 PF00498 0.367
LIG_FHA_2 403 409 PF00498 0.314
LIG_LIR_Gen_1 152 163 PF02991 0.540
LIG_LIR_Gen_1 393 404 PF02991 0.434
LIG_LIR_LC3C_4 483 488 PF02991 0.405
LIG_LIR_Nem_3 152 158 PF02991 0.578
LIG_LIR_Nem_3 393 399 PF02991 0.373
LIG_Pex14_2 151 155 PF04695 0.595
LIG_PTB_Apo_2 145 152 PF02174 0.631
LIG_RPA_C_Fungi 351 363 PF08784 0.512
LIG_SH2_CRK 472 476 PF00017 0.395
LIG_SH2_PTP2 463 466 PF00017 0.337
LIG_SH2_STAP1 369 373 PF00017 0.511
LIG_SH2_STAT3 628 631 PF00017 0.375
LIG_SH2_STAT5 219 222 PF00017 0.447
LIG_SH2_STAT5 463 466 PF00017 0.337
LIG_SH2_STAT5 628 631 PF00017 0.386
LIG_SH3_1 321 327 PF00018 0.598
LIG_SH3_3 14 20 PF00018 0.487
LIG_SH3_3 308 314 PF00018 0.655
LIG_SH3_3 321 327 PF00018 0.740
LIG_SH3_3 84 90 PF00018 0.475
LIG_SUMO_SIM_anti_2 19 25 PF11976 0.427
LIG_SUMO_SIM_par_1 128 133 PF11976 0.587
LIG_SUMO_SIM_par_1 21 27 PF11976 0.426
LIG_SUMO_SIM_par_1 370 375 PF11976 0.357
LIG_SUMO_SIM_par_1 591 598 PF11976 0.379
LIG_TYR_ITIM 577 582 PF00017 0.329
LIG_UBA3_1 473 480 PF00899 0.415
LIG_WRC_WIRS_1 437 442 PF05994 0.441
MOD_CDC14_SPxK_1 99 102 PF00782 0.660
MOD_CDK_SPxK_1 96 102 PF00069 0.658
MOD_CK1_1 119 125 PF00069 0.560
MOD_CK1_1 135 141 PF00069 0.571
MOD_CK1_1 147 153 PF00069 0.443
MOD_CK1_1 186 192 PF00069 0.534
MOD_CK1_1 27 33 PF00069 0.480
MOD_CK1_1 282 288 PF00069 0.761
MOD_CK1_1 309 315 PF00069 0.680
MOD_CK1_1 320 326 PF00069 0.792
MOD_CK1_1 328 334 PF00069 0.675
MOD_CK1_1 34 40 PF00069 0.675
MOD_CK1_1 355 361 PF00069 0.649
MOD_CK1_1 532 538 PF00069 0.438
MOD_CK1_1 618 624 PF00069 0.522
MOD_CK2_1 178 184 PF00069 0.555
MOD_CK2_1 402 408 PF00069 0.393
MOD_CK2_1 416 422 PF00069 0.319
MOD_CK2_1 49 55 PF00069 0.724
MOD_GlcNHglycan 114 117 PF01048 0.684
MOD_GlcNHglycan 133 137 PF01048 0.529
MOD_GlcNHglycan 188 191 PF01048 0.665
MOD_GlcNHglycan 277 280 PF01048 0.661
MOD_GlcNHglycan 36 39 PF01048 0.677
MOD_GlcNHglycan 385 388 PF01048 0.444
MOD_GlcNHglycan 488 491 PF01048 0.393
MOD_GlcNHglycan 67 70 PF01048 0.640
MOD_GlcNHglycan 75 78 PF01048 0.587
MOD_GSK3_1 112 119 PF00069 0.719
MOD_GSK3_1 122 129 PF00069 0.577
MOD_GSK3_1 147 154 PF00069 0.565
MOD_GSK3_1 199 206 PF00069 0.637
MOD_GSK3_1 240 247 PF00069 0.576
MOD_GSK3_1 27 34 PF00069 0.485
MOD_GSK3_1 275 282 PF00069 0.747
MOD_GSK3_1 309 316 PF00069 0.676
MOD_GSK3_1 357 364 PF00069 0.656
MOD_GSK3_1 450 457 PF00069 0.484
MOD_GSK3_1 508 515 PF00069 0.472
MOD_GSK3_1 609 616 PF00069 0.438
MOD_GSK3_1 618 625 PF00069 0.440
MOD_N-GLC_1 112 117 PF02516 0.621
MOD_N-GLC_1 142 147 PF02516 0.619
MOD_N-GLC_1 199 204 PF02516 0.610
MOD_N-GLC_1 207 212 PF02516 0.619
MOD_N-GLC_1 343 348 PF02516 0.726
MOD_N-GLC_1 390 395 PF02516 0.524
MOD_N-GLC_1 435 440 PF02516 0.375
MOD_N-GLC_1 589 594 PF02516 0.343
MOD_N-GLC_1 595 600 PF02516 0.390
MOD_NEK2_1 114 119 PF00069 0.577
MOD_NEK2_1 142 147 PF00069 0.563
MOD_NEK2_1 149 154 PF00069 0.499
MOD_NEK2_1 183 188 PF00069 0.508
MOD_NEK2_1 203 208 PF00069 0.670
MOD_NEK2_1 29 34 PF00069 0.680
MOD_NEK2_1 350 355 PF00069 0.744
MOD_NEK2_1 372 377 PF00069 0.346
MOD_NEK2_1 397 402 PF00069 0.595
MOD_NEK2_1 416 421 PF00069 0.369
MOD_NEK2_1 508 513 PF00069 0.422
MOD_NEK2_1 514 519 PF00069 0.383
MOD_NEK2_1 521 526 PF00069 0.395
MOD_NEK2_1 557 562 PF00069 0.359
MOD_NEK2_1 595 600 PF00069 0.411
MOD_NEK2_1 633 638 PF00069 0.421
MOD_NEK2_1 73 78 PF00069 0.484
MOD_NEK2_2 450 455 PF00069 0.366
MOD_PIKK_1 277 283 PF00454 0.764
MOD_PIKK_1 424 430 PF00454 0.510
MOD_PIKK_1 609 615 PF00454 0.415
MOD_PKA_2 101 107 PF00069 0.592
MOD_PKA_2 126 132 PF00069 0.739
MOD_PKA_2 240 246 PF00069 0.602
MOD_PKA_2 355 361 PF00069 0.790
MOD_PKA_2 512 518 PF00069 0.457
MOD_Plk_1 119 125 PF00069 0.494
MOD_Plk_1 142 148 PF00069 0.661
MOD_Plk_1 183 189 PF00069 0.513
MOD_Plk_1 199 205 PF00069 0.566
MOD_Plk_1 306 312 PF00069 0.626
MOD_Plk_1 328 334 PF00069 0.608
MOD_Plk_1 343 349 PF00069 0.614
MOD_Plk_1 390 396 PF00069 0.495
MOD_Plk_1 435 441 PF00069 0.388
MOD_Plk_1 508 514 PF00069 0.509
MOD_Plk_1 589 595 PF00069 0.343
MOD_Plk_2-3 128 134 PF00069 0.594
MOD_Plk_2-3 390 396 PF00069 0.473
MOD_Plk_4 101 107 PF00069 0.625
MOD_Plk_4 178 184 PF00069 0.504
MOD_Plk_4 249 255 PF00069 0.420
MOD_Plk_4 306 312 PF00069 0.649
MOD_Plk_4 344 350 PF00069 0.802
MOD_Plk_4 450 456 PF00069 0.521
MOD_Plk_4 514 520 PF00069 0.411
MOD_Plk_4 589 595 PF00069 0.369
MOD_ProDKin_1 16 22 PF00069 0.454
MOD_ProDKin_1 320 326 PF00069 0.679
MOD_ProDKin_1 96 102 PF00069 0.696
MOD_SUMO_rev_2 47 52 PF00179 0.558
MOD_SUMO_rev_2 499 503 PF00179 0.580
TRG_DiLeu_BaLyEn_6 17 22 PF01217 0.444
TRG_ENDOCYTIC_2 139 142 PF00928 0.566
TRG_ENDOCYTIC_2 369 372 PF00928 0.383
TRG_ENDOCYTIC_2 463 466 PF00928 0.337
TRG_ENDOCYTIC_2 579 582 PF00928 0.331
TRG_ER_diArg_1 240 242 PF00400 0.655
TRG_ER_diArg_1 266 269 PF00400 0.398

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HX36 Leptomonas seymouri 52% 100%
A0A0S4IMR2 Bodo saltans 34% 96%
A0A1X0P052 Trypanosomatidae 39% 100%
A0A3R7K490 Trypanosoma rangeli 36% 100%
A0A3S7WU54 Leishmania donovani 100% 100%
A4H8S7 Leishmania braziliensis 74% 100%
C9ZVU6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AQW1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QEL7 Leishmania major 92% 100%
V5BS91 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS