Putative kinesin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin - putative

Species:

Leishmania infantum

UniProt:

A4HX45_LEIIN

TriTrypDb:

LINF_160020800

Length:

793

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	2
GO:0020016	ciliary pocket	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1

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Expansion

Sequence features

A4HX45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX45

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	17
GO:0007018	microtubule-based movement	3	17
GO:0009987	cellular process	1	17

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003774	cytoskeletal motor activity	1	17
GO:0003777	microtubule motor activity	2	17
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	17
GO:0005515	protein binding	2	17
GO:0005524	ATP binding	5	17
GO:0008017	microtubule binding	5	17
GO:0008092	cytoskeletal protein binding	3	17
GO:0015631	tubulin binding	4	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.362
CLV_C14_Caspase3-7	507	511	PF00656	0.541
CLV_NRD_NRD_1	170	172	PF00675	0.301
CLV_NRD_NRD_1	2	4	PF00675	0.718
CLV_NRD_NRD_1	384	386	PF00675	0.542
CLV_NRD_NRD_1	524	526	PF00675	0.466
CLV_NRD_NRD_1	741	743	PF00675	0.443
CLV_NRD_NRD_1	763	765	PF00675	0.595
CLV_NRD_NRD_1	774	776	PF00675	0.539
CLV_NRD_NRD_1	787	789	PF00675	0.517

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A068FIK2	Gossypium hirsutum	29%	77%
A0A0N1I5H5	Leptomonas seymouri	27%	67%
A0A0N1IH46	Leptomonas seymouri	77%	100%
A0A0S4IR67	Bodo saltans	27%	100%
A0A0S4JEF6	Bodo saltans	26%	100%
A0A1X0NDZ3	Trypanosomatidae	30%	71%
A0A1X0NP27	Trypanosomatidae	32%	100%
A0A1X0NPH9	Trypanosomatidae	26%	86%
A0A1X0P0C2	Trypanosomatidae	56%	97%
A0A3Q8IBS7	Leishmania donovani	27%	100%

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