LeishMANIAdb
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Putative kinesin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative kinesin
Gene product:
kinesin - putative
Species:
Leishmania infantum
UniProt:
A4HX45_LEIIN
TriTrypDb:
LINF_160020800
Length:
793

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 40
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005871 kinesin complex 3 2
GO:0005874 microtubule 6 4
GO:0005875 microtubule associated complex 2 2
GO:0032991 protein-containing complex 1 2
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0099080 supramolecular complex 2 4
GO:0099081 supramolecular polymer 3 4
GO:0099512 supramolecular fiber 4 4
GO:0099513 polymeric cytoskeletal fiber 5 4
GO:0110165 cellular anatomical entity 1 4
GO:0005856 cytoskeleton 5 1
GO:0020016 ciliary pocket 2 1
GO:0030863 cortical cytoskeleton 6 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

A4HX45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX45

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 17
GO:0007018 microtubule-based movement 3 17
GO:0009987 cellular process 1 17
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 17
GO:0003774 cytoskeletal motor activity 1 17
GO:0003777 microtubule motor activity 2 17
GO:0003824 catalytic activity 1 8
GO:0005488 binding 1 17
GO:0005515 protein binding 2 17
GO:0005524 ATP binding 5 17
GO:0008017 microtubule binding 5 17
GO:0008092 cytoskeletal protein binding 3 17
GO:0015631 tubulin binding 4 17
GO:0016787 hydrolase activity 2 8
GO:0017076 purine nucleotide binding 4 17
GO:0030554 adenyl nucleotide binding 5 17
GO:0032553 ribonucleotide binding 3 17
GO:0032555 purine ribonucleotide binding 4 17
GO:0032559 adenyl ribonucleotide binding 5 17
GO:0035639 purine ribonucleoside triphosphate binding 4 17
GO:0036094 small molecule binding 2 17
GO:0043167 ion binding 2 17
GO:0043168 anion binding 3 17
GO:0097159 organic cyclic compound binding 2 17
GO:0097367 carbohydrate derivative binding 2 17
GO:0140657 ATP-dependent activity 1 17
GO:1901265 nucleoside phosphate binding 3 17
GO:1901363 heterocyclic compound binding 2 17
GO:0016462 pyrophosphatase activity 5 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0016887 ATP hydrolysis activity 7 2
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 334 338 PF00656 0.362
CLV_C14_Caspase3-7 507 511 PF00656 0.541
CLV_NRD_NRD_1 170 172 PF00675 0.301
CLV_NRD_NRD_1 2 4 PF00675 0.718
CLV_NRD_NRD_1 384 386 PF00675 0.542
CLV_NRD_NRD_1 524 526 PF00675 0.466
CLV_NRD_NRD_1 741 743 PF00675 0.443
CLV_NRD_NRD_1 763 765 PF00675 0.595
CLV_NRD_NRD_1 774 776 PF00675 0.539
CLV_NRD_NRD_1 787 789 PF00675 0.517
CLV_PCSK_KEX2_1 2 4 PF00082 0.618
CLV_PCSK_KEX2_1 495 497 PF00082 0.536
CLV_PCSK_KEX2_1 524 526 PF00082 0.560
CLV_PCSK_KEX2_1 741 743 PF00082 0.443
CLV_PCSK_KEX2_1 763 765 PF00082 0.595
CLV_PCSK_KEX2_1 774 776 PF00082 0.539
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.557
CLV_PCSK_SKI1_1 146 150 PF00082 0.329
CLV_PCSK_SKI1_1 246 250 PF00082 0.313
CLV_PCSK_SKI1_1 313 317 PF00082 0.319
CLV_PCSK_SKI1_1 352 356 PF00082 0.314
CLV_PCSK_SKI1_1 387 391 PF00082 0.427
CLV_PCSK_SKI1_1 435 439 PF00082 0.447
CLV_PCSK_SKI1_1 448 452 PF00082 0.361
CLV_PCSK_SKI1_1 741 745 PF00082 0.565
CLV_Separin_Metazoa 209 213 PF03568 0.349
DEG_APCC_DBOX_1 740 748 PF00400 0.437
DEG_Nend_UBRbox_1 1 4 PF02207 0.551
DOC_CYCLIN_RxL_1 246 254 PF00134 0.308
DOC_MAPK_MEF2A_6 8 17 PF00069 0.564
DOC_MAPK_RevD_3 157 172 PF00069 0.319
DOC_MIT_MIM_1 543 551 PF04212 0.436
DOC_PP4_FxxP_1 115 118 PF00568 0.428
DOC_PP4_FxxP_1 238 241 PF00568 0.428
DOC_SPAK_OSR1_1 736 740 PF12202 0.390
DOC_USP7_MATH_1 140 144 PF00917 0.319
DOC_USP7_MATH_1 194 198 PF00917 0.362
DOC_USP7_MATH_1 284 288 PF00917 0.363
DOC_USP7_MATH_1 504 508 PF00917 0.558
DOC_USP7_MATH_1 67 71 PF00917 0.353
DOC_USP7_MATH_1 73 77 PF00917 0.333
DOC_WW_Pin1_4 329 334 PF00397 0.394
DOC_WW_Pin1_4 769 774 PF00397 0.591
LIG_14-3-3_CanoR_1 139 148 PF00244 0.307
LIG_14-3-3_CanoR_1 171 177 PF00244 0.428
LIG_14-3-3_CanoR_1 225 230 PF00244 0.329
LIG_14-3-3_CanoR_1 307 312 PF00244 0.319
LIG_14-3-3_CanoR_1 503 513 PF00244 0.575
LIG_14-3-3_CanoR_1 52 56 PF00244 0.301
LIG_14-3-3_CanoR_1 547 555 PF00244 0.570
LIG_14-3-3_CanoR_1 564 573 PF00244 0.516
LIG_14-3-3_CanoR_1 586 592 PF00244 0.493
LIG_Actin_WH2_2 192 208 PF00022 0.279
LIG_Actin_WH2_2 690 708 PF00022 0.404
LIG_APCC_ABBA_1 157 162 PF00400 0.352
LIG_APCC_ABBAyCdc20_2 387 393 PF00400 0.419
LIG_APCC_ABBAyCdc20_2 448 454 PF00400 0.529
LIG_BRCT_BRCA1_1 181 185 PF00533 0.331
LIG_Clathr_ClatBox_1 229 233 PF01394 0.319
LIG_eIF4E_1 452 458 PF01652 0.442
LIG_FHA_1 147 153 PF00498 0.354
LIG_FHA_1 182 188 PF00498 0.343
LIG_FHA_1 190 196 PF00498 0.356
LIG_FHA_1 310 316 PF00498 0.322
LIG_FHA_1 324 330 PF00498 0.322
LIG_FHA_1 425 431 PF00498 0.531
LIG_FHA_1 515 521 PF00498 0.547
LIG_FHA_1 649 655 PF00498 0.494
LIG_FHA_1 764 770 PF00498 0.562
LIG_FHA_2 121 127 PF00498 0.344
LIG_FHA_2 234 240 PF00498 0.301
LIG_FHA_2 25 31 PF00498 0.327
LIG_FHA_2 426 432 PF00498 0.469
LIG_FHA_2 436 442 PF00498 0.540
LIG_FHA_2 612 618 PF00498 0.612
LIG_FHA_2 626 632 PF00498 0.737
LIG_GBD_Chelix_1 526 534 PF00786 0.556
LIG_KLC1_Yacidic_2 158 162 PF13176 0.319
LIG_LIR_Apic_2 113 118 PF02991 0.428
LIG_LIR_Apic_2 236 241 PF02991 0.428
LIG_LIR_Gen_1 111 118 PF02991 0.352
LIG_LIR_Gen_1 182 193 PF02991 0.312
LIG_LIR_Gen_1 197 205 PF02991 0.315
LIG_LIR_Gen_1 454 462 PF02991 0.564
LIG_LIR_Gen_1 721 730 PF02991 0.430
LIG_LIR_Gen_1 78 89 PF02991 0.316
LIG_LIR_Nem_3 111 115 PF02991 0.333
LIG_LIR_Nem_3 162 168 PF02991 0.291
LIG_LIR_Nem_3 182 188 PF02991 0.312
LIG_LIR_Nem_3 197 201 PF02991 0.315
LIG_LIR_Nem_3 388 394 PF02991 0.418
LIG_LIR_Nem_3 454 458 PF02991 0.565
LIG_LIR_Nem_3 721 726 PF02991 0.436
LIG_LIR_Nem_3 78 84 PF02991 0.319
LIG_MYND_1 241 245 PF01753 0.428
LIG_NRBOX 310 316 PF00104 0.352
LIG_PCNA_PIPBox_1 231 240 PF02747 0.331
LIG_PCNA_yPIPBox_3 301 315 PF02747 0.341
LIG_Pex14_1 379 383 PF04695 0.588
LIG_Pex14_2 53 57 PF04695 0.329
LIG_PTB_Apo_2 131 138 PF02174 0.428
LIG_PTB_Apo_2 673 680 PF02174 0.381
LIG_PTB_Phospho_1 673 679 PF10480 0.378
LIG_SH2_CRK 723 727 PF00017 0.386
LIG_SH2_GRB2like 667 670 PF00017 0.424
LIG_SH2_GRB2like 674 677 PF00017 0.382
LIG_SH2_NCK_1 723 727 PF00017 0.417
LIG_SH2_PTP2 16 19 PF00017 0.482
LIG_SH2_SRC 674 677 PF00017 0.401
LIG_SH2_STAP1 150 154 PF00017 0.428
LIG_SH2_STAP1 498 502 PF00017 0.500
LIG_SH2_STAT3 667 670 PF00017 0.424
LIG_SH2_STAT5 112 115 PF00017 0.284
LIG_SH2_STAT5 150 153 PF00017 0.318
LIG_SH2_STAT5 16 19 PF00017 0.482
LIG_SH2_STAT5 160 163 PF00017 0.247
LIG_SH2_STAT5 318 321 PF00017 0.319
LIG_SH2_STAT5 383 386 PF00017 0.482
LIG_SH2_STAT5 674 677 PF00017 0.442
LIG_SH2_STAT5 703 706 PF00017 0.566
LIG_SH3_3 42 48 PF00018 0.328
LIG_SH3_3 81 87 PF00018 0.428
LIG_SUMO_SIM_anti_2 200 206 PF11976 0.378
LIG_SUMO_SIM_par_1 230 236 PF11976 0.344
LIG_SUMO_SIM_par_1 281 287 PF11976 0.319
LIG_SUMO_SIM_par_1 325 332 PF11976 0.428
LIG_TRAF2_1 123 126 PF00917 0.344
LIG_TRAF2_1 610 613 PF00917 0.612
LIG_TRAF2_1 614 617 PF00917 0.628
LIG_TRAF2_1 628 631 PF00917 0.475
LIG_TRAF2_1 75 78 PF00917 0.319
LIG_UBA3_1 739 746 PF00899 0.438
LIG_WRC_WIRS_1 112 117 PF05994 0.428
LIG_WRC_WIRS_1 211 216 PF05994 0.319
MOD_CDK_SPK_2 769 774 PF00069 0.560
MOD_CDK_SPxK_1 769 775 PF00069 0.593
MOD_CDK_SPxxK_3 329 336 PF00069 0.300
MOD_CK1_1 108 114 PF00069 0.322
MOD_CK1_1 120 126 PF00069 0.322
MOD_CK1_1 309 315 PF00069 0.329
MOD_CK1_1 323 329 PF00069 0.322
MOD_CK1_1 341 347 PF00069 0.330
MOD_CK2_1 120 126 PF00069 0.344
MOD_CK2_1 152 158 PF00069 0.366
MOD_CK2_1 284 290 PF00069 0.326
MOD_CK2_1 329 335 PF00069 0.428
MOD_CK2_1 38 44 PF00069 0.331
MOD_CK2_1 425 431 PF00069 0.475
MOD_CK2_1 513 519 PF00069 0.538
MOD_CK2_1 564 570 PF00069 0.436
MOD_CK2_1 607 613 PF00069 0.587
MOD_CK2_1 625 631 PF00069 0.595
MOD_CK2_1 646 652 PF00069 0.633
MOD_CK2_1 656 662 PF00069 0.654
MOD_CK2_1 777 783 PF00069 0.585
MOD_GlcNHglycan 107 110 PF01048 0.324
MOD_GlcNHglycan 142 145 PF01048 0.428
MOD_GlcNHglycan 152 155 PF01048 0.428
MOD_GlcNHglycan 24 30 PF01048 0.403
MOD_GlcNHglycan 39 43 PF01048 0.405
MOD_GlcNHglycan 548 551 PF01048 0.543
MOD_GlcNHglycan 617 621 PF01048 0.517
MOD_GlcNHglycan 631 635 PF01048 0.456
MOD_GlcNHglycan 69 72 PF01048 0.415
MOD_GlcNHglycan 73 76 PF01048 0.381
MOD_GSK3_1 117 124 PF00069 0.339
MOD_GSK3_1 146 153 PF00069 0.396
MOD_GSK3_1 179 186 PF00069 0.331
MOD_GSK3_1 210 217 PF00069 0.342
MOD_GSK3_1 221 228 PF00069 0.365
MOD_GSK3_1 323 330 PF00069 0.339
MOD_GSK3_1 593 600 PF00069 0.595
MOD_GSK3_1 607 614 PF00069 0.557
MOD_GSK3_1 625 632 PF00069 0.625
MOD_GSK3_1 67 74 PF00069 0.400
MOD_GSK3_1 765 772 PF00069 0.618
MOD_LATS_1 170 176 PF00433 0.344
MOD_N-GLC_1 278 283 PF02516 0.322
MOD_N-GLC_1 307 312 PF02516 0.292
MOD_N-GLC_1 338 343 PF02516 0.418
MOD_N-GLC_1 679 684 PF02516 0.444
MOD_NEK2_1 135 140 PF00069 0.383
MOD_NEK2_1 214 219 PF00069 0.361
MOD_NEK2_1 306 311 PF00069 0.341
MOD_NEK2_1 327 332 PF00069 0.321
MOD_NEK2_1 38 43 PF00069 0.474
MOD_NEK2_1 615 620 PF00069 0.663
MOD_NEK2_1 629 634 PF00069 0.672
MOD_NEK2_1 689 694 PF00069 0.388
MOD_NEK2_1 722 727 PF00069 0.384
MOD_PIKK_1 121 127 PF00454 0.331
MOD_PIKK_1 585 591 PF00454 0.469
MOD_PIKK_1 73 79 PF00454 0.331
MOD_PK_1 172 178 PF00069 0.378
MOD_PK_1 752 758 PF00069 0.512
MOD_PK_1 782 788 PF00069 0.489
MOD_PKA_1 763 769 PF00069 0.594
MOD_PKA_2 296 302 PF00069 0.355
MOD_PKA_2 306 312 PF00069 0.327
MOD_PKA_2 51 57 PF00069 0.301
MOD_PKA_2 546 552 PF00069 0.529
MOD_PKA_2 585 591 PF00069 0.401
MOD_PKA_2 763 769 PF00069 0.594
MOD_PKB_1 295 303 PF00069 0.428
MOD_Plk_1 278 284 PF00069 0.322
MOD_Plk_1 307 313 PF00069 0.301
MOD_Plk_1 338 344 PF00069 0.378
MOD_Plk_1 38 44 PF00069 0.323
MOD_Plk_1 593 599 PF00069 0.662
MOD_Plk_1 611 617 PF00069 0.619
MOD_Plk_1 625 631 PF00069 0.695
MOD_Plk_1 679 685 PF00069 0.447
MOD_Plk_1 752 758 PF00069 0.525
MOD_Plk_1 782 788 PF00069 0.576
MOD_Plk_2-3 646 652 PF00069 0.456
MOD_Plk_4 152 158 PF00069 0.352
MOD_Plk_4 194 200 PF00069 0.398
MOD_Plk_4 225 231 PF00069 0.300
MOD_Plk_4 278 284 PF00069 0.357
MOD_Plk_4 323 329 PF00069 0.424
MOD_ProDKin_1 329 335 PF00069 0.394
MOD_ProDKin_1 769 775 PF00069 0.593
MOD_SUMO_for_1 472 475 PF00179 0.503
MOD_SUMO_rev_2 748 754 PF00179 0.459
MOD_SUMO_rev_2 783 791 PF00179 0.550
TRG_ENDOCYTIC_2 112 115 PF00928 0.288
TRG_ENDOCYTIC_2 16 19 PF00928 0.373
TRG_ENDOCYTIC_2 198 201 PF00928 0.303
TRG_ENDOCYTIC_2 452 455 PF00928 0.545
TRG_ENDOCYTIC_2 723 726 PF00928 0.431
TRG_ER_diArg_1 1 3 PF00400 0.771
TRG_ER_diArg_1 17 20 PF00400 0.330
TRG_ER_diArg_1 260 263 PF00400 0.331
TRG_ER_diArg_1 523 525 PF00400 0.468
TRG_ER_diArg_1 740 742 PF00400 0.444
TRG_ER_diArg_1 773 775 PF00400 0.562
TRG_NES_CRM1_1 543 556 PF08389 0.322
TRG_NLS_MonoExtN_4 48 53 PF00514 0.383
TRG_Pf-PMV_PEXEL_1 301 305 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 435 439 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 503 508 PF00026 0.532
TRG_Pf-PMV_PEXEL_1 524 529 PF00026 0.474
TRG_Pf-PMV_PEXEL_1 774 778 PF00026 0.567
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.319

Homologs

Protein Taxonomy Sequence identity Coverage
A0A068FIK2 Gossypium hirsutum 29% 77%
A0A0N1I5H5 Leptomonas seymouri 27% 67%
A0A0N1IH46 Leptomonas seymouri 77% 100%
A0A0S4IR67 Bodo saltans 27% 100%
A0A0S4JEF6 Bodo saltans 26% 100%
A0A1X0NDZ3 Trypanosomatidae 30% 71%
A0A1X0NP27 Trypanosomatidae 32% 100%
A0A1X0NPH9 Trypanosomatidae 26% 86%
A0A1X0P0C2 Trypanosomatidae 56% 97%
A0A3Q8IBS7 Leishmania donovani 27% 100%
A0A3Q8IG23 Leishmania donovani 28% 67%
A0A3Q8IHG6 Leishmania donovani 32% 100%
A0A3R7KHX7 Trypanosoma rangeli 28% 100%
A0A3R7KM83 Trypanosoma rangeli 29% 72%
A0A3R7RD86 Trypanosoma rangeli 57% 99%
A0A3S5H5N6 Leishmania donovani 25% 100%
A0A3S5IRH3 Trypanosoma rangeli 26% 100%
A0A3S7WU64 Leishmania donovani 87% 92%
A4H8S6 Leishmania braziliensis 83% 76%
A4HIP0 Leishmania braziliensis 26% 67%
A4HSQ9 Leishmania infantum 25% 100%
A4I4V2 Leishmania infantum 32% 100%
A4I562 Leishmania infantum 27% 100%
A4I5Y7 Leishmania infantum 28% 67%
C9ZRB3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 71%
E9AEA0 Leishmania major 32% 100%
E9ALI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AQW0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 75%
E9B0F9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
F4IJK6 Arabidopsis thaliana 29% 73%
Q0DV28 Oryza sativa subsp. japonica 30% 84%
Q4Q0P7 Leishmania major 22% 100%
Q4Q6Y4 Leishmania major 28% 67%
Q4QEL8 Leishmania major 91% 100%
Q5R706 Pongo abelii 29% 100%
Q5W7C6 Oryza sativa subsp. japonica 29% 75%
Q8S905 Arabidopsis thaliana 27% 81%
Q8VWI7 Arabidopsis thaliana 26% 91%
Q9AWM8 Oryza sativa subsp. japonica 27% 83%
Q9SV36 Arabidopsis thaliana 27% 75%
Q9V877 Drosophila melanogaster 25% 100%
V5B325 Trypanosoma cruzi 31% 96%
V5BMP0 Trypanosoma cruzi 58% 100%
V5DNV9 Trypanosoma cruzi 26% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS