Paraflagellar rod protein 2C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 1D - putative

Species:

Leishmania infantum

UniProt:

A4HX40_LEIIN

TriTrypDb:

LINF_160020200

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 41
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	42
GO:0031514	motile cilium	5	42
GO:0042995	cell projection	2	42
GO:0043226	organelle	2	42
GO:0043227	membrane-bounded organelle	3	42
GO:0110165	cellular anatomical entity	1	42
GO:0120025	plasma membrane bounded cell projection	3	42
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3

Expansion

Sequence features

A4HX40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX40

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	42
GO:0005515	protein binding	2	42
GO:0005516	calmodulin binding	3	42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.503
CLV_NRD_NRD_1	132	134	PF00675	0.356
CLV_NRD_NRD_1	185	187	PF00675	0.379
CLV_NRD_NRD_1	208	210	PF00675	0.366
CLV_NRD_NRD_1	219	221	PF00675	0.358
CLV_NRD_NRD_1	292	294	PF00675	0.370
CLV_NRD_NRD_1	397	399	PF00675	0.354
CLV_PCSK_KEX2_1	118	120	PF00082	0.547
CLV_PCSK_KEX2_1	131	133	PF00082	0.310
CLV_PCSK_KEX2_1	161	163	PF00082	0.366
CLV_PCSK_KEX2_1	207	209	PF00082	0.360
CLV_PCSK_KEX2_1	218	220	PF00082	0.366
CLV_PCSK_KEX2_1	292	294	PF00082	0.379
CLV_PCSK_KEX2_1	307	309	PF00082	0.362
CLV_PCSK_KEX2_1	397	399	PF00082	0.370
CLV_PCSK_KEX2_1	424	426	PF00082	0.534
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.572
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.314
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.375
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.369
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.369
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.534
CLV_PCSK_PC7_1	215	221	PF00082	0.389
CLV_PCSK_PC7_1	420	426	PF00082	0.539
CLV_PCSK_SKI1_1	118	122	PF00082	0.511
CLV_PCSK_SKI1_1	132	136	PF00082	0.328
CLV_PCSK_SKI1_1	162	166	PF00082	0.456
CLV_PCSK_SKI1_1	234	238	PF00082	0.365
CLV_PCSK_SKI1_1	440	444	PF00082	0.735
DEG_Nend_UBRbox_2	1	3	PF02207	0.373
DOC_CYCLIN_RxL_1	231	240	PF00134	0.373
DOC_MAPK_gen_1	234	241	PF00069	0.372
DOC_MAPK_gen_1	314	323	PF00069	0.363
DOC_MAPK_MEF2A_6	234	241	PF00069	0.373
DOC_MAPK_MEF2A_6	317	325	PF00069	0.368
DOC_MAPK_NFAT4_5	234	242	PF00069	0.373
DOC_PP4_FxxP_1	383	386	PF00568	0.347
DOC_USP7_UBL2_3	131	135	PF12436	0.347
DOC_USP7_UBL2_3	342	346	PF12436	0.350
LIG_14-3-3_CanoR_1	293	299	PF00244	0.377
LIG_14-3-3_CanoR_1	314	323	PF00244	0.306
LIG_14-3-3_CanoR_1	435	440	PF00244	0.656
LIG_14-3-3_CterR_2	440	444	PF00244	0.501
LIG_Actin_WH2_2	234	251	PF00022	0.483
LIG_APCC_ABBA_1	281	286	PF00400	0.373
LIG_APCC_ABBAyCdc20_2	280	286	PF00400	0.373
LIG_eIF4E_1	80	86	PF01652	0.429
LIG_FHA_1	122	128	PF00498	0.415
LIG_FHA_1	316	322	PF00498	0.323
LIG_FHA_1	424	430	PF00498	0.679
LIG_FHA_2	101	107	PF00498	0.462
LIG_FHA_2	163	169	PF00498	0.412
LIG_FHA_2	265	271	PF00498	0.404
LIG_LIR_Apic_2	382	386	PF02991	0.371
LIG_LIR_Gen_1	109	114	PF02991	0.606
LIG_LIR_Gen_1	200	210	PF02991	0.378
LIG_LIR_Gen_1	222	229	PF02991	0.321
LIG_LIR_Nem_3	109	113	PF02991	0.612
LIG_LIR_Nem_3	182	188	PF02991	0.359
LIG_LIR_Nem_3	200	206	PF02991	0.360
LIG_LIR_Nem_3	222	226	PF02991	0.321
LIG_LIR_Nem_3	289	294	PF02991	0.350
LIG_LIR_Nem_3	95	100	PF02991	0.405
LIG_SH2_CRK	295	299	PF00017	0.383
LIG_SH2_SRC	287	290	PF00017	0.383
LIG_SH2_STAT3	163	166	PF00017	0.458
LIG_SH2_STAT5	287	290	PF00017	0.351
LIG_SH2_STAT5	80	83	PF00017	0.420
LIG_SH3_3	18	24	PF00018	0.551
LIG_SUMO_SIM_par_1	235	240	PF11976	0.373
LIG_TRAF2_1	120	123	PF00917	0.482
LIG_TRAF2_1	272	275	PF00917	0.340
LIG_TRAF2_1	386	389	PF00917	0.350
LIG_TRAF2_1	4	7	PF00917	0.603
LIG_TRAF2_1	409	412	PF00917	0.522
LIG_WRC_WIRS_1	327	332	PF05994	0.349
MOD_CK2_1	100	106	PF00069	0.426
MOD_CK2_1	162	168	PF00069	0.363
MOD_CK2_1	269	275	PF00069	0.341
MOD_Cter_Amidation	129	132	PF01082	0.469
MOD_GlcNHglycan	250	253	PF01048	0.383
MOD_GlcNHglycan	262	265	PF01048	0.319
MOD_GSK3_1	260	267	PF00069	0.377
MOD_N-GLC_1	106	111	PF02516	0.507
MOD_N-GLC_1	33	38	PF02516	0.480
MOD_NEK2_1	121	126	PF00069	0.377
MOD_NEK2_1	237	242	PF00069	0.343
MOD_NEK2_1	248	253	PF00069	0.334
MOD_NEK2_1	294	299	PF00069	0.354
MOD_NEK2_1	33	38	PF00069	0.484
MOD_NEK2_1	423	428	PF00069	0.551
MOD_NEK2_1	8	13	PF00069	0.524
MOD_PIKK_1	113	119	PF00454	0.510
MOD_PIKK_1	162	168	PF00454	0.396
MOD_PIKK_1	428	434	PF00454	0.584
MOD_PIKK_1	8	14	PF00454	0.520
MOD_PKA_1	335	341	PF00069	0.383
MOD_PKA_2	248	254	PF00069	0.397
MOD_PKA_2	316	322	PF00069	0.321
MOD_PKA_2	396	402	PF00069	0.364
MOD_PKA_2	8	14	PF00069	0.514
MOD_Plk_1	106	112	PF00069	0.530
MOD_Plk_1	237	243	PF00069	0.401
MOD_Plk_1	33	39	PF00069	0.488
MOD_Plk_2-3	106	112	PF00069	0.389
MOD_Plk_2-3	141	147	PF00069	0.447
MOD_Plk_4	237	243	PF00069	0.365
MOD_Plk_4	33	39	PF00069	0.501
MOD_SUMO_for_1	340	343	PF00179	0.371
MOD_SUMO_for_1	409	412	PF00179	0.534
MOD_SUMO_rev_2	104	110	PF00179	0.450
MOD_SUMO_rev_2	412	417	PF00179	0.499
MOD_SUMO_rev_2	419	426	PF00179	0.536
TRG_DiLeu_BaEn_2	221	227	PF01217	0.373
TRG_DiLeu_BaEn_3	352	358	PF01217	0.375
TRG_DiLeu_BaEn_4	274	280	PF01217	0.419
TRG_DiLeu_BaEn_4	353	359	PF01217	0.360
TRG_ENDOCYTIC_2	223	226	PF00928	0.300
TRG_ENDOCYTIC_2	295	298	PF00928	0.345
TRG_ER_diArg_1	132	134	PF00400	0.369
TRG_ER_diArg_1	208	210	PF00400	0.353
TRG_ER_diArg_1	218	220	PF00400	0.350
TRG_ER_diArg_1	291	293	PF00400	0.383
TRG_NES_CRM1_1	87	102	PF08389	0.409
TRG_NLS_Bipartite_1	118	135	PF00514	0.383
TRG_NLS_MonoExtC_3	130	135	PF00514	0.373
TRG_NLS_MonoExtN_4	128	135	PF00514	0.373
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	65%	75%
A0A0N0P573	Leptomonas seymouri	26%	73%
A0A0N1IFZ5	Leptomonas seymouri	95%	74%
A0A0S4ITZ0	Bodo saltans	22%	75%
A0A0S4IW44	Bodo saltans	29%	67%
A0A0S4IZY8	Bodo saltans	82%	76%
A0A0S4J013	Bodo saltans	29%	68%
A0A0S4J193	Bodo saltans	29%	72%
A0A0S4JS20	Bodo saltans	68%	77%
A0A1X0NYU4	Trypanosomatidae	85%	74%
A0A1X0P0B7	Trypanosomatidae	67%	75%
A0A381MH18	Leishmania infantum	100%	100%
A0A381MN58	Leishmania infantum	65%	100%
A0A3Q8IAP5	Leishmania donovani	100%	74%
A0A3Q8IEH2	Leishmania donovani	65%	75%
A0A3R7KDB9	Trypanosoma rangeli	85%	74%
A0A3R7NHV7	Trypanosoma rangeli	30%	69%
A0A3R7P0W8	Trypanosoma rangeli	22%	75%
A0A3S5IRI8	Trypanosoma rangeli	67%	75%
A0A3S7WQV4	Leishmania donovani	23%	73%
A0A3S7X2K1	Leishmania donovani	65%	75%
A4H5W0	Leishmania braziliensis	24%	100%
A4H8S1	Leishmania braziliensis	95%	100%
A4H8S2	Leishmania braziliensis	93%	100%
A4HIY0	Leishmania braziliensis	64%	100%
A4HU55	Leishmania infantum	23%	73%
C9ZLC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	75%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	87%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	74%
E9AE36	Leishmania major	65%	100%
E9AE37	Leishmania major	65%	100%
E9AHJ2	Leishmania infantum	65%	75%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9AMY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	73%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	66%
P22225	Trypanosoma brucei brucei	83%	74%
Q26789	Trypanosoma brucei brucei	65%	75%
Q4QEM2	Leishmania major	99%	100%
Q4QHP3	Leishmania major	22%	73%
V5BDF9	Trypanosoma cruzi	24%	74%
V5BDW8	Trypanosoma cruzi	67%	75%