LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HX38_LEIIN
TriTrypDb:
LINF_160020100
Length:
356

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HX38
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX38

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 103 105 PF00675 0.586
CLV_NRD_NRD_1 12 14 PF00675 0.640
CLV_NRD_NRD_1 312 314 PF00675 0.450
CLV_NRD_NRD_1 95 97 PF00675 0.566
CLV_PCSK_KEX2_1 102 104 PF00082 0.475
CLV_PCSK_KEX2_1 12 14 PF00082 0.640
CLV_PCSK_KEX2_1 120 122 PF00082 0.471
CLV_PCSK_KEX2_1 95 97 PF00082 0.458
CLV_PCSK_PC1ET2_1 102 104 PF00082 0.457
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.471
CLV_PCSK_PC1ET2_1 95 97 PF00082 0.435
CLV_PCSK_SKI1_1 191 195 PF00082 0.426
CLV_PCSK_SKI1_1 26 30 PF00082 0.650
CLV_PCSK_SKI1_1 299 303 PF00082 0.440
CLV_PCSK_SKI1_1 313 317 PF00082 0.371
CLV_PCSK_SKI1_1 43 47 PF00082 0.356
DOC_MAPK_gen_1 146 155 PF00069 0.528
DOC_MAPK_gen_1 50 58 PF00069 0.551
DOC_MAPK_MEF2A_6 236 244 PF00069 0.502
DOC_PP1_RVXF_1 297 304 PF00149 0.463
DOC_USP7_MATH_1 36 40 PF00917 0.587
DOC_USP7_UBL2_3 120 124 PF12436 0.611
DOC_USP7_UBL2_3 146 150 PF12436 0.563
DOC_USP7_UBL2_3 187 191 PF12436 0.449
DOC_WW_Pin1_4 317 322 PF00397 0.559
LIG_14-3-3_CanoR_1 26 34 PF00244 0.581
LIG_14-3-3_CanoR_1 3 7 PF00244 0.664
LIG_BRCT_BRCA1_1 19 23 PF00533 0.637
LIG_EH1_1 223 231 PF00400 0.367
LIG_FHA_1 320 326 PF00498 0.426
LIG_FHA_1 61 67 PF00498 0.482
LIG_FHA_2 139 145 PF00498 0.599
LIG_FHA_2 246 252 PF00498 0.493
LIG_LIR_Nem_3 33 37 PF02991 0.530
LIG_LIR_Nem_3 88 92 PF02991 0.509
LIG_SH2_CRK 298 302 PF00017 0.470
LIG_SH2_STAP1 78 82 PF00017 0.489
LIG_SH2_STAT5 283 286 PF00017 0.561
LIG_SH2_STAT5 34 37 PF00017 0.510
LIG_SH2_STAT5 44 47 PF00017 0.415
LIG_SH3_3 285 291 PF00018 0.492
LIG_SH3_3 298 304 PF00018 0.383
LIG_SUMO_SIM_anti_2 328 334 PF11976 0.424
LIG_SUMO_SIM_par_1 238 243 PF11976 0.552
LIG_SUMO_SIM_par_1 253 259 PF11976 0.404
LIG_SUMO_SIM_par_1 328 334 PF11976 0.418
LIG_TRFH_1 58 62 PF08558 0.544
LIG_UBA3_1 178 187 PF00899 0.429
LIG_WRC_WIRS_1 338 343 PF05994 0.421
MOD_CK1_1 17 23 PF00069 0.652
MOD_CK1_1 243 249 PF00069 0.528
MOD_CK1_1 39 45 PF00069 0.456
MOD_CK2_1 138 144 PF00069 0.584
MOD_GlcNHglycan 16 19 PF01048 0.540
MOD_GlcNHglycan 162 165 PF01048 0.452
MOD_GlcNHglycan 226 229 PF01048 0.498
MOD_GlcNHglycan 248 251 PF01048 0.360
MOD_GlcNHglycan 271 274 PF01048 0.535
MOD_GlcNHglycan 335 338 PF01048 0.416
MOD_GlcNHglycan 7 10 PF01048 0.624
MOD_GSK3_1 220 227 PF00069 0.450
MOD_GSK3_1 32 39 PF00069 0.569
MOD_GSK3_1 333 340 PF00069 0.443
MOD_GSK3_1 7 14 PF00069 0.637
MOD_N-GLC_1 199 204 PF02516 0.514
MOD_N-GLC_1 224 229 PF02516 0.490
MOD_NEK2_1 189 194 PF00069 0.378
MOD_NEK2_1 224 229 PF00069 0.458
MOD_NEK2_1 333 338 PF00069 0.492
MOD_NEK2_1 341 346 PF00069 0.349
MOD_NEK2_1 7 12 PF00069 0.619
MOD_PKA_2 11 17 PF00069 0.595
MOD_PKA_2 2 8 PF00069 0.632
MOD_PKA_2 235 241 PF00069 0.389
MOD_Plk_1 224 230 PF00069 0.510
MOD_Plk_1 240 246 PF00069 0.364
MOD_Plk_1 32 38 PF00069 0.522
MOD_Plk_4 148 154 PF00069 0.598
MOD_Plk_4 2 8 PF00069 0.651
MOD_Plk_4 235 241 PF00069 0.465
MOD_ProDKin_1 317 323 PF00069 0.555
MOD_SUMO_for_1 286 289 PF00179 0.573
MOD_SUMO_rev_2 249 255 PF00179 0.346
TRG_DiLeu_BaEn_2 84 90 PF01217 0.531
TRG_ENDOCYTIC_2 298 301 PF00928 0.476
TRG_ENDOCYTIC_2 335 338 PF00928 0.486
TRG_ENDOCYTIC_2 78 81 PF00928 0.492
TRG_ER_diArg_1 11 13 PF00400 0.625
TRG_ER_diArg_1 49 52 PF00400 0.420
TRG_NES_CRM1_1 144 156 PF08389 0.563

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBL8 Leptomonas seymouri 63% 69%
A0A1X0NYW3 Trypanosomatidae 42% 100%
A0A3R7JY16 Trypanosoma rangeli 36% 94%
A0A3S7WU51 Leishmania donovani 100% 100%
A4H8S0 Leishmania braziliensis 81% 100%
E9AQV4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QEM4 Leishmania major 95% 100%
V5BMN4 Trypanosoma cruzi 40% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS