LeishMANIAdb
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DNA-directed RNA polymerase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA-directed RNA polymerase
Gene product:
DNA-directed rna polymerase I largest subunit - putative
Species:
Leishmania infantum
UniProt:
A4HX31_LEIIN
TriTrypDb:
LINF_160019300
Length:
1810

Annotations

Annotations by Jardim et al.

Polymerase, DNA-directed RNA polymerase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000428 DNA-directed RNA polymerase complex 4 12
GO:0005634 nucleus 5 11
GO:0030880 RNA polymerase complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 12
GO:0110165 cellular anatomical entity 1 11
GO:0140535 intracellular protein-containing complex 2 12
GO:1902494 catalytic complex 2 12
GO:1990234 transferase complex 3 12
GO:0005736 RNA polymerase I complex 4 1
GO:0055029 nuclear DNA-directed RNA polymerase complex 3 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4HX31
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX31

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006351 DNA-templated transcription 7 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009059 macromolecule biosynthetic process 4 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0018130 heterocycle biosynthetic process 4 12
GO:0019438 aromatic compound biosynthetic process 4 12
GO:0032774 RNA biosynthetic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034654 nucleobase-containing compound biosynthetic process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:0097659 nucleic acid-templated transcription 6 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6 12
GO:0005488 binding 1 12
GO:0008270 zinc ion binding 6 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0034062 5'-3' RNA polymerase activity 5 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0046914 transition metal ion binding 5 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097747 RNA polymerase activity 4 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1063 1067 PF00656 0.388
CLV_C14_Caspase3-7 1491 1495 PF00656 0.470
CLV_C14_Caspase3-7 1518 1522 PF00656 0.352
CLV_C14_Caspase3-7 712 716 PF00656 0.393
CLV_NRD_NRD_1 1103 1105 PF00675 0.271
CLV_NRD_NRD_1 117 119 PF00675 0.483
CLV_NRD_NRD_1 1220 1222 PF00675 0.249
CLV_NRD_NRD_1 1501 1503 PF00675 0.291
CLV_NRD_NRD_1 1511 1513 PF00675 0.163
CLV_NRD_NRD_1 1638 1640 PF00675 0.234
CLV_NRD_NRD_1 200 202 PF00675 0.505
CLV_NRD_NRD_1 224 226 PF00675 0.495
CLV_NRD_NRD_1 23 25 PF00675 0.484
CLV_NRD_NRD_1 266 268 PF00675 0.394
CLV_NRD_NRD_1 340 342 PF00675 0.503
CLV_NRD_NRD_1 590 592 PF00675 0.188
CLV_NRD_NRD_1 64 66 PF00675 0.532
CLV_NRD_NRD_1 820 822 PF00675 0.255
CLV_NRD_NRD_1 900 902 PF00675 0.328
CLV_NRD_NRD_1 981 983 PF00675 0.210
CLV_PCSK_FUR_1 1199 1203 PF00082 0.217
CLV_PCSK_FUR_1 196 200 PF00082 0.505
CLV_PCSK_FUR_1 982 986 PF00082 0.188
CLV_PCSK_KEX2_1 1000 1002 PF00082 0.158
CLV_PCSK_KEX2_1 1130 1132 PF00082 0.226
CLV_PCSK_KEX2_1 117 119 PF00082 0.483
CLV_PCSK_KEX2_1 1201 1203 PF00082 0.197
CLV_PCSK_KEX2_1 1219 1221 PF00082 0.152
CLV_PCSK_KEX2_1 1500 1502 PF00082 0.273
CLV_PCSK_KEX2_1 1710 1712 PF00082 0.228
CLV_PCSK_KEX2_1 1757 1759 PF00082 0.328
CLV_PCSK_KEX2_1 198 200 PF00082 0.480
CLV_PCSK_KEX2_1 223 225 PF00082 0.481
CLV_PCSK_KEX2_1 340 342 PF00082 0.377
CLV_PCSK_KEX2_1 504 506 PF00082 0.188
CLV_PCSK_KEX2_1 553 555 PF00082 0.210
CLV_PCSK_KEX2_1 590 592 PF00082 0.188
CLV_PCSK_KEX2_1 64 66 PF00082 0.532
CLV_PCSK_KEX2_1 900 902 PF00082 0.315
CLV_PCSK_KEX2_1 981 983 PF00082 0.191
CLV_PCSK_KEX2_1 984 986 PF00082 0.185
CLV_PCSK_PC1ET2_1 1000 1002 PF00082 0.165
CLV_PCSK_PC1ET2_1 1130 1132 PF00082 0.199
CLV_PCSK_PC1ET2_1 1201 1203 PF00082 0.209
CLV_PCSK_PC1ET2_1 1710 1712 PF00082 0.228
CLV_PCSK_PC1ET2_1 1757 1759 PF00082 0.371
CLV_PCSK_PC1ET2_1 504 506 PF00082 0.188
CLV_PCSK_PC1ET2_1 553 555 PF00082 0.210
CLV_PCSK_PC1ET2_1 984 986 PF00082 0.196
CLV_PCSK_PC7_1 196 202 PF00082 0.617
CLV_PCSK_SKI1_1 1146 1150 PF00082 0.293
CLV_PCSK_SKI1_1 1270 1274 PF00082 0.188
CLV_PCSK_SKI1_1 1360 1364 PF00082 0.243
CLV_PCSK_SKI1_1 1659 1663 PF00082 0.218
CLV_PCSK_SKI1_1 1673 1677 PF00082 0.210
CLV_PCSK_SKI1_1 1699 1703 PF00082 0.215
CLV_PCSK_SKI1_1 1707 1711 PF00082 0.205
CLV_PCSK_SKI1_1 1757 1761 PF00082 0.395
CLV_PCSK_SKI1_1 268 272 PF00082 0.446
CLV_PCSK_SKI1_1 279 283 PF00082 0.269
CLV_PCSK_SKI1_1 396 400 PF00082 0.268
CLV_PCSK_SKI1_1 40 44 PF00082 0.378
CLV_PCSK_SKI1_1 533 537 PF00082 0.281
CLV_PCSK_SKI1_1 548 552 PF00082 0.175
CLV_PCSK_SKI1_1 610 614 PF00082 0.191
CLV_PCSK_SKI1_1 901 905 PF00082 0.451
CLV_PCSK_SKI1_1 981 985 PF00082 0.270
DOC_CKS1_1 1334 1339 PF01111 0.413
DOC_CKS1_1 1447 1452 PF01111 0.493
DOC_CKS1_1 58 63 PF01111 0.342
DOC_CYCLIN_RxL_1 1142 1152 PF00134 0.493
DOC_CYCLIN_RxL_1 1267 1277 PF00134 0.388
DOC_CYCLIN_RxL_1 529 539 PF00134 0.388
DOC_CYCLIN_yCln2_LP_2 404 407 PF00134 0.263
DOC_MAPK_DCC_7 402 410 PF00069 0.275
DOC_MAPK_gen_1 1569 1575 PF00069 0.481
DOC_MAPK_gen_1 24 32 PF00069 0.401
DOC_MAPK_gen_1 267 273 PF00069 0.457
DOC_MAPK_MEF2A_6 1280 1287 PF00069 0.428
DOC_MAPK_MEF2A_6 24 32 PF00069 0.378
DOC_MAPK_MEF2A_6 40 48 PF00069 0.300
DOC_MAPK_MEF2A_6 402 410 PF00069 0.275
DOC_MAPK_MEF2A_6 767 774 PF00069 0.375
DOC_MAPK_RevD_3 11 25 PF00069 0.467
DOC_MAPK_RevD_3 211 225 PF00069 0.456
DOC_PP1_RVXF_1 38 44 PF00149 0.444
DOC_PP1_RVXF_1 394 400 PF00149 0.287
DOC_PP1_RVXF_1 531 538 PF00149 0.388
DOC_PP1_RVXF_1 641 648 PF00149 0.388
DOC_PP2B_LxvP_1 381 384 PF13499 0.433
DOC_PP2B_LxvP_1 403 406 PF13499 0.268
DOC_PP2B_LxvP_1 583 586 PF13499 0.398
DOC_PP2B_LxvP_1 913 916 PF13499 0.350
DOC_PP4_FxxP_1 155 158 PF00568 0.255
DOC_PP4_FxxP_1 266 269 PF00568 0.446
DOC_SPAK_OSR1_1 154 158 PF12202 0.410
DOC_USP7_MATH_1 1067 1071 PF00917 0.493
DOC_USP7_MATH_1 123 127 PF00917 0.502
DOC_USP7_MATH_1 1496 1500 PF00917 0.485
DOC_USP7_MATH_1 1548 1552 PF00917 0.428
DOC_USP7_MATH_1 281 285 PF00917 0.432
DOC_USP7_MATH_1 450 454 PF00917 0.482
DOC_USP7_MATH_1 509 513 PF00917 0.388
DOC_USP7_MATH_1 959 963 PF00917 0.388
DOC_USP7_UBL2_3 1197 1201 PF12436 0.401
DOC_WW_Pin1_4 1333 1338 PF00397 0.502
DOC_WW_Pin1_4 1446 1451 PF00397 0.432
DOC_WW_Pin1_4 1506 1511 PF00397 0.465
DOC_WW_Pin1_4 1743 1748 PF00397 0.454
DOC_WW_Pin1_4 296 301 PF00397 0.298
DOC_WW_Pin1_4 451 456 PF00397 0.386
DOC_WW_Pin1_4 512 517 PF00397 0.388
DOC_WW_Pin1_4 542 547 PF00397 0.493
DOC_WW_Pin1_4 57 62 PF00397 0.405
LIG_14-3-3_CanoR_1 1001 1006 PF00244 0.418
LIG_14-3-3_CanoR_1 1011 1018 PF00244 0.313
LIG_14-3-3_CanoR_1 1085 1090 PF00244 0.493
LIG_14-3-3_CanoR_1 129 133 PF00244 0.409
LIG_14-3-3_CanoR_1 1309 1317 PF00244 0.493
LIG_14-3-3_CanoR_1 1332 1337 PF00244 0.479
LIG_14-3-3_CanoR_1 1342 1352 PF00244 0.432
LIG_14-3-3_CanoR_1 1443 1450 PF00244 0.456
LIG_14-3-3_CanoR_1 1659 1668 PF00244 0.414
LIG_14-3-3_CanoR_1 1681 1688 PF00244 0.419
LIG_14-3-3_CanoR_1 17 22 PF00244 0.467
LIG_14-3-3_CanoR_1 1711 1715 PF00244 0.405
LIG_14-3-3_CanoR_1 1758 1768 PF00244 0.320
LIG_14-3-3_CanoR_1 301 309 PF00244 0.376
LIG_14-3-3_CanoR_1 341 349 PF00244 0.353
LIG_14-3-3_CanoR_1 350 354 PF00244 0.299
LIG_14-3-3_CanoR_1 411 418 PF00244 0.340
LIG_14-3-3_CanoR_1 431 440 PF00244 0.171
LIG_14-3-3_CanoR_1 457 466 PF00244 0.385
LIG_14-3-3_CanoR_1 533 538 PF00244 0.388
LIG_14-3-3_CanoR_1 875 880 PF00244 0.493
LIG_14-3-3_CanoR_1 900 908 PF00244 0.465
LIG_Actin_WH2_2 1787 1804 PF00022 0.389
LIG_Actin_WH2_2 396 413 PF00022 0.276
LIG_APCC_ABBA_1 1166 1171 PF00400 0.352
LIG_BIR_II_1 1 5 PF00653 0.385
LIG_BIR_III_4 1066 1070 PF00653 0.493
LIG_BIR_III_4 245 249 PF00653 0.466
LIG_BRCT_BRCA1_1 1745 1749 PF00533 0.296
LIG_BRCT_BRCA1_1 1755 1759 PF00533 0.326
LIG_CaM_IQ_9 893 908 PF13499 0.351
LIG_CSL_BTD_1 58 61 PF09270 0.335
LIG_DLG_GKlike_1 1001 1009 PF00625 0.388
LIG_EH1_1 397 405 PF00400 0.346
LIG_eIF4E_1 1716 1722 PF01652 0.493
LIG_FHA_1 1011 1017 PF00498 0.451
LIG_FHA_1 1084 1090 PF00498 0.493
LIG_FHA_1 1108 1114 PF00498 0.381
LIG_FHA_1 1261 1267 PF00498 0.388
LIG_FHA_1 1351 1357 PF00498 0.454
LIG_FHA_1 1380 1386 PF00498 0.398
LIG_FHA_1 1447 1453 PF00498 0.469
LIG_FHA_1 1559 1565 PF00498 0.523
LIG_FHA_1 16 22 PF00498 0.445
LIG_FHA_1 1660 1666 PF00498 0.444
LIG_FHA_1 1736 1742 PF00498 0.398
LIG_FHA_1 1763 1769 PF00498 0.393
LIG_FHA_1 1787 1793 PF00498 0.351
LIG_FHA_1 327 333 PF00498 0.360
LIG_FHA_1 349 355 PF00498 0.421
LIG_FHA_1 428 434 PF00498 0.297
LIG_FHA_1 482 488 PF00498 0.458
LIG_FHA_1 576 582 PF00498 0.493
LIG_FHA_1 58 64 PF00498 0.343
LIG_FHA_1 747 753 PF00498 0.467
LIG_FHA_1 776 782 PF00498 0.493
LIG_FHA_1 796 802 PF00498 0.402
LIG_FHA_1 811 817 PF00498 0.398
LIG_FHA_1 836 842 PF00498 0.493
LIG_FHA_1 900 906 PF00498 0.465
LIG_FHA_1 962 968 PF00498 0.453
LIG_FHA_2 1112 1118 PF00498 0.455
LIG_FHA_2 1289 1295 PF00498 0.410
LIG_FHA_2 1322 1328 PF00498 0.397
LIG_FHA_2 1412 1418 PF00498 0.535
LIG_FHA_2 1540 1546 PF00498 0.393
LIG_FHA_2 1628 1634 PF00498 0.523
LIG_FHA_2 1643 1649 PF00498 0.374
LIG_FHA_2 18 24 PF00498 0.582
LIG_FHA_2 32 38 PF00498 0.289
LIG_FHA_2 460 466 PF00498 0.365
LIG_FHA_2 534 540 PF00498 0.493
LIG_FHA_2 565 571 PF00498 0.388
LIG_FHA_2 69 75 PF00498 0.285
LIG_FHA_2 710 716 PF00498 0.388
LIG_FHA_2 805 811 PF00498 0.442
LIG_GBD_Chelix_1 1306 1314 PF00786 0.210
LIG_KLC1_Yacidic_2 1167 1171 PF13176 0.387
LIG_LIR_Apic_2 263 269 PF02991 0.467
LIG_LIR_Gen_1 1020 1027 PF02991 0.417
LIG_LIR_Gen_1 1555 1564 PF02991 0.423
LIG_LIR_Gen_1 159 168 PF02991 0.394
LIG_LIR_Gen_1 1630 1637 PF02991 0.460
LIG_LIR_Gen_1 1662 1672 PF02991 0.430
LIG_LIR_Gen_1 1713 1723 PF02991 0.516
LIG_LIR_Gen_1 480 491 PF02991 0.332
LIG_LIR_Gen_1 577 588 PF02991 0.410
LIG_LIR_Gen_1 644 655 PF02991 0.388
LIG_LIR_Gen_1 722 731 PF02991 0.399
LIG_LIR_LC3C_4 1054 1058 PF02991 0.428
LIG_LIR_Nem_3 1555 1559 PF02991 0.390
LIG_LIR_Nem_3 1630 1635 PF02991 0.460
LIG_LIR_Nem_3 1662 1667 PF02991 0.430
LIG_LIR_Nem_3 1695 1701 PF02991 0.401
LIG_LIR_Nem_3 1706 1712 PF02991 0.404
LIG_LIR_Nem_3 1713 1719 PF02991 0.398
LIG_LIR_Nem_3 284 288 PF02991 0.366
LIG_LIR_Nem_3 391 397 PF02991 0.292
LIG_LIR_Nem_3 444 449 PF02991 0.293
LIG_LIR_Nem_3 480 486 PF02991 0.313
LIG_LIR_Nem_3 536 540 PF02991 0.493
LIG_LIR_Nem_3 577 583 PF02991 0.410
LIG_LIR_Nem_3 644 650 PF02991 0.390
LIG_LIR_Nem_3 722 726 PF02991 0.399
LIG_LIR_Nem_3 868 873 PF02991 0.436
LIG_NRBOX 1268 1274 PF00104 0.388
LIG_PCNA_TLS_4 1163 1170 PF02747 0.387
LIG_PCNA_yPIPBox_3 1065 1075 PF02747 0.458
LIG_PCNA_yPIPBox_3 473 483 PF02747 0.309
LIG_PCNA_yPIPBox_3 843 857 PF02747 0.453
LIG_Pex14_1 1628 1632 PF04695 0.410
LIG_Pex14_2 151 155 PF04695 0.280
LIG_Pex14_2 1664 1668 PF04695 0.410
LIG_Pex14_2 1749 1753 PF04695 0.284
LIG_Pex14_2 349 353 PF04695 0.452
LIG_REV1ctd_RIR_1 148 157 PF16727 0.270
LIG_REV1ctd_RIR_1 309 320 PF16727 0.290
LIG_REV1ctd_RIR_1 396 405 PF16727 0.257
LIG_SH2_CRK 110 114 PF00017 0.442
LIG_SH2_CRK 1275 1279 PF00017 0.453
LIG_SH2_CRK 1698 1702 PF00017 0.398
LIG_SH2_CRK 728 732 PF00017 0.453
LIG_SH2_CRK 948 952 PF00017 0.352
LIG_SH2_GRB2like 649 652 PF00017 0.388
LIG_SH2_NCK_1 1275 1279 PF00017 0.453
LIG_SH2_SRC 1007 1010 PF00017 0.305
LIG_SH2_SRC 649 652 PF00017 0.388
LIG_SH2_STAP1 1021 1025 PF00017 0.388
LIG_SH2_STAP1 1488 1492 PF00017 0.393
LIG_SH2_STAP1 1637 1641 PF00017 0.493
LIG_SH2_STAP1 1712 1716 PF00017 0.465
LIG_SH2_STAP1 385 389 PF00017 0.419
LIG_SH2_STAP1 483 487 PF00017 0.401
LIG_SH2_STAP1 73 77 PF00017 0.322
LIG_SH2_STAT5 1021 1024 PF00017 0.388
LIG_SH2_STAT5 112 115 PF00017 0.436
LIG_SH2_STAT5 1169 1172 PF00017 0.398
LIG_SH2_STAT5 12 15 PF00017 0.444
LIG_SH2_STAT5 1225 1228 PF00017 0.486
LIG_SH2_STAT5 1637 1640 PF00017 0.493
LIG_SH2_STAT5 348 351 PF00017 0.297
LIG_SH2_STAT5 447 450 PF00017 0.448
LIG_SH2_STAT5 483 486 PF00017 0.464
LIG_SH2_STAT5 518 521 PF00017 0.493
LIG_SH2_STAT5 597 600 PF00017 0.410
LIG_SH2_STAT5 649 652 PF00017 0.388
LIG_SH2_STAT5 688 691 PF00017 0.398
LIG_SH2_STAT5 776 779 PF00017 0.428
LIG_SH2_STAT5 806 809 PF00017 0.453
LIG_SH3_1 117 123 PF00018 0.394
LIG_SH3_1 55 61 PF00018 0.341
LIG_SH3_2 120 125 PF14604 0.479
LIG_SH3_2 406 411 PF14604 0.282
LIG_SH3_3 117 123 PF00018 0.387
LIG_SH3_3 129 135 PF00018 0.332
LIG_SH3_3 1586 1592 PF00018 0.481
LIG_SH3_3 224 230 PF00018 0.443
LIG_SH3_3 403 409 PF00018 0.277
LIG_SH3_3 510 516 PF00018 0.388
LIG_SH3_3 522 528 PF00018 0.388
LIG_SH3_3 55 61 PF00018 0.341
LIG_SH3_3 754 760 PF00018 0.398
LIG_SUMO_SIM_anti_2 128 134 PF11976 0.407
LIG_SUMO_SIM_anti_2 1353 1359 PF11976 0.410
LIG_SUMO_SIM_anti_2 29 37 PF11976 0.333
LIG_SUMO_SIM_anti_2 848 855 PF11976 0.393
LIG_SUMO_SIM_par_1 210 216 PF11976 0.481
LIG_SUMO_SIM_par_1 709 715 PF11976 0.398
LIG_SUMO_SIM_par_1 909 919 PF11976 0.558
LIG_TRAF2_1 1114 1117 PF00917 0.493
LIG_TRAF2_1 462 465 PF00917 0.432
LIG_TYR_ITIM 1273 1278 PF00017 0.453
LIG_TYR_ITIM 1714 1719 PF00017 0.493
LIG_UBA3_1 1701 1710 PF00899 0.453
LIG_UBA3_1 496 504 PF00899 0.321
LIG_UBA3_1 751 759 PF00899 0.431
LIG_UBA3_1 836 843 PF00899 0.428
LIG_WRC_WIRS_1 1249 1254 PF05994 0.388
LIG_WRC_WIRS_1 1378 1383 PF05994 0.398
LIG_WRC_WIRS_1 282 287 PF05994 0.454
LIG_WW_2 230 233 PF00397 0.475
LIG_WW_2 406 409 PF00397 0.272
LIG_WW_3 1509 1513 PF00397 0.352
MOD_CDC14_SPxK_1 1509 1512 PF00782 0.489
MOD_CDC14_SPxK_1 545 548 PF00782 0.493
MOD_CDK_SPK_2 296 301 PF00069 0.311
MOD_CDK_SPxK_1 1506 1512 PF00069 0.493
MOD_CDK_SPxK_1 451 457 PF00069 0.392
MOD_CDK_SPxK_1 542 548 PF00069 0.493
MOD_CDK_SPxxK_3 1506 1513 PF00069 0.493
MOD_CDK_SPxxK_3 57 64 PF00069 0.341
MOD_CK1_1 1124 1130 PF00069 0.479
MOD_CK1_1 1254 1260 PF00069 0.389
MOD_CK1_1 1456 1462 PF00069 0.476
MOD_CK1_1 1480 1486 PF00069 0.523
MOD_CK1_1 1601 1607 PF00069 0.551
MOD_CK1_1 1627 1633 PF00069 0.446
MOD_CK1_1 1654 1660 PF00069 0.440
MOD_CK1_1 1774 1780 PF00069 0.325
MOD_CK1_1 2 8 PF00069 0.390
MOD_CK1_1 26 32 PF00069 0.381
MOD_CK1_1 388 394 PF00069 0.395
MOD_CK1_1 512 518 PF00069 0.388
MOD_CK1_1 542 548 PF00069 0.479
MOD_CK1_1 575 581 PF00069 0.491
MOD_CK1_1 804 810 PF00069 0.426
MOD_CK1_1 849 855 PF00069 0.384
MOD_CK1_1 988 994 PF00069 0.388
MOD_CK2_1 1111 1117 PF00069 0.446
MOD_CK2_1 1370 1376 PF00069 0.394
MOD_CK2_1 1397 1403 PF00069 0.453
MOD_CK2_1 1431 1437 PF00069 0.491
MOD_CK2_1 1512 1518 PF00069 0.501
MOD_CK2_1 1539 1545 PF00069 0.393
MOD_CK2_1 1642 1648 PF00069 0.428
MOD_CK2_1 17 23 PF00069 0.638
MOD_CK2_1 281 287 PF00069 0.438
MOD_CK2_1 450 456 PF00069 0.400
MOD_CK2_1 459 465 PF00069 0.365
MOD_CK2_1 533 539 PF00069 0.388
MOD_CK2_1 564 570 PF00069 0.388
MOD_Cter_Amidation 1102 1105 PF01082 0.210
MOD_Cter_Amidation 1128 1131 PF01082 0.210
MOD_Cter_Amidation 502 505 PF01082 0.217
MOD_Cter_Amidation 979 982 PF01082 0.210
MOD_GlcNHglycan 1013 1016 PF01048 0.302
MOD_GlcNHglycan 1041 1044 PF01048 0.188
MOD_GlcNHglycan 1253 1256 PF01048 0.198
MOD_GlcNHglycan 1345 1348 PF01048 0.326
MOD_GlcNHglycan 1480 1483 PF01048 0.331
MOD_GlcNHglycan 1550 1553 PF01048 0.327
MOD_GlcNHglycan 1617 1620 PF01048 0.279
MOD_GlcNHglycan 1645 1648 PF01048 0.195
MOD_GlcNHglycan 1654 1657 PF01048 0.195
MOD_GlcNHglycan 1695 1698 PF01048 0.210
MOD_GlcNHglycan 1743 1746 PF01048 0.263
MOD_GlcNHglycan 1776 1779 PF01048 0.309
MOD_GlcNHglycan 236 239 PF01048 0.577
MOD_GlcNHglycan 25 28 PF01048 0.509
MOD_GlcNHglycan 365 368 PF01048 0.407
MOD_GlcNHglycan 413 416 PF01048 0.361
MOD_GlcNHglycan 420 423 PF01048 0.373
MOD_GlcNHglycan 574 577 PF01048 0.253
MOD_GlcNHglycan 639 642 PF01048 0.188
MOD_GlcNHglycan 692 695 PF01048 0.188
MOD_GlcNHglycan 742 745 PF01048 0.243
MOD_GlcNHglycan 909 912 PF01048 0.314
MOD_GlcNHglycan 956 959 PF01048 0.188
MOD_GlcNHglycan 987 990 PF01048 0.198
MOD_GSK3_1 1032 1039 PF00069 0.388
MOD_GSK3_1 1107 1114 PF00069 0.453
MOD_GSK3_1 1211 1218 PF00069 0.428
MOD_GSK3_1 1241 1248 PF00069 0.388
MOD_GSK3_1 1251 1258 PF00069 0.388
MOD_GSK3_1 1343 1350 PF00069 0.438
MOD_GSK3_1 1377 1384 PF00069 0.464
MOD_GSK3_1 1412 1419 PF00069 0.476
MOD_GSK3_1 1442 1449 PF00069 0.407
MOD_GSK3_1 1452 1459 PF00069 0.390
MOD_GSK3_1 1535 1542 PF00069 0.528
MOD_GSK3_1 1548 1555 PF00069 0.452
MOD_GSK3_1 1598 1605 PF00069 0.417
MOD_GSK3_1 1627 1634 PF00069 0.415
MOD_GSK3_1 1735 1742 PF00069 0.422
MOD_GSK3_1 1749 1756 PF00069 0.284
MOD_GSK3_1 28 35 PF00069 0.386
MOD_GSK3_1 296 303 PF00069 0.311
MOD_GSK3_1 344 351 PF00069 0.403
MOD_GSK3_1 427 434 PF00069 0.306
MOD_GSK3_1 477 484 PF00069 0.371
MOD_GSK3_1 637 644 PF00069 0.388
MOD_GSK3_1 68 75 PF00069 0.387
MOD_GSK3_1 740 747 PF00069 0.463
MOD_GSK3_1 787 794 PF00069 0.405
MOD_GSK3_1 801 808 PF00069 0.377
MOD_GSK3_1 831 838 PF00069 0.453
MOD_GSK3_1 845 852 PF00069 0.453
MOD_GSK3_1 88 95 PF00069 0.227
MOD_GSK3_1 907 914 PF00069 0.289
MOD_GSK3_1 950 957 PF00069 0.488
MOD_N-GLC_1 1067 1072 PF02516 0.188
MOD_N-GLC_1 123 128 PF02516 0.446
MOD_N-GLC_1 1505 1510 PF02516 0.238
MOD_N-GLC_1 1598 1603 PF02516 0.217
MOD_N-GLC_1 1735 1740 PF02516 0.198
MOD_N-GLC_1 203 208 PF02516 0.569
MOD_N-GLC_1 450 455 PF02516 0.353
MOD_N-GLC_1 602 607 PF02516 0.193
MOD_N-GLC_1 650 655 PF02516 0.228
MOD_N-GLC_1 849 854 PF02516 0.228
MOD_N-GLC_2 290 292 PF02516 0.326
MOD_NEK2_1 1 6 PF00069 0.534
MOD_NEK2_1 1032 1037 PF00069 0.388
MOD_NEK2_1 1084 1089 PF00069 0.493
MOD_NEK2_1 1356 1361 PF00069 0.399
MOD_NEK2_1 1370 1375 PF00069 0.393
MOD_NEK2_1 1381 1386 PF00069 0.416
MOD_NEK2_1 1411 1416 PF00069 0.481
MOD_NEK2_1 1452 1457 PF00069 0.458
MOD_NEK2_1 1533 1538 PF00069 0.417
MOD_NEK2_1 1565 1570 PF00069 0.378
MOD_NEK2_1 1651 1656 PF00069 0.473
MOD_NEK2_1 1688 1693 PF00069 0.453
MOD_NEK2_1 1749 1754 PF00069 0.396
MOD_NEK2_1 1759 1764 PF00069 0.304
MOD_NEK2_1 349 354 PF00069 0.436
MOD_NEK2_1 376 381 PF00069 0.325
MOD_NEK2_1 410 415 PF00069 0.340
MOD_NEK2_1 459 464 PF00069 0.374
MOD_NEK2_1 540 545 PF00069 0.417
MOD_NEK2_1 72 77 PF00069 0.383
MOD_NEK2_1 795 800 PF00069 0.398
MOD_NEK2_1 846 851 PF00069 0.395
MOD_NEK2_1 877 882 PF00069 0.398
MOD_NEK2_1 929 934 PF00069 0.429
MOD_NEK2_1 952 957 PF00069 0.388
MOD_NEK2_2 1019 1024 PF00069 0.388
MOD_NEK2_2 1060 1065 PF00069 0.388
MOD_NEK2_2 1666 1671 PF00069 0.456
MOD_NEK2_2 281 286 PF00069 0.431
MOD_NEK2_2 377 382 PF00069 0.387
MOD_NEK2_2 604 609 PF00069 0.493
MOD_NEK2_2 641 646 PF00069 0.388
MOD_PIKK_1 1124 1130 PF00454 0.479
MOD_PIKK_1 1180 1186 PF00454 0.398
MOD_PIKK_1 123 129 PF00454 0.596
MOD_PIKK_1 1242 1248 PF00454 0.388
MOD_PIKK_1 1347 1353 PF00454 0.450
MOD_PIKK_1 1379 1385 PF00454 0.417
MOD_PIKK_1 1412 1418 PF00454 0.492
MOD_PIKK_1 1442 1448 PF00454 0.486
MOD_PIKK_1 1627 1633 PF00454 0.486
MOD_PIKK_1 327 333 PF00454 0.335
MOD_PK_1 1202 1208 PF00069 0.453
MOD_PK_1 1710 1716 PF00069 0.453
MOD_PKA_1 1180 1186 PF00069 0.453
MOD_PKA_1 1512 1518 PF00069 0.438
MOD_PKA_1 1710 1716 PF00069 0.453
MOD_PKA_2 1010 1016 PF00069 0.445
MOD_PKA_2 1084 1090 PF00069 0.496
MOD_PKA_2 1124 1130 PF00069 0.450
MOD_PKA_2 1186 1192 PF00069 0.370
MOD_PKA_2 128 134 PF00069 0.417
MOD_PKA_2 1308 1314 PF00069 0.465
MOD_PKA_2 1341 1347 PF00069 0.459
MOD_PKA_2 1411 1417 PF00069 0.417
MOD_PKA_2 1442 1448 PF00069 0.436
MOD_PKA_2 1680 1686 PF00069 0.410
MOD_PKA_2 1710 1716 PF00069 0.428
MOD_PKA_2 23 29 PF00069 0.545
MOD_PKA_2 300 306 PF00069 0.314
MOD_PKA_2 349 355 PF00069 0.442
MOD_PKA_2 363 369 PF00069 0.432
MOD_PKA_2 410 416 PF00069 0.337
MOD_PKA_2 899 905 PF00069 0.465
MOD_PKB_1 1784 1792 PF00069 0.388
MOD_Plk_1 1019 1025 PF00069 0.388
MOD_Plk_1 1060 1066 PF00069 0.388
MOD_Plk_1 1202 1208 PF00069 0.513
MOD_Plk_1 1598 1604 PF00069 0.417
MOD_Plk_1 203 209 PF00069 0.454
MOD_Plk_1 377 383 PF00069 0.439
MOD_Plk_1 849 855 PF00069 0.453
MOD_Plk_2-3 1288 1294 PF00069 0.493
MOD_Plk_4 1052 1058 PF00069 0.395
MOD_Plk_4 1067 1073 PF00069 0.369
MOD_Plk_4 128 134 PF00069 0.417
MOD_Plk_4 1607 1613 PF00069 0.506
MOD_Plk_4 1624 1630 PF00069 0.343
MOD_Plk_4 1717 1723 PF00069 0.398
MOD_Plk_4 203 209 PF00069 0.454
MOD_Plk_4 28 34 PF00069 0.335
MOD_Plk_4 344 350 PF00069 0.328
MOD_Plk_4 388 394 PF00069 0.387
MOD_Plk_4 627 633 PF00069 0.388
MOD_Plk_4 68 74 PF00069 0.295
MOD_Plk_4 719 725 PF00069 0.410
MOD_Plk_4 796 802 PF00069 0.398
MOD_Plk_4 849 855 PF00069 0.493
MOD_ProDKin_1 1333 1339 PF00069 0.502
MOD_ProDKin_1 1446 1452 PF00069 0.432
MOD_ProDKin_1 1506 1512 PF00069 0.465
MOD_ProDKin_1 1743 1749 PF00069 0.451
MOD_ProDKin_1 296 302 PF00069 0.293
MOD_ProDKin_1 451 457 PF00069 0.390
MOD_ProDKin_1 512 518 PF00069 0.388
MOD_ProDKin_1 542 548 PF00069 0.493
MOD_ProDKin_1 57 63 PF00069 0.415
MOD_SUMO_for_1 491 494 PF00179 0.361
MOD_SUMO_for_1 674 677 PF00179 0.384
MOD_SUMO_rev_2 1165 1174 PF00179 0.493
MOD_SUMO_rev_2 671 676 PF00179 0.384
TRG_DiLeu_BaEn_1 1230 1235 PF01217 0.388
TRG_DiLeu_BaEn_1 140 145 PF01217 0.276
TRG_DiLeu_BaEn_1 677 682 PF01217 0.388
TRG_DiLeu_BaEn_2 178 184 PF01217 0.338
TRG_DiLeu_LyEn_5 1574 1579 PF01217 0.486
TRG_ENDOCYTIC_2 110 113 PF00928 0.443
TRG_ENDOCYTIC_2 1176 1179 PF00928 0.493
TRG_ENDOCYTIC_2 1209 1212 PF00928 0.410
TRG_ENDOCYTIC_2 1275 1278 PF00928 0.453
TRG_ENDOCYTIC_2 1556 1559 PF00928 0.388
TRG_ENDOCYTIC_2 1698 1701 PF00928 0.402
TRG_ENDOCYTIC_2 1716 1719 PF00928 0.398
TRG_ENDOCYTIC_2 394 397 PF00928 0.282
TRG_ENDOCYTIC_2 446 449 PF00928 0.307
TRG_ENDOCYTIC_2 483 486 PF00928 0.331
TRG_ENDOCYTIC_2 597 600 PF00928 0.402
TRG_ENDOCYTIC_2 728 731 PF00928 0.388
TRG_ENDOCYTIC_2 948 951 PF00928 0.352
TRG_ER_diArg_1 116 118 PF00400 0.411
TRG_ER_diArg_1 1219 1221 PF00400 0.412
TRG_ER_diArg_1 1267 1270 PF00400 0.388
TRG_ER_diArg_1 1396 1399 PF00400 0.398
TRG_ER_diArg_1 1500 1502 PF00400 0.553
TRG_ER_diArg_1 16 19 PF00400 0.451
TRG_ER_diArg_1 1670 1673 PF00400 0.531
TRG_ER_diArg_1 1784 1787 PF00400 0.384
TRG_ER_diArg_1 195 198 PF00400 0.497
TRG_ER_diArg_1 199 201 PF00400 0.506
TRG_ER_diArg_1 222 225 PF00400 0.421
TRG_ER_diArg_1 46 49 PF00400 0.294
TRG_ER_diArg_1 589 591 PF00400 0.493
TRG_ER_diArg_1 63 65 PF00400 0.398
TRG_ER_diArg_1 981 983 PF00400 0.410
TRG_NES_CRM1_1 1684 1695 PF08389 0.410
TRG_NES_CRM1_1 868 882 PF08389 0.468
TRG_NLS_Bipartite_1 1500 1517 PF00514 0.415
TRG_NLS_MonoExtC_3 1511 1516 PF00514 0.519
TRG_NLS_MonoExtC_3 1568 1574 PF00514 0.417
TRG_NLS_MonoExtN_4 1510 1517 PF00514 0.475
TRG_Pf-PMV_PEXEL_1 1146 1150 PF00026 0.252
TRG_Pf-PMV_PEXEL_1 431 435 PF00026 0.314
TRG_Pf-PMV_PEXEL_1 610 614 PF00026 0.198

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4V8 Leptomonas seymouri 82% 99%
A0A0S4JSQ7 Bodo saltans 56% 94%
A0A1X0NZF6 Trypanosomatidae 62% 96%
A0A3S7WU48 Leishmania donovani 100% 100%
A0A422NDG9 Trypanosoma rangeli 58% 99%
A4H8R3 Leishmania braziliensis 90% 100%
C9ZVW2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9AQU6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O54889 Rattus norvegicus 30% 100%
P10964 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P15398 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
P16355 Trypanosoma brucei brucei 53% 100%
P91875 Drosophila melanogaster 29% 100%
Q4QEN2 Leishmania major 97% 100%
Q86H36 Dictyostelium discoideum 31% 100%
V5BMM9 Trypanosoma cruzi 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS