Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HX27_LEIIN

TriTrypDb:

LINF_160018800

Length:

1000

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HX27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	744	748	PF00656	0.521
CLV_NRD_NRD_1	292	294	PF00675	0.853
CLV_NRD_NRD_1	405	407	PF00675	0.558
CLV_NRD_NRD_1	459	461	PF00675	0.666
CLV_NRD_NRD_1	685	687	PF00675	0.541
CLV_NRD_NRD_1	69	71	PF00675	0.684
CLV_NRD_NRD_1	715	717	PF00675	0.537
CLV_NRD_NRD_1	799	801	PF00675	0.631
CLV_NRD_NRD_1	911	913	PF00675	0.806
CLV_PCSK_FUR_1	797	801	PF00082	0.683
CLV_PCSK_KEX2_1	292	294	PF00082	0.853
CLV_PCSK_KEX2_1	405	407	PF00082	0.656
CLV_PCSK_KEX2_1	459	461	PF00082	0.666
CLV_PCSK_KEX2_1	69	71	PF00082	0.638
CLV_PCSK_KEX2_1	715	717	PF00082	0.537
CLV_PCSK_KEX2_1	799	801	PF00082	0.631
CLV_PCSK_KEX2_1	910	912	PF00082	0.814
CLV_PCSK_SKI1_1	33	37	PF00082	0.773
CLV_PCSK_SKI1_1	43	47	PF00082	0.619
CLV_PCSK_SKI1_1	640	644	PF00082	0.670
CLV_PCSK_SKI1_1	664	668	PF00082	0.642
CLV_PCSK_SKI1_1	673	677	PF00082	0.485
CLV_PCSK_SKI1_1	764	768	PF00082	0.462
CLV_PCSK_SKI1_1	870	874	PF00082	0.618
CLV_PCSK_SKI1_1	912	916	PF00082	0.698
CLV_PCSK_SKI1_1	939	943	PF00082	0.692
DEG_APCC_DBOX_1	493	501	PF00400	0.666
DEG_APCC_DBOX_1	734	742	PF00400	0.538
DEG_APCC_DBOX_1	840	848	PF00400	0.664
DEG_SCF_FBW7_1	413	420	PF00400	0.572
DEG_SCF_FBW7_1	81	87	PF00400	0.748
DEG_SCF_FBW7_1	916	923	PF00400	0.829
DEG_SPOP_SBC_1	190	194	PF00917	0.776
DEG_SPOP_SBC_1	227	231	PF00917	0.756
DEG_SPOP_SBC_1	720	724	PF00917	0.585
DOC_CKS1_1	117	122	PF01111	0.699
DOC_CKS1_1	323	328	PF01111	0.738
DOC_CKS1_1	81	86	PF01111	0.747
DOC_CKS1_1	922	927	PF01111	0.828
DOC_CYCLIN_yClb3_PxF_3	756	764	PF00134	0.662
DOC_CYCLIN_yCln2_LP_2	785	791	PF00134	0.573
DOC_MAPK_gen_1	405	413	PF00069	0.537
DOC_MAPK_gen_1	671	679	PF00069	0.538
DOC_MAPK_gen_1	684	693	PF00069	0.539
DOC_MAPK_gen_1	733	741	PF00069	0.521
DOC_MAPK_gen_1	987	995	PF00069	0.576
DOC_MAPK_MEF2A_6	406	415	PF00069	0.544
DOC_MAPK_MEF2A_6	673	681	PF00069	0.618
DOC_MAPK_MEF2A_6	989	997	PF00069	0.664
DOC_PP1_RVXF_1	19	26	PF00149	0.525
DOC_PP2B_LxvP_1	233	236	PF13499	0.755
DOC_PP2B_LxvP_1	528	531	PF13499	0.751
DOC_USP7_MATH_1	227	231	PF00917	0.773
DOC_USP7_MATH_1	336	340	PF00917	0.823
DOC_USP7_MATH_1	363	367	PF00917	0.800
DOC_USP7_MATH_1	417	421	PF00917	0.639
DOC_USP7_MATH_1	501	505	PF00917	0.791
DOC_USP7_MATH_1	582	586	PF00917	0.744
DOC_USP7_MATH_1	600	604	PF00917	0.705
DOC_USP7_MATH_1	662	666	PF00917	0.722
DOC_USP7_MATH_1	720	724	PF00917	0.585
DOC_USP7_MATH_1	837	841	PF00917	0.630
DOC_USP7_MATH_1	865	869	PF00917	0.693
DOC_USP7_MATH_1	878	882	PF00917	0.606
DOC_USP7_MATH_1	887	891	PF00917	0.664
DOC_USP7_MATH_1	902	906	PF00917	0.651
DOC_WW_Pin1_4	112	117	PF00397	0.697
DOC_WW_Pin1_4	13	18	PF00397	0.638
DOC_WW_Pin1_4	163	168	PF00397	0.778
DOC_WW_Pin1_4	213	218	PF00397	0.789
DOC_WW_Pin1_4	228	233	PF00397	0.801
DOC_WW_Pin1_4	312	317	PF00397	0.749
DOC_WW_Pin1_4	322	327	PF00397	0.697
DOC_WW_Pin1_4	366	371	PF00397	0.826
DOC_WW_Pin1_4	413	418	PF00397	0.582
DOC_WW_Pin1_4	566	571	PF00397	0.826
DOC_WW_Pin1_4	572	577	PF00397	0.681
DOC_WW_Pin1_4	578	583	PF00397	0.665
DOC_WW_Pin1_4	590	595	PF00397	0.570
DOC_WW_Pin1_4	664	669	PF00397	0.551
DOC_WW_Pin1_4	80	85	PF00397	0.745
DOC_WW_Pin1_4	896	901	PF00397	0.784
DOC_WW_Pin1_4	916	921	PF00397	0.627
DOC_WW_Pin1_4	925	930	PF00397	0.764
LIG_14-3-3_CanoR_1	157	165	PF00244	0.551
LIG_14-3-3_CanoR_1	226	232	PF00244	0.759
LIG_14-3-3_CanoR_1	292	296	PF00244	0.772
LIG_14-3-3_CanoR_1	338	345	PF00244	0.700
LIG_14-3-3_CanoR_1	433	443	PF00244	0.633
LIG_14-3-3_CanoR_1	764	774	PF00244	0.530
LIG_Actin_WH2_2	8	23	PF00022	0.539
LIG_Actin_WH2_2	934	952	PF00022	0.658
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BIR_III_2	147	151	PF00653	0.776
LIG_BRCT_BRCA1_1	564	568	PF00533	0.615
LIG_BRCT_BRCA1_1	721	725	PF00533	0.501
LIG_deltaCOP1_diTrp_1	633	637	PF00928	0.659
LIG_deltaCOP1_diTrp_1	647	651	PF00928	0.516
LIG_deltaCOP1_diTrp_1	990	994	PF00928	0.550
LIG_FHA_1	160	166	PF00498	0.550
LIG_FHA_1	203	209	PF00498	0.713
LIG_FHA_1	312	318	PF00498	0.586
LIG_FHA_1	329	335	PF00498	0.553
LIG_FHA_1	406	412	PF00498	0.612
LIG_FHA_1	473	479	PF00498	0.727
LIG_FHA_1	523	529	PF00498	0.762
LIG_FHA_1	771	777	PF00498	0.483
LIG_FHA_1	872	878	PF00498	0.674
LIG_FHA_1	917	923	PF00498	0.786
LIG_FHA_1	928	934	PF00498	0.678
LIG_FHA_2	164	170	PF00498	0.837
LIG_FHA_2	643	649	PF00498	0.591
LIG_FHA_2	742	748	PF00498	0.542
LIG_IRF3_LxIS_1	965	972	PF10401	0.573
LIG_IRF3_LxIS_1	993	998	PF10401	0.527
LIG_LIR_Apic_2	115	120	PF02991	0.696
LIG_LIR_Apic_2	667	672	PF02991	0.670
LIG_LIR_Gen_1	44	51	PF02991	0.648
LIG_LIR_Gen_1	724	734	PF02991	0.474
LIG_LIR_Gen_1	863	873	PF02991	0.715
LIG_LIR_Gen_1	990	997	PF02991	0.537
LIG_LIR_Nem_3	106	111	PF02991	0.792
LIG_LIR_Nem_3	24	28	PF02991	0.539
LIG_LIR_Nem_3	262	267	PF02991	0.543
LIG_LIR_Nem_3	44	48	PF02991	0.448
LIG_LIR_Nem_3	722	728	PF02991	0.512
LIG_LIR_Nem_3	784	789	PF02991	0.508
LIG_LIR_Nem_3	851	855	PF02991	0.640
LIG_LIR_Nem_3	863	869	PF02991	0.660
LIG_LIR_Nem_3	990	994	PF02991	0.558
LIG_MYND_1	372	376	PF01753	0.659
LIG_PCNA_yPIPBox_3	375	386	PF02747	0.702
LIG_Pex14_1	634	638	PF04695	0.578
LIG_SH2_CRK	276	280	PF00017	0.752
LIG_SH2_CRK	393	397	PF00017	0.650
LIG_SH2_CRK	685	689	PF00017	0.592
LIG_SH2_CRK	786	790	PF00017	0.542
LIG_SH2_SRC	449	452	PF00017	0.498
LIG_SH2_STAP1	3	7	PF00017	0.714
LIG_SH2_STAP1	951	955	PF00017	0.732
LIG_SH2_STAT3	62	65	PF00017	0.750
LIG_SH2_STAT3	636	639	PF00017	0.575
LIG_SH2_STAT5	118	121	PF00017	0.676
LIG_SH2_STAT5	430	433	PF00017	0.624
LIG_SH2_STAT5	449	452	PF00017	0.321
LIG_SH2_STAT5	854	857	PF00017	0.643
LIG_SH3_1	753	759	PF00018	0.679
LIG_SH3_2	288	293	PF14604	0.727
LIG_SH3_2	574	579	PF14604	0.762
LIG_SH3_3	164	170	PF00018	0.773
LIG_SH3_3	197	203	PF00018	0.726
LIG_SH3_3	231	237	PF00018	0.681
LIG_SH3_3	285	291	PF00018	0.712
LIG_SH3_3	32	38	PF00018	0.735
LIG_SH3_3	320	326	PF00018	0.806
LIG_SH3_3	365	371	PF00018	0.830
LIG_SH3_3	528	534	PF00018	0.730
LIG_SH3_3	571	577	PF00018	0.806
LIG_SH3_3	611	617	PF00018	0.779
LIG_SH3_3	753	759	PF00018	0.577
LIG_SH3_3	90	96	PF00018	0.805
LIG_SH3_3	926	932	PF00018	0.767
LIG_SH3_3	937	943	PF00018	0.595
LIG_SUMO_SIM_par_1	314	321	PF11976	0.534
LIG_SUMO_SIM_par_1	966	972	PF11976	0.573
LIG_TRAF2_1	463	466	PF00917	0.806
LIG_TRAF2_1	63	66	PF00917	0.668
LIG_TRFH_1	13	17	PF08558	0.639
LIG_TYR_ITIM	274	279	PF00017	0.523
LIG_TYR_ITSM	782	789	PF00017	0.576
LIG_UBA3_1	993	1000	PF00899	0.551
MOD_CDK_SPK_2	322	327	PF00069	0.736
MOD_CDK_SPxxK_3	572	579	PF00069	0.759
MOD_CDK_SPxxK_3	664	671	PF00069	0.605
MOD_CK1_1	112	118	PF00069	0.736
MOD_CK1_1	193	199	PF00069	0.811
MOD_CK1_1	2	8	PF00069	0.609
MOD_CK1_1	328	334	PF00069	0.705
MOD_CK1_1	340	346	PF00069	0.565
MOD_CK1_1	366	372	PF00069	0.756
MOD_CK1_1	469	475	PF00069	0.812
MOD_CK1_1	53	59	PF00069	0.720
MOD_CK1_1	540	546	PF00069	0.771
MOD_CK1_1	593	599	PF00069	0.768
MOD_CK1_1	74	80	PF00069	0.791
MOD_CK1_1	823	829	PF00069	0.714
MOD_CK1_1	857	863	PF00069	0.653
MOD_CK1_1	864	870	PF00069	0.651
MOD_CK1_1	879	885	PF00069	0.759
MOD_CK1_1	982	988	PF00069	0.695
MOD_CK2_1	163	169	PF00069	0.844
MOD_CK2_1	189	195	PF00069	0.741
MOD_CK2_1	336	342	PF00069	0.719
MOD_CK2_1	481	487	PF00069	0.757
MOD_CK2_1	642	648	PF00069	0.584
MOD_CMANNOS	634	637	PF00535	0.684
MOD_Cter_Amidation	457	460	PF01082	0.633
MOD_DYRK1A_RPxSP_1	664	668	PF00069	0.711
MOD_GlcNHglycan	111	114	PF01048	0.763
MOD_GlcNHglycan	123	126	PF01048	0.654
MOD_GlcNHglycan	197	200	PF01048	0.700
MOD_GlcNHglycan	211	214	PF01048	0.791
MOD_GlcNHglycan	222	225	PF01048	0.837
MOD_GlcNHglycan	320	323	PF01048	0.787
MOD_GlcNHglycan	327	330	PF01048	0.752
MOD_GlcNHglycan	342	345	PF01048	0.668
MOD_GlcNHglycan	364	368	PF01048	0.728
MOD_GlcNHglycan	419	422	PF01048	0.616
MOD_GlcNHglycan	468	471	PF01048	0.802
MOD_GlcNHglycan	585	588	PF01048	0.850
MOD_GlcNHglycan	664	667	PF01048	0.585
MOD_GlcNHglycan	697	700	PF01048	0.493
MOD_GlcNHglycan	707	710	PF01048	0.485
MOD_GlcNHglycan	76	80	PF01048	0.693
MOD_GlcNHglycan	767	770	PF01048	0.555
MOD_GlcNHglycan	814	817	PF01048	0.718
MOD_GlcNHglycan	828	831	PF01048	0.802
MOD_GlcNHglycan	863	866	PF01048	0.671
MOD_GlcNHglycan	881	884	PF01048	0.605
MOD_GlcNHglycan	916	919	PF01048	0.828
MOD_GlcNHglycan	97	100	PF01048	0.751
MOD_GSK3_1	112	119	PF00069	0.687
MOD_GSK3_1	159	166	PF00069	0.767
MOD_GSK3_1	173	180	PF00069	0.671
MOD_GSK3_1	186	193	PF00069	0.681
MOD_GSK3_1	209	216	PF00069	0.775
MOD_GSK3_1	307	314	PF00069	0.716
MOD_GSK3_1	318	325	PF00069	0.740
MOD_GSK3_1	336	343	PF00069	0.609
MOD_GSK3_1	366	373	PF00069	0.819
MOD_GSK3_1	413	420	PF00069	0.572
MOD_GSK3_1	466	473	PF00069	0.714
MOD_GSK3_1	49	56	PF00069	0.704
MOD_GSK3_1	522	529	PF00069	0.695
MOD_GSK3_1	546	553	PF00069	0.780
MOD_GSK3_1	562	569	PF00069	0.619
MOD_GSK3_1	578	585	PF00069	0.621
MOD_GSK3_1	596	603	PF00069	0.811
MOD_GSK3_1	71	78	PF00069	0.769
MOD_GSK3_1	715	722	PF00069	0.499
MOD_GSK3_1	737	744	PF00069	0.561
MOD_GSK3_1	765	772	PF00069	0.506
MOD_GSK3_1	791	798	PF00069	0.573
MOD_GSK3_1	80	87	PF00069	0.738
MOD_GSK3_1	820	827	PF00069	0.615
MOD_GSK3_1	854	861	PF00069	0.666
MOD_GSK3_1	878	885	PF00069	0.783
MOD_GSK3_1	914	921	PF00069	0.818
MOD_GSK3_1	974	981	PF00069	0.543
MOD_N-GLC_1	177	182	PF02516	0.702
MOD_N-GLC_1	209	214	PF02516	0.736
MOD_N-GLC_1	336	341	PF02516	0.704
MOD_N-GLC_1	53	58	PF02516	0.671
MOD_N-GLC_1	570	575	PF02516	0.752
MOD_N-GLC_1	769	774	PF02516	0.537
MOD_N-GLC_1	974	979	PF02516	0.542
MOD_NEK2_1	186	191	PF00069	0.828
MOD_NEK2_1	705	710	PF00069	0.479
MOD_NEK2_1	728	733	PF00069	0.530
MOD_NEK2_1	741	746	PF00069	0.564
MOD_NEK2_1	765	770	PF00069	0.644
MOD_NEK2_1	855	860	PF00069	0.650
MOD_NEK2_1	873	878	PF00069	0.582
MOD_NEK2_1	969	974	PF00069	0.554
MOD_NEK2_2	865	870	PF00069	0.765
MOD_NEK2_2	945	950	PF00069	0.652
MOD_PIKK_1	241	247	PF00454	0.688
MOD_PIKK_1	381	387	PF00454	0.706
MOD_PKA_1	405	411	PF00069	0.533
MOD_PKA_1	715	721	PF00069	0.506
MOD_PKA_2	227	233	PF00069	0.757
MOD_PKA_2	291	297	PF00069	0.847
MOD_PKA_2	337	343	PF00069	0.781
MOD_PKA_2	405	411	PF00069	0.635
MOD_PKA_2	537	543	PF00069	0.731
MOD_PKA_2	546	552	PF00069	0.661
MOD_PKA_2	715	721	PF00069	0.572
MOD_PKA_2	74	80	PF00069	0.711
MOD_PKA_2	791	797	PF00069	0.661
MOD_PKB_1	987	995	PF00069	0.596
MOD_Plk_1	43	49	PF00069	0.695
MOD_Plk_1	437	443	PF00069	0.524
MOD_Plk_1	53	59	PF00069	0.547
MOD_Plk_1	728	734	PF00069	0.481
MOD_Plk_1	823	829	PF00069	0.812
MOD_Plk_1	974	980	PF00069	0.545
MOD_Plk_1	989	995	PF00069	0.557
MOD_Plk_4	437	443	PF00069	0.524
MOD_Plk_4	781	787	PF00069	0.573
MOD_ProDKin_1	112	118	PF00069	0.698
MOD_ProDKin_1	13	19	PF00069	0.636
MOD_ProDKin_1	163	169	PF00069	0.779
MOD_ProDKin_1	213	219	PF00069	0.792
MOD_ProDKin_1	228	234	PF00069	0.801
MOD_ProDKin_1	312	318	PF00069	0.752
MOD_ProDKin_1	322	328	PF00069	0.699
MOD_ProDKin_1	366	372	PF00069	0.826
MOD_ProDKin_1	413	419	PF00069	0.588
MOD_ProDKin_1	566	572	PF00069	0.826
MOD_ProDKin_1	578	584	PF00069	0.667
MOD_ProDKin_1	590	596	PF00069	0.617
MOD_ProDKin_1	664	670	PF00069	0.549
MOD_ProDKin_1	80	86	PF00069	0.744
MOD_ProDKin_1	896	902	PF00069	0.785
MOD_ProDKin_1	916	922	PF00069	0.629
MOD_ProDKin_1	925	931	PF00069	0.764
MOD_SUMO_for_1	297	300	PF00179	0.835
TRG_DiLeu_BaEn_2	989	995	PF01217	0.581
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.645
TRG_ENDOCYTIC_2	276	279	PF00928	0.747
TRG_ENDOCYTIC_2	393	396	PF00928	0.659
TRG_ENDOCYTIC_2	786	789	PF00928	0.542
TRG_ER_diArg_1	291	293	PF00400	0.855
TRG_ER_diArg_1	405	407	PF00400	0.656
TRG_ER_diArg_1	459	462	PF00400	0.770
TRG_ER_diArg_1	69	71	PF00400	0.684
TRG_ER_diArg_1	714	716	PF00400	0.557
TRG_ER_diArg_1	732	735	PF00400	0.490
TRG_ER_diArg_1	796	799	PF00400	0.592
TRG_ER_diArg_1	909	912	PF00400	0.815
TRG_NLS_MonoCore_2	685	690	PF00514	0.583
TRG_NLS_MonoExtN_4	684	690	PF00514	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G9	Leptomonas seymouri	41%	99%
A0A3Q8IAI0	Leishmania donovani	100%	100%
A4H8Q8	Leishmania braziliensis	71%	99%
E9AQU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QEN7	Leishmania major	92%	100%