LeishMANIAdb
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Diacylglycerol kinase (ATP)

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Diacylglycerol kinase (ATP)
Gene product:
diacylglycerol kinase - putative
Species:
Leishmania infantum
UniProt:
A4HX26_LEIIN
TriTrypDb:
LINF_160018700
Length:
732

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, diacylglycerol kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HX26
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX26

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0007165 signal transduction 2 10
GO:0007186 G protein-coupled receptor signaling pathway 3 10
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 4 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0016310 phosphorylation 5 10
GO:0044237 cellular metabolic process 2 10
GO:0050789 regulation of biological process 2 10
GO:0050794 regulation of cellular process 3 10
GO:0065007 biological regulation 1 10
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0004143 diacylglycerol kinase activity 5 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0016301 kinase activity 4 10
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 49 53 PF00656 0.531
CLV_NRD_NRD_1 256 258 PF00675 0.293
CLV_NRD_NRD_1 332 334 PF00675 0.388
CLV_NRD_NRD_1 477 479 PF00675 0.229
CLV_NRD_NRD_1 83 85 PF00675 0.609
CLV_PCSK_KEX2_1 195 197 PF00082 0.416
CLV_PCSK_KEX2_1 216 218 PF00082 0.362
CLV_PCSK_KEX2_1 256 258 PF00082 0.328
CLV_PCSK_KEX2_1 332 334 PF00082 0.388
CLV_PCSK_KEX2_1 477 479 PF00082 0.238
CLV_PCSK_KEX2_1 571 573 PF00082 0.249
CLV_PCSK_PC1ET2_1 195 197 PF00082 0.416
CLV_PCSK_PC1ET2_1 216 218 PF00082 0.287
CLV_PCSK_PC1ET2_1 571 573 PF00082 0.249
CLV_PCSK_PC7_1 212 218 PF00082 0.433
CLV_PCSK_PC7_1 328 334 PF00082 0.381
CLV_PCSK_SKI1_1 196 200 PF00082 0.287
CLV_PCSK_SKI1_1 578 582 PF00082 0.293
CLV_PCSK_SKI1_1 84 88 PF00082 0.602
DEG_APCC_DBOX_1 518 526 PF00400 0.238
DEG_COP1_1 102 110 PF00400 0.570
DEG_COP1_1 52 64 PF00400 0.457
DEG_Nend_UBRbox_3 1 3 PF02207 0.587
DEG_SCF_FBW7_1 587 592 PF00400 0.249
DEG_SCF_TRCP1_1 157 163 PF00400 0.345
DEG_SPOP_SBC_1 34 38 PF00917 0.658
DOC_CKS1_1 600 605 PF01111 0.310
DOC_CKS1_1 606 611 PF01111 0.268
DOC_CKS1_1 654 659 PF01111 0.381
DOC_CYCLIN_RxL_1 548 556 PF00134 0.293
DOC_MAPK_DCC_7 365 375 PF00069 0.384
DOC_MAPK_DCC_7 507 517 PF00069 0.297
DOC_MAPK_gen_1 506 517 PF00069 0.249
DOC_MAPK_gen_1 95 103 PF00069 0.565
DOC_MAPK_MEF2A_6 510 517 PF00069 0.268
DOC_MAPK_MEF2A_6 539 546 PF00069 0.377
DOC_MAPK_MEF2A_6 690 697 PF00069 0.375
DOC_PP2B_LxvP_1 544 547 PF13499 0.364
DOC_PP4_FxxP_1 205 208 PF00568 0.309
DOC_PP4_FxxP_1 298 301 PF00568 0.287
DOC_USP7_MATH_1 106 110 PF00917 0.488
DOC_USP7_MATH_1 118 122 PF00917 0.386
DOC_USP7_MATH_1 135 139 PF00917 0.599
DOC_USP7_MATH_1 15 19 PF00917 0.694
DOC_USP7_MATH_1 323 327 PF00917 0.480
DOC_USP7_MATH_1 359 363 PF00917 0.459
DOC_USP7_MATH_1 379 383 PF00917 0.461
DOC_USP7_MATH_1 411 415 PF00917 0.518
DOC_USP7_MATH_1 531 535 PF00917 0.278
DOC_USP7_MATH_1 64 68 PF00917 0.606
DOC_USP7_MATH_1 90 94 PF00917 0.672
DOC_USP7_UBL2_3 506 510 PF12436 0.324
DOC_WW_Pin1_4 137 142 PF00397 0.543
DOC_WW_Pin1_4 419 424 PF00397 0.630
DOC_WW_Pin1_4 585 590 PF00397 0.332
DOC_WW_Pin1_4 599 604 PF00397 0.200
DOC_WW_Pin1_4 605 610 PF00397 0.243
DOC_WW_Pin1_4 653 658 PF00397 0.376
DOC_WW_Pin1_4 78 83 PF00397 0.488
LIG_14-3-3_CanoR_1 196 201 PF00244 0.336
LIG_14-3-3_CanoR_1 500 504 PF00244 0.298
LIG_14-3-3_CanoR_1 578 583 PF00244 0.249
LIG_14-3-3_CanoR_1 690 694 PF00244 0.438
LIG_14-3-3_CanoR_1 724 731 PF00244 0.338
LIG_14-3-3_CanoR_1 95 101 PF00244 0.625
LIG_APCC_ABBA_1 275 280 PF00400 0.227
LIG_BRCT_BRCA1_1 38 42 PF00533 0.635
LIG_BRCT_BRCA1_1 52 56 PF00533 0.576
LIG_deltaCOP1_diTrp_1 330 334 PF00928 0.387
LIG_EH1_1 164 172 PF00400 0.297
LIG_FHA_1 192 198 PF00498 0.371
LIG_FHA_1 233 239 PF00498 0.204
LIG_FHA_1 284 290 PF00498 0.365
LIG_FHA_1 452 458 PF00498 0.428
LIG_FHA_1 586 592 PF00498 0.448
LIG_FHA_1 639 645 PF00498 0.277
LIG_FHA_1 717 723 PF00498 0.490
LIG_FHA_2 248 254 PF00498 0.439
LIG_FHA_2 308 314 PF00498 0.228
LIG_FHA_2 654 660 PF00498 0.380
LIG_FHA_2 97 103 PF00498 0.481
LIG_LIR_Apic_2 203 208 PF02991 0.376
LIG_LIR_Gen_1 161 171 PF02991 0.312
LIG_LIR_Gen_1 442 448 PF02991 0.321
LIG_LIR_Gen_1 538 547 PF02991 0.353
LIG_LIR_Gen_1 647 657 PF02991 0.291
LIG_LIR_Gen_1 668 675 PF02991 0.436
LIG_LIR_Nem_3 161 167 PF02991 0.346
LIG_LIR_Nem_3 260 266 PF02991 0.304
LIG_LIR_Nem_3 329 334 PF02991 0.439
LIG_LIR_Nem_3 442 446 PF02991 0.317
LIG_LIR_Nem_3 454 458 PF02991 0.272
LIG_LIR_Nem_3 538 544 PF02991 0.353
LIG_LIR_Nem_3 647 653 PF02991 0.306
LIG_LIR_Nem_3 668 673 PF02991 0.439
LIG_MYND_1 301 305 PF01753 0.345
LIG_PCNA_yPIPBox_3 485 497 PF02747 0.351
LIG_Pex14_2 320 324 PF04695 0.345
LIG_SH2_CRK 164 168 PF00017 0.370
LIG_SH2_CRK 222 226 PF00017 0.331
LIG_SH2_CRK 455 459 PF00017 0.248
LIG_SH2_CRK 509 513 PF00017 0.195
LIG_SH2_CRK 577 581 PF00017 0.345
LIG_SH2_CRK 630 634 PF00017 0.345
LIG_SH2_CRK 670 674 PF00017 0.439
LIG_SH2_GRB2like 314 317 PF00017 0.252
LIG_SH2_STAP1 152 156 PF00017 0.391
LIG_SH2_STAP1 314 318 PF00017 0.252
LIG_SH2_STAP1 679 683 PF00017 0.429
LIG_SH2_STAT5 152 155 PF00017 0.377
LIG_SH2_STAT5 166 169 PF00017 0.297
LIG_SH2_STAT5 297 300 PF00017 0.345
LIG_SH2_STAT5 460 463 PF00017 0.228
LIG_SH2_STAT5 468 471 PF00017 0.228
LIG_SH2_STAT5 630 633 PF00017 0.293
LIG_SH2_STAT5 670 673 PF00017 0.432
LIG_SH3_2 397 402 PF14604 0.472
LIG_SH3_2 567 572 PF14604 0.249
LIG_SH3_3 105 111 PF00018 0.592
LIG_SH3_3 353 359 PF00018 0.292
LIG_SH3_3 394 400 PF00018 0.583
LIG_SH3_3 512 518 PF00018 0.326
LIG_SH3_3 564 570 PF00018 0.345
LIG_SH3_3 597 603 PF00018 0.262
LIG_SH3_3 65 71 PF00018 0.573
LIG_SH3_3 698 704 PF00018 0.305
LIG_SUMO_SIM_anti_2 250 256 PF11976 0.271
LIG_SUMO_SIM_par_1 610 616 PF11976 0.375
LIG_SUMO_SIM_par_1 99 104 PF11976 0.676
LIG_TRAF2_2 145 150 PF00917 0.372
LIG_TYR_ITIM 220 225 PF00017 0.248
LIG_TYR_ITIM 458 463 PF00017 0.228
LIG_TYR_ITIM 575 580 PF00017 0.345
LIG_TYR_ITIM 628 633 PF00017 0.345
LIG_WW_3 81 85 PF00397 0.506
MOD_CDC14_SPxK_1 81 84 PF00782 0.481
MOD_CDK_SPxK_1 78 84 PF00069 0.489
MOD_CDK_SPxxK_3 78 85 PF00069 0.490
MOD_CK1_1 155 161 PF00069 0.483
MOD_CK1_1 175 181 PF00069 0.322
MOD_CK1_1 32 38 PF00069 0.563
MOD_CK1_1 326 332 PF00069 0.554
MOD_CK1_1 382 388 PF00069 0.612
MOD_CK1_1 534 540 PF00069 0.250
MOD_CK1_1 562 568 PF00069 0.361
MOD_CK1_1 638 644 PF00069 0.293
MOD_CK1_1 668 674 PF00069 0.382
MOD_CK1_1 685 691 PF00069 0.499
MOD_CK2_1 155 161 PF00069 0.436
MOD_CK2_1 5 11 PF00069 0.533
MOD_CK2_1 678 684 PF00069 0.449
MOD_CK2_1 96 102 PF00069 0.613
MOD_GlcNHglycan 126 129 PF01048 0.632
MOD_GlcNHglycan 13 16 PF01048 0.591
MOD_GlcNHglycan 137 140 PF01048 0.616
MOD_GlcNHglycan 157 160 PF01048 0.433
MOD_GlcNHglycan 17 20 PF01048 0.593
MOD_GlcNHglycan 174 177 PF01048 0.262
MOD_GlcNHglycan 280 284 PF01048 0.318
MOD_GlcNHglycan 413 416 PF01048 0.653
MOD_GlcNHglycan 448 451 PF01048 0.341
MOD_GlcNHglycan 522 525 PF01048 0.419
MOD_GlcNHglycan 56 59 PF01048 0.590
MOD_GlcNHglycan 561 564 PF01048 0.361
MOD_GlcNHglycan 595 598 PF01048 0.293
MOD_GlcNHglycan 62 65 PF01048 0.636
MOD_GlcNHglycan 663 666 PF01048 0.465
MOD_GlcNHglycan 667 670 PF01048 0.434
MOD_GlcNHglycan 726 729 PF01048 0.360
MOD_GSK3_1 137 144 PF00069 0.486
MOD_GSK3_1 243 250 PF00069 0.286
MOD_GSK3_1 279 286 PF00069 0.357
MOD_GSK3_1 29 36 PF00069 0.749
MOD_GSK3_1 479 486 PF00069 0.324
MOD_GSK3_1 5 12 PF00069 0.576
MOD_GSK3_1 50 57 PF00069 0.545
MOD_GSK3_1 531 538 PF00069 0.251
MOD_GSK3_1 585 592 PF00069 0.273
MOD_GSK3_1 60 67 PF00069 0.680
MOD_GSK3_1 661 668 PF00069 0.398
MOD_GSK3_1 678 685 PF00069 0.463
MOD_LATS_1 576 582 PF00433 0.249
MOD_N-GLC_1 29 34 PF02516 0.751
MOD_N-GLC_1 50 55 PF02516 0.549
MOD_N-GLC_2 615 617 PF02516 0.227
MOD_NEK2_1 247 252 PF00069 0.304
MOD_NEK2_1 267 272 PF00069 0.216
MOD_NEK2_1 284 289 PF00069 0.293
MOD_NEK2_1 324 329 PF00069 0.513
MOD_NEK2_1 473 478 PF00069 0.264
MOD_NEK2_1 553 558 PF00069 0.228
MOD_NEK2_1 628 633 PF00069 0.345
MOD_NEK2_1 637 642 PF00069 0.315
MOD_NEK2_2 90 95 PF00069 0.451
MOD_PIKK_1 247 253 PF00454 0.335
MOD_PIKK_1 267 273 PF00454 0.129
MOD_PIKK_1 382 388 PF00454 0.534
MOD_PIKK_1 389 395 PF00454 0.455
MOD_PIKK_1 668 674 PF00454 0.453
MOD_PK_1 726 732 PF00069 0.454
MOD_PKA_2 232 238 PF00069 0.228
MOD_PKA_2 429 435 PF00069 0.347
MOD_PKA_2 499 505 PF00069 0.338
MOD_PKA_2 689 695 PF00069 0.405
MOD_PKA_2 96 102 PF00069 0.537
MOD_PKB_1 724 732 PF00069 0.441
MOD_Plk_1 160 166 PF00069 0.457
MOD_Plk_1 279 285 PF00069 0.293
MOD_Plk_1 366 372 PF00069 0.374
MOD_Plk_1 685 691 PF00069 0.420
MOD_Plk_1 706 712 PF00069 0.389
MOD_Plk_4 232 238 PF00069 0.228
MOD_Plk_4 243 249 PF00069 0.228
MOD_Plk_4 366 372 PF00069 0.374
MOD_Plk_4 64 70 PF00069 0.619
MOD_Plk_4 706 712 PF00069 0.377
MOD_Plk_4 726 732 PF00069 0.221
MOD_Plk_4 96 102 PF00069 0.728
MOD_ProDKin_1 137 143 PF00069 0.532
MOD_ProDKin_1 419 425 PF00069 0.624
MOD_ProDKin_1 585 591 PF00069 0.332
MOD_ProDKin_1 599 605 PF00069 0.200
MOD_ProDKin_1 653 659 PF00069 0.376
MOD_ProDKin_1 78 84 PF00069 0.489
TRG_DiLeu_BaEn_2 261 267 PF01217 0.335
TRG_DiLeu_BaEn_2 279 285 PF01217 0.335
TRG_DiLeu_BaEn_2 647 653 PF01217 0.252
TRG_DiLeu_BaLyEn_6 209 214 PF01217 0.438
TRG_ENDOCYTIC_2 164 167 PF00928 0.324
TRG_ENDOCYTIC_2 222 225 PF00928 0.269
TRG_ENDOCYTIC_2 297 300 PF00928 0.368
TRG_ENDOCYTIC_2 455 458 PF00928 0.265
TRG_ENDOCYTIC_2 460 463 PF00928 0.235
TRG_ENDOCYTIC_2 494 497 PF00928 0.324
TRG_ENDOCYTIC_2 509 512 PF00928 0.195
TRG_ENDOCYTIC_2 577 580 PF00928 0.381
TRG_ENDOCYTIC_2 630 633 PF00928 0.345
TRG_ENDOCYTIC_2 670 673 PF00928 0.436
TRG_ER_diArg_1 255 257 PF00400 0.293
TRG_ER_diArg_1 331 333 PF00400 0.385
TRG_ER_diArg_1 723 726 PF00400 0.320
TRG_NLS_MonoExtN_4 570 575 PF00514 0.249
TRG_Pf-PMV_PEXEL_1 257 261 PF00026 0.294

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRI7 Leptomonas seymouri 51% 98%
A0A3Q8IAN3 Leishmania donovani 100% 100%
A0A3R7MJ80 Trypanosoma rangeli 32% 100%
A4H8Q7 Leishmania braziliensis 72% 96%
C9ZVX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AQU0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QEN8 Leishmania major 91% 99%
V5DJ39 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS