Sm domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HX22_LEIIN

TriTrypDb:

LINF_160018300

Length:

147

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HX22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.510
CLV_NRD_NRD_1	59	61	PF00675	0.545
CLV_NRD_NRD_1	90	92	PF00675	0.611
CLV_PCSK_FUR_1	57	61	PF00082	0.496
CLV_PCSK_KEX2_1	57	59	PF00082	0.484
DEG_SPOP_SBC_1	76	80	PF00917	0.691
DOC_CYCLIN_RxL_1	113	126	PF00134	0.482
DOC_MAPK_gen_1	91	99	PF00069	0.560
DOC_MAPK_RevD_3	46	60	PF00069	0.467
DOC_PP1_RVXF_1	116	123	PF00149	0.415
DOC_USP7_MATH_1	76	80	PF00917	0.660
DOC_WW_Pin1_4	77	82	PF00397	0.644
LIG_14-3-3_CanoR_1	71	81	PF00244	0.484
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_Clathr_ClatBox_1	21	25	PF01394	0.357
LIG_Clathr_ClatBox_1	36	40	PF01394	0.383
LIG_FHA_1	28	34	PF00498	0.369
LIG_FHA_1	41	47	PF00498	0.372
LIG_FHA_1	68	74	PF00498	0.587
LIG_FHA_1	94	100	PF00498	0.501
LIG_LIR_Nem_3	131	136	PF02991	0.532
LIG_SH2_STAT5	119	122	PF00017	0.469
LIG_TYR_ITSM	129	136	PF00017	0.543
MOD_CK1_1	4	10	PF00069	0.550
MOD_CK2_1	129	135	PF00069	0.552
MOD_GSK3_1	72	79	PF00069	0.657
MOD_N-GLC_1	27	32	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.630
MOD_PKB_1	58	66	PF00069	0.526
MOD_Plk_1	93	99	PF00069	0.519
MOD_Plk_4	106	112	PF00069	0.386
MOD_Plk_4	27	33	PF00069	0.410
MOD_ProDKin_1	77	83	PF00069	0.647
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.457
TRG_ENDOCYTIC_2	119	122	PF00928	0.410
TRG_ENDOCYTIC_2	133	136	PF00928	0.408
TRG_ER_diArg_1	56	59	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	35	40	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4W6	Leptomonas seymouri	63%	100%
A0A1X0NYY2	Trypanosomatidae	42%	95%
A0A3R7LUA9	Trypanosoma rangeli	44%	100%
A0A3S7WU38	Leishmania donovani	100%	100%
A4H8Q3	Leishmania braziliensis	79%	100%
C9ZVX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AQT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QEP2	Leishmania major	93%	100%