Putative cyclophilin 13

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 13 - putative

Species:

Leishmania infantum

UniProt:

A4HX17_LEIIN

TriTrypDb:

LINF_160017800

Length:

366

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Annotations by Jardim et al.

Chaperone/Protein Folding, cyclophilin 13 CYP13

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HX17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX17

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018208	peptidyl-proline modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0005488	binding	1	1
GO:0016018	cyclosporin A binding	4	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.258
CLV_NRD_NRD_1	7	9	PF00675	0.682
CLV_NRD_NRD_1	97	99	PF00675	0.358
CLV_PCSK_KEX2_1	166	168	PF00082	0.259
CLV_PCSK_KEX2_1	7	9	PF00082	0.674
CLV_PCSK_KEX2_1	97	99	PF00082	0.409
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.258
CLV_PCSK_SKI1_1	281	285	PF00082	0.558
CLV_PCSK_SKI1_1	360	364	PF00082	0.667
DEG_Nend_UBRbox_3	1	3	PF02207	0.578
DOC_CDC14_PxL_1	46	54	PF14671	0.424
DOC_CKS1_1	12	17	PF01111	0.459
DOC_MAPK_DCC_7	297	305	PF00069	0.463
DOC_MAPK_gen_1	165	174	PF00069	0.266
DOC_MAPK_gen_1	30	40	PF00069	0.456
DOC_MAPK_MEF2A_6	297	305	PF00069	0.463
DOC_MAPK_MEF2A_6	33	42	PF00069	0.313
DOC_PP2B_LxvP_1	221	224	PF13499	0.396
DOC_USP7_MATH_1	257	261	PF00917	0.521
DOC_USP7_MATH_1	339	343	PF00917	0.753
DOC_USP7_UBL2_3	341	345	PF12436	0.655
DOC_USP7_UBL2_3	356	360	PF12436	0.595
DOC_WW_Pin1_4	11	16	PF00397	0.536
DOC_WW_Pin1_4	115	120	PF00397	0.342
DOC_WW_Pin1_4	252	257	PF00397	0.701
DOC_WW_Pin1_4	272	277	PF00397	0.697
DOC_WW_Pin1_4	318	323	PF00397	0.651
DOC_WW_Pin1_4	332	337	PF00397	0.501
DOC_WW_Pin1_4	69	74	PF00397	0.535
LIG_14-3-3_CanoR_1	281	286	PF00244	0.756
LIG_14-3-3_CanoR_1	30	36	PF00244	0.402
LIG_APCC_ABBA_1	82	87	PF00400	0.315
LIG_BRCT_BRCA1_1	186	190	PF00533	0.291
LIG_CSL_BTD_1	158	161	PF09270	0.250
LIG_FHA_1	139	145	PF00498	0.266
LIG_FHA_1	20	26	PF00498	0.569
LIG_FHA_1	4	10	PF00498	0.550
LIG_FHA_2	282	288	PF00498	0.670
LIG_FHA_2	70	76	PF00498	0.527
LIG_Integrin_isoDGR_2	202	204	PF01839	0.285
LIG_LIR_Gen_1	124	133	PF02991	0.266
LIG_LIR_Gen_1	216	225	PF02991	0.362
LIG_LIR_Gen_1	233	239	PF02991	0.166
LIG_LIR_Gen_1	34	43	PF02991	0.306
LIG_LIR_Gen_1	76	85	PF02991	0.329
LIG_LIR_Nem_3	124	129	PF02991	0.280
LIG_LIR_Nem_3	216	221	PF02991	0.373
LIG_LIR_Nem_3	233	238	PF02991	0.166
LIG_LIR_Nem_3	34	40	PF02991	0.310
LIG_LIR_Nem_3	44	49	PF02991	0.409
LIG_LIR_Nem_3	76	82	PF02991	0.409
LIG_MLH1_MIPbox_1	186	190	PF16413	0.266
LIG_PDZ_Class_2	361	366	PF00595	0.600
LIG_SH2_CRK	114	118	PF00017	0.256
LIG_SH2_CRK	235	239	PF00017	0.315
LIG_SH2_NCK_1	152	156	PF00017	0.396
LIG_SH2_STAP1	235	239	PF00017	0.315
LIG_SH2_STAT3	112	115	PF00017	0.266
LIG_SH2_STAT3	133	136	PF00017	0.396
LIG_SH2_STAT3	296	299	PF00017	0.549
LIG_SH2_STAT5	112	115	PF00017	0.309
LIG_SH2_STAT5	121	124	PF00017	0.292
LIG_SH2_STAT5	125	128	PF00017	0.276
LIG_SH2_STAT5	133	136	PF00017	0.270
LIG_SH2_STAT5	24	27	PF00017	0.565
LIG_SH3_2	336	341	PF14604	0.549
LIG_SH3_3	333	339	PF00018	0.724
LIG_SH3_3	44	50	PF00018	0.373
LIG_TRAF2_1	284	287	PF00917	0.699
LIG_TRAF2_1	72	75	PF00917	0.544
MOD_CK1_1	151	157	PF00069	0.396
MOD_CK1_1	17	23	PF00069	0.481
MOD_CK1_1	184	190	PF00069	0.266
MOD_CK1_1	251	257	PF00069	0.726
MOD_CK1_1	26	32	PF00069	0.462
MOD_CK1_1	260	266	PF00069	0.605
MOD_CK1_1	352	358	PF00069	0.530
MOD_CK2_1	264	270	PF00069	0.592
MOD_CK2_1	281	287	PF00069	0.663
MOD_CK2_1	69	75	PF00069	0.534
MOD_GlcNHglycan	153	156	PF01048	0.396
MOD_GlcNHglycan	16	19	PF01048	0.454
MOD_GlcNHglycan	193	196	PF01048	0.322
MOD_GlcNHglycan	250	253	PF01048	0.614
MOD_GlcNHglycan	281	284	PF01048	0.653
MOD_GlcNHglycan	322	325	PF01048	0.701
MOD_GSK3_1	117	124	PF00069	0.345
MOD_GSK3_1	146	153	PF00069	0.347
MOD_GSK3_1	19	26	PF00069	0.461
MOD_GSK3_1	248	255	PF00069	0.578
MOD_GSK3_1	260	267	PF00069	0.593
MOD_GSK3_1	268	275	PF00069	0.629
MOD_GSK3_1	277	284	PF00069	0.725
MOD_GSK3_1	345	352	PF00069	0.715
MOD_GSK3_1	48	55	PF00069	0.432
MOD_GSK3_1	69	76	PF00069	0.418
MOD_LATS_1	358	364	PF00433	0.555
MOD_N-GLC_1	184	189	PF02516	0.313
MOD_NEK2_1	189	194	PF00069	0.283
MOD_NEK2_1	19	24	PF00069	0.489
MOD_NEK2_1	250	255	PF00069	0.585
MOD_NEK2_1	340	345	PF00069	0.694
MOD_NEK2_1	52	57	PF00069	0.462
MOD_NEK2_1	63	68	PF00069	0.439
MOD_NEK2_2	138	143	PF00069	0.266
MOD_PIKK_1	184	190	PF00454	0.266
MOD_PIKK_1	257	263	PF00454	0.701
MOD_PIKK_1	41	47	PF00454	0.505
MOD_PIKK_1	52	58	PF00454	0.521
MOD_Plk_1	138	144	PF00069	0.266
MOD_Plk_1	73	79	PF00069	0.516
MOD_Plk_4	121	127	PF00069	0.262
MOD_Plk_4	245	251	PF00069	0.571
MOD_Plk_4	74	80	PF00069	0.443
MOD_ProDKin_1	11	17	PF00069	0.535
MOD_ProDKin_1	115	121	PF00069	0.342
MOD_ProDKin_1	252	258	PF00069	0.699
MOD_ProDKin_1	272	278	PF00069	0.696
MOD_ProDKin_1	318	324	PF00069	0.651
MOD_ProDKin_1	332	338	PF00069	0.503
MOD_ProDKin_1	69	75	PF00069	0.534
TRG_DiLeu_BaEn_1	245	250	PF01217	0.453
TRG_DiLeu_BaEn_3	74	80	PF01217	0.489
TRG_ENDOCYTIC_2	114	117	PF00928	0.304
TRG_ENDOCYTIC_2	235	238	PF00928	0.368
TRG_ER_diArg_1	7	9	PF00400	0.628
TRG_ER_diArg_1	96	98	PF00400	0.370
TRG_NLS_MonoCore_2	164	169	PF00514	0.256
TRG_NLS_MonoExtC_3	165	171	PF00514	0.388
TRG_NLS_MonoExtN_4	165	170	PF00514	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJB8	Leptomonas seymouri	79%	100%
A0A1X0P0F8	Trypanosomatidae	58%	100%
A0A3Q8IDR1	Leishmania donovani	100%	100%
A0A3R7MER6	Trypanosoma rangeli	57%	100%
A4H8P7	Leishmania braziliensis	78%	95%
A4HHU7	Leishmania braziliensis	30%	100%
C9ZVY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AQT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4IPB3	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	24%	67%
Q4QEP7	Leishmania major	94%	100%
V5DJ29	Trypanosoma cruzi	59%	100%