LeishMANIAdb
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Coatomer subunit delta

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Coatomer subunit delta
Gene product:
coatomer delta subunit-like protein
Species:
Leishmania infantum
UniProt:
A4HX15_LEIIN
TriTrypDb:
LINF_160017600
Length:
536

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Coatomer delta subunit-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 12
GO:0016020 membrane 2 12
GO:0030117 membrane coat 3 12
GO:0030120 vesicle coat 4 12
GO:0030126 COPI vesicle coat 5 12
GO:0031090 organelle membrane 3 12
GO:0032991 protein-containing complex 1 12
GO:0098588 bounding membrane of organelle 4 12
GO:0098796 membrane protein complex 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HX15
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX15

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 6 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0016192 vesicle-mediated transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0048193 Golgi vesicle transport 5 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 1
GO:0046907 intracellular transport 3 1
GO:0051640 organelle localization 2 1
GO:0051645 Golgi localization 3 1
GO:0051649 establishment of localization in cell 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 462 466 PF00656 0.385
CLV_C14_Caspase3-7 49 53 PF00656 0.364
CLV_NRD_NRD_1 166 168 PF00675 0.433
CLV_NRD_NRD_1 172 174 PF00675 0.494
CLV_NRD_NRD_1 251 253 PF00675 0.630
CLV_PCSK_FUR_1 170 174 PF00082 0.475
CLV_PCSK_KEX2_1 124 126 PF00082 0.366
CLV_PCSK_KEX2_1 172 174 PF00082 0.471
CLV_PCSK_PC1ET2_1 124 126 PF00082 0.382
CLV_PCSK_SKI1_1 14 18 PF00082 0.374
CLV_PCSK_SKI1_1 145 149 PF00082 0.517
CLV_PCSK_SKI1_1 159 163 PF00082 0.479
CLV_PCSK_SKI1_1 19 23 PF00082 0.387
CLV_PCSK_SKI1_1 341 345 PF00082 0.263
CLV_PCSK_SKI1_1 361 365 PF00082 0.079
CLV_PCSK_SKI1_1 46 50 PF00082 0.423
CLV_PCSK_SKI1_1 494 498 PF00082 0.326
DEG_SPOP_SBC_1 406 410 PF00917 0.371
DOC_CYCLIN_RxL_1 356 367 PF00134 0.348
DOC_CYCLIN_yCln2_LP_2 489 495 PF00134 0.433
DOC_MAPK_DCC_7 315 324 PF00069 0.332
DOC_MAPK_MEF2A_6 325 332 PF00069 0.278
DOC_MAPK_MEF2A_6 423 432 PF00069 0.412
DOC_PP2B_LxvP_1 430 433 PF13499 0.383
DOC_USP7_MATH_1 222 226 PF00917 0.659
DOC_USP7_MATH_1 406 410 PF00917 0.383
DOC_USP7_MATH_1 477 481 PF00917 0.323
DOC_USP7_MATH_1 496 500 PF00917 0.394
DOC_WW_Pin1_4 317 322 PF00397 0.332
LIG_14-3-3_CanoR_1 19 27 PF00244 0.423
LIG_14-3-3_CanoR_1 252 260 PF00244 0.647
LIG_14-3-3_CanoR_1 390 400 PF00244 0.315
LIG_14-3-3_CanoR_1 494 503 PF00244 0.388
LIG_14-3-3_CanoR_1 527 536 PF00244 0.380
LIG_APCC_ABBA_1 133 138 PF00400 0.440
LIG_BH_BH3_1 518 534 PF00452 0.406
LIG_BIR_III_4 273 277 PF00653 0.642
LIG_BRCT_BRCA1_1 347 351 PF00533 0.278
LIG_EH1_1 85 93 PF00400 0.308
LIG_FHA_1 178 184 PF00498 0.518
LIG_FHA_1 327 333 PF00498 0.333
LIG_FHA_1 395 401 PF00498 0.409
LIG_FHA_1 420 426 PF00498 0.293
LIG_FHA_1 507 513 PF00498 0.392
LIG_FHA_1 82 88 PF00498 0.314
LIG_FHA_2 302 308 PF00498 0.370
LIG_FHA_2 318 324 PF00498 0.263
LIG_FHA_2 47 53 PF00498 0.372
LIG_LIR_Apic_2 218 224 PF02991 0.679
LIG_LIR_Gen_1 109 116 PF02991 0.432
LIG_LIR_Gen_1 446 457 PF02991 0.387
LIG_LIR_Gen_1 64 71 PF02991 0.312
LIG_LIR_Nem_3 109 113 PF02991 0.405
LIG_LIR_Nem_3 191 197 PF02991 0.559
LIG_LIR_Nem_3 34 39 PF02991 0.410
LIG_LIR_Nem_3 446 452 PF02991 0.387
LIG_LIR_Nem_3 487 493 PF02991 0.334
LIG_LIR_Nem_3 64 70 PF02991 0.316
LIG_Pex14_2 110 114 PF04695 0.325
LIG_SH2_CRK 184 188 PF00017 0.546
LIG_SH2_NCK_1 415 419 PF00017 0.383
LIG_SH2_SRC 50 53 PF00017 0.340
LIG_SH2_SRC 60 63 PF00017 0.313
LIG_SH2_STAP1 142 146 PF00017 0.520
LIG_SH2_STAT3 58 61 PF00017 0.288
LIG_SH2_STAT5 136 139 PF00017 0.382
LIG_SH2_STAT5 210 213 PF00017 0.688
LIG_SH2_STAT5 50 53 PF00017 0.327
LIG_SH2_STAT5 58 61 PF00017 0.277
LIG_SH2_STAT5 95 98 PF00017 0.394
LIG_SH3_2 424 429 PF14604 0.383
LIG_SH3_3 286 292 PF00018 0.498
LIG_SH3_3 329 335 PF00018 0.278
LIG_SH3_3 377 383 PF00018 0.338
LIG_SH3_3 393 399 PF00018 0.207
LIG_SH3_3 421 427 PF00018 0.362
LIG_SH3_3 56 62 PF00018 0.301
LIG_SUMO_SIM_anti_2 327 332 PF11976 0.280
LIG_SUMO_SIM_par_1 327 334 PF11976 0.383
LIG_SUMO_SIM_par_1 67 74 PF11976 0.294
LIG_TRAF2_1 141 144 PF00917 0.397
LIG_TRAF2_1 147 150 PF00917 0.401
LIG_TRAF2_1 304 307 PF00917 0.383
LIG_TRAF2_1 62 65 PF00917 0.406
LIG_UBA3_1 66 75 PF00899 0.319
MOD_CK1_1 208 214 PF00069 0.602
MOD_CK1_1 229 235 PF00069 0.608
MOD_CK1_1 392 398 PF00069 0.396
MOD_CK1_1 409 415 PF00069 0.132
MOD_CK1_1 42 48 PF00069 0.490
MOD_CK1_1 445 451 PF00069 0.265
MOD_CK1_1 499 505 PF00069 0.366
MOD_CK2_1 125 131 PF00069 0.366
MOD_CK2_1 138 144 PF00069 0.384
MOD_CK2_1 301 307 PF00069 0.377
MOD_Cter_Amidation 122 125 PF01082 0.355
MOD_GlcNHglycan 200 203 PF01048 0.522
MOD_GlcNHglycan 224 227 PF01048 0.639
MOD_GlcNHglycan 232 235 PF01048 0.613
MOD_GlcNHglycan 243 246 PF01048 0.540
MOD_GlcNHglycan 309 312 PF01048 0.273
MOD_GlcNHglycan 33 36 PF01048 0.303
MOD_GlcNHglycan 4 7 PF01048 0.370
MOD_GlcNHglycan 470 473 PF01048 0.270
MOD_GSK3_1 222 229 PF00069 0.599
MOD_GSK3_1 251 258 PF00069 0.606
MOD_GSK3_1 345 352 PF00069 0.343
MOD_GSK3_1 359 366 PF00069 0.297
MOD_GSK3_1 405 412 PF00069 0.297
MOD_GSK3_1 42 49 PF00069 0.502
MOD_GSK3_1 495 502 PF00069 0.337
MOD_GSK3_1 506 513 PF00069 0.361
MOD_GSK3_1 69 76 PF00069 0.307
MOD_N-GLC_1 126 131 PF02516 0.379
MOD_N-GLC_1 205 210 PF02516 0.585
MOD_N-GLC_1 301 306 PF02516 0.383
MOD_N-GLC_1 359 364 PF02516 0.410
MOD_N-GLC_1 392 397 PF02516 0.349
MOD_N-GLC_1 400 405 PF02516 0.306
MOD_N-GLC_1 468 473 PF02516 0.295
MOD_N-GLC_1 506 511 PF02516 0.419
MOD_NEK2_1 197 202 PF00069 0.571
MOD_NEK2_1 264 269 PF00069 0.645
MOD_NEK2_1 309 314 PF00069 0.379
MOD_NEK2_1 39 44 PF00069 0.385
MOD_NEK2_1 391 396 PF00069 0.349
MOD_NEK2_1 70 75 PF00069 0.313
MOD_NEK2_2 205 210 PF00069 0.614
MOD_PIKK_1 266 272 PF00454 0.706
MOD_PIKK_1 496 502 PF00454 0.450
MOD_PIKK_1 511 517 PF00454 0.305
MOD_PIKK_1 520 526 PF00454 0.307
MOD_PKA_1 159 165 PF00069 0.539
MOD_PKA_2 251 257 PF00069 0.669
MOD_PKA_2 389 395 PF00069 0.383
MOD_Plk_1 101 107 PF00069 0.359
MOD_Plk_1 125 131 PF00069 0.396
MOD_Plk_1 205 211 PF00069 0.701
MOD_Plk_1 22 28 PF00069 0.350
MOD_Plk_1 301 307 PF00069 0.354
MOD_Plk_1 326 332 PF00069 0.268
MOD_Plk_1 359 365 PF00069 0.364
MOD_Plk_1 392 398 PF00069 0.397
MOD_Plk_1 40 46 PF00069 0.390
MOD_Plk_1 400 406 PF00069 0.357
MOD_Plk_2-3 106 112 PF00069 0.453
MOD_Plk_2-3 126 132 PF00069 0.182
MOD_Plk_2-3 138 144 PF00069 0.414
MOD_Plk_4 205 211 PF00069 0.703
MOD_Plk_4 326 332 PF00069 0.280
MOD_Plk_4 359 365 PF00069 0.410
MOD_Plk_4 382 388 PF00069 0.278
MOD_Plk_4 46 52 PF00069 0.373
MOD_ProDKin_1 317 323 PF00069 0.332
MOD_SUMO_for_1 324 327 PF00179 0.383
TRG_DiLeu_BaEn_1 327 332 PF01217 0.297
TRG_DiLeu_BaEn_1 64 69 PF01217 0.330
TRG_DiLeu_BaEn_4 143 149 PF01217 0.521
TRG_DiLeu_BaLyEn_6 35 40 PF01217 0.357
TRG_DiLeu_BaLyEn_6 87 92 PF01217 0.322
TRG_ENDOCYTIC_2 136 139 PF00928 0.382
TRG_ENDOCYTIC_2 184 187 PF00928 0.539
TRG_ENDOCYTIC_2 194 197 PF00928 0.569
TRG_ENDOCYTIC_2 449 452 PF00928 0.410
TRG_ENDOCYTIC_2 60 63 PF00928 0.307
TRG_ER_diArg_1 172 174 PF00400 0.558
TRG_ER_diArg_1 26 29 PF00400 0.353
TRG_NES_CRM1_1 255 270 PF08389 0.646
TRG_Pf-PMV_PEXEL_1 90 94 PF00026 0.351

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I039 Leptomonas seymouri 75% 100%
A0A0S4KK09 Bodo saltans 44% 100%
A0A1X0NYY5 Trypanosomatidae 52% 97%
A0A3Q8IAE4 Leishmania donovani 100% 100%
A0A422N6V7 Trypanosoma rangeli 52% 100%
A4H8P5 Leishmania braziliensis 87% 100%
C9ZVY7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9AQS9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P43621 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 98%
P48444 Homo sapiens 31% 100%
P49661 Oryza sativa subsp. japonica 32% 100%
P53619 Bos taurus 32% 100%
Q09236 Caenorhabditis elegans 31% 100%
Q0DJ99 Oryza sativa subsp. japonica 32% 100%
Q0DJA0 Oryza sativa subsp. japonica 32% 100%
Q4QEP9 Leishmania major 97% 100%
Q55EZ6 Dictyostelium discoideum 31% 99%
Q5RA77 Pongo abelii 31% 100%
Q5XJY5 Mus musculus 31% 100%
Q5ZL57 Gallus gallus 31% 100%
Q66H80 Rattus norvegicus 31% 100%
Q93Y22 Arabidopsis thaliana 31% 100%
V5BI39 Trypanosoma cruzi 51% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS