Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HX13_LEIIN

TriTrypDb:

LINF_160017400

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HX13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.748
CLV_NRD_NRD_1	169	171	PF00675	0.641
CLV_NRD_NRD_1	300	302	PF00675	0.711
CLV_NRD_NRD_1	374	376	PF00675	0.713
CLV_NRD_NRD_1	482	484	PF00675	0.630
CLV_PCSK_KEX2_1	158	160	PF00082	0.748
CLV_PCSK_KEX2_1	169	171	PF00082	0.641
CLV_PCSK_KEX2_1	300	302	PF00082	0.711
CLV_PCSK_KEX2_1	323	325	PF00082	0.641
CLV_PCSK_KEX2_1	374	376	PF00082	0.713
CLV_PCSK_KEX2_1	438	440	PF00082	0.662
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.637
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.742
CLV_PCSK_PC7_1	154	160	PF00082	0.743
CLV_PCSK_SKI1_1	238	242	PF00082	0.702
CLV_PCSK_SKI1_1	403	407	PF00082	0.483
CLV_PCSK_SKI1_1	435	439	PF00082	0.717
CLV_Separin_Metazoa	21	25	PF03568	0.612
DEG_APCC_DBOX_1	237	245	PF00400	0.639
DEG_APCC_DBOX_1	299	307	PF00400	0.666
DEG_APCC_DBOX_1	402	410	PF00400	0.472
DOC_CKS1_1	215	220	PF01111	0.565
DOC_CKS1_1	306	311	PF01111	0.658
DOC_CYCLIN_RxL_1	235	245	PF00134	0.700
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.569
DOC_MAPK_gen_1	24	32	PF00069	0.552
DOC_MAPK_MEF2A_6	399	406	PF00069	0.590
DOC_MAPK_NFAT4_5	399	407	PF00069	0.594
DOC_MAPK_RevD_3	469	484	PF00069	0.458
DOC_PP2B_LxvP_1	213	216	PF13499	0.718
DOC_PP4_FxxP_1	3	6	PF00568	0.643
DOC_PP4_FxxP_1	95	98	PF00568	0.733
DOC_USP7_MATH_1	392	396	PF00917	0.491
DOC_USP7_MATH_1	96	100	PF00917	0.613
DOC_WW_Pin1_4	206	211	PF00397	0.701
DOC_WW_Pin1_4	214	219	PF00397	0.559
DOC_WW_Pin1_4	305	310	PF00397	0.690
DOC_WW_Pin1_4	364	369	PF00397	0.573
DOC_WW_Pin1_4	5	10	PF00397	0.643
DOC_WW_Pin1_4	76	81	PF00397	0.769
LIG_14-3-3_CanoR_1	334	341	PF00244	0.591
LIG_14-3-3_CanoR_1	354	359	PF00244	0.381
LIG_14-3-3_CanoR_1	374	380	PF00244	0.485
LIG_APCC_ABBA_1	23	28	PF00400	0.634
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_eIF4E_1	113	119	PF01652	0.510
LIG_EVH1_1	3	7	PF00568	0.515
LIG_EVH1_2	180	184	PF00568	0.720
LIG_FHA_1	234	240	PF00498	0.675
LIG_FHA_1	306	312	PF00498	0.723
LIG_FHA_1	376	382	PF00498	0.705
LIG_FHA_2	368	374	PF00498	0.618
LIG_FHA_2	413	419	PF00498	0.598
LIG_LIR_Apic_2	2	6	PF02991	0.649
LIG_LIR_Apic_2	92	98	PF02991	0.733
LIG_LIR_Gen_1	247	257	PF02991	0.464
LIG_LIR_Gen_1	342	353	PF02991	0.564
LIG_LIR_Nem_3	247	252	PF02991	0.503
LIG_LIR_Nem_3	342	348	PF02991	0.505
LIG_NRBOX	114	120	PF00104	0.509
LIG_PCNA_yPIPBox_3	19	27	PF02747	0.617
LIG_SH2_CRK	422	426	PF00017	0.655
LIG_SH2_STAT5	358	361	PF00017	0.619
LIG_SH2_STAT5	422	425	PF00017	0.652
LIG_SH3_3	1	7	PF00018	0.677
LIG_SH3_3	187	193	PF00018	0.724
LIG_SH3_3	200	206	PF00018	0.610
LIG_SH3_3	303	309	PF00018	0.728
LIG_SH3_3	377	383	PF00018	0.704
LIG_SH3_3	446	452	PF00018	0.626
LIG_SUMO_SIM_anti_2	250	255	PF11976	0.464
LIG_TRFH_1	3	7	PF08558	0.515
LIG_TYR_ITIM	222	227	PF00017	0.702
LIG_UBA3_1	252	261	PF00899	0.599
MOD_CDK_SPK_2	364	369	PF00069	0.645
MOD_CK1_1	183	189	PF00069	0.635
MOD_CK1_1	336	342	PF00069	0.667
MOD_CK1_1	367	373	PF00069	0.649
MOD_CK1_1	384	390	PF00069	0.520
MOD_CK1_1	391	397	PF00069	0.592
MOD_CK1_1	79	85	PF00069	0.752
MOD_CK1_1	99	105	PF00069	0.611
MOD_CK2_1	111	117	PF00069	0.499
MOD_CK2_1	130	136	PF00069	0.759
MOD_CK2_1	141	147	PF00069	0.784
MOD_CK2_1	154	160	PF00069	0.615
MOD_CK2_1	367	373	PF00069	0.658
MOD_CK2_1	412	418	PF00069	0.634
MOD_GlcNHglycan	107	110	PF01048	0.507
MOD_GlcNHglycan	140	144	PF01048	0.676
MOD_GlcNHglycan	282	285	PF01048	0.728
MOD_GlcNHglycan	292	295	PF01048	0.759
MOD_GlcNHglycan	390	393	PF01048	0.619
MOD_GlcNHglycan	443	446	PF01048	0.662
MOD_GlcNHglycan	83	87	PF01048	0.612
MOD_GlcNHglycan	98	101	PF01048	0.562
MOD_GSK3_1	122	129	PF00069	0.656
MOD_GSK3_1	132	139	PF00069	0.642
MOD_GSK3_1	141	148	PF00069	0.554
MOD_GSK3_1	180	187	PF00069	0.740
MOD_GSK3_1	329	336	PF00069	0.689
MOD_GSK3_1	384	391	PF00069	0.548
MOD_GSK3_1	85	92	PF00069	0.710
MOD_N-GLC_1	247	252	PF02516	0.443
MOD_N-GLC_2	172	174	PF02516	0.624
MOD_NEK2_1	348	353	PF00069	0.440
MOD_NEK2_1	463	468	PF00069	0.662
MOD_NEK2_2	145	150	PF00069	0.608
MOD_PKA_1	374	380	PF00069	0.691
MOD_PKA_2	257	263	PF00069	0.581
MOD_PKA_2	289	295	PF00069	0.763
MOD_PKA_2	333	339	PF00069	0.747
MOD_PKA_2	374	380	PF00069	0.691
MOD_PKA_2	412	418	PF00069	0.593
MOD_PKB_1	439	447	PF00069	0.690
MOD_Plk_1	247	253	PF00069	0.438
MOD_Plk_2-3	136	142	PF00069	0.774
MOD_Plk_4	336	342	PF00069	0.706
MOD_Plk_4	348	354	PF00069	0.415
MOD_Plk_4	381	387	PF00069	0.622
MOD_Plk_4	412	418	PF00069	0.634
MOD_Plk_4	99	105	PF00069	0.690
MOD_ProDKin_1	206	212	PF00069	0.696
MOD_ProDKin_1	214	220	PF00069	0.557
MOD_ProDKin_1	305	311	PF00069	0.690
MOD_ProDKin_1	364	370	PF00069	0.582
MOD_ProDKin_1	5	11	PF00069	0.642
MOD_ProDKin_1	76	82	PF00069	0.767
TRG_DiLeu_BaEn_1	38	43	PF01217	0.512
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.613
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.637
TRG_DiLeu_LyEn_5	38	43	PF01217	0.557
TRG_ENDOCYTIC_2	224	227	PF00928	0.699
TRG_ENDOCYTIC_2	422	425	PF00928	0.575
TRG_ER_diArg_1	168	170	PF00400	0.705
TRG_ER_diArg_1	300	302	PF00400	0.703
TRG_ER_diArg_1	324	327	PF00400	0.662
TRG_NLS_MonoCore_2	437	442	PF00514	0.746
TRG_NLS_MonoExtC_3	322	327	PF00514	0.657
TRG_NLS_MonoExtC_3	437	443	PF00514	0.748
TRG_NLS_MonoExtN_4	435	442	PF00514	0.740
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q0	Leptomonas seymouri	32%	100%
A0A3Q8IAM2	Leishmania donovani	100%	100%
A4H8P3	Leishmania braziliensis	72%	99%
E9AQS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEQ1	Leishmania major	90%	99%