LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

WW domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
WW domain-containing protein
Gene product:
WW domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HX11_LEIIN
TriTrypDb:
LINF_160017100
Length:
643

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005681 spliceosomal complex 3 1
GO:0005684 U2-type spliceosomal complex 4 1
GO:0005685 U1 snRNP 5 1
GO:0030532 small nuclear ribonucleoprotein complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0071004 U2-type prespliceosome 5 1
GO:0071010 prespliceosome 4 1
GO:0097525 spliceosomal snRNP complex 4 1
GO:0120114 Sm-like protein family complex 2 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4HX11
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX11

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 1
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 1
GO:0000398 mRNA splicing, via spliceosome 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008380 RNA splicing 7 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 462 464 PF00675 0.366
CLV_NRD_NRD_1 78 80 PF00675 0.590
CLV_PCSK_KEX2_1 462 464 PF00082 0.437
CLV_PCSK_KEX2_1 78 80 PF00082 0.590
CLV_PCSK_SKI1_1 28 32 PF00082 0.651
CLV_PCSK_SKI1_1 53 57 PF00082 0.574
DEG_Kelch_Keap1_1 154 159 PF01344 0.559
DEG_SPOP_SBC_1 337 341 PF00917 0.740
DEG_SPOP_SBC_1 359 363 PF00917 0.810
DOC_CKS1_1 138 143 PF01111 0.643
DOC_CKS1_1 594 599 PF01111 0.694
DOC_CKS1_1 94 99 PF01111 0.601
DOC_CYCLIN_RxL_1 102 110 PF00134 0.663
DOC_CYCLIN_RxL_1 419 431 PF00134 0.649
DOC_CYCLIN_RxL_1 75 84 PF00134 0.595
DOC_CYCLIN_yCln2_LP_2 37 43 PF00134 0.715
DOC_CYCLIN_yCln2_LP_2 611 617 PF00134 0.485
DOC_MAPK_DCC_7 299 309 PF00069 0.638
DOC_PP1_RVXF_1 51 58 PF00149 0.545
DOC_PP1_RVXF_1 76 83 PF00149 0.574
DOC_PP2B_LxvP_1 271 274 PF13499 0.795
DOC_PP2B_LxvP_1 611 614 PF13499 0.485
DOC_PP4_FxxP_1 272 275 PF00568 0.786
DOC_PP4_MxPP_1 356 359 PF00568 0.722
DOC_USP7_MATH_1 252 256 PF00917 0.762
DOC_USP7_MATH_1 282 286 PF00917 0.732
DOC_USP7_MATH_1 291 295 PF00917 0.661
DOC_USP7_MATH_1 324 328 PF00917 0.686
DOC_USP7_MATH_1 381 385 PF00917 0.484
DOC_USP7_MATH_1 479 483 PF00917 0.665
DOC_USP7_MATH_1 49 53 PF00917 0.627
DOC_USP7_MATH_1 490 494 PF00917 0.689
DOC_USP7_MATH_1 603 607 PF00917 0.755
DOC_WW_Pin1_4 137 142 PF00397 0.647
DOC_WW_Pin1_4 339 344 PF00397 0.664
DOC_WW_Pin1_4 348 353 PF00397 0.667
DOC_WW_Pin1_4 360 365 PF00397 0.709
DOC_WW_Pin1_4 536 541 PF00397 0.715
DOC_WW_Pin1_4 593 598 PF00397 0.820
DOC_WW_Pin1_4 599 604 PF00397 0.776
DOC_WW_Pin1_4 93 98 PF00397 0.538
LIG_14-3-3_CanoR_1 15 22 PF00244 0.686
LIG_14-3-3_CanoR_1 28 37 PF00244 0.461
LIG_14-3-3_CanoR_1 412 418 PF00244 0.620
LIG_14-3-3_CanoR_1 462 466 PF00244 0.425
LIG_14-3-3_CanoR_1 515 521 PF00244 0.408
LIG_14-3-3_CanoR_1 578 583 PF00244 0.494
LIG_14-3-3_CanoR_1 81 90 PF00244 0.645
LIG_FHA_1 102 108 PF00498 0.326
LIG_FHA_1 183 189 PF00498 0.695
LIG_FHA_1 329 335 PF00498 0.771
LIG_FHA_1 360 366 PF00498 0.809
LIG_FHA_1 384 390 PF00498 0.646
LIG_FHA_1 46 52 PF00498 0.655
LIG_FHA_1 462 468 PF00498 0.420
LIG_FHA_1 517 523 PF00498 0.498
LIG_FHA_1 568 574 PF00498 0.434
LIG_FHA_1 624 630 PF00498 0.498
LIG_FHA_1 82 88 PF00498 0.576
LIG_FHA_2 145 151 PF00498 0.607
LIG_FHA_2 15 21 PF00498 0.603
LIG_FHA_2 29 35 PF00498 0.581
LIG_FHA_2 472 478 PF00498 0.485
LIG_FHA_2 527 533 PF00498 0.485
LIG_FHA_2 634 640 PF00498 0.424
LIG_FHA_2 94 100 PF00498 0.630
LIG_LIR_Apic_2 270 275 PF02991 0.789
LIG_LIR_Apic_2 415 420 PF02991 0.539
LIG_LIR_Apic_2 473 479 PF02991 0.372
LIG_LIR_Apic_2 528 534 PF02991 0.401
LIG_LIR_Apic_2 580 585 PF02991 0.444
LIG_LIR_Apic_2 635 641 PF02991 0.370
LIG_LIR_Gen_1 390 398 PF02991 0.558
LIG_LIR_Nem_3 159 165 PF02991 0.617
LIG_LIR_Nem_3 390 394 PF02991 0.573
LIG_Pex14_1 391 395 PF04695 0.457
LIG_SH2_GRB2like 521 524 PF00017 0.401
LIG_SH2_GRB2like 572 575 PF00017 0.444
LIG_SH2_GRB2like 628 631 PF00017 0.369
LIG_SH2_SRC 466 469 PF00017 0.444
LIG_SH2_SRC 521 524 PF00017 0.401
LIG_SH2_SRC 628 631 PF00017 0.369
LIG_SH2_STAT5 144 147 PF00017 0.530
LIG_SH2_STAT5 406 409 PF00017 0.505
LIG_SH2_STAT5 466 469 PF00017 0.369
LIG_SH2_STAT5 521 524 PF00017 0.401
LIG_SH2_STAT5 572 575 PF00017 0.429
LIG_SH2_STAT5 628 631 PF00017 0.401
LIG_SH2_STAT5 9 12 PF00017 0.565
LIG_SH3_2 420 425 PF14604 0.666
LIG_SH3_3 246 252 PF00018 0.735
LIG_SH3_3 257 263 PF00018 0.701
LIG_SH3_3 272 278 PF00018 0.751
LIG_SH3_3 302 308 PF00018 0.721
LIG_SH3_3 417 423 PF00018 0.664
LIG_SH3_3 480 486 PF00018 0.733
LIG_SH3_3 586 592 PF00018 0.808
LIG_SH3_3 595 601 PF00018 0.756
LIG_SH3_3 606 612 PF00018 0.561
LIG_SH3_3 91 97 PF00018 0.634
LIG_SH3_4 586 593 PF00018 0.629
LIG_SH3_CIN85_PxpxPR_1 262 267 PF14604 0.567
LIG_TRAF2_1 17 20 PF00917 0.569
MOD_CK1_1 154 160 PF00069 0.553
MOD_CK1_1 224 230 PF00069 0.482
MOD_CK1_1 285 291 PF00069 0.683
MOD_CK1_1 351 357 PF00069 0.779
MOD_CK1_1 363 369 PF00069 0.593
MOD_CK1_1 471 477 PF00069 0.491
MOD_CK1_1 494 500 PF00069 0.738
MOD_CK2_1 14 20 PF00069 0.553
MOD_CK2_1 144 150 PF00069 0.568
MOD_CK2_1 28 34 PF00069 0.546
MOD_CK2_1 324 330 PF00069 0.738
MOD_CK2_1 374 380 PF00069 0.719
MOD_CK2_1 471 477 PF00069 0.485
MOD_CK2_1 526 532 PF00069 0.485
MOD_CK2_1 633 639 PF00069 0.424
MOD_DYRK1A_RPxSP_1 93 97 PF00069 0.583
MOD_GlcNHglycan 11 14 PF01048 0.582
MOD_GlcNHglycan 119 122 PF01048 0.733
MOD_GlcNHglycan 123 126 PF01048 0.730
MOD_GlcNHglycan 156 159 PF01048 0.619
MOD_GlcNHglycan 178 181 PF01048 0.550
MOD_GlcNHglycan 223 226 PF01048 0.664
MOD_GlcNHglycan 293 296 PF01048 0.706
MOD_GlcNHglycan 311 314 PF01048 0.738
MOD_GlcNHglycan 353 356 PF01048 0.803
MOD_GlcNHglycan 446 449 PF01048 0.669
MOD_GlcNHglycan 496 499 PF01048 0.790
MOD_GlcNHglycan 547 550 PF01048 0.806
MOD_GlcNHglycan 58 61 PF01048 0.657
MOD_GlcNHglycan 605 608 PF01048 0.643
MOD_GSK3_1 107 114 PF00069 0.679
MOD_GSK3_1 117 124 PF00069 0.679
MOD_GSK3_1 195 202 PF00069 0.647
MOD_GSK3_1 281 288 PF00069 0.659
MOD_GSK3_1 316 323 PF00069 0.736
MOD_GSK3_1 324 331 PF00069 0.660
MOD_GSK3_1 333 340 PF00069 0.575
MOD_GSK3_1 359 366 PF00069 0.756
MOD_GSK3_1 406 413 PF00069 0.525
MOD_GSK3_1 45 52 PF00069 0.627
MOD_GSK3_1 454 461 PF00069 0.466
MOD_GSK3_1 468 475 PF00069 0.280
MOD_GSK3_1 490 497 PF00069 0.750
MOD_GSK3_1 523 530 PF00069 0.390
MOD_GSK3_1 574 581 PF00069 0.444
MOD_GSK3_1 599 606 PF00069 0.620
MOD_GSK3_1 630 637 PF00069 0.374
MOD_N-GLC_1 219 224 PF02516 0.686
MOD_N-GLC_1 289 294 PF02516 0.706
MOD_N-GLC_1 490 495 PF02516 0.751
MOD_NEK2_1 107 112 PF00069 0.636
MOD_NEK2_1 221 226 PF00069 0.637
MOD_NEK2_1 309 314 PF00069 0.650
MOD_NEK2_1 328 333 PF00069 0.714
MOD_NEK2_1 382 387 PF00069 0.580
MOD_NEK2_1 56 61 PF00069 0.574
MOD_NEK2_1 72 77 PF00069 0.532
MOD_PIKK_1 282 288 PF00454 0.678
MOD_PKA_2 14 20 PF00069 0.657
MOD_PKA_2 154 160 PF00069 0.553
MOD_PKA_2 413 419 PF00069 0.617
MOD_PKA_2 461 467 PF00069 0.409
MOD_PKA_2 544 550 PF00069 0.791
MOD_PKA_2 577 583 PF00069 0.485
MOD_PKB_1 79 87 PF00069 0.588
MOD_Plk_1 219 225 PF00069 0.685
MOD_Plk_4 107 113 PF00069 0.600
MOD_Plk_4 195 201 PF00069 0.747
MOD_Plk_4 245 251 PF00069 0.787
MOD_Plk_4 324 330 PF00069 0.728
MOD_ProDKin_1 137 143 PF00069 0.643
MOD_ProDKin_1 339 345 PF00069 0.667
MOD_ProDKin_1 348 354 PF00069 0.666
MOD_ProDKin_1 360 366 PF00069 0.707
MOD_ProDKin_1 536 542 PF00069 0.717
MOD_ProDKin_1 593 599 PF00069 0.823
MOD_ProDKin_1 93 99 PF00069 0.535
MOD_SUMO_rev_2 18 25 PF00179 0.609
MOD_SUMO_rev_2 222 232 PF00179 0.587
TRG_ER_diArg_1 77 79 PF00400 0.563
TRG_Pf-PMV_PEXEL_1 63 67 PF00026 0.555
TRG_Pf-PMV_PEXEL_1 78 83 PF00026 0.526

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZ37 Leptomonas seymouri 50% 100%
A0A3Q8IJ47 Leishmania donovani 98% 100%
A0A3R7LE31 Trypanosoma rangeli 34% 98%
A4H8P0 Leishmania braziliensis 73% 93%
C9ZVZ1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9AQS4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 98%
Q4QEQ3 Leishmania major 93% 99%
V5BML0 Trypanosoma cruzi 36% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS