Tyrosyl or methionyl-tRNA synthetase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosyl or methionyl-tRNA synthetase-like protein

Species:

Leishmania infantum

UniProt:

A4HX10_LEIIN

TriTrypDb:

LINF_160016900

Length:

237

Annotations

Annotations by Jardim et al.

tRNA synthetase, Tyrosyl or methionyl-tRNA synthetase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HX10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX10

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0005488	binding	1	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.536
CLV_NRD_NRD_1	11	13	PF00675	0.444
CLV_NRD_NRD_1	128	130	PF00675	0.270
CLV_NRD_NRD_1	159	161	PF00675	0.356
CLV_PCSK_KEX2_1	11	13	PF00082	0.444
CLV_PCSK_SKI1_1	100	104	PF00082	0.270
CLV_PCSK_SKI1_1	118	122	PF00082	0.270
CLV_PCSK_SKI1_1	161	165	PF00082	0.300
CLV_PCSK_SKI1_1	176	180	PF00082	0.343
CLV_PCSK_SKI1_1	193	197	PF00082	0.425
DEG_APCC_DBOX_1	99	107	PF00400	0.470
DOC_MAPK_gen_1	160	167	PF00069	0.532
DOC_MAPK_MEF2A_6	160	167	PF00069	0.511
DOC_PP1_RVXF_1	174	180	PF00149	0.534
DOC_PP2B_LxvP_1	165	168	PF13499	0.470
DOC_USP7_MATH_1	28	32	PF00917	0.630
DOC_USP7_UBL2_3	192	196	PF12436	0.443
DOC_USP7_UBL2_3	40	44	PF12436	0.581
DOC_WW_Pin1_4	22	27	PF00397	0.581
LIG_14-3-3_CanoR_1	11	15	PF00244	0.531
LIG_14-3-3_CterR_2	235	237	PF00244	0.501
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_FHA_2	143	149	PF00498	0.513
LIG_FHA_2	48	54	PF00498	0.533
LIG_KLC1_Yacidic_2	78	83	PF13176	0.511
LIG_LIR_Nem_3	183	189	PF02991	0.412
LIG_MAD2	67	75	PF02301	0.511
LIG_SH2_SRC	16	19	PF00017	0.548
LIG_SH2_SRC	186	189	PF00017	0.442
LIG_SH2_STAT5	16	19	PF00017	0.459
LIG_SH2_STAT5	81	84	PF00017	0.470
LIG_SH3_3	146	152	PF00018	0.547
LIG_SH3_3	182	188	PF00018	0.397
LIG_SUMO_SIM_par_1	161	166	PF11976	0.509
LIG_SUMO_SIM_par_1	67	72	PF11976	0.531
LIG_UBA3_1	102	111	PF00899	0.338
MOD_CDK_SPK_2	22	27	PF00069	0.460
MOD_CK1_1	49	55	PF00069	0.539
MOD_CK2_1	141	147	PF00069	0.379
MOD_CK2_1	47	53	PF00069	0.530
MOD_CK2_1	92	98	PF00069	0.443
MOD_GlcNHglycan	103	106	PF01048	0.322
MOD_GlcNHglycan	135	138	PF01048	0.409
MOD_GlcNHglycan	207	210	PF01048	0.485
MOD_GlcNHglycan	222	225	PF01048	0.348
MOD_GlcNHglycan	30	33	PF01048	0.477
MOD_GSK3_1	49	56	PF00069	0.497
MOD_N-GLC_1	53	58	PF02516	0.495
MOD_NEK2_1	10	15	PF00069	0.425
MOD_NEK2_1	141	146	PF00069	0.338
MOD_NEK2_1	220	225	PF00069	0.388
MOD_NEK2_1	69	74	PF00069	0.443
MOD_PKA_2	10	16	PF00069	0.446
MOD_Plk_1	53	59	PF00069	0.408
MOD_Plk_4	16	22	PF00069	0.541
MOD_ProDKin_1	22	28	PF00069	0.588
MOD_SUMO_for_1	110	113	PF00179	0.407
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.490
TRG_ENDOCYTIC_2	186	189	PF00928	0.432
TRG_ER_diArg_1	10	12	PF00400	0.472
TRG_NLS_MonoExtN_4	188	195	PF00514	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I419	Leptomonas seymouri	85%	98%
A0A0S4IPY2	Bodo saltans	49%	100%
A0A1X0NZC6	Trypanosomatidae	53%	96%
A0A3S5H6Y3	Leishmania donovani	100%	100%
A0A422MWG6	Trypanosoma rangeli	49%	98%
A4H8N9	Leishmania braziliensis	94%	100%
C9ZVZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AQS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O54873	Cricetulus griseus	32%	66%
P31230	Mus musculus	32%	76%
Q12904	Homo sapiens	31%	76%
Q4QEQ4	Leishmania major	98%	100%
V5BI34	Trypanosoma cruzi	51%	98%