LeishMANIAdb
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SEC7 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SEC7 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HX04_LEIIN
TriTrypDb:
LINF_160016300
Length:
633

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HX04
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX04

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 380 384 PF00656 0.778
CLV_C14_Caspase3-7 421 425 PF00656 0.759
CLV_C14_Caspase3-7 432 436 PF00656 0.638
CLV_NRD_NRD_1 173 175 PF00675 0.770
CLV_NRD_NRD_1 186 188 PF00675 0.607
CLV_NRD_NRD_1 285 287 PF00675 0.757
CLV_NRD_NRD_1 303 305 PF00675 0.525
CLV_NRD_NRD_1 58 60 PF00675 0.800
CLV_NRD_NRD_1 599 601 PF00675 0.720
CLV_NRD_NRD_1 616 618 PF00675 0.642
CLV_PCSK_FUR_1 270 274 PF00082 0.786
CLV_PCSK_FUR_1 55 59 PF00082 0.800
CLV_PCSK_KEX2_1 173 175 PF00082 0.770
CLV_PCSK_KEX2_1 186 188 PF00082 0.607
CLV_PCSK_KEX2_1 272 274 PF00082 0.700
CLV_PCSK_KEX2_1 285 287 PF00082 0.757
CLV_PCSK_KEX2_1 303 305 PF00082 0.525
CLV_PCSK_KEX2_1 513 515 PF00082 0.731
CLV_PCSK_KEX2_1 57 59 PF00082 0.803
CLV_PCSK_KEX2_1 599 601 PF00082 0.704
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.795
CLV_PCSK_PC1ET2_1 513 515 PF00082 0.723
CLV_PCSK_SKI1_1 158 162 PF00082 0.725
CLV_PCSK_SKI1_1 527 531 PF00082 0.744
DEG_SCF_TRCP1_1 608 614 PF00400 0.742
DOC_ANK_TNKS_1 566 573 PF00023 0.722
DOC_MAPK_DCC_7 118 126 PF00069 0.718
DOC_MAPK_gen_1 335 345 PF00069 0.759
DOC_MAPK_gen_1 599 605 PF00069 0.704
DOC_PP2B_LxvP_1 441 444 PF13499 0.774
DOC_PP2B_LxvP_1 580 583 PF13499 0.751
DOC_USP7_MATH_1 114 118 PF00917 0.842
DOC_USP7_MATH_1 284 288 PF00917 0.859
DOC_USP7_MATH_1 453 457 PF00917 0.784
DOC_USP7_MATH_2 243 249 PF00917 0.746
DOC_USP7_UBL2_3 513 517 PF12436 0.721
DOC_USP7_UBL2_3 76 80 PF12436 0.676
DOC_WW_Pin1_4 117 122 PF00397 0.757
DOC_WW_Pin1_4 180 185 PF00397 0.723
DOC_WW_Pin1_4 581 586 PF00397 0.813
LIG_14-3-3_CanoR_1 107 113 PF00244 0.789
LIG_14-3-3_CanoR_1 173 182 PF00244 0.739
LIG_14-3-3_CanoR_1 229 236 PF00244 0.617
LIG_14-3-3_CanoR_1 285 295 PF00244 0.704
LIG_14-3-3_CanoR_1 3 12 PF00244 0.645
LIG_14-3-3_CanoR_1 458 462 PF00244 0.779
LIG_14-3-3_CanoR_1 532 538 PF00244 0.827
LIG_14-3-3_CanoR_1 573 583 PF00244 0.714
LIG_14-3-3_CanoR_1 599 606 PF00244 0.776
LIG_CtBP_PxDLS_1 131 135 PF00389 0.593
LIG_deltaCOP1_diTrp_1 387 395 PF00928 0.762
LIG_FHA_1 476 482 PF00498 0.856
LIG_FHA_1 541 547 PF00498 0.815
LIG_FHA_1 550 556 PF00498 0.650
LIG_FHA_2 264 270 PF00498 0.831
LIG_GSK3_LRP6_1 581 587 PF00069 0.753
LIG_Integrin_isoDGR_2 615 617 PF01839 0.757
LIG_LIR_Apic_2 135 141 PF02991 0.760
LIG_LIR_Nem_3 71 77 PF02991 0.757
LIG_SH2_CRK 138 142 PF00017 0.654
LIG_SH2_GRB2like 412 415 PF00017 0.757
LIG_SH2_STAP1 77 81 PF00017 0.585
LIG_SH2_STAT3 264 267 PF00017 0.759
LIG_SH3_1 163 169 PF00018 0.742
LIG_SH3_1 233 239 PF00018 0.841
LIG_SH3_1 96 102 PF00018 0.772
LIG_SH3_2 625 630 PF14604 0.800
LIG_SH3_3 163 169 PF00018 0.815
LIG_SH3_3 233 239 PF00018 0.789
LIG_SH3_3 28 34 PF00018 0.567
LIG_SH3_3 440 446 PF00018 0.775
LIG_SH3_3 463 469 PF00018 0.842
LIG_SH3_3 543 549 PF00018 0.824
LIG_SH3_3 551 557 PF00018 0.677
LIG_SH3_3 563 569 PF00018 0.471
LIG_SH3_3 576 582 PF00018 0.645
LIG_SH3_3 622 628 PF00018 0.804
LIG_SH3_3 8 14 PF00018 0.834
LIG_SH3_3 96 102 PF00018 0.772
LIG_SUMO_SIM_anti_2 42 48 PF11976 0.689
LIG_TRAF2_1 250 253 PF00917 0.660
LIG_TRFH_1 180 184 PF08558 0.745
LIG_WW_3 335 339 PF00397 0.615
MOD_CDC14_SPxK_1 183 186 PF00782 0.702
MOD_CDK_SPxK_1 180 186 PF00069 0.707
MOD_CDK_SPxxK_3 180 187 PF00069 0.631
MOD_CK1_1 117 123 PF00069 0.747
MOD_CK1_1 175 181 PF00069 0.628
MOD_CK1_1 247 253 PF00069 0.775
MOD_CK1_1 287 293 PF00069 0.804
MOD_CK1_1 436 442 PF00069 0.789
MOD_CK1_1 495 501 PF00069 0.759
MOD_CK1_1 539 545 PF00069 0.823
MOD_CK1_1 584 590 PF00069 0.824
MOD_CK1_1 6 12 PF00069 0.713
MOD_CK1_1 609 615 PF00069 0.706
MOD_CK2_1 247 253 PF00069 0.673
MOD_CK2_1 263 269 PF00069 0.691
MOD_CK2_1 598 604 PF00069 0.818
MOD_Cter_Amidation 171 174 PF01082 0.763
MOD_Cter_Amidation 184 187 PF01082 0.606
MOD_Cter_Amidation 615 618 PF01082 0.754
MOD_GlcNHglycan 134 137 PF01048 0.688
MOD_GlcNHglycan 177 180 PF01048 0.623
MOD_GlcNHglycan 197 200 PF01048 0.805
MOD_GlcNHglycan 211 216 PF01048 0.653
MOD_GlcNHglycan 261 264 PF01048 0.735
MOD_GlcNHglycan 28 31 PF01048 0.707
MOD_GlcNHglycan 304 307 PF01048 0.771
MOD_GlcNHglycan 312 315 PF01048 0.775
MOD_GlcNHglycan 35 38 PF01048 0.646
MOD_GlcNHglycan 558 561 PF01048 0.700
MOD_GlcNHglycan 576 579 PF01048 0.528
MOD_GlcNHglycan 607 611 PF01048 0.760
MOD_GlcNHglycan 88 91 PF01048 0.771
MOD_GSK3_1 2 9 PF00069 0.666
MOD_GSK3_1 201 208 PF00069 0.714
MOD_GSK3_1 255 262 PF00069 0.769
MOD_GSK3_1 453 460 PF00069 0.808
MOD_GSK3_1 491 498 PF00069 0.738
MOD_GSK3_1 533 540 PF00069 0.824
MOD_GSK3_1 86 93 PF00069 0.689
MOD_LATS_1 156 162 PF00433 0.723
MOD_LATS_1 474 480 PF00433 0.635
MOD_N-GLC_1 255 260 PF02516 0.835
MOD_N-GLC_1 530 535 PF02516 0.824
MOD_N-GLC_1 540 545 PF02516 0.654
MOD_NEK2_1 457 462 PF00069 0.781
MOD_NEK2_1 530 535 PF00069 0.750
MOD_NEK2_1 606 611 PF00069 0.743
MOD_NEK2_1 75 80 PF00069 0.572
MOD_PIKK_1 12 18 PF00454 0.657
MOD_PIKK_1 247 253 PF00454 0.740
MOD_PIKK_1 263 269 PF00454 0.547
MOD_PIKK_1 467 473 PF00454 0.773
MOD_PIKK_1 495 501 PF00454 0.792
MOD_PIKK_1 587 593 PF00454 0.801
MOD_PIKK_1 598 604 PF00454 0.676
MOD_PKA_1 173 179 PF00069 0.734
MOD_PKA_1 285 291 PF00069 0.754
MOD_PKA_1 516 522 PF00069 0.775
MOD_PKA_2 106 112 PF00069 0.789
MOD_PKA_2 172 178 PF00069 0.794
MOD_PKA_2 2 8 PF00069 0.735
MOD_PKA_2 228 234 PF00069 0.617
MOD_PKA_2 284 290 PF00069 0.828
MOD_PKA_2 302 308 PF00069 0.574
MOD_PKA_2 362 368 PF00069 0.637
MOD_PKA_2 457 463 PF00069 0.788
MOD_PKA_2 475 481 PF00069 0.625
MOD_PKA_2 598 604 PF00069 0.818
MOD_PKB_1 257 265 PF00069 0.617
MOD_Plk_2-3 205 211 PF00069 0.726
MOD_Plk_4 533 539 PF00069 0.827
MOD_Plk_4 542 548 PF00069 0.674
MOD_ProDKin_1 117 123 PF00069 0.756
MOD_ProDKin_1 180 186 PF00069 0.723
MOD_ProDKin_1 581 587 PF00069 0.816
MOD_SUMO_rev_2 509 519 PF00179 0.668
TRG_ER_diArg_1 284 286 PF00400 0.752
TRG_ER_diArg_1 56 59 PF00400 0.796
TRG_NLS_MonoExtN_4 514 521 PF00514 0.792

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IDQ3 Leishmania donovani 98% 99%
A4H8N4 Leishmania braziliensis 52% 96%
E9AQR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4QEQ9 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS