LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184) - putative
Species:
Leishmania infantum
UniProt:
A4HX01_LEIIN
TriTrypDb:
LINF_160016000 *
Length:
785

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 40
NetGPI no yes: 0, no: 40
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 26
GO:0005794 Golgi apparatus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9

Expansion

Sequence features

A4HX01
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX01

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 39
GO:0016740 transferase activity 2 39
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 115 119 PF00656 0.605
CLV_C14_Caspase3-7 227 231 PF00656 0.393
CLV_C14_Caspase3-7 314 318 PF00656 0.430
CLV_NRD_NRD_1 18 20 PF00675 0.443
CLV_NRD_NRD_1 642 644 PF00675 0.549
CLV_NRD_NRD_1 65 67 PF00675 0.591
CLV_NRD_NRD_1 652 654 PF00675 0.583
CLV_NRD_NRD_1 71 73 PF00675 0.570
CLV_PCSK_KEX2_1 18 20 PF00082 0.345
CLV_PCSK_KEX2_1 642 644 PF00082 0.547
CLV_PCSK_KEX2_1 652 654 PF00082 0.586
CLV_PCSK_KEX2_1 71 73 PF00082 0.593
CLV_PCSK_SKI1_1 121 125 PF00082 0.599
CLV_PCSK_SKI1_1 175 179 PF00082 0.542
CLV_PCSK_SKI1_1 19 23 PF00082 0.387
CLV_PCSK_SKI1_1 530 534 PF00082 0.570
CLV_PCSK_SKI1_1 539 543 PF00082 0.471
CLV_PCSK_SKI1_1 652 656 PF00082 0.423
DEG_APCC_DBOX_1 529 537 PF00400 0.336
DEG_APCC_DBOX_1 87 95 PF00400 0.595
DEG_Nend_Nbox_1 1 3 PF02207 0.255
DOC_CYCLIN_yCln2_LP_2 375 381 PF00134 0.332
DOC_MAPK_DCC_7 459 467 PF00069 0.459
DOC_MAPK_gen_1 173 182 PF00069 0.522
DOC_MAPK_gen_1 368 377 PF00069 0.389
DOC_MAPK_gen_1 99 108 PF00069 0.528
DOC_MAPK_MEF2A_6 175 184 PF00069 0.517
DOC_MAPK_MEF2A_6 290 297 PF00069 0.384
DOC_MAPK_MEF2A_6 370 379 PF00069 0.418
DOC_MAPK_MEF2A_6 449 456 PF00069 0.724
DOC_MAPK_MEF2A_6 591 598 PF00069 0.580
DOC_PP1_RVXF_1 28 35 PF00149 0.316
DOC_PP1_RVXF_1 739 746 PF00149 0.446
DOC_PP1_RVXF_1 771 778 PF00149 0.457
DOC_PP2B_LxvP_1 375 378 PF13499 0.387
DOC_PP2B_LxvP_1 705 708 PF13499 0.466
DOC_PP4_FxxP_1 537 540 PF00568 0.525
DOC_USP7_MATH_1 135 139 PF00917 0.617
DOC_USP7_MATH_1 322 326 PF00917 0.563
DOC_USP7_MATH_1 452 456 PF00917 0.556
DOC_USP7_MATH_1 482 486 PF00917 0.570
DOC_USP7_MATH_1 620 624 PF00917 0.316
DOC_USP7_MATH_1 749 753 PF00917 0.555
DOC_WW_Pin1_4 106 111 PF00397 0.490
DOC_WW_Pin1_4 175 180 PF00397 0.406
DOC_WW_Pin1_4 276 281 PF00397 0.446
DOC_WW_Pin1_4 300 305 PF00397 0.480
DOC_WW_Pin1_4 390 395 PF00397 0.485
DOC_WW_Pin1_4 414 419 PF00397 0.600
DOC_WW_Pin1_4 687 692 PF00397 0.448
LIG_14-3-3_CanoR_1 144 149 PF00244 0.510
LIG_14-3-3_CanoR_1 159 163 PF00244 0.410
LIG_14-3-3_CanoR_1 334 344 PF00244 0.406
LIG_14-3-3_CanoR_1 368 377 PF00244 0.339
LIG_14-3-3_CanoR_1 409 418 PF00244 0.566
LIG_14-3-3_CanoR_1 504 513 PF00244 0.368
LIG_14-3-3_CanoR_1 595 599 PF00244 0.597
LIG_14-3-3_CanoR_1 699 708 PF00244 0.485
LIG_14-3-3_CanoR_1 72 78 PF00244 0.707
LIG_14-3-3_CanoR_1 88 92 PF00244 0.564
LIG_14-3-3_CterR_2 780 785 PF00244 0.485
LIG_Actin_WH2_2 129 146 PF00022 0.652
LIG_Actin_WH2_2 399 414 PF00022 0.360
LIG_Actin_WH2_2 603 620 PF00022 0.489
LIG_BIR_III_4 429 433 PF00653 0.534
LIG_BRCT_BRCA1_1 324 328 PF00533 0.521
LIG_BRCT_BRCA1_1 375 379 PF00533 0.366
LIG_BRCT_BRCA1_1 392 396 PF00533 0.446
LIG_BRCT_BRCA1_1 553 557 PF00533 0.549
LIG_DCNL_PONY_1 1 4 PF03556 0.251
LIG_deltaCOP1_diTrp_1 771 777 PF00928 0.381
LIG_DLG_GKlike_1 643 650 PF00625 0.366
LIG_eIF4E_1 17 23 PF01652 0.302
LIG_FHA_1 162 168 PF00498 0.449
LIG_FHA_1 238 244 PF00498 0.474
LIG_FHA_1 344 350 PF00498 0.254
LIG_FHA_1 411 417 PF00498 0.439
LIG_FHA_1 475 481 PF00498 0.583
LIG_FHA_1 51 57 PF00498 0.392
LIG_FHA_1 669 675 PF00498 0.419
LIG_FHA_1 709 715 PF00498 0.452
LIG_FHA_1 755 761 PF00498 0.425
LIG_FHA_2 113 119 PF00498 0.604
LIG_FHA_2 225 231 PF00498 0.597
LIG_FHA_2 265 271 PF00498 0.555
LIG_FHA_2 519 525 PF00498 0.354
LIG_FHA_2 59 65 PF00498 0.500
LIG_FHA_2 607 613 PF00498 0.502
LIG_FHA_2 76 82 PF00498 0.608
LIG_LIR_Apic_2 535 540 PF02991 0.382
LIG_LIR_Apic_2 757 761 PF02991 0.416
LIG_LIR_Gen_1 763 772 PF02991 0.568
LIG_LIR_LC3C_4 728 733 PF02991 0.561
LIG_LIR_Nem_3 197 203 PF02991 0.544
LIG_LIR_Nem_3 325 331 PF02991 0.521
LIG_LIR_Nem_3 393 399 PF02991 0.566
LIG_LIR_Nem_3 486 492 PF02991 0.489
LIG_LIR_Nem_3 554 560 PF02991 0.451
LIG_LIR_Nem_3 715 720 PF02991 0.491
LIG_MYND_1 418 422 PF01753 0.512
LIG_PCNA_yPIPBox_3 30 42 PF02747 0.370
LIG_PCNA_yPIPBox_3 58 69 PF02747 0.424
LIG_PTB_Apo_2 182 189 PF02174 0.469
LIG_PTB_Apo_2 28 35 PF02174 0.535
LIG_PTB_Apo_2 288 295 PF02174 0.351
LIG_PTB_Phospho_1 182 188 PF10480 0.472
LIG_RPA_C_Fungi 730 742 PF08784 0.453
LIG_SH2_CRK 17 21 PF00017 0.465
LIG_SH2_CRK 5 9 PF00017 0.486
LIG_SH2_GRB2like 183 186 PF00017 0.589
LIG_SH2_PTP2 399 402 PF00017 0.331
LIG_SH2_SRC 571 574 PF00017 0.538
LIG_SH2_STAP1 336 340 PF00017 0.456
LIG_SH2_STAP1 632 636 PF00017 0.398
LIG_SH2_STAT3 619 622 PF00017 0.429
LIG_SH2_STAT5 188 191 PF00017 0.407
LIG_SH2_STAT5 28 31 PF00017 0.462
LIG_SH2_STAT5 344 347 PF00017 0.376
LIG_SH2_STAT5 351 354 PF00017 0.377
LIG_SH2_STAT5 399 402 PF00017 0.454
LIG_SH2_STAT5 5 8 PF00017 0.378
LIG_SH3_2 691 696 PF14604 0.482
LIG_SH3_3 281 287 PF00018 0.381
LIG_SH3_3 391 397 PF00018 0.388
LIG_SH3_3 419 425 PF00018 0.606
LIG_SH3_3 440 446 PF00018 0.569
LIG_SH3_3 663 669 PF00018 0.542
LIG_SH3_3 688 694 PF00018 0.461
LIG_SH3_3 753 759 PF00018 0.525
LIG_SUMO_SIM_anti_2 728 734 PF11976 0.505
LIG_SUMO_SIM_par_1 104 109 PF11976 0.521
LIG_SUMO_SIM_par_1 710 716 PF11976 0.461
LIG_SUMO_SIM_par_1 728 734 PF11976 0.354
LIG_TRAF2_1 455 458 PF00917 0.577
LIG_TRAF2_1 570 573 PF00917 0.529
LIG_TYR_ITIM 3 8 PF00017 0.536
LIG_TYR_ITIM 349 354 PF00017 0.471
LIG_WRC_WIRS_1 4 9 PF05994 0.474
LIG_WW_3 303 307 PF00397 0.475
MOD_CDC14_SPxK_1 303 306 PF00782 0.472
MOD_CDK_SPK_2 390 395 PF00069 0.473
MOD_CDK_SPxK_1 300 306 PF00069 0.467
MOD_CK1_1 138 144 PF00069 0.615
MOD_CK1_1 324 330 PF00069 0.440
MOD_CK1_1 373 379 PF00069 0.311
MOD_CK1_1 90 96 PF00069 0.500
MOD_CK2_1 452 458 PF00069 0.512
MOD_CK2_1 518 524 PF00069 0.606
MOD_CK2_1 567 573 PF00069 0.458
MOD_CK2_1 58 64 PF00069 0.515
MOD_CK2_1 606 612 PF00069 0.547
MOD_CK2_1 661 667 PF00069 0.422
MOD_CMANNOS 774 777 PF00535 0.487
MOD_GlcNHglycan 138 141 PF01048 0.604
MOD_GlcNHglycan 211 214 PF01048 0.616
MOD_GlcNHglycan 222 225 PF01048 0.647
MOD_GlcNHglycan 370 373 PF01048 0.412
MOD_GlcNHglycan 622 625 PF01048 0.478
MOD_GlcNHglycan 663 666 PF01048 0.396
MOD_GlcNHglycan 675 678 PF01048 0.374
MOD_GSK3_1 203 210 PF00069 0.462
MOD_GSK3_1 220 227 PF00069 0.526
MOD_GSK3_1 300 307 PF00069 0.557
MOD_GSK3_1 360 367 PF00069 0.339
MOD_GSK3_1 410 417 PF00069 0.592
MOD_GSK3_1 46 53 PF00069 0.661
MOD_GSK3_1 634 641 PF00069 0.588
MOD_GSK3_1 71 78 PF00069 0.507
MOD_LATS_1 142 148 PF00433 0.497
MOD_N-GLC_1 175 180 PF02516 0.478
MOD_N-GLC_1 8 13 PF02516 0.488
MOD_N-GLC_2 468 470 PF02516 0.621
MOD_NEK2_1 136 141 PF00069 0.606
MOD_NEK2_1 143 148 PF00069 0.631
MOD_NEK2_1 3 8 PF00069 0.328
MOD_NEK2_1 335 340 PF00069 0.354
MOD_NEK2_1 360 365 PF00069 0.417
MOD_NEK2_1 51 56 PF00069 0.696
MOD_NEK2_1 578 583 PF00069 0.400
MOD_NEK2_1 754 759 PF00069 0.415
MOD_NEK2_1 87 92 PF00069 0.480
MOD_NEK2_2 398 403 PF00069 0.346
MOD_NEK2_2 52 57 PF00069 0.391
MOD_NEK2_2 634 639 PF00069 0.347
MOD_PIKK_1 441 447 PF00454 0.570
MOD_PIKK_1 504 510 PF00454 0.336
MOD_PKA_1 71 77 PF00069 0.569
MOD_PKA_2 136 142 PF00069 0.566
MOD_PKA_2 143 149 PF00069 0.457
MOD_PKA_2 158 164 PF00069 0.429
MOD_PKA_2 594 600 PF00069 0.499
MOD_PKA_2 71 77 PF00069 0.594
MOD_PKA_2 81 87 PF00069 0.549
MOD_PKB_1 368 376 PF00069 0.301
MOD_Plk_1 373 379 PF00069 0.234
MOD_Plk_1 606 612 PF00069 0.424
MOD_Plk_2-3 264 270 PF00069 0.404
MOD_Plk_2-3 81 87 PF00069 0.639
MOD_Plk_4 112 118 PF00069 0.583
MOD_Plk_4 203 209 PF00069 0.457
MOD_Plk_4 264 270 PF00069 0.439
MOD_Plk_4 3 9 PF00069 0.443
MOD_Plk_4 360 366 PF00069 0.372
MOD_Plk_4 416 422 PF00069 0.643
MOD_Plk_4 474 480 PF00069 0.446
MOD_ProDKin_1 106 112 PF00069 0.492
MOD_ProDKin_1 175 181 PF00069 0.399
MOD_ProDKin_1 276 282 PF00069 0.444
MOD_ProDKin_1 300 306 PF00069 0.483
MOD_ProDKin_1 390 396 PF00069 0.484
MOD_ProDKin_1 414 420 PF00069 0.605
MOD_ProDKin_1 687 693 PF00069 0.449
MOD_SUMO_rev_2 270 280 PF00179 0.606
MOD_SUMO_rev_2 419 428 PF00179 0.641
MOD_SUMO_rev_2 455 460 PF00179 0.520
MOD_SUMO_rev_2 734 743 PF00179 0.513
TRG_DiLeu_BaEn_1 751 756 PF01217 0.437
TRG_ENDOCYTIC_2 17 20 PF00928 0.568
TRG_ENDOCYTIC_2 351 354 PF00928 0.477
TRG_ENDOCYTIC_2 381 384 PF00928 0.401
TRG_ENDOCYTIC_2 399 402 PF00928 0.471
TRG_ENDOCYTIC_2 5 8 PF00928 0.483
TRG_ENDOCYTIC_2 765 768 PF00928 0.440
TRG_ER_diArg_1 102 105 PF00400 0.557
TRG_ER_diArg_1 17 19 PF00400 0.338
TRG_ER_diArg_1 172 175 PF00400 0.527
TRG_ER_diArg_1 331 334 PF00400 0.471
TRG_ER_diArg_1 652 654 PF00400 0.525
TRG_ER_diArg_1 679 682 PF00400 0.523
TRG_ER_diArg_1 777 780 PF00400 0.428
TRG_NES_CRM1_1 697 710 PF08389 0.432
TRG_NLS_MonoExtC_3 638 643 PF00514 0.359
TRG_PTS1 782 785 PF00515 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q7 Leptomonas seymouri 55% 100%
A0A0S4JNL6 Bodo saltans 28% 72%
A0A1X0NYY7 Trypanosomatidae 39% 99%
A0A3Q8IAD3 Leishmania donovani 100% 80%
A0A3Q8IAF8 Leishmania donovani 52% 82%
A0A3Q8IAK8 Leishmania donovani 54% 81%
A0A3Q8IJ32 Leishmania donovani 54% 95%
A0A3S5H6Y1 Leishmania donovani 53% 83%
A0A3S7WTZ8 Leishmania donovani 52% 76%
A0A3S7WU13 Leishmania donovani 53% 84%
A0A422NAR5 Trypanosoma rangeli 39% 99%
A4H8M5 Leishmania braziliensis 50% 100%
A4H8M6 Leishmania braziliensis 54% 87%
A4H8M7 Leishmania braziliensis 55% 100%
A4H8N0 Leishmania braziliensis 44% 100%
A4H8N1 Leishmania braziliensis 82% 100%
A4HWZ5 Leishmania infantum 54% 100%
A4HWZ6 Leishmania infantum 50% 100%
A4HWZ8 Leishmania infantum 55% 100%
A4HX00 Leishmania infantum 53% 100%
A4HX05 Leishmania infantum 57% 81%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9AGP0 Leishmania infantum 56% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QER2 Leishmania major 93% 100%
Q4QER3 Leishmania major 53% 100%
Q4QER4 Leishmania major 57% 94%
Q4QER5 Leishmania major 54% 100%
Q4QER6 Leishmania major 54% 100%
Q4QER7 Leishmania major 55% 100%
Q4QER8 Leishmania major 55% 100%
Q4QER9 Leishmania major 55% 100%
Q4QES0 Leishmania major 54% 100%
V5ANJ8 Trypanosoma cruzi 39% 98%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS