LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184) - putative
Species:
Leishmania infantum
UniProt:
A4HWZ8_LEIIN
TriTrypDb:
LINF_160015800 *
Length:
917

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 37
NetGPI no yes: 0, no: 37
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 26
GO:0005794 Golgi apparatus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9

Expansion

Sequence features

A4HWZ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWZ8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 36
GO:0016740 transferase activity 2 36
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 29 33 PF00656 0.390
CLV_C14_Caspase3-7 307 311 PF00656 0.501
CLV_C14_Caspase3-7 588 592 PF00656 0.338
CLV_MEL_PAP_1 178 184 PF00089 0.615
CLV_NRD_NRD_1 170 172 PF00675 0.671
CLV_NRD_NRD_1 201 203 PF00675 0.588
CLV_NRD_NRD_1 45 47 PF00675 0.635
CLV_NRD_NRD_1 496 498 PF00675 0.669
CLV_NRD_NRD_1 499 501 PF00675 0.621
CLV_NRD_NRD_1 534 536 PF00675 0.587
CLV_NRD_NRD_1 572 574 PF00675 0.678
CLV_NRD_NRD_1 650 652 PF00675 0.624
CLV_NRD_NRD_1 796 798 PF00675 0.695
CLV_PCSK_FUR_1 497 501 PF00082 0.629
CLV_PCSK_FUR_1 570 574 PF00082 0.644
CLV_PCSK_KEX2_1 170 172 PF00082 0.660
CLV_PCSK_KEX2_1 45 47 PF00082 0.636
CLV_PCSK_KEX2_1 454 456 PF00082 0.584
CLV_PCSK_KEX2_1 496 498 PF00082 0.669
CLV_PCSK_KEX2_1 499 501 PF00082 0.579
CLV_PCSK_KEX2_1 572 574 PF00082 0.671
CLV_PCSK_KEX2_1 650 652 PF00082 0.624
CLV_PCSK_KEX2_1 796 798 PF00082 0.695
CLV_PCSK_PC1ET2_1 454 456 PF00082 0.577
CLV_PCSK_SKI1_1 171 175 PF00082 0.634
CLV_PCSK_SKI1_1 313 317 PF00082 0.684
CLV_PCSK_SKI1_1 367 371 PF00082 0.610
CLV_PCSK_SKI1_1 37 41 PF00082 0.613
CLV_PCSK_SKI1_1 421 425 PF00082 0.665
CLV_PCSK_SKI1_1 538 542 PF00082 0.538
CLV_PCSK_SKI1_1 650 654 PF00082 0.658
CLV_PCSK_SKI1_1 758 762 PF00082 0.682
CLV_PCSK_SKI1_1 842 846 PF00082 0.656
CLV_PCSK_SKI1_1 89 93 PF00082 0.698
DEG_APCC_DBOX_1 279 287 PF00400 0.475
DEG_Nend_Nbox_1 1 3 PF02207 0.220
DEG_SPOP_SBC_1 69 73 PF00917 0.475
DEG_SPOP_SBC_1 90 94 PF00917 0.454
DOC_CKS1_1 657 662 PF01111 0.457
DOC_CYCLIN_yCln2_LP_2 540 546 PF00134 0.336
DOC_MAPK_DCC_7 625 634 PF00069 0.403
DOC_MAPK_gen_1 291 300 PF00069 0.404
DOC_MAPK_gen_1 365 374 PF00069 0.398
DOC_MAPK_gen_1 533 542 PF00069 0.447
DOC_MAPK_gen_1 625 634 PF00069 0.427
DOC_MAPK_HePTP_8 653 665 PF00069 0.457
DOC_MAPK_MEF2A_6 367 376 PF00069 0.396
DOC_MAPK_MEF2A_6 535 544 PF00069 0.447
DOC_MAPK_MEF2A_6 656 665 PF00069 0.456
DOC_MAPK_MEF2A_6 739 746 PF00069 0.502
DOC_PP1_RVXF_1 19 25 PF00149 0.432
DOC_PP1_RVXF_1 879 886 PF00149 0.372
DOC_PP2B_LxvP_1 540 543 PF13499 0.447
DOC_PP2B_LxvP_1 845 848 PF13499 0.411
DOC_PP4_FxxP_1 657 660 PF00568 0.406
DOC_USP7_MATH_1 327 331 PF00917 0.474
DOC_USP7_MATH_1 413 417 PF00917 0.335
DOC_USP7_MATH_1 489 493 PF00917 0.509
DOC_USP7_MATH_1 602 606 PF00917 0.395
DOC_USP7_MATH_1 67 71 PF00917 0.503
DOC_USP7_MATH_1 78 82 PF00917 0.482
DOC_USP7_MATH_1 834 838 PF00917 0.454
DOC_USP7_MATH_1 889 893 PF00917 0.463
DOC_USP7_MATH_1 99 103 PF00917 0.477
DOC_WW_Pin1_4 113 118 PF00397 0.461
DOC_WW_Pin1_4 121 126 PF00397 0.456
DOC_WW_Pin1_4 171 176 PF00397 0.460
DOC_WW_Pin1_4 298 303 PF00397 0.382
DOC_WW_Pin1_4 367 372 PF00397 0.317
DOC_WW_Pin1_4 50 55 PF00397 0.491
DOC_WW_Pin1_4 555 560 PF00397 0.447
DOC_WW_Pin1_4 656 661 PF00397 0.458
DOC_WW_Pin1_4 72 77 PF00397 0.515
DOC_WW_Pin1_4 79 84 PF00397 0.497
DOC_WW_Pin1_4 95 100 PF00397 0.501
LIG_14-3-3_CanoR_1 170 174 PF00244 0.502
LIG_14-3-3_CanoR_1 21 25 PF00244 0.441
LIG_14-3-3_CanoR_1 280 284 PF00244 0.455
LIG_14-3-3_CanoR_1 336 341 PF00244 0.396
LIG_14-3-3_CanoR_1 351 355 PF00244 0.333
LIG_14-3-3_CanoR_1 415 420 PF00244 0.344
LIG_14-3-3_CanoR_1 455 465 PF00244 0.438
LIG_14-3-3_CanoR_1 499 509 PF00244 0.323
LIG_14-3-3_CanoR_1 743 747 PF00244 0.493
LIG_14-3-3_CanoR_1 764 772 PF00244 0.394
LIG_14-3-3_CanoR_1 89 99 PF00244 0.508
LIG_14-3-3_CanoR_1 913 917 PF00244 0.465
LIG_Actin_WH2_2 321 338 PF00022 0.516
LIG_Actin_WH2_2 439 456 PF00022 0.346
LIG_BIR_III_2 578 582 PF00653 0.422
LIG_BRCT_BRCA1_1 217 221 PF00533 0.307
LIG_BRCT_BRCA1_1 557 561 PF00533 0.363
LIG_BRCT_BRCA1_1 701 705 PF00533 0.499
LIG_eIF4E_1 441 447 PF01652 0.382
LIG_FHA_1 127 133 PF00498 0.502
LIG_FHA_1 183 189 PF00498 0.471
LIG_FHA_1 274 280 PF00498 0.545
LIG_FHA_1 581 587 PF00498 0.474
LIG_FHA_1 849 855 PF00498 0.404
LIG_FHA_1 86 92 PF00498 0.498
LIG_FHA_1 895 901 PF00498 0.375
LIG_FHA_2 128 134 PF00498 0.438
LIG_FHA_2 172 178 PF00498 0.379
LIG_FHA_2 21 27 PF00498 0.456
LIG_FHA_2 251 257 PF00498 0.390
LIG_FHA_2 305 311 PF00498 0.499
LIG_FHA_2 517 523 PF00498 0.285
LIG_FHA_2 601 607 PF00498 0.335
LIG_FHA_2 615 621 PF00498 0.383
LIG_FHA_2 90 96 PF00498 0.456
LIG_LIR_Apic_2 897 901 PF02991 0.364
LIG_LIR_Apic_2 911 917 PF02991 0.408
LIG_LIR_Gen_1 186 197 PF02991 0.388
LIG_LIR_Gen_1 426 437 PF02991 0.309
LIG_LIR_Gen_1 606 616 PF02991 0.360
LIG_LIR_Gen_1 659 670 PF02991 0.412
LIG_LIR_Gen_1 903 912 PF02991 0.483
LIG_LIR_LC3C_4 868 873 PF02991 0.466
LIG_LIR_Nem_3 186 192 PF02991 0.359
LIG_LIR_Nem_3 242 248 PF02991 0.323
LIG_LIR_Nem_3 389 395 PF02991 0.394
LIG_LIR_Nem_3 511 517 PF02991 0.298
LIG_LIR_Nem_3 539 544 PF02991 0.325
LIG_LIR_Nem_3 558 564 PF02991 0.436
LIG_LIR_Nem_3 606 612 PF02991 0.350
LIG_LIR_Nem_3 659 665 PF02991 0.448
LIG_LIR_Nem_3 702 708 PF02991 0.400
LIG_LIR_Nem_3 855 860 PF02991 0.440
LIG_MAD2 764 772 PF02301 0.428
LIG_MYND_1 160 164 PF01753 0.435
LIG_Pex14_2 34 38 PF04695 0.396
LIG_PTB_Apo_2 374 381 PF02174 0.365
LIG_PTB_Apo_2 627 634 PF02174 0.376
LIG_PTB_Phospho_1 374 380 PF10480 0.367
LIG_PTB_Phospho_1 627 633 PF10480 0.416
LIG_REV1ctd_RIR_1 514 524 PF16727 0.310
LIG_RPA_C_Fungi 870 882 PF08784 0.466
LIG_SH2_CRK 189 193 PF00017 0.470
LIG_SH2_GRB2like 232 235 PF00017 0.438
LIG_SH2_GRB2like 375 378 PF00017 0.585
LIG_SH2_GRB2like 633 636 PF00017 0.505
LIG_SH2_SRC 662 665 PF00017 0.547
LIG_SH2_SRC 719 722 PF00017 0.608
LIG_SH2_STAP1 501 505 PF00017 0.474
LIG_SH2_STAP1 521 525 PF00017 0.216
LIG_SH2_STAT3 201 204 PF00017 0.365
LIG_SH2_STAT3 776 779 PF00017 0.593
LIG_SH2_STAT5 380 383 PF00017 0.408
LIG_SH2_STAT5 441 444 PF00017 0.493
LIG_SH2_STAT5 501 504 PF00017 0.443
LIG_SH2_STAT5 509 512 PF00017 0.372
LIG_SH2_STAT5 564 567 PF00017 0.430
LIG_SH2_STAT5 633 636 PF00017 0.501
LIG_SH2_STAT5 662 665 PF00017 0.541
LIG_SH2_STAT5 9 12 PF00017 0.445
LIG_SH3_1 108 114 PF00018 0.571
LIG_SH3_2 495 500 PF14604 0.427
LIG_SH3_3 108 114 PF00018 0.577
LIG_SH3_3 154 160 PF00018 0.540
LIG_SH3_3 222 228 PF00018 0.480
LIG_SH3_3 492 498 PF00018 0.460
LIG_SH3_3 77 83 PF00018 0.664
LIG_SH3_3 803 809 PF00018 0.504
LIG_SH3_3 84 90 PF00018 0.680
LIG_SH3_3 893 899 PF00018 0.435
LIG_SUMO_SIM_anti_2 433 440 PF11976 0.422
LIG_SUMO_SIM_anti_2 868 874 PF11976 0.526
LIG_SUMO_SIM_par_1 129 136 PF11976 0.509
LIG_SUMO_SIM_par_1 296 301 PF11976 0.481
LIG_SUMO_SIM_par_1 850 856 PF11976 0.512
LIG_SUMO_SIM_par_1 868 874 PF11976 0.340
LIG_SxIP_EBH_1 487 500 PF03271 0.407
LIG_TRAF2_1 695 698 PF00917 0.508
LIG_TRAF2_1 718 721 PF00917 0.588
LIG_TYR_ITIM 187 192 PF00017 0.564
LIG_TYR_ITIM 7 12 PF00017 0.435
LIG_WRC_WIRS_1 188 193 PF05994 0.460
MOD_CDK_SPK_2 555 560 PF00069 0.454
MOD_CK1_1 282 288 PF00069 0.508
MOD_CK1_1 330 336 PF00069 0.587
MOD_CK1_1 597 603 PF00069 0.408
MOD_CK1_1 70 76 PF00069 0.649
MOD_CK2_1 171 177 PF00069 0.474
MOD_CK2_1 516 522 PF00069 0.312
MOD_CK2_1 614 620 PF00069 0.474
MOD_CK2_1 638 644 PF00069 0.559
MOD_CK2_1 715 721 PF00069 0.441
MOD_CK2_1 787 793 PF00069 0.583
MOD_CK2_1 99 105 PF00069 0.574
MOD_GlcNHglycan 229 232 PF01048 0.619
MOD_GlcNHglycan 330 333 PF01048 0.568
MOD_GlcNHglycan 414 418 PF01048 0.535
MOD_GlcNHglycan 458 461 PF01048 0.610
MOD_GlcNHglycan 599 602 PF01048 0.394
MOD_GlcNHglycan 641 644 PF01048 0.519
MOD_GlcNHglycan 766 769 PF01048 0.480
MOD_GlcNHglycan 836 839 PF01048 0.582
MOD_GSK3_1 124 131 PF00069 0.540
MOD_GSK3_1 16 23 PF00069 0.518
MOD_GSK3_1 395 402 PF00069 0.420
MOD_GSK3_1 50 57 PF00069 0.654
MOD_GSK3_1 61 68 PF00069 0.670
MOD_GSK3_1 70 77 PF00069 0.639
MOD_GSK3_1 85 92 PF00069 0.594
MOD_GSK3_1 95 102 PF00069 0.591
MOD_LATS_1 334 340 PF00433 0.448
MOD_N-GLC_1 192 197 PF02516 0.500
MOD_N-GLC_1 367 372 PF02516 0.445
MOD_N-GLC_1 456 461 PF02516 0.588
MOD_NEK2_1 126 131 PF00069 0.574
MOD_NEK2_1 144 149 PF00069 0.575
MOD_NEK2_1 16 21 PF00069 0.605
MOD_NEK2_1 221 226 PF00069 0.441
MOD_NEK2_1 279 284 PF00069 0.446
MOD_NEK2_1 328 333 PF00069 0.572
MOD_NEK2_1 335 340 PF00069 0.515
MOD_NEK2_1 449 454 PF00069 0.447
MOD_NEK2_1 516 521 PF00069 0.486
MOD_NEK2_1 525 530 PF00069 0.420
MOD_NEK2_1 568 573 PF00069 0.524
MOD_NEK2_1 61 66 PF00069 0.642
MOD_NEK2_1 726 731 PF00069 0.410
MOD_NEK2_1 894 899 PF00069 0.421
MOD_PIKK_1 144 150 PF00454 0.524
MOD_PIKK_1 16 22 PF00454 0.517
MOD_PIKK_1 423 429 PF00454 0.372
MOD_PK_1 787 793 PF00069 0.671
MOD_PKA_1 499 505 PF00069 0.320
MOD_PKA_2 169 175 PF00069 0.613
MOD_PKA_2 20 26 PF00069 0.524
MOD_PKA_2 273 279 PF00069 0.534
MOD_PKA_2 328 334 PF00069 0.521
MOD_PKA_2 335 341 PF00069 0.413
MOD_PKA_2 350 356 PF00069 0.424
MOD_PKA_2 499 505 PF00069 0.330
MOD_PKA_2 742 748 PF00069 0.567
MOD_PKB_1 497 505 PF00069 0.334
MOD_Plk_1 250 256 PF00069 0.336
MOD_Plk_1 614 620 PF00069 0.443
MOD_Plk_2-3 273 279 PF00069 0.666
MOD_Plk_2-3 778 784 PF00069 0.602
MOD_Plk_4 187 193 PF00069 0.454
MOD_Plk_4 221 227 PF00069 0.473
MOD_Plk_4 240 246 PF00069 0.437
MOD_Plk_4 304 310 PF00069 0.554
MOD_Plk_4 395 401 PF00069 0.420
MOD_Plk_4 489 495 PF00069 0.454
MOD_Plk_4 594 600 PF00069 0.383
MOD_ProDKin_1 113 119 PF00069 0.559
MOD_ProDKin_1 121 127 PF00069 0.551
MOD_ProDKin_1 171 177 PF00069 0.556
MOD_ProDKin_1 298 304 PF00069 0.451
MOD_ProDKin_1 367 373 PF00069 0.352
MOD_ProDKin_1 50 56 PF00069 0.601
MOD_ProDKin_1 555 561 PF00069 0.537
MOD_ProDKin_1 656 662 PF00069 0.553
MOD_ProDKin_1 72 78 PF00069 0.634
MOD_ProDKin_1 79 85 PF00069 0.610
MOD_ProDKin_1 95 101 PF00069 0.617
MOD_SUMO_rev_2 41 51 PF00179 0.498
MOD_SUMO_rev_2 874 883 PF00179 0.650
TRG_DiLeu_BaEn_1 158 163 PF01217 0.525
TRG_DiLeu_BaEn_1 891 896 PF01217 0.426
TRG_DiLeu_BaEn_4 158 164 PF01217 0.511
TRG_ENDOCYTIC_2 189 192 PF00928 0.491
TRG_ENDOCYTIC_2 546 549 PF00928 0.390
TRG_ENDOCYTIC_2 633 636 PF00928 0.505
TRG_ENDOCYTIC_2 662 665 PF00928 0.562
TRG_ENDOCYTIC_2 9 12 PF00928 0.506
TRG_ENDOCYTIC_2 905 908 PF00928 0.433
TRG_ER_diArg_1 294 297 PF00400 0.507
TRG_ER_diArg_1 364 367 PF00400 0.475
TRG_ER_diArg_1 495 497 PF00400 0.516
TRG_ER_diArg_1 498 500 PF00400 0.447
TRG_ER_diArg_1 530 533 PF00400 0.400
TRG_ER_diArg_1 570 573 PF00400 0.539
TRG_ER_diArg_1 649 651 PF00400 0.502
TRG_ER_diArg_1 819 822 PF00400 0.542
TRG_Pf-PMV_PEXEL_1 238 242 PF00026 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NYY7 Trypanosomatidae 43% 100%
A0A3Q8IAD3 Leishmania donovani 54% 94%
A0A3Q8IAF8 Leishmania donovani 80% 95%
A0A3Q8IAK8 Leishmania donovani 97% 94%
A0A3Q8IJ32 Leishmania donovani 81% 100%
A0A3S5H6Y1 Leishmania donovani 91% 97%
A0A3S7WTZ8 Leishmania donovani 66% 89%
A0A3S7WU13 Leishmania donovani 81% 98%
A0A422NAR5 Trypanosoma rangeli 43% 100%
A4H8M5 Leishmania braziliensis 67% 100%
A4H8M7 Leishmania braziliensis 68% 100%
A4H8N0 Leishmania braziliensis 51% 100%
A4H8N1 Leishmania braziliensis 52% 100%
A4HWZ5 Leishmania infantum 79% 100%
A4HWZ6 Leishmania infantum 90% 100%
A4HX00 Leishmania infantum 66% 89%
A4HX01 Leishmania infantum 55% 100%
A4HX05 Leishmania infantum 85% 95%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
E9AGP0 Leishmania infantum 100% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
Q4QER2 Leishmania major 53% 100%
Q4QER3 Leishmania major 63% 100%
Q4QER4 Leishmania major 92% 97%
Q4QER5 Leishmania major 74% 100%
Q4QER6 Leishmania major 74% 100%
Q4QER7 Leishmania major 81% 100%
Q4QER8 Leishmania major 88% 100%
Q4QER9 Leishmania major 85% 100%
Q4QES0 Leishmania major 76% 100%
V5ANJ8 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS