LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184) - putative
Species:
Leishmania infantum
UniProt:
A4HWZ6_LEIIN
TriTrypDb:
LINF_160015700 *
Length:
912

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 37
NetGPI no yes: 0, no: 37
Cellular components
Term Name Level Count
GO:0016020 membrane 2 20
GO:0110165 cellular anatomical entity 1 27
GO:0005794 Golgi apparatus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9

Expansion

Sequence features

A4HWZ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWZ6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 36
GO:0016740 transferase activity 2 36
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 391 395 PF00656 0.510
CLV_C14_Caspase3-7 672 676 PF00656 0.341
CLV_MEL_PAP_1 242 248 PF00089 0.615
CLV_NRD_NRD_1 208 210 PF00675 0.669
CLV_NRD_NRD_1 234 236 PF00675 0.674
CLV_NRD_NRD_1 265 267 PF00675 0.603
CLV_NRD_NRD_1 28 30 PF00675 0.452
CLV_NRD_NRD_1 580 582 PF00675 0.660
CLV_NRD_NRD_1 583 585 PF00675 0.623
CLV_NRD_NRD_1 618 620 PF00675 0.587
CLV_NRD_NRD_1 656 658 PF00675 0.685
CLV_NRD_NRD_1 7 9 PF00675 0.457
CLV_NRD_NRD_1 734 736 PF00675 0.621
CLV_NRD_NRD_1 880 882 PF00675 0.708
CLV_NRD_NRD_1 91 93 PF00675 0.732
CLV_PCSK_FUR_1 581 585 PF00082 0.625
CLV_PCSK_FUR_1 654 658 PF00082 0.647
CLV_PCSK_KEX2_1 208 210 PF00082 0.667
CLV_PCSK_KEX2_1 234 236 PF00082 0.662
CLV_PCSK_KEX2_1 27 29 PF00082 0.446
CLV_PCSK_KEX2_1 538 540 PF00082 0.585
CLV_PCSK_KEX2_1 580 582 PF00082 0.660
CLV_PCSK_KEX2_1 583 585 PF00082 0.580
CLV_PCSK_KEX2_1 656 658 PF00082 0.677
CLV_PCSK_KEX2_1 7 9 PF00082 0.456
CLV_PCSK_KEX2_1 734 736 PF00082 0.621
CLV_PCSK_KEX2_1 880 882 PF00082 0.708
CLV_PCSK_KEX2_1 91 93 PF00082 0.732
CLV_PCSK_PC1ET2_1 538 540 PF00082 0.578
CLV_PCSK_SKI1_1 181 185 PF00082 0.679
CLV_PCSK_SKI1_1 290 294 PF00082 0.651
CLV_PCSK_SKI1_1 32 36 PF00082 0.222
CLV_PCSK_SKI1_1 397 401 PF00082 0.702
CLV_PCSK_SKI1_1 451 455 PF00082 0.620
CLV_PCSK_SKI1_1 505 509 PF00082 0.664
CLV_PCSK_SKI1_1 622 626 PF00082 0.538
CLV_PCSK_SKI1_1 734 738 PF00082 0.656
CLV_PCSK_SKI1_1 842 846 PF00082 0.720
DEG_APCC_DBOX_1 363 371 PF00400 0.479
DOC_CKS1_1 218 223 PF01111 0.388
DOC_CKS1_1 291 296 PF01111 0.452
DOC_CKS1_1 741 746 PF01111 0.459
DOC_CYCLIN_yCln2_LP_2 127 133 PF00134 0.465
DOC_CYCLIN_yCln2_LP_2 624 630 PF00134 0.336
DOC_MAPK_DCC_7 709 718 PF00069 0.404
DOC_MAPK_gen_1 375 384 PF00069 0.410
DOC_MAPK_gen_1 449 458 PF00069 0.404
DOC_MAPK_gen_1 617 626 PF00069 0.447
DOC_MAPK_gen_1 709 718 PF00069 0.428
DOC_MAPK_gen_1 75 82 PF00069 0.446
DOC_MAPK_HePTP_8 737 749 PF00069 0.459
DOC_MAPK_MEF2A_6 225 232 PF00069 0.362
DOC_MAPK_MEF2A_6 451 460 PF00069 0.400
DOC_MAPK_MEF2A_6 619 628 PF00069 0.447
DOC_MAPK_MEF2A_6 740 749 PF00069 0.458
DOC_MAPK_MEF2A_6 823 830 PF00069 0.509
DOC_PP2B_LxvP_1 127 130 PF13499 0.485
DOC_PP2B_LxvP_1 624 627 PF13499 0.447
DOC_PP4_FxxP_1 291 294 PF00568 0.447
DOC_PP4_FxxP_1 741 744 PF00568 0.407
DOC_USP7_MATH_1 123 127 PF00917 0.473
DOC_USP7_MATH_1 158 162 PF00917 0.492
DOC_USP7_MATH_1 302 306 PF00917 0.571
DOC_USP7_MATH_1 411 415 PF00917 0.480
DOC_USP7_MATH_1 497 501 PF00917 0.333
DOC_USP7_MATH_1 573 577 PF00917 0.508
DOC_USP7_MATH_1 686 690 PF00917 0.396
DOC_WW_Pin1_4 135 140 PF00397 0.483
DOC_WW_Pin1_4 201 206 PF00397 0.488
DOC_WW_Pin1_4 217 222 PF00397 0.573
DOC_WW_Pin1_4 290 295 PF00397 0.519
DOC_WW_Pin1_4 382 387 PF00397 0.393
DOC_WW_Pin1_4 451 456 PF00397 0.325
DOC_WW_Pin1_4 639 644 PF00397 0.449
DOC_WW_Pin1_4 740 745 PF00397 0.459
LIG_14-3-3_CanoR_1 108 115 PF00244 0.489
LIG_14-3-3_CanoR_1 181 189 PF00244 0.492
LIG_14-3-3_CanoR_1 234 238 PF00244 0.503
LIG_14-3-3_CanoR_1 364 368 PF00244 0.459
LIG_14-3-3_CanoR_1 420 425 PF00244 0.423
LIG_14-3-3_CanoR_1 435 439 PF00244 0.347
LIG_14-3-3_CanoR_1 499 504 PF00244 0.347
LIG_14-3-3_CanoR_1 539 549 PF00244 0.441
LIG_14-3-3_CanoR_1 583 593 PF00244 0.323
LIG_14-3-3_CanoR_1 827 831 PF00244 0.501
LIG_14-3-3_CanoR_1 848 856 PF00244 0.472
LIG_Actin_WH2_2 314 331 PF00022 0.358
LIG_Actin_WH2_2 405 422 PF00022 0.525
LIG_Actin_WH2_2 523 540 PF00022 0.348
LIG_BIR_III_2 662 666 PF00653 0.430
LIG_BRCT_BRCA1_1 161 165 PF00533 0.499
LIG_BRCT_BRCA1_1 641 645 PF00533 0.365
LIG_BRCT_BRCA1_1 785 789 PF00533 0.505
LIG_EH_1 311 315 PF12763 0.390
LIG_EH1_1 271 279 PF00400 0.309
LIG_eIF4E_1 525 531 PF01652 0.383
LIG_FHA_1 178 184 PF00498 0.541
LIG_FHA_1 247 253 PF00498 0.469
LIG_FHA_1 336 342 PF00498 0.395
LIG_FHA_1 358 364 PF00498 0.550
LIG_FHA_1 665 671 PF00498 0.479
LIG_FHA_2 218 224 PF00498 0.493
LIG_FHA_2 335 341 PF00498 0.436
LIG_FHA_2 389 395 PF00498 0.510
LIG_FHA_2 601 607 PF00498 0.285
LIG_FHA_2 685 691 PF00498 0.335
LIG_FHA_2 699 705 PF00498 0.392
LIG_LIR_Gen_1 250 261 PF02991 0.389
LIG_LIR_Gen_1 35 46 PF02991 0.220
LIG_LIR_Gen_1 510 521 PF02991 0.311
LIG_LIR_Gen_1 690 700 PF02991 0.365
LIG_LIR_Gen_1 743 754 PF02991 0.414
LIG_LIR_Nem_3 250 256 PF02991 0.356
LIG_LIR_Nem_3 35 41 PF02991 0.220
LIG_LIR_Nem_3 473 479 PF02991 0.392
LIG_LIR_Nem_3 595 601 PF02991 0.298
LIG_LIR_Nem_3 623 628 PF02991 0.325
LIG_LIR_Nem_3 642 648 PF02991 0.438
LIG_LIR_Nem_3 690 696 PF02991 0.353
LIG_LIR_Nem_3 743 749 PF02991 0.451
LIG_LIR_Nem_3 786 792 PF02991 0.406
LIG_MAD2 181 189 PF02301 0.460
LIG_MAD2 848 856 PF02301 0.507
LIG_MYND_1 224 228 PF01753 0.463
LIG_NRBOX 141 147 PF00104 0.467
LIG_PDZ_Class_2 907 912 PF00595 0.284
LIG_Pex14_2 314 318 PF04695 0.364
LIG_Pex14_2 51 55 PF04695 0.228
LIG_PTB_Apo_2 458 465 PF02174 0.363
LIG_PTB_Apo_2 711 718 PF02174 0.377
LIG_PTB_Phospho_1 458 464 PF10480 0.365
LIG_PTB_Phospho_1 711 717 PF10480 0.418
LIG_REV1ctd_RIR_1 598 608 PF16727 0.310
LIG_SH2_CRK 253 257 PF00017 0.397
LIG_SH2_GRB2like 459 462 PF00017 0.478
LIG_SH2_GRB2like 717 720 PF00017 0.421
LIG_SH2_SRC 746 749 PF00017 0.457
LIG_SH2_SRC 803 806 PF00017 0.534
LIG_SH2_STAP1 585 589 PF00017 0.400
LIG_SH2_STAP1 605 609 PF00017 0.216
LIG_SH2_STAT3 860 863 PF00017 0.527
LIG_SH2_STAT5 219 222 PF00017 0.528
LIG_SH2_STAT5 464 467 PF00017 0.351
LIG_SH2_STAT5 525 528 PF00017 0.416
LIG_SH2_STAT5 585 588 PF00017 0.377
LIG_SH2_STAT5 593 596 PF00017 0.327
LIG_SH2_STAT5 648 651 PF00017 0.374
LIG_SH2_STAT5 717 720 PF00017 0.418
LIG_SH2_STAT5 746 749 PF00017 0.453
LIG_SH3_2 579 584 PF14604 0.359
LIG_SH3_3 12 18 PF00018 0.657
LIG_SH3_3 127 133 PF00018 0.471
LIG_SH3_3 150 156 PF00018 0.487
LIG_SH3_3 188 194 PF00018 0.539
LIG_SH3_3 207 213 PF00018 0.523
LIG_SH3_3 218 224 PF00018 0.505
LIG_SH3_3 3 9 PF00018 0.642
LIG_SH3_3 307 313 PF00018 0.627
LIG_SH3_3 576 582 PF00018 0.384
LIG_SH3_3 79 85 PF00018 0.506
LIG_SH3_3 887 893 PF00018 0.425
LIG_SUMO_SIM_anti_2 517 524 PF11976 0.370
LIG_SUMO_SIM_par_1 276 281 PF11976 0.356
LIG_SUMO_SIM_par_1 380 385 PF11976 0.412
LIG_SxIP_EBH_1 571 584 PF03271 0.348
LIG_TRAF2_1 10 13 PF00917 0.633
LIG_TRAF2_1 220 223 PF00917 0.398
LIG_TRAF2_1 779 782 PF00917 0.433
LIG_TRAF2_1 802 805 PF00917 0.517
LIG_TYR_ITIM 251 256 PF00017 0.560
LIG_WRC_WIRS_1 252 257 PF05994 0.458
MOD_CDK_SPK_2 290 295 PF00069 0.514
MOD_CDK_SPK_2 639 644 PF00069 0.457
MOD_CDK_SPxxK_3 201 208 PF00069 0.562
MOD_CK1_1 110 116 PF00069 0.615
MOD_CK1_1 122 128 PF00069 0.556
MOD_CK1_1 305 311 PF00069 0.556
MOD_CK1_1 366 372 PF00069 0.515
MOD_CK1_1 414 420 PF00069 0.596
MOD_CK1_1 61 67 PF00069 0.563
MOD_CK1_1 681 687 PF00069 0.424
MOD_CK2_1 217 223 PF00069 0.630
MOD_CK2_1 600 606 PF00069 0.312
MOD_CK2_1 698 704 PF00069 0.484
MOD_CK2_1 7 13 PF00069 0.524
MOD_CK2_1 722 728 PF00069 0.556
MOD_CK2_1 799 805 PF00069 0.474
MOD_CK2_1 871 877 PF00069 0.606
MOD_GlcNHglycan 121 124 PF01048 0.582
MOD_GlcNHglycan 161 164 PF01048 0.641
MOD_GlcNHglycan 166 170 PF01048 0.605
MOD_GlcNHglycan 307 310 PF01048 0.529
MOD_GlcNHglycan 414 417 PF01048 0.570
MOD_GlcNHglycan 498 502 PF01048 0.540
MOD_GlcNHglycan 542 545 PF01048 0.615
MOD_GlcNHglycan 60 63 PF01048 0.549
MOD_GlcNHglycan 65 68 PF01048 0.593
MOD_GlcNHglycan 683 686 PF01048 0.404
MOD_GlcNHglycan 725 728 PF01048 0.515
MOD_GlcNHglycan 850 853 PF01048 0.572
MOD_GlcNHglycan 9 12 PF01048 0.525
MOD_GSK3_1 106 113 PF00069 0.612
MOD_GSK3_1 118 125 PF00069 0.556
MOD_GSK3_1 147 154 PF00069 0.683
MOD_GSK3_1 177 184 PF00069 0.603
MOD_GSK3_1 276 283 PF00069 0.397
MOD_GSK3_1 32 39 PF00069 0.227
MOD_GSK3_1 479 486 PF00069 0.419
MOD_GSK3_1 57 64 PF00069 0.517
MOD_LATS_1 418 424 PF00433 0.476
MOD_N-GLC_1 118 123 PF02516 0.578
MOD_N-GLC_1 256 261 PF02516 0.507
MOD_N-GLC_1 451 456 PF02516 0.456
MOD_N-GLC_1 540 545 PF02516 0.591
MOD_NEK2_1 165 170 PF00069 0.628
MOD_NEK2_1 280 285 PF00069 0.421
MOD_NEK2_1 328 333 PF00069 0.663
MOD_NEK2_1 363 368 PF00069 0.452
MOD_NEK2_1 412 417 PF00069 0.577
MOD_NEK2_1 419 424 PF00069 0.548
MOD_NEK2_1 533 538 PF00069 0.446
MOD_NEK2_1 58 63 PF00069 0.573
MOD_NEK2_1 600 605 PF00069 0.486
MOD_NEK2_1 609 614 PF00069 0.420
MOD_NEK2_1 652 657 PF00069 0.529
MOD_NEK2_1 810 815 PF00069 0.472
MOD_PIKK_1 147 153 PF00454 0.564
MOD_PIKK_1 328 334 PF00454 0.628
MOD_PIKK_1 507 513 PF00454 0.371
MOD_PK_1 871 877 PF00069 0.694
MOD_PKA_1 583 589 PF00069 0.317
MOD_PKA_1 7 13 PF00069 0.534
MOD_PKA_2 107 113 PF00069 0.732
MOD_PKA_2 233 239 PF00069 0.614
MOD_PKA_2 328 334 PF00069 0.439
MOD_PKA_2 335 341 PF00069 0.647
MOD_PKA_2 357 363 PF00069 0.540
MOD_PKA_2 412 418 PF00069 0.525
MOD_PKA_2 419 425 PF00069 0.446
MOD_PKA_2 434 440 PF00069 0.440
MOD_PKA_2 583 589 PF00069 0.327
MOD_PKA_2 7 13 PF00069 0.536
MOD_PKA_2 826 832 PF00069 0.583
MOD_PKB_1 581 589 PF00069 0.328
MOD_Plk_1 698 704 PF00069 0.452
MOD_Plk_2-3 276 282 PF00069 0.404
MOD_Plk_2-3 357 363 PF00069 0.672
MOD_Plk_2-3 862 868 PF00069 0.626
MOD_Plk_4 251 257 PF00069 0.453
MOD_Plk_4 388 394 PF00069 0.572
MOD_Plk_4 479 485 PF00069 0.419
MOD_Plk_4 573 579 PF00069 0.450
MOD_Plk_4 678 684 PF00069 0.404
MOD_ProDKin_1 135 141 PF00069 0.591
MOD_ProDKin_1 201 207 PF00069 0.598
MOD_ProDKin_1 217 223 PF00069 0.711
MOD_ProDKin_1 290 296 PF00069 0.648
MOD_ProDKin_1 382 388 PF00069 0.467
MOD_ProDKin_1 451 457 PF00069 0.362
MOD_ProDKin_1 639 645 PF00069 0.540
MOD_ProDKin_1 740 746 PF00069 0.556
TRG_DiLeu_BaEn_1 222 227 PF01217 0.569
TRG_DiLeu_BaEn_4 222 228 PF01217 0.551
TRG_DiLeu_LyEn_5 222 227 PF01217 0.418
TRG_ENDOCYTIC_2 253 256 PF00928 0.487
TRG_ENDOCYTIC_2 630 633 PF00928 0.390
TRG_ENDOCYTIC_2 717 720 PF00928 0.503
TRG_ENDOCYTIC_2 746 749 PF00928 0.568
TRG_ER_diArg_1 207 209 PF00400 0.579
TRG_ER_diArg_1 26 29 PF00400 0.545
TRG_ER_diArg_1 378 381 PF00400 0.514
TRG_ER_diArg_1 448 451 PF00400 0.491
TRG_ER_diArg_1 579 581 PF00400 0.512
TRG_ER_diArg_1 582 584 PF00400 0.430
TRG_ER_diArg_1 6 8 PF00400 0.554
TRG_ER_diArg_1 614 617 PF00400 0.400
TRG_ER_diArg_1 654 657 PF00400 0.544
TRG_ER_diArg_1 733 735 PF00400 0.497
TRG_ER_diArg_1 90 92 PF00400 0.673
TRG_ER_diArg_1 902 905 PF00400 0.580
TRG_NLS_MonoExtN_4 27 33 PF00514 0.537

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NYY7 Trypanosomatidae 40% 100%
A0A3Q8IAD3 Leishmania donovani 49% 93%
A0A3Q8IAF8 Leishmania donovani 84% 95%
A0A3Q8IAK8 Leishmania donovani 88% 94%
A0A3Q8IJ32 Leishmania donovani 79% 100%
A0A3S5H6Y1 Leishmania donovani 99% 97%
A0A3S7WTZ8 Leishmania donovani 61% 89%
A0A3S7WU13 Leishmania donovani 79% 97%
A0A422NAR5 Trypanosoma rangeli 41% 100%
A4H8M5 Leishmania braziliensis 63% 100%
A4H8M7 Leishmania braziliensis 67% 100%
A4H8N0 Leishmania braziliensis 51% 100%
A4H8N1 Leishmania braziliensis 47% 100%
A4HWZ5 Leishmania infantum 67% 100%
A4HWZ8 Leishmania infantum 90% 99%
A4HX00 Leishmania infantum 61% 89%
A4HX01 Leishmania infantum 50% 100%
A4HX05 Leishmania infantum 87% 95%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9AGP0 Leishmania infantum 100% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
Q4QER2 Leishmania major 48% 100%
Q4QER3 Leishmania major 58% 100%
Q4QER4 Leishmania major 84% 100%
Q4QER5 Leishmania major 70% 100%
Q4QER6 Leishmania major 70% 100%
Q4QER7 Leishmania major 79% 100%
Q4QER8 Leishmania major 69% 100%
Q4QER9 Leishmania major 86% 100%
Q4QES0 Leishmania major 73% 100%
V5ANJ8 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS