Stealth_CR3 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3184) - putative

Species:

Leishmania infantum

UniProt:

A4HWZ6_LEIIN

TriTrypDb:

LINF_160015700

Length:

912

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 32

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 37
NetGPI	no	yes: 0, no: 37

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Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	9
GO:0016020	membrane	2	20
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	27

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Expansion

Sequence features

A4HWZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWZ6

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	36
GO:0016740	transferase activity	2	36
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.510
CLV_C14_Caspase3-7	672	676	PF00656	0.341
CLV_MEL_PAP_1	242	248	PF00089	0.615
CLV_NRD_NRD_1	208	210	PF00675	0.669
CLV_NRD_NRD_1	234	236	PF00675	0.674
CLV_NRD_NRD_1	265	267	PF00675	0.603
CLV_NRD_NRD_1	28	30	PF00675	0.452
CLV_NRD_NRD_1	580	582	PF00675	0.660
CLV_NRD_NRD_1	583	585	PF00675	0.623
CLV_NRD_NRD_1	618	620	PF00675	0.587

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYY7	Trypanosomatidae	40%	100%
A0A3Q8IAD3	Leishmania donovani	49%	93%
A0A3Q8IAF8	Leishmania donovani	84%	95%
A0A3Q8IAK8	Leishmania donovani	88%	94%
A0A3Q8IJ32	Leishmania donovani	79%	100%
A0A3S5H6Y1	Leishmania donovani	99%	97%
A0A3S7WTZ8	Leishmania donovani	61%	89%
A0A3S7WU13	Leishmania donovani	79%	97%
A0A422NAR5	Trypanosoma rangeli	41%	100%
A4H8M5	Leishmania braziliensis	63%	100%

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