LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184) - putative
Species:
Leishmania infantum
UniProt:
A4HWZ5_LEIIN
TriTrypDb:
LINF_160015600 *
Length:
940

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Annotations by Jardim et al.

Protein kinase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 36
NetGPI no yes: 0, no: 36
Cellular components
TermNameLevelCount
GO:0005794 Golgi apparatus 5 9
GO:0016020 membrane 2 20
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 27
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Expansion

Sequence features

A4HWZ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWZ5

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 35
GO:0016740 transferase activity 2 35
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 332 336 PF00656 0.468
CLV_C14_Caspase3-7 499 503 PF00656 0.310
CLV_C14_Caspase3-7 611 615 PF00656 0.336
CLV_MEL_PAP_1 202 208 PF00089 0.598
CLV_NRD_NRD_1 158 160 PF00675 0.658
CLV_NRD_NRD_1 194 196 PF00675 0.665
CLV_NRD_NRD_1 225 227 PF00675 0.564
CLV_NRD_NRD_1 39 41 PF00675 0.539
CLV_NRD_NRD_1 519 521 PF00675 0.662
CLV_NRD_NRD_1 522 524 PF00675 0.627
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Homologs

ProteinTaxonomySequence identityCoverage
A0A1X0NYY7 Trypanosomatidae 42% 100%
A0A3Q8IAD3 Leishmania donovani 53% 96%
A0A3Q8IAF8 Leishmania donovani 77% 98%
A0A3Q8IAK8 Leishmania donovani 80% 97%
A0A3Q8IJ32 Leishmania donovani 99% 100%
A0A3S5H6Y1 Leishmania donovani 81% 100%
A0A3S7WTZ8 Leishmania donovani 66% 91%
A0A3S7WU13 Leishmania donovani 99% 100%
A0A422NAR5 Trypanosoma rangeli 43% 100%
A4H8M5 Leishmania braziliensis 64% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS