Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HWZ4_LEIIN

TriTrypDb:

LINF_160015500

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HWZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWZ4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	97	101	PF00082	0.413
CLV_PCSK_KEX2_1	36	38	PF00082	0.413
CLV_PCSK_KEX2_1	361	363	PF00082	0.453
CLV_PCSK_KEX2_1	91	93	PF00082	0.413
CLV_PCSK_KEX2_1	99	101	PF00082	0.318
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.413
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.413
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.413
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.318
CLV_PCSK_SKI1_1	109	113	PF00082	0.294
CLV_PCSK_SKI1_1	130	134	PF00082	0.413
CLV_PCSK_SKI1_1	273	277	PF00082	0.427
CLV_PCSK_SKI1_1	394	398	PF00082	0.462
CLV_PCSK_SKI1_1	99	103	PF00082	0.413
DEG_APCC_DBOX_1	108	116	PF00400	0.413
DEG_SPOP_SBC_1	377	381	PF00917	0.259
DOC_CYCLIN_RxL_1	270	277	PF00134	0.357
DOC_CYCLIN_RxL_1	96	105	PF00134	0.413
DOC_MAPK_gen_1	130	139	PF00069	0.413
DOC_MAPK_gen_1	59	69	PF00069	0.413
DOC_MAPK_gen_1	6	13	PF00069	0.413
DOC_MAPK_MEF2A_6	133	141	PF00069	0.413
DOC_PP1_RVXF_1	271	277	PF00149	0.413
DOC_PP1_RVXF_1	29	36	PF00149	0.413
DOC_PP2B_LxvP_1	160	163	PF13499	0.613
DOC_PP4_FxxP_1	392	395	PF00568	0.413
DOC_PP4_FxxP_1	74	77	PF00568	0.413
DOC_USP7_MATH_1	151	155	PF00917	0.652
DOC_USP7_MATH_1	179	183	PF00917	0.686
DOC_USP7_MATH_1	203	207	PF00917	0.527
DOC_USP7_MATH_1	377	381	PF00917	0.413
DOC_USP7_UBL2_3	8	12	PF12436	0.413
DOC_WW_Pin1_4	149	154	PF00397	0.710
DOC_WW_Pin1_4	205	210	PF00397	0.561
DOC_WW_Pin1_4	240	245	PF00397	0.451
DOC_WW_Pin1_4	291	296	PF00397	0.413
LIG_14-3-3_CanoR_1	362	368	PF00244	0.413
LIG_14-3-3_CanoR_1	37	47	PF00244	0.413
LIG_14-3-3_CanoR_1	378	386	PF00244	0.223
LIG_14-3-3_CanoR_1	429	436	PF00244	0.413
LIG_APCC_ABBAyCdc20_2	125	131	PF00400	0.413
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_deltaCOP1_diTrp_1	258	267	PF00928	0.413
LIG_deltaCOP1_diTrp_1	389	397	PF00928	0.413
LIG_EH_1	186	190	PF12763	0.623
LIG_FAT_LD_1	452	460	PF03623	0.586
LIG_FHA_1	269	275	PF00498	0.413
LIG_FHA_1	27	33	PF00498	0.413
LIG_FHA_1	381	387	PF00498	0.477
LIG_FHA_1	455	461	PF00498	0.575
LIG_FHA_2	39	45	PF00498	0.413
LIG_FHA_2	402	408	PF00498	0.357
LIG_LIR_Apic_2	238	244	PF02991	0.413
LIG_LIR_Apic_2	250	256	PF02991	0.271
LIG_LIR_Apic_2	381	387	PF02991	0.398
LIG_LIR_Apic_2	389	395	PF02991	0.333
LIG_LIR_Apic_2	71	77	PF02991	0.413
LIG_LIR_Gen_1	145	153	PF02991	0.653
LIG_LIR_Gen_1	68	77	PF02991	0.413
LIG_LIR_Nem_3	145	149	PF02991	0.632
LIG_LIR_Nem_3	15	21	PF02991	0.413
LIG_LIR_Nem_3	68	73	PF02991	0.413
LIG_Pex14_2	70	74	PF04695	0.413
LIG_SH2_CRK	18	22	PF00017	0.413
LIG_SH2_CRK	253	257	PF00017	0.413
LIG_SH2_CRK	364	368	PF00017	0.413
LIG_SH2_CRK	384	388	PF00017	0.175
LIG_SH2_SRC	121	124	PF00017	0.413
LIG_SH2_SRC	440	443	PF00017	0.480
LIG_SH2_STAP1	232	236	PF00017	0.413
LIG_SH2_STAT3	333	336	PF00017	0.259
LIG_SH2_STAT5	121	124	PF00017	0.413
LIG_SH2_STAT5	333	336	PF00017	0.259
LIG_SH2_STAT5	440	443	PF00017	0.480
LIG_SH3_3	138	144	PF00018	0.413
LIG_SH3_3	441	447	PF00018	0.497
LIG_SUMO_SIM_par_1	254	261	PF11976	0.413
LIG_SUMO_SIM_par_1	64	71	PF11976	0.413
LIG_UBA3_1	265	273	PF00899	0.413
LIG_UBA3_1	354	361	PF00899	0.413
LIG_UBA3_1	69	78	PF00899	0.413
MOD_CAAXbox	466	469	PF01239	0.565
MOD_CDC14_SPxK_1	294	297	PF00782	0.413
MOD_CDK_SPxK_1	291	297	PF00069	0.413
MOD_CDK_SPxxK_3	149	156	PF00069	0.605
MOD_CK1_1	152	158	PF00069	0.629
MOD_CK1_1	302	308	PF00069	0.413
MOD_CK1_1	342	348	PF00069	0.448
MOD_CK1_1	376	382	PF00069	0.378
MOD_CK1_1	408	414	PF00069	0.413
MOD_CK1_1	445	451	PF00069	0.428
MOD_CK2_1	39	45	PF00069	0.413
MOD_GlcNHglycan	165	168	PF01048	0.714
MOD_GlcNHglycan	177	180	PF01048	0.579
MOD_GlcNHglycan	249	252	PF01048	0.447
MOD_GlcNHglycan	276	279	PF01048	0.357
MOD_GlcNHglycan	346	349	PF01048	0.329
MOD_GlcNHglycan	374	378	PF01048	0.413
MOD_GlcNHglycan	401	404	PF01048	0.413
MOD_GSK3_1	147	154	PF00069	0.670
MOD_GSK3_1	163	170	PF00069	0.515
MOD_GSK3_1	175	182	PF00069	0.569
MOD_GSK3_1	22	29	PF00069	0.413
MOD_GSK3_1	247	254	PF00069	0.455
MOD_GSK3_1	340	347	PF00069	0.357
MOD_GSK3_1	373	380	PF00069	0.413
MOD_GSK3_1	401	408	PF00069	0.357
MOD_GSK3_1	455	462	PF00069	0.644
MOD_NEK2_1	247	252	PF00069	0.413
MOD_NEK2_1	269	274	PF00069	0.413
MOD_NEK2_1	363	368	PF00069	0.413
MOD_NEK2_1	401	406	PF00069	0.357
MOD_NEK2_1	455	460	PF00069	0.677
MOD_NEK2_1	93	98	PF00069	0.413
MOD_PIKK_1	340	346	PF00454	0.413
MOD_PIKK_1	353	359	PF00454	0.258
MOD_PKA_1	230	236	PF00069	0.413
MOD_PKA_2	296	302	PF00069	0.413
MOD_PKA_2	314	320	PF00069	0.199
MOD_PKA_2	377	383	PF00069	0.413
MOD_PKA_2	428	434	PF00069	0.430
MOD_Plk_4	17	23	PF00069	0.413
MOD_Plk_4	235	241	PF00069	0.413
MOD_Plk_4	299	305	PF00069	0.385
MOD_Plk_4	455	461	PF00069	0.575
MOD_ProDKin_1	149	155	PF00069	0.713
MOD_ProDKin_1	205	211	PF00069	0.547
MOD_ProDKin_1	240	246	PF00069	0.451
MOD_ProDKin_1	291	297	PF00069	0.413
MOD_SUMO_rev_2	126	134	PF00179	0.357
MOD_SUMO_rev_2	84	93	PF00179	0.413
TRG_DiLeu_BaEn_1	281	286	PF01217	0.343
TRG_DiLeu_BaEn_1	413	418	PF01217	0.413
TRG_DiLeu_BaEn_1	464	469	PF01217	0.560
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.413
TRG_ENDOCYTIC_2	18	21	PF00928	0.282
TRG_ENDOCYTIC_2	364	367	PF00928	0.413
TRG_ENDOCYTIC_2	7	10	PF00928	0.413
TRG_NES_CRM1_1	211	225	PF08389	0.413
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P759	Leptomonas seymouri	74%	99%
A0A0S4JZV2	Bodo saltans	31%	100%
A0A0S4KIN4	Bodo saltans	26%	69%
A0A1X0NYA7	Trypanosomatidae	23%	71%
A0A1X0NZD5	Trypanosomatidae	40%	94%
A0A1X0P018	Trypanosomatidae	29%	85%
A0A3R7K7C3	Trypanosoma rangeli	27%	92%
A0A3R7KDC2	Trypanosoma rangeli	26%	100%
A0A3R7NBN7	Trypanosoma rangeli	36%	100%
A0A3S5H6Y0	Leishmania donovani	99%	99%
A0A3S5IQV1	Trypanosoma rangeli	42%	99%
A4H4A1	Leishmania braziliensis	28%	100%
A4H601	Leishmania braziliensis	25%	100%
A4H8M3	Leishmania braziliensis	90%	99%
A4H9U7	Leishmania braziliensis	24%	93%
A4HFI2	Leishmania braziliensis	31%	100%
C9ZLG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZVG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZW07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AQQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AYV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O43077	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	84%
O80345	Arabidopsis thaliana	24%	98%
Q01917	Crithidia fasciculata	75%	99%
Q45FA5	Physarum polycephalum	26%	100%
Q4QES1	Leishmania major	96%	99%
Q6BV06	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	77%
Q6FQ83	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	70%
V5D488	Trypanosoma cruzi	42%	100%
V5DCN7	Trypanosoma cruzi	29%	79%