Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWZ3_LEIIN

TriTrypDb:

LINF_160015400

Length:

971

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.701
CLV_C14_Caspase3-7	342	346	PF00656	0.574
CLV_C14_Caspase3-7	888	892	PF00656	0.607
CLV_NRD_NRD_1	259	261	PF00675	0.495
CLV_NRD_NRD_1	419	421	PF00675	0.567
CLV_NRD_NRD_1	452	454	PF00675	0.624
CLV_NRD_NRD_1	514	516	PF00675	0.580
CLV_NRD_NRD_1	682	684	PF00675	0.527
CLV_NRD_NRD_1	690	692	PF00675	0.511
CLV_NRD_NRD_1	746	748	PF00675	0.588
CLV_NRD_NRD_1	842	844	PF00675	0.494
CLV_NRD_NRD_1	930	932	PF00675	0.552
CLV_NRD_NRD_1	951	953	PF00675	0.566
CLV_PCSK_KEX2_1	188	190	PF00082	0.515
CLV_PCSK_KEX2_1	259	261	PF00082	0.600
CLV_PCSK_KEX2_1	419	421	PF00082	0.547
CLV_PCSK_KEX2_1	452	454	PF00082	0.622
CLV_PCSK_KEX2_1	602	604	PF00082	0.607
CLV_PCSK_KEX2_1	682	684	PF00082	0.527
CLV_PCSK_KEX2_1	690	692	PF00082	0.511
CLV_PCSK_KEX2_1	720	722	PF00082	0.558
CLV_PCSK_KEX2_1	746	748	PF00082	0.614
CLV_PCSK_KEX2_1	842	844	PF00082	0.494
CLV_PCSK_KEX2_1	930	932	PF00082	0.552
CLV_PCSK_KEX2_1	941	943	PF00082	0.543
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.494
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.643
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.627
CLV_PCSK_PC1ET2_1	941	943	PF00082	0.649
CLV_PCSK_SKI1_1	169	173	PF00082	0.500
CLV_PCSK_SKI1_1	262	266	PF00082	0.599
CLV_PCSK_SKI1_1	295	299	PF00082	0.474
CLV_PCSK_SKI1_1	301	305	PF00082	0.462
CLV_PCSK_SKI1_1	377	381	PF00082	0.625
CLV_PCSK_SKI1_1	462	466	PF00082	0.594
CLV_PCSK_SKI1_1	483	487	PF00082	0.586
CLV_PCSK_SKI1_1	573	577	PF00082	0.654
CLV_Separin_Metazoa	523	527	PF03568	0.622
DEG_APCC_DBOX_1	203	211	PF00400	0.475
DEG_APCC_DBOX_1	232	240	PF00400	0.588
DEG_APCC_DBOX_1	300	308	PF00400	0.538
DEG_APCC_DBOX_1	425	433	PF00400	0.621
DEG_APCC_DBOX_1	572	580	PF00400	0.645
DEG_SPOP_SBC_1	112	116	PF00917	0.566
DOC_CYCLIN_RxL_1	259	269	PF00134	0.597
DOC_MAPK_gen_1	230	238	PF00069	0.591
DOC_MAPK_gen_1	259	267	PF00069	0.493
DOC_MAPK_gen_1	515	524	PF00069	0.601
DOC_USP7_MATH_1	143	147	PF00917	0.684
DOC_USP7_MATH_1	153	157	PF00917	0.659
DOC_USP7_MATH_1	248	252	PF00917	0.619
DOC_USP7_MATH_1	966	970	PF00917	0.719
DOC_USP7_UBL2_3	395	399	PF12436	0.668
DOC_WW_Pin1_4	113	118	PF00397	0.642
DOC_WW_Pin1_4	123	128	PF00397	0.532
DOC_WW_Pin1_4	141	146	PF00397	0.425
DOC_WW_Pin1_4	158	163	PF00397	0.638
DOC_WW_Pin1_4	28	33	PF00397	0.597
DOC_WW_Pin1_4	39	44	PF00397	0.515
DOC_WW_Pin1_4	69	74	PF00397	0.687
LIG_14-3-3_CanoR_1	401	409	PF00244	0.637
LIG_14-3-3_CanoR_1	53	63	PF00244	0.657
LIG_14-3-3_CanoR_1	573	581	PF00244	0.578
LIG_14-3-3_CanoR_1	619	625	PF00244	0.675
LIG_14-3-3_CanoR_1	682	686	PF00244	0.578
LIG_14-3-3_CanoR_1	921	929	PF00244	0.555
LIG_14-3-3_CanoR_1	96	105	PF00244	0.683
LIG_FHA_1	227	233	PF00498	0.516
LIG_FHA_1	284	290	PF00498	0.476
LIG_FHA_1	334	340	PF00498	0.620
LIG_FHA_1	348	354	PF00498	0.505
LIG_FHA_1	363	369	PF00498	0.513
LIG_FHA_1	388	394	PF00498	0.614
LIG_FHA_1	420	426	PF00498	0.599
LIG_FHA_1	602	608	PF00498	0.641
LIG_FHA_1	673	679	PF00498	0.619
LIG_FHA_1	912	918	PF00498	0.522
LIG_FHA_2	101	107	PF00498	0.606
LIG_FHA_2	152	158	PF00498	0.699
LIG_FHA_2	401	407	PF00498	0.554
LIG_FHA_2	649	655	PF00498	0.532
LIG_FHA_2	921	927	PF00498	0.570
LIG_LIR_Gen_1	310	315	PF02991	0.594
LIG_LIR_Nem_3	310	314	PF02991	0.556
LIG_NRBOX	263	269	PF00104	0.480
LIG_Pex14_2	35	39	PF04695	0.555
LIG_RPA_C_Fungi	691	703	PF08784	0.622
LIG_SH2_PTP2	135	138	PF00017	0.631
LIG_SH2_STAP1	105	109	PF00017	0.718
LIG_SH2_STAP1	214	218	PF00017	0.484
LIG_SH2_STAP1	311	315	PF00017	0.553
LIG_SH2_STAT3	282	285	PF00017	0.482
LIG_SH2_STAT3	903	906	PF00017	0.558
LIG_SH2_STAT5	125	128	PF00017	0.760
LIG_SH2_STAT5	135	138	PF00017	0.514
LIG_SH2_STAT5	277	280	PF00017	0.552
LIG_SH2_STAT5	299	302	PF00017	0.536
LIG_SH2_STAT5	409	412	PF00017	0.530
LIG_SH3_3	133	139	PF00018	0.735
LIG_SH3_3	79	85	PF00018	0.715
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.624
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.583
LIG_SUMO_SIM_anti_2	612	618	PF11976	0.452
LIG_SUMO_SIM_par_1	263	269	PF11976	0.523
LIG_SUMO_SIM_par_1	612	618	PF11976	0.588
LIG_TRAF2_1	221	224	PF00917	0.587
LIG_TRAF2_1	370	373	PF00917	0.642
LIG_TRAF2_1	403	406	PF00917	0.577
LIG_TRAF2_1	468	471	PF00917	0.623
LIG_TRAF2_1	684	687	PF00917	0.573
LIG_TRAF2_1	924	927	PF00917	0.567
MOD_CDC14_SPxK_1	161	164	PF00782	0.601
MOD_CDK_SPxK_1	158	164	PF00069	0.664
MOD_CDK_SPxxK_3	123	130	PF00069	0.632
MOD_CK1_1	123	129	PF00069	0.642
MOD_CK1_1	28	34	PF00069	0.729
MOD_CK1_1	69	75	PF00069	0.649
MOD_CK1_1	858	864	PF00069	0.642
MOD_CK1_1	920	926	PF00069	0.598
MOD_CK1_1	99	105	PF00069	0.609
MOD_CK2_1	400	406	PF00069	0.564
MOD_CK2_1	421	427	PF00069	0.604
MOD_CK2_1	602	608	PF00069	0.613
MOD_CK2_1	618	624	PF00069	0.589
MOD_CK2_1	648	654	PF00069	0.524
MOD_CK2_1	681	687	PF00069	0.631
MOD_CK2_1	878	884	PF00069	0.609
MOD_CK2_1	920	926	PF00069	0.598
MOD_Cter_Amidation	950	953	PF01082	0.552
MOD_GlcNHglycan	109	112	PF01048	0.671
MOD_GlcNHglycan	122	125	PF01048	0.617
MOD_GlcNHglycan	27	30	PF01048	0.703
MOD_GlcNHglycan	604	607	PF01048	0.648
MOD_GlcNHglycan	620	623	PF01048	0.713
MOD_GlcNHglycan	68	71	PF01048	0.734
MOD_GlcNHglycan	8	11	PF01048	0.626
MOD_GlcNHglycan	875	878	PF01048	0.670
MOD_GlcNHglycan	89	92	PF01048	0.701
MOD_GSK3_1	107	114	PF00069	0.694
MOD_GSK3_1	119	126	PF00069	0.717
MOD_GSK3_1	139	146	PF00069	0.655
MOD_GSK3_1	21	28	PF00069	0.536
MOD_GSK3_1	341	348	PF00069	0.598
MOD_GSK3_1	472	479	PF00069	0.635
MOD_GSK3_1	549	556	PF00069	0.641
MOD_GSK3_1	567	574	PF00069	0.524
MOD_GSK3_1	6	13	PF00069	0.678
MOD_GSK3_1	641	648	PF00069	0.552
MOD_GSK3_1	916	923	PF00069	0.553
MOD_GSK3_1	96	103	PF00069	0.612
MOD_N-GLC_1	120	125	PF02516	0.752
MOD_N-GLC_1	33	38	PF02516	0.667
MOD_N-GLC_1	333	338	PF02516	0.491
MOD_N-GLC_1	39	44	PF02516	0.686
MOD_NEK2_1	120	125	PF00069	0.693
MOD_NEK2_1	432	437	PF00069	0.650
MOD_NEK2_1	501	506	PF00069	0.591
MOD_NEK2_1	6	11	PF00069	0.740
MOD_NEK2_1	646	651	PF00069	0.558
MOD_NEK2_1	777	782	PF00069	0.542
MOD_NEK2_1	855	860	PF00069	0.530
MOD_NEK2_1	911	916	PF00069	0.517
MOD_NEK2_1	917	922	PF00069	0.532
MOD_NEK2_1	936	941	PF00069	0.541
MOD_NEK2_2	21	26	PF00069	0.640
MOD_PIKK_1	125	131	PF00454	0.668
MOD_PIKK_1	377	383	PF00454	0.614
MOD_PIKK_1	584	590	PF00454	0.675
MOD_PIKK_1	641	647	PF00454	0.555
MOD_PIKK_1	648	654	PF00454	0.474
MOD_PIKK_1	855	861	PF00454	0.542
MOD_PIKK_1	867	873	PF00454	0.504
MOD_PK_1	472	478	PF00069	0.646
MOD_PKA_1	419	425	PF00069	0.606
MOD_PKA_1	452	458	PF00069	0.651
MOD_PKA_1	602	608	PF00069	0.647
MOD_PKA_2	107	113	PF00069	0.717
MOD_PKA_2	400	406	PF00069	0.662
MOD_PKA_2	419	425	PF00069	0.357
MOD_PKA_2	452	458	PF00069	0.627
MOD_PKA_2	537	543	PF00069	0.551
MOD_PKA_2	54	60	PF00069	0.717
MOD_PKA_2	554	560	PF00069	0.565
MOD_PKA_2	602	608	PF00069	0.649
MOD_PKA_2	618	624	PF00069	0.641
MOD_PKA_2	646	652	PF00069	0.602
MOD_PKA_2	664	670	PF00069	0.606
MOD_PKA_2	681	687	PF00069	0.538
MOD_PKA_2	711	717	PF00069	0.579
MOD_PKA_2	920	926	PF00069	0.598
MOD_PKB_1	551	559	PF00069	0.609
MOD_Plk_1	100	106	PF00069	0.688
MOD_Plk_1	273	279	PF00069	0.501
MOD_Plk_1	295	301	PF00069	0.491
MOD_Plk_1	33	39	PF00069	0.641
MOD_Plk_1	472	478	PF00069	0.598
MOD_Plk_1	501	507	PF00069	0.612
MOD_Plk_1	867	873	PF00069	0.642
MOD_Plk_2-3	421	427	PF00069	0.604
MOD_Plk_2-3	454	460	PF00069	0.611
MOD_Plk_2-3	681	687	PF00069	0.610
MOD_Plk_4	100	106	PF00069	0.736
MOD_Plk_4	273	279	PF00069	0.561
MOD_Plk_4	285	291	PF00069	0.447
MOD_Plk_4	711	717	PF00069	0.613
MOD_Plk_4	945	951	PF00069	0.549
MOD_ProDKin_1	113	119	PF00069	0.643
MOD_ProDKin_1	123	129	PF00069	0.533
MOD_ProDKin_1	141	147	PF00069	0.427
MOD_ProDKin_1	158	164	PF00069	0.631
MOD_ProDKin_1	28	34	PF00069	0.595
MOD_ProDKin_1	39	45	PF00069	0.515
MOD_ProDKin_1	69	75	PF00069	0.689
MOD_SUMO_for_1	307	310	PF00179	0.612
MOD_SUMO_rev_2	269	276	PF00179	0.494
MOD_SUMO_rev_2	448	458	PF00179	0.601
MOD_SUMO_rev_2	724	732	PF00179	0.585
TRG_DiLeu_BaEn_1	263	268	PF01217	0.576
TRG_DiLeu_BaEn_2	710	716	PF01217	0.513
TRG_DiLeu_BaEn_3	273	279	PF01217	0.515
TRG_DiLeu_BaEn_4	323	329	PF01217	0.634
TRG_DiLeu_BaEn_4	427	433	PF01217	0.616
TRG_DiLeu_BaEn_4	680	686	PF01217	0.574
TRG_DiLeu_BaEn_4	810	816	PF01217	0.524
TRG_DiLeu_BaEn_4	828	834	PF01217	0.530
TRG_DiLeu_BaLyEn_6	913	918	PF01217	0.566
TRG_ENDOCYTIC_2	311	314	PF00928	0.594
TRG_ER_diArg_1	418	420	PF00400	0.653
TRG_ER_diArg_1	525	528	PF00400	0.619
TRG_ER_diArg_1	690	692	PF00400	0.612
TRG_ER_diArg_1	746	748	PF00400	0.580
TRG_ER_diArg_1	841	843	PF00400	0.493
TRG_ER_diArg_1	929	931	PF00400	0.549
TRG_NES_CRM1_1	231	244	PF08389	0.585
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	690	694	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	725	729	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	746	750	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	757	761	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	867	871	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R5	Leptomonas seymouri	71%	84%
A0A0S4JQ17	Bodo saltans	33%	100%
A0A3R7LSL7	Trypanosoma rangeli	41%	100%
A0A3S7WU05	Leishmania donovani	100%	84%
A4H8M2	Leishmania braziliensis	87%	100%
C9ZW08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AQQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QES2	Leishmania major	97%	100%
V5B8F4	Trypanosoma cruzi	41%	100%