LeishMANIAdb
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Putative flagellar calcium-binding protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative flagellar calcium-binding protein
Gene product:
EF-hand domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HWY7_LEIIN
TriTrypDb:
LINF_160014800
Length:
203

Annotations

Annotations by Jardim et al.

Flagella, flagellar calcium-binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005929 cilium 4 18
GO:0031514 motile cilium 5 18
GO:0042995 cell projection 2 18
GO:0043226 organelle 2 18
GO:0043227 membrane-bounded organelle 3 18
GO:0110165 cellular anatomical entity 1 18
GO:0120025 plasma membrane bounded cell projection 3 18
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HWY7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWY7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 19
GO:0005509 calcium ion binding 5 19
GO:0043167 ion binding 2 19
GO:0043169 cation binding 3 19
GO:0046872 metal ion binding 4 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 190 192 PF00675 0.400
CLV_NRD_NRD_1 20 22 PF00675 0.364
CLV_NRD_NRD_1 9 11 PF00675 0.614
CLV_PCSK_KEX2_1 49 51 PF00082 0.329
CLV_PCSK_KEX2_1 86 88 PF00082 0.384
CLV_PCSK_PC1ET2_1 49 51 PF00082 0.451
CLV_PCSK_PC1ET2_1 86 88 PF00082 0.384
CLV_PCSK_PC7_1 82 88 PF00082 0.337
CLV_PCSK_SKI1_1 115 119 PF00082 0.329
CLV_PCSK_SKI1_1 145 149 PF00082 0.460
CLV_PCSK_SKI1_1 86 90 PF00082 0.398
DEG_APCC_DBOX_1 114 122 PF00400 0.330
DOC_CKS1_1 35 40 PF01111 0.436
DOC_PP1_RVXF_1 19 26 PF00149 0.370
DOC_USP7_MATH_1 199 203 PF00917 0.647
DOC_USP7_UBL2_3 7 11 PF12436 0.707
DOC_WW_Pin1_4 34 39 PF00397 0.457
LIG_14-3-3_CanoR_1 50 59 PF00244 0.344
LIG_Actin_WH2_2 67 84 PF00022 0.410
LIG_FHA_1 54 60 PF00498 0.391
LIG_FHA_1 76 82 PF00498 0.385
LIG_FHA_1 96 102 PF00498 0.341
LIG_FHA_2 15 21 PF00498 0.506
LIG_FHA_2 35 41 PF00498 0.244
LIG_FHA_2 58 64 PF00498 0.388
LIG_LIR_Gen_1 105 116 PF02991 0.398
LIG_LIR_Gen_1 123 131 PF02991 0.269
LIG_LIR_Nem_3 105 111 PF02991 0.413
LIG_LIR_Nem_3 123 127 PF02991 0.282
LIG_LIR_Nem_3 128 134 PF02991 0.426
LIG_LIR_Nem_3 156 160 PF02991 0.455
LIG_LIR_Nem_3 165 171 PF02991 0.387
LIG_LIR_Nem_3 46 51 PF02991 0.306
LIG_SH2_STAT5 120 123 PF00017 0.309
LIG_SH2_STAT5 124 127 PF00017 0.314
LIG_SUMO_SIM_anti_2 126 133 PF11976 0.356
LIG_TRAF2_1 60 63 PF00917 0.490
MOD_CDK_SPxxK_3 34 41 PF00069 0.452
MOD_CK2_1 14 20 PF00069 0.505
MOD_CK2_1 51 57 PF00069 0.411
MOD_GlcNHglycan 135 139 PF01048 0.474
MOD_GlcNHglycan 175 178 PF01048 0.423
MOD_GSK3_1 10 17 PF00069 0.633
MOD_GSK3_1 53 60 PF00069 0.425
MOD_GSK3_1 76 83 PF00069 0.412
MOD_GSK3_1 87 94 PF00069 0.453
MOD_N-GLC_1 173 178 PF02516 0.474
MOD_N-GLC_1 3 8 PF02516 0.714
MOD_NEK2_1 125 130 PF00069 0.366
MOD_NEK2_1 95 100 PF00069 0.520
MOD_NMyristoyl 1 7 PF02799 0.581
MOD_PK_1 80 86 PF00069 0.342
MOD_PKA_1 10 16 PF00069 0.456
MOD_Plk_1 125 131 PF00069 0.347
MOD_Plk_2-3 57 63 PF00069 0.334
MOD_Plk_4 125 131 PF00069 0.368
MOD_Plk_4 163 169 PF00069 0.485
MOD_Plk_4 67 73 PF00069 0.324
MOD_ProDKin_1 34 40 PF00069 0.451
MOD_SUMO_rev_2 13 18 PF00179 0.476
MOD_SUMO_rev_2 143 150 PF00179 0.428
TRG_AP2beta_CARGO_1 105 115 PF09066 0.401
TRG_DiLeu_BaEn_2 106 112 PF01217 0.489
TRG_ENDOCYTIC_2 122 125 PF00928 0.304
TRG_Pf-PMV_PEXEL_1 191 196 PF00026 0.366

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6S0 Leptomonas seymouri 63% 99%
A0A0S4J8L5 Bodo saltans 36% 100%
A0A0S4KMR0 Bodo saltans 40% 100%
A0A1X0NZ95 Trypanosomatidae 59% 99%
A0A1X0P0A5 Trypanosomatidae 56% 100%
A0A1X0P0I3 Trypanosomatidae 63% 93%
A0A3R7KL32 Trypanosoma rangeli 64% 100%
A0A3S7WTZ3 Leishmania donovani 97% 100%
A0A422NDP3 Trypanosoma rangeli 59% 99%
A4H8L5 Leishmania braziliensis 74% 100%
A4H8L6 Leishmania braziliensis 73% 100%
A4HWY6 Leishmania infantum 99% 100%
C9ZW14 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 93%
C9ZW16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 87%
E9AQQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
E9AQQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
P07749 Trypanosoma cruzi 56% 96%
P17882 Trypanosoma brucei brucei 52% 87%
Q26677 Trypanosoma brucei brucei 55% 89%
Q26680 Trypanosoma brucei brucei 53% 93%
Q27052 Trypanosoma rangeli 59% 100%
V5D941 Trypanosoma cruzi 56% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS