Putative flagellar calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair/EF-hand domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HWY6_LEIIN

TriTrypDb:

LINF_160014700

Length:

135

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0031514	motile cilium	5	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A4HWY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWY6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	26	28	PF00082	0.397
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.397
CLV_PCSK_PC7_1	22	28	PF00082	0.340
CLV_PCSK_SKI1_1	26	30	PF00082	0.391
CLV_PCSK_SKI1_1	55	59	PF00082	0.380
CLV_PCSK_SKI1_1	85	89	PF00082	0.459
DEG_APCC_DBOX_1	54	62	PF00400	0.378
DEG_Nend_UBRbox_2	1	3	PF02207	0.320
DOC_USP7_MATH_1	126	130	PF00917	0.428
LIG_Actin_WH2_2	7	24	PF00022	0.406
LIG_FHA_1	16	22	PF00498	0.458
LIG_FHA_1	36	42	PF00498	0.368
LIG_LIR_Gen_1	45	56	PF02991	0.469
LIG_LIR_Gen_1	63	71	PF02991	0.294
LIG_LIR_Nem_3	105	111	PF02991	0.429
LIG_LIR_Nem_3	45	51	PF02991	0.456
LIG_LIR_Nem_3	63	67	PF02991	0.389
LIG_LIR_Nem_3	68	74	PF02991	0.420
LIG_LIR_Nem_3	96	100	PF02991	0.481
LIG_SH2_STAT5	60	63	PF00017	0.385
LIG_SH2_STAT5	64	67	PF00017	0.379
LIG_SUMO_SIM_anti_2	66	73	PF11976	0.386
MOD_CK1_1	129	135	PF00069	0.420
MOD_GlcNHglycan	115	118	PF01048	0.480
MOD_GlcNHglycan	131	134	PF01048	0.536
MOD_GlcNHglycan	75	79	PF01048	0.440
MOD_GSK3_1	16	23	PF00069	0.374
MOD_GSK3_1	27	34	PF00069	0.390
MOD_N-GLC_1	113	118	PF02516	0.529
MOD_NEK2_1	35	40	PF00069	0.470
MOD_NEK2_1	65	70	PF00069	0.457
MOD_PK_1	20	26	PF00069	0.308
MOD_PKA_2	129	135	PF00069	0.382
MOD_Plk_1	65	71	PF00069	0.435
MOD_Plk_4	103	109	PF00069	0.384
MOD_Plk_4	65	71	PF00069	0.453
MOD_Plk_4	7	13	PF00069	0.321
MOD_SUMO_rev_2	83	90	PF00179	0.402
TRG_AP2beta_CARGO_1	45	55	PF09066	0.412
TRG_DiLeu_BaEn_2	46	52	PF01217	0.553
TRG_ENDOCYTIC_2	62	65	PF00928	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8L5	Bodo saltans	37%	74%
A0A0S4KMR0	Bodo saltans	41%	74%
A0A1X0P0A5	Trypanosomatidae	63%	82%
A0A3R7KL32	Trypanosoma rangeli	66%	80%
A0A3S7WTZ3	Leishmania donovani	97%	69%
A4H8L5	Leishmania braziliensis	78%	100%
A4H8L6	Leishmania braziliensis	78%	67%
A4HWY7	Leishmania infantum	99%	67%
E9AQQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AQQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	67%
Q27052	Trypanosoma rangeli	66%	66%