Nucleolar protein, Nop52 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein -Nop52 - putative

Species:

Leishmania infantum

UniProt:

A4HWY4_LEIIN

TriTrypDb:

LINF_160014400

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	11
GO:0030688	preribosome, small subunit precursor	4	11
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWY4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.542
CLV_NRD_NRD_1	144	146	PF00675	0.492
CLV_NRD_NRD_1	277	279	PF00675	0.339
CLV_NRD_NRD_1	455	457	PF00675	0.431
CLV_NRD_NRD_1	471	473	PF00675	0.612
CLV_NRD_NRD_1	514	516	PF00675	0.420
CLV_NRD_NRD_1	557	559	PF00675	0.525
CLV_NRD_NRD_1	619	621	PF00675	0.562
CLV_NRD_NRD_1	631	633	PF00675	0.525
CLV_NRD_NRD_1	639	641	PF00675	0.606
CLV_NRD_NRD_1	8	10	PF00675	0.554
CLV_PCSK_FUR_1	629	633	PF00082	0.672
CLV_PCSK_KEX2_1	10	12	PF00082	0.617
CLV_PCSK_KEX2_1	128	130	PF00082	0.548
CLV_PCSK_KEX2_1	144	146	PF00082	0.473
CLV_PCSK_KEX2_1	277	279	PF00082	0.426
CLV_PCSK_KEX2_1	306	308	PF00082	0.755
CLV_PCSK_KEX2_1	327	329	PF00082	0.730
CLV_PCSK_KEX2_1	437	439	PF00082	0.413
CLV_PCSK_KEX2_1	455	457	PF00082	0.340
CLV_PCSK_KEX2_1	473	475	PF00082	0.703
CLV_PCSK_KEX2_1	477	479	PF00082	0.561
CLV_PCSK_KEX2_1	48	50	PF00082	0.418
CLV_PCSK_KEX2_1	556	558	PF00082	0.511
CLV_PCSK_KEX2_1	631	633	PF00082	0.617
CLV_PCSK_KEX2_1	639	641	PF00082	0.645
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.683
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.790
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.730
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.413
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.698
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.561
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.437
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.628
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.634
CLV_PCSK_PC7_1	125	131	PF00082	0.539
CLV_PCSK_SKI1_1	246	250	PF00082	0.355
CLV_PCSK_SKI1_1	278	282	PF00082	0.378
CLV_PCSK_SKI1_1	285	289	PF00082	0.378
CLV_PCSK_SKI1_1	324	328	PF00082	0.705
CLV_PCSK_SKI1_1	384	388	PF00082	0.473
CLV_PCSK_SKI1_1	437	441	PF00082	0.479
CLV_PCSK_SKI1_1	528	532	PF00082	0.426
CLV_PCSK_SKI1_1	561	565	PF00082	0.517
CLV_PCSK_SKI1_1	581	585	PF00082	0.565
CLV_PCSK_SKI1_1	616	620	PF00082	0.622
CLV_Separin_Metazoa	406	410	PF03568	0.483
DEG_Nend_UBRbox_1	1	4	PF02207	0.588
DOC_CKS1_1	549	554	PF01111	0.460
DOC_CKS1_1	98	103	PF01111	0.667
DOC_CYCLIN_yClb5_NLxxxL_5	105	113	PF00134	0.591
DOC_MAPK_gen_1	241	249	PF00069	0.441
DOC_MAPK_gen_1	266	275	PF00069	0.355
DOC_MAPK_gen_1	9	17	PF00069	0.574
DOC_MAPK_MEF2A_6	105	113	PF00069	0.567
DOC_PP1_RVXF_1	244	250	PF00149	0.355
DOC_PP2B_LxvP_1	237	240	PF13499	0.408
DOC_PP4_FxxP_1	443	446	PF00568	0.383
DOC_USP7_MATH_1	326	330	PF00917	0.736
DOC_USP7_MATH_1	354	358	PF00917	0.454
DOC_USP7_MATH_1	612	616	PF00917	0.628
DOC_USP7_UBL2_3	2	6	PF12436	0.592
DOC_USP7_UBL2_3	323	327	PF12436	0.762
DOC_USP7_UBL2_3	473	477	PF12436	0.703
DOC_USP7_UBL2_3	95	99	PF12436	0.618
DOC_WW_Pin1_4	300	305	PF00397	0.754
DOC_WW_Pin1_4	314	319	PF00397	0.706
DOC_WW_Pin1_4	548	553	PF00397	0.648
DOC_WW_Pin1_4	97	102	PF00397	0.667
LIG_14-3-3_CanoR_1	191	196	PF00244	0.517
LIG_14-3-3_CanoR_1	384	393	PF00244	0.514
LIG_14-3-3_CanoR_1	528	538	PF00244	0.453
LIG_14-3-3_CanoR_1	539	547	PF00244	0.522
LIG_14-3-3_CanoR_1	71	79	PF00244	0.490
LIG_APCC_ABBAyCdc20_2	648	654	PF00400	0.615
LIG_FHA_1	341	347	PF00498	0.637
LIG_FHA_1	369	375	PF00498	0.479
LIG_FHA_1	394	400	PF00498	0.419
LIG_FHA_1	483	489	PF00498	0.637
LIG_FHA_2	192	198	PF00498	0.559
LIG_FHA_2	645	651	PF00498	0.567
LIG_GBD_Chelix_1	374	382	PF00786	0.505
LIG_IBAR_NPY_1	102	104	PF08397	0.607
LIG_LIR_Apic_2	441	446	PF02991	0.389
LIG_LIR_Gen_1	197	207	PF02991	0.397
LIG_LIR_Gen_1	270	280	PF02991	0.336
LIG_LIR_Gen_1	401	412	PF02991	0.363
LIG_LIR_Gen_1	414	425	PF02991	0.332
LIG_LIR_Nem_3	148	153	PF02991	0.663
LIG_LIR_Nem_3	197	202	PF02991	0.404
LIG_LIR_Nem_3	260	264	PF02991	0.372
LIG_LIR_Nem_3	270	275	PF02991	0.298
LIG_LIR_Nem_3	377	382	PF02991	0.474
LIG_LIR_Nem_3	401	407	PF02991	0.357
LIG_LIR_Nem_3	414	420	PF02991	0.337
LIG_LIR_Nem_3	441	447	PF02991	0.447
LIG_LIR_Nem_3	545	550	PF02991	0.544
LIG_MAD2	438	446	PF02301	0.417
LIG_PCNA_TLS_4	266	273	PF02747	0.447
LIG_PCNA_TLS_4	437	444	PF02747	0.402
LIG_PCNA_yPIPBox_3	351	365	PF02747	0.501
LIG_REV1ctd_RIR_1	510	520	PF16727	0.446
LIG_SH2_CRK	153	157	PF00017	0.727
LIG_SH2_CRK	250	254	PF00017	0.408
LIG_SH2_GRB2like	106	109	PF00017	0.574
LIG_SH2_GRB2like	153	156	PF00017	0.608
LIG_SH2_NCK_1	153	157	PF00017	0.649
LIG_SH2_SRC	153	156	PF00017	0.608
LIG_SH2_STAP1	83	87	PF00017	0.575
LIG_SH2_STAT3	380	383	PF00017	0.404
LIG_SH2_STAT5	215	218	PF00017	0.361
LIG_SH2_STAT5	272	275	PF00017	0.402
LIG_SH2_STAT5	283	286	PF00017	0.408
LIG_SH2_STAT5	364	367	PF00017	0.510
LIG_SH2_STAT5	380	383	PF00017	0.381
LIG_SH2_STAT5	434	437	PF00017	0.439
LIG_SH2_STAT5	68	71	PF00017	0.437
LIG_SH2_STAT5	93	96	PF00017	0.612
LIG_SH3_1	95	101	PF00018	0.621
LIG_SH3_3	333	339	PF00018	0.682
LIG_SH3_3	546	552	PF00018	0.470
LIG_SH3_3	95	101	PF00018	0.634
LIG_SH3_4	222	229	PF00018	0.335
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.334
LIG_SUMO_SIM_par_1	32	39	PF11976	0.540
LIG_TRAF2_1	121	124	PF00917	0.560
LIG_TYR_ITIM	248	253	PF00017	0.447
MOD_CDC14_SPxK_1	303	306	PF00782	0.692
MOD_CDK_SPxK_1	300	306	PF00069	0.698
MOD_CDK_SPxxK_3	300	307	PF00069	0.754
MOD_CDK_SPxxK_3	314	321	PF00069	0.710
MOD_CK1_1	296	302	PF00069	0.721
MOD_CK1_1	322	328	PF00069	0.735
MOD_CK1_1	388	394	PF00069	0.565
MOD_CK2_1	191	197	PF00069	0.567
MOD_CK2_1	314	320	PF00069	0.772
MOD_CK2_1	529	535	PF00069	0.474
MOD_GlcNHglycan	294	298	PF01048	0.650
MOD_GlcNHglycan	308	311	PF01048	0.572
MOD_GlcNHglycan	324	327	PF01048	0.699
MOD_GlcNHglycan	346	349	PF01048	0.595
MOD_GlcNHglycan	420	423	PF01048	0.503
MOD_GlcNHglycan	540	543	PF01048	0.563
MOD_GSK3_1	296	303	PF00069	0.698
MOD_GSK3_1	322	329	PF00069	0.742
MOD_GSK3_1	340	347	PF00069	0.501
MOD_GSK3_1	364	371	PF00069	0.518
MOD_GSK3_1	385	392	PF00069	0.491
MOD_NEK2_1	349	354	PF00069	0.563
MOD_NEK2_1	387	392	PF00069	0.485
MOD_NEK2_1	418	423	PF00069	0.504
MOD_PIKK_1	354	360	PF00454	0.484
MOD_PIKK_1	427	433	PF00454	0.457
MOD_PK_1	610	616	PF00069	0.448
MOD_PKA_1	306	312	PF00069	0.793
MOD_PKA_1	473	479	PF00069	0.747
MOD_PKA_2	240	246	PF00069	0.441
MOD_PKA_2	306	312	PF00069	0.714
MOD_PKA_2	473	479	PF00069	0.767
MOD_PKA_2	538	544	PF00069	0.563
MOD_PKA_2	70	76	PF00069	0.508
MOD_PKB_1	189	197	PF00069	0.577
MOD_Plk_1	79	85	PF00069	0.566
MOD_Plk_2-3	260	266	PF00069	0.355
MOD_Plk_4	191	197	PF00069	0.567
MOD_ProDKin_1	300	306	PF00069	0.754
MOD_ProDKin_1	314	320	PF00069	0.707
MOD_ProDKin_1	548	554	PF00069	0.641
MOD_ProDKin_1	97	103	PF00069	0.663
MOD_SUMO_for_1	305	308	PF00179	0.735
MOD_SUMO_rev_2	325	335	PF00179	0.570
MOD_SUMO_rev_2	560	566	PF00179	0.624
TRG_ENDOCYTIC_2	106	109	PF00928	0.542
TRG_ENDOCYTIC_2	250	253	PF00928	0.386
TRG_ENDOCYTIC_2	272	275	PF00928	0.378
TRG_ENDOCYTIC_2	283	286	PF00928	0.378
TRG_ER_diArg_1	128	130	PF00400	0.582
TRG_ER_diArg_1	136	139	PF00400	0.542
TRG_ER_diArg_1	276	278	PF00400	0.434
TRG_ER_diArg_1	556	558	PF00400	0.498
TRG_ER_diArg_1	8	11	PF00400	0.605
TRG_NLS_Bipartite_1	455	476	PF00514	0.627
TRG_NLS_Bipartite_1	620	635	PF00514	0.578
TRG_NLS_MonoCore_2	638	643	PF00514	0.625
TRG_NLS_MonoExtN_4	469	476	PF00514	0.680
TRG_NLS_MonoExtN_4	629	635	PF00514	0.585
TRG_NLS_MonoExtN_4	639	644	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R2	Leptomonas seymouri	68%	98%
A0A0S4JIU4	Bodo saltans	37%	100%
A0A3S7WTZ9	Leishmania donovani	100%	100%
A0A422NDR1	Trypanosoma rangeli	38%	100%
A4H8L2	Leishmania braziliensis	84%	100%
C9ZW19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QET0	Leishmania major	95%	100%
V5BD23	Trypanosoma cruzi	37%	100%