Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HWY3_LEIIN

TriTrypDb:

LINF_160014200

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWY3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	520	524	PF00656	0.415
CLV_NRD_NRD_1	200	202	PF00675	0.557
CLV_NRD_NRD_1	352	354	PF00675	0.622
CLV_NRD_NRD_1	445	447	PF00675	0.415
CLV_NRD_NRD_1	643	645	PF00675	0.401
CLV_NRD_NRD_1	95	97	PF00675	0.646
CLV_PCSK_KEX2_1	200	202	PF00082	0.509
CLV_PCSK_KEX2_1	352	354	PF00082	0.622
CLV_PCSK_KEX2_1	445	447	PF00082	0.415
CLV_PCSK_KEX2_1	665	667	PF00082	0.358
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.391
CLV_PCSK_SKI1_1	201	205	PF00082	0.607
CLV_PCSK_SKI1_1	228	232	PF00082	0.582
CLV_PCSK_SKI1_1	400	404	PF00082	0.444
CLV_PCSK_SKI1_1	423	427	PF00082	0.395
CLV_PCSK_SKI1_1	526	530	PF00082	0.461
DEG_SPOP_SBC_1	104	108	PF00917	0.742
DOC_ANK_TNKS_1	351	358	PF00023	0.560
DOC_CKS1_1	156	161	PF01111	0.621
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.605
DOC_MAPK_gen_1	218	227	PF00069	0.458
DOC_MAPK_gen_1	275	285	PF00069	0.538
DOC_MAPK_gen_1	442	450	PF00069	0.425
DOC_MAPK_HePTP_8	215	227	PF00069	0.508
DOC_MAPK_MEF2A_6	218	227	PF00069	0.430
DOC_MAPK_MEF2A_6	445	452	PF00069	0.436
DOC_MAPK_MEF2A_6	649	658	PF00069	0.376
DOC_PP1_RVXF_1	179	186	PF00149	0.634
DOC_PP1_RVXF_1	198	205	PF00149	0.456
DOC_PP1_RVXF_1	267	273	PF00149	0.533
DOC_PP1_RVXF_1	418	425	PF00149	0.438
DOC_PP2B_LxvP_1	169	172	PF13499	0.654
DOC_PP4_FxxP_1	46	49	PF00568	0.760
DOC_USP7_MATH_1	104	108	PF00917	0.716
DOC_USP7_MATH_1	116	120	PF00917	0.612
DOC_USP7_MATH_1	165	169	PF00917	0.702
DOC_USP7_MATH_1	237	241	PF00917	0.705
DOC_USP7_MATH_1	378	382	PF00917	0.671
DOC_USP7_MATH_1	49	53	PF00917	0.655
DOC_USP7_MATH_1	535	539	PF00917	0.438
DOC_USP7_MATH_1	605	609	PF00917	0.422
DOC_USP7_MATH_1	75	79	PF00917	0.751
DOC_USP7_UBL2_3	400	404	PF12436	0.438
DOC_WW_Pin1_4	125	130	PF00397	0.725
DOC_WW_Pin1_4	155	160	PF00397	0.603
DOC_WW_Pin1_4	167	172	PF00397	0.628
DOC_WW_Pin1_4	176	181	PF00397	0.624
DOC_WW_Pin1_4	347	352	PF00397	0.538
DOC_WW_Pin1_4	56	61	PF00397	0.779
DOC_WW_Pin1_4	66	71	PF00397	0.695
DOC_WW_Pin1_4	85	90	PF00397	0.754
LIG_14-3-3_CanoR_1	103	113	PF00244	0.742
LIG_14-3-3_CanoR_1	133	141	PF00244	0.737
LIG_14-3-3_CanoR_1	164	170	PF00244	0.645
LIG_14-3-3_CanoR_1	278	283	PF00244	0.508
LIG_14-3-3_CanoR_1	423	428	PF00244	0.383
LIG_14-3-3_CanoR_1	445	449	PF00244	0.415
LIG_14-3-3_CanoR_1	675	683	PF00244	0.569
LIG_14-3-3_CanoR_1	73	80	PF00244	0.792
LIG_BIR_II_1	1	5	PF00653	0.747
LIG_BRCT_BRCA1_1	126	130	PF00533	0.761
LIG_BRCT_BRCA1_1	275	279	PF00533	0.521
LIG_BRCT_BRCA1_1	404	408	PF00533	0.438
LIG_BRCT_BRCA1_1	420	424	PF00533	0.438
LIG_CaM_IQ_9	285	300	PF13499	0.541
LIG_deltaCOP1_diTrp_1	561	568	PF00928	0.422
LIG_DLG_GKlike_1	278	285	PF00625	0.581
LIG_FHA_1	266	272	PF00498	0.465
LIG_FHA_1	445	451	PF00498	0.427
LIG_FHA_1	548	554	PF00498	0.438
LIG_FHA_1	584	590	PF00498	0.438
LIG_FHA_1	666	672	PF00498	0.356
LIG_FHA_1	679	685	PF00498	0.487
LIG_FHA_2	328	334	PF00498	0.631
LIG_FHA_2	369	375	PF00498	0.599
LIG_FHA_2	518	524	PF00498	0.422
LIG_FHA_2	597	603	PF00498	0.438
LIG_FHA_2	631	637	PF00498	0.427
LIG_FXI_DFP_1	575	579	PF00024	0.391
LIG_GBD_Chelix_1	433	441	PF00786	0.391
LIG_GBD_Chelix_1	480	488	PF00786	0.422
LIG_Integrin_RGD_1	468	470	PF01839	0.454
LIG_LIR_Apic_2	135	141	PF02991	0.742
LIG_LIR_Apic_2	182	188	PF02991	0.628
LIG_LIR_Apic_2	44	49	PF02991	0.580
LIG_LIR_Apic_2	542	548	PF02991	0.357
LIG_LIR_Gen_1	281	288	PF02991	0.575
LIG_LIR_Gen_1	421	431	PF02991	0.430
LIG_LIR_Gen_1	435	443	PF02991	0.277
LIG_LIR_Nem_3	226	230	PF02991	0.506
LIG_LIR_Nem_3	251	257	PF02991	0.560
LIG_LIR_Nem_3	276	282	PF02991	0.606
LIG_LIR_Nem_3	325	329	PF02991	0.639
LIG_LIR_Nem_3	382	388	PF02991	0.647
LIG_LIR_Nem_3	421	427	PF02991	0.430
LIG_LIR_Nem_3	435	439	PF02991	0.277
LIG_LIR_Nem_3	577	581	PF02991	0.357
LIG_LIR_Nem_3	660	664	PF02991	0.417
LIG_LYPXL_SIV_4	384	392	PF13949	0.573
LIG_PDZ_Class_2	682	687	PF00595	0.630
LIG_Pex14_2	472	476	PF04695	0.438
LIG_PTB_Apo_2	504	511	PF02174	0.438
LIG_REV1ctd_RIR_1	202	210	PF16727	0.630
LIG_SH2_CRK	257	261	PF00017	0.517
LIG_SH2_CRK	385	389	PF00017	0.652
LIG_SH2_CRK	661	665	PF00017	0.438
LIG_SH2_PTP2	282	285	PF00017	0.568
LIG_SH2_SRC	455	458	PF00017	0.438
LIG_SH2_SRC	532	535	PF00017	0.415
LIG_SH2_STAP1	609	613	PF00017	0.422
LIG_SH2_STAP1	647	651	PF00017	0.422
LIG_SH2_STAT5	155	158	PF00017	0.577
LIG_SH2_STAT5	282	285	PF00017	0.568
LIG_SH2_STAT5	436	439	PF00017	0.357
LIG_SH2_STAT5	570	573	PF00017	0.357
LIG_SH2_STAT5	683	686	PF00017	0.524
LIG_SH3_1	138	144	PF00018	0.683
LIG_SH3_2	159	164	PF14604	0.661
LIG_SH3_3	138	144	PF00018	0.683
LIG_SH3_3	156	162	PF00018	0.549
LIG_SH3_3	172	178	PF00018	0.676
LIG_SH3_3	190	196	PF00018	0.431
LIG_SH3_3	364	370	PF00018	0.549
LIG_SH3_3	573	579	PF00018	0.357
LIG_SH3_3	59	65	PF00018	0.803
LIG_SH3_CIN85_PxpxPR_1	176	181	PF14604	0.645
LIG_Sin3_3	235	242	PF02671	0.643
LIG_SUMO_SIM_par_1	360	366	PF11976	0.490
LIG_SUMO_SIM_par_1	654	660	PF11976	0.438
LIG_TRAF2_1	371	374	PF00917	0.604
LIG_TRAF2_1	598	601	PF00917	0.422
LIG_TYR_ITIM	434	439	PF00017	0.381
LIG_TYR_ITIM	659	664	PF00017	0.438
LIG_WRC_WIRS_1	464	469	PF05994	0.376
MOD_CDC14_SPxK_1	161	164	PF00782	0.622
MOD_CDC14_SPxK_1	350	353	PF00782	0.631
MOD_CDK_SPK_2	176	181	PF00069	0.645
MOD_CDK_SPK_2	347	352	PF00069	0.622
MOD_CDK_SPxK_1	158	164	PF00069	0.612
MOD_CDK_SPxK_1	347	353	PF00069	0.622
MOD_CDK_SPxxK_3	66	73	PF00069	0.701
MOD_CK1_1	111	117	PF00069	0.707
MOD_CK1_1	119	125	PF00069	0.661
MOD_CK1_1	167	173	PF00069	0.601
MOD_CK1_1	249	255	PF00069	0.612
MOD_CK1_1	256	262	PF00069	0.447
MOD_CK1_1	281	287	PF00069	0.463
MOD_CK1_1	393	399	PF00069	0.371
MOD_CK1_1	539	545	PF00069	0.438
MOD_CK1_1	608	614	PF00069	0.490
MOD_CK1_1	69	75	PF00069	0.727
MOD_CK1_1	78	84	PF00069	0.782
MOD_CK1_1	85	91	PF00069	0.810
MOD_CK2_1	176	182	PF00069	0.716
MOD_CK2_1	20	26	PF00069	0.751
MOD_CK2_1	319	325	PF00069	0.693
MOD_CK2_1	327	333	PF00069	0.628
MOD_CK2_1	368	374	PF00069	0.605
MOD_CK2_1	630	636	PF00069	0.427
MOD_Cter_Amidation	198	201	PF01082	0.481
MOD_GlcNHglycan	114	117	PF01048	0.708
MOD_GlcNHglycan	121	124	PF01048	0.734
MOD_GlcNHglycan	197	200	PF01048	0.578
MOD_GlcNHglycan	23	26	PF01048	0.710
MOD_GlcNHglycan	239	242	PF01048	0.702
MOD_GlcNHglycan	294	297	PF01048	0.574
MOD_GlcNHglycan	3	6	PF01048	0.695
MOD_GlcNHglycan	321	324	PF01048	0.699
MOD_GlcNHglycan	341	344	PF01048	0.557
MOD_GlcNHglycan	381	384	PF01048	0.639
MOD_GlcNHglycan	45	49	PF01048	0.757
MOD_GlcNHglycan	610	613	PF01048	0.503
MOD_GlcNHglycan	626	629	PF01048	0.455
MOD_GlcNHglycan	77	80	PF01048	0.787
MOD_GSK3_1	104	111	PF00069	0.705
MOD_GSK3_1	112	119	PF00069	0.664
MOD_GSK3_1	21	28	PF00069	0.768
MOD_GSK3_1	245	252	PF00069	0.659
MOD_GSK3_1	261	268	PF00069	0.362
MOD_GSK3_1	283	290	PF00069	0.520
MOD_GSK3_1	327	334	PF00069	0.686
MOD_GSK3_1	386	393	PF00069	0.549
MOD_GSK3_1	402	409	PF00069	0.337
MOD_GSK3_1	44	51	PF00069	0.713
MOD_GSK3_1	472	479	PF00069	0.438
MOD_GSK3_1	535	542	PF00069	0.415
MOD_GSK3_1	557	564	PF00069	0.391
MOD_GSK3_1	615	622	PF00069	0.430
MOD_GSK3_1	674	681	PF00069	0.454
MOD_GSK3_1	69	76	PF00069	0.786
MOD_GSK3_1	78	85	PF00069	0.693
MOD_GSK3_1	8	15	PF00069	0.662
MOD_N-GLC_1	640	645	PF02516	0.492
MOD_N-GLC_2	41	43	PF02516	0.703
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	109	114	PF00069	0.619
MOD_NEK2_1	245	250	PF00069	0.709
MOD_NEK2_1	463	468	PF00069	0.448
MOD_NEK2_1	472	477	PF00069	0.400
MOD_NEK2_1	482	487	PF00069	0.324
MOD_NEK2_1	540	545	PF00069	0.410
MOD_NEK2_2	418	423	PF00069	0.364
MOD_PIKK_1	583	589	PF00454	0.438
MOD_PIKK_1	73	79	PF00454	0.742
MOD_PKA_1	319	325	PF00069	0.693
MOD_PKA_1	665	671	PF00069	0.438
MOD_PKA_2	132	138	PF00069	0.748
MOD_PKA_2	292	298	PF00069	0.569
MOD_PKA_2	444	450	PF00069	0.415
MOD_PKA_2	665	671	PF00069	0.438
MOD_PKA_2	674	680	PF00069	0.508
MOD_Plk_1	331	337	PF00069	0.630
MOD_Plk_1	472	478	PF00069	0.438
MOD_Plk_4	170	176	PF00069	0.644
MOD_Plk_4	256	262	PF00069	0.432
MOD_Plk_4	278	284	PF00069	0.576
MOD_Plk_4	423	429	PF00069	0.387
MOD_Plk_4	472	478	PF00069	0.393
MOD_Plk_4	570	576	PF00069	0.438
MOD_ProDKin_1	125	131	PF00069	0.721
MOD_ProDKin_1	155	161	PF00069	0.610
MOD_ProDKin_1	167	173	PF00069	0.635
MOD_ProDKin_1	176	182	PF00069	0.618
MOD_ProDKin_1	347	353	PF00069	0.537
MOD_ProDKin_1	56	62	PF00069	0.779
MOD_ProDKin_1	66	72	PF00069	0.695
MOD_ProDKin_1	85	91	PF00069	0.754
MOD_SUMO_for_1	307	310	PF00179	0.578
MOD_SUMO_for_1	503	506	PF00179	0.357
MOD_SUMO_for_1	551	554	PF00179	0.438
MOD_SUMO_rev_2	405	415	PF00179	0.492
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.647
TRG_ENDOCYTIC_2	257	260	PF00928	0.519
TRG_ENDOCYTIC_2	282	285	PF00928	0.568
TRG_ENDOCYTIC_2	326	329	PF00928	0.626
TRG_ENDOCYTIC_2	385	388	PF00928	0.646
TRG_ENDOCYTIC_2	436	439	PF00928	0.375
TRG_ENDOCYTIC_2	661	664	PF00928	0.438
TRG_ER_diArg_1	200	202	PF00400	0.509
TRG_ER_diArg_1	351	353	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	649	653	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE38	Leptomonas seymouri	68%	100%
A0A0S4JLW5	Bodo saltans	36%	90%
A0A3S5H6X9	Leishmania donovani	99%	100%
A4H8L1	Leishmania braziliensis	76%	100%
C9ZW20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QET2	Leishmania major	94%	100%