Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWY2_LEIIN

TriTrypDb:

LINF_160014100

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.449
CLV_PCSK_KEX2_1	197	199	PF00082	0.488
CLV_PCSK_KEX2_1	203	205	PF00082	0.449
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.488
CLV_PCSK_SKI1_1	110	114	PF00082	0.461
DEG_SPOP_SBC_1	29	33	PF00917	0.722
DOC_CKS1_1	4	9	PF01111	0.468
DOC_MAPK_gen_1	203	209	PF00069	0.427
DOC_MAPK_MEF2A_6	84	92	PF00069	0.480
DOC_PP4_FxxP_1	161	164	PF00568	0.483
DOC_SPAK_OSR1_1	204	208	PF12202	0.431
DOC_USP7_MATH_1	100	104	PF00917	0.661
DOC_USP7_MATH_1	141	145	PF00917	0.646
DOC_USP7_MATH_1	187	191	PF00917	0.585
DOC_USP7_MATH_1	29	33	PF00917	0.691
DOC_USP7_MATH_1	50	54	PF00917	0.458
DOC_USP7_UBL2_3	80	84	PF12436	0.661
DOC_WW_Pin1_4	121	126	PF00397	0.710
DOC_WW_Pin1_4	160	165	PF00397	0.479
DOC_WW_Pin1_4	22	27	PF00397	0.445
DOC_WW_Pin1_4	3	8	PF00397	0.460
LIG_14-3-3_CanoR_1	142	152	PF00244	0.613
LIG_14-3-3_CanoR_1	89	93	PF00244	0.449
LIG_Actin_WH2_2	5	21	PF00022	0.493
LIG_BRCT_BRCA1_1	115	119	PF00533	0.449
LIG_BRCT_BRCA1_1	162	166	PF00533	0.483
LIG_FHA_1	109	115	PF00498	0.459
LIG_FHA_2	151	157	PF00498	0.606
LIG_LIR_Apic_2	158	164	PF02991	0.480
LIG_LIR_Gen_1	47	56	PF02991	0.490
LIG_LIR_Gen_1	6	14	PF02991	0.572
LIG_LIR_Nem_3	6	12	PF02991	0.571
LIG_PTB_Apo_2	2	9	PF02174	0.519
LIG_SH2_CRK	199	203	PF00017	0.539
LIG_SH3_3	23	29	PF00018	0.622
LIG_SH3_3	93	99	PF00018	0.528
LIG_SH3_4	80	87	PF00018	0.627
LIG_SUMO_SIM_anti_2	175	182	PF11976	0.423
LIG_SUMO_SIM_par_1	110	116	PF11976	0.461
LIG_TRAF2_1	14	17	PF00917	0.599
LIG_WRC_WIRS_1	114	119	PF05994	0.463
MOD_CK1_1	121	127	PF00069	0.549
MOD_CK1_1	144	150	PF00069	0.682
MOD_CK1_1	169	175	PF00069	0.446
MOD_CK1_1	189	195	PF00069	0.476
MOD_CK1_1	33	39	PF00069	0.610
MOD_CK2_1	100	106	PF00069	0.636
MOD_CK2_1	150	156	PF00069	0.623
MOD_GlcNHglycan	169	172	PF01048	0.644
MOD_GlcNHglycan	189	192	PF01048	0.470
MOD_GlcNHglycan	35	38	PF01048	0.623
MOD_GlcNHglycan	52	55	PF01048	0.343
MOD_GSK3_1	113	120	PF00069	0.454
MOD_GSK3_1	127	134	PF00069	0.624
MOD_GSK3_1	143	150	PF00069	0.534
MOD_GSK3_1	182	189	PF00069	0.681
MOD_GSK3_1	29	36	PF00069	0.613
MOD_N-GLC_1	117	122	PF02516	0.475
MOD_NEK2_1	108	113	PF00069	0.494
MOD_NEK2_1	166	171	PF00069	0.558
MOD_NEK2_1	183	188	PF00069	0.600
MOD_PKA_2	141	147	PF00069	0.636
MOD_PKA_2	88	94	PF00069	0.429
MOD_Plk_1	155	161	PF00069	0.543
MOD_Plk_4	174	180	PF00069	0.531
MOD_Plk_4	212	218	PF00069	0.394
MOD_Plk_4	83	89	PF00069	0.493
MOD_ProDKin_1	121	127	PF00069	0.711
MOD_ProDKin_1	160	166	PF00069	0.479
MOD_ProDKin_1	22	28	PF00069	0.448
MOD_ProDKin_1	3	9	PF00069	0.466
MOD_SUMO_for_1	44	47	PF00179	0.548
MOD_SUMO_rev_2	11	21	PF00179	0.461
MOD_SUMO_rev_2	59	68	PF00179	0.600
TRG_DiLeu_BaEn_1	219	224	PF01217	0.480
TRG_DiLeu_BaEn_3	219	225	PF01217	0.494
TRG_ER_diArg_1	202	204	PF00400	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G6	Leptomonas seymouri	50%	100%
A0A3Q8IAC4	Leishmania donovani	100%	100%
A4H8L0	Leishmania braziliensis	74%	98%
E9AQP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QET3	Leishmania major	93%	100%