LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Iron-sulfur assembly protein 1 - putative
Species:
Leishmania infantum
UniProt:
A4HWY0_LEIIN
TriTrypDb:
LINF_160013800
Length:
293

Annotations

Annotations by Jardim et al.

Metal Binding, Iron-sulfur assembly 1 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWY0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWY0

Function

Biological processes
Term Name Level Count
GO:0006790 sulfur compound metabolic process 3 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0016226 iron-sulfur cluster assembly 4 11
GO:0022607 cellular component assembly 4 11
GO:0031163 metallo-sulfur cluster assembly 5 11
GO:0044237 cellular metabolic process 2 11
GO:0071840 cellular component organization or biogenesis 2 11
GO:0006807 nitrogen compound metabolic process 2 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0097428 protein maturation by iron-sulfur cluster transfer 5 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0051536 iron-sulfur cluster binding 3 11
GO:0051540 metal cluster binding 2 11
GO:0051537 2 iron, 2 sulfur cluster binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 153 155 PF00675 0.445
CLV_NRD_NRD_1 193 195 PF00675 0.269
CLV_NRD_NRD_1 220 222 PF00675 0.295
CLV_PCSK_KEX2_1 134 136 PF00082 0.455
CLV_PCSK_KEX2_1 153 155 PF00082 0.345
CLV_PCSK_KEX2_1 17 19 PF00082 0.669
CLV_PCSK_KEX2_1 192 194 PF00082 0.246
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.568
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.532
CLV_PCSK_PC7_1 188 194 PF00082 0.257
CLV_PCSK_SKI1_1 142 146 PF00082 0.432
CLV_PCSK_SKI1_1 153 157 PF00082 0.415
CLV_PCSK_SKI1_1 17 21 PF00082 0.563
CLV_PCSK_SKI1_1 215 219 PF00082 0.283
DEG_COP1_1 177 187 PF00400 0.407
DEG_Nend_UBRbox_3 1 3 PF02207 0.530
DEG_SCF_TRCP1_1 43 49 PF00400 0.543
DEG_SPOP_SBC_1 28 32 PF00917 0.683
DOC_CKS1_1 146 151 PF01111 0.496
DOC_CYCLIN_RxL_1 14 23 PF00134 0.560
DOC_CYCLIN_RxL_1 153 163 PF00134 0.486
DOC_PP1_RVXF_1 133 140 PF00149 0.502
DOC_PP2B_LxvP_1 106 109 PF13499 0.522
DOC_PP4_FxxP_1 267 270 PF00568 0.444
DOC_USP7_MATH_1 113 117 PF00917 0.677
DOC_USP7_MATH_1 174 178 PF00917 0.647
DOC_USP7_MATH_1 210 214 PF00917 0.553
DOC_USP7_MATH_1 217 221 PF00917 0.538
DOC_USP7_MATH_1 46 50 PF00917 0.704
DOC_USP7_MATH_1 95 99 PF00917 0.703
DOC_USP7_UBL2_3 264 268 PF12436 0.501
DOC_USP7_UBL2_3 63 67 PF12436 0.597
DOC_WW_Pin1_4 127 132 PF00397 0.476
DOC_WW_Pin1_4 145 150 PF00397 0.373
DOC_WW_Pin1_4 170 175 PF00397 0.552
DOC_WW_Pin1_4 215 220 PF00397 0.538
DOC_WW_Pin1_4 69 74 PF00397 0.721
LIG_BIR_III_2 120 124 PF00653 0.626
LIG_FHA_1 1 7 PF00498 0.552
LIG_FHA_1 56 62 PF00498 0.585
LIG_FHA_1 69 75 PF00498 0.491
LIG_FHA_2 250 256 PF00498 0.444
LIG_FHA_2 257 263 PF00498 0.529
LIG_LIR_Apic_2 266 270 PF02991 0.444
LIG_LIR_Apic_2 77 81 PF02991 0.587
LIG_LIR_LC3C_4 228 232 PF02991 0.482
LIG_LIR_Nem_3 244 250 PF02991 0.518
LIG_LIR_Nem_3 280 285 PF02991 0.376
LIG_SH2_CRK 162 166 PF00017 0.330
LIG_SH2_CRK 62 66 PF00017 0.633
LIG_SH2_SRC 248 251 PF00017 0.444
LIG_SH2_STAP1 199 203 PF00017 0.444
LIG_SH2_STAT5 157 160 PF00017 0.349
LIG_SH2_STAT5 201 204 PF00017 0.444
LIG_SH2_STAT5 206 209 PF00017 0.444
LIG_SH2_STAT5 248 251 PF00017 0.462
LIG_SH2_STAT5 256 259 PF00017 0.444
LIG_SH3_3 143 149 PF00018 0.505
LIG_SxIP_EBH_1 67 79 PF03271 0.584
LIG_TRFH_1 145 149 PF08558 0.359
MOD_CDK_SPxK_1 215 221 PF00069 0.520
MOD_CDK_SPxxK_3 127 134 PF00069 0.460
MOD_CDK_SPxxK_3 215 222 PF00069 0.501
MOD_CDK_SPxxK_3 69 76 PF00069 0.630
MOD_CK1_1 177 183 PF00069 0.591
MOD_CK1_1 197 203 PF00069 0.417
MOD_CK1_1 38 44 PF00069 0.762
MOD_CK1_1 49 55 PF00069 0.683
MOD_CK2_1 113 119 PF00069 0.531
MOD_CK2_1 256 262 PF00069 0.540
MOD_CK2_1 74 80 PF00069 0.634
MOD_DYRK1A_RPxSP_1 127 131 PF00069 0.455
MOD_GlcNHglycan 166 169 PF01048 0.550
MOD_GlcNHglycan 184 187 PF01048 0.204
MOD_GlcNHglycan 196 199 PF01048 0.230
MOD_GlcNHglycan 208 211 PF01048 0.259
MOD_GlcNHglycan 212 215 PF01048 0.269
MOD_GlcNHglycan 43 46 PF01048 0.697
MOD_GlcNHglycan 48 51 PF01048 0.706
MOD_GlcNHglycan 90 93 PF01048 0.659
MOD_GlcNHglycan 97 100 PF01048 0.573
MOD_GSK3_1 160 167 PF00069 0.503
MOD_GSK3_1 170 177 PF00069 0.502
MOD_GSK3_1 206 213 PF00069 0.550
MOD_GSK3_1 28 35 PF00069 0.676
MOD_GSK3_1 48 55 PF00069 0.532
MOD_N-GLC_1 36 41 PF02516 0.738
MOD_N-GLC_1 46 51 PF02516 0.528
MOD_NEK2_1 1 6 PF00069 0.677
MOD_NEK2_1 19 24 PF00069 0.565
MOD_NEK2_1 61 66 PF00069 0.655
MOD_PIKK_1 55 61 PF00454 0.616
MOD_PKA_2 113 119 PF00069 0.579
MOD_PKA_2 39 45 PF00069 0.689
MOD_PKA_2 68 74 PF00069 0.672
MOD_PKB_1 192 200 PF00069 0.457
MOD_Plk_1 52 58 PF00069 0.509
MOD_Plk_4 1 7 PF00069 0.616
MOD_Plk_4 278 284 PF00069 0.508
MOD_ProDKin_1 127 133 PF00069 0.473
MOD_ProDKin_1 145 151 PF00069 0.366
MOD_ProDKin_1 170 176 PF00069 0.554
MOD_ProDKin_1 215 221 PF00069 0.538
MOD_ProDKin_1 69 75 PF00069 0.718
TRG_ENDOCYTIC_2 162 165 PF00928 0.328
TRG_ENDOCYTIC_2 62 65 PF00928 0.669
TRG_ER_diArg_1 152 154 PF00400 0.346
TRG_ER_diArg_1 191 194 PF00400 0.457
TRG_ER_diArg_1 83 86 PF00400 0.640

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I6U6 Leptomonas seymouri 66% 100%
A0A1X0NZ22 Trypanosomatidae 60% 100%
A0A3Q8IAJ0 Leishmania donovani 100% 100%
A0A422NDJ9 Trypanosoma rangeli 51% 100%
A4H8K7 Leishmania braziliensis 78% 100%
C9ZW24 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AQP2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QET6 Leishmania major 93% 100%
V5BHL1 Trypanosoma cruzi 47% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS