PAS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWX9_LEIIN

TriTrypDb:

LINF_160013700

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.731
CLV_C14_Caspase3-7	279	283	PF00656	0.516
CLV_NRD_NRD_1	171	173	PF00675	0.720
CLV_NRD_NRD_1	294	296	PF00675	0.726
CLV_NRD_NRD_1	305	307	PF00675	0.573
CLV_NRD_NRD_1	36	38	PF00675	0.689
CLV_NRD_NRD_1	370	372	PF00675	0.768
CLV_NRD_NRD_1	389	391	PF00675	0.723
CLV_NRD_NRD_1	90	92	PF00675	0.661
CLV_PCSK_FUR_1	292	296	PF00082	0.728
CLV_PCSK_KEX2_1	171	173	PF00082	0.727
CLV_PCSK_KEX2_1	294	296	PF00082	0.712
CLV_PCSK_KEX2_1	305	307	PF00082	0.559
CLV_PCSK_KEX2_1	389	391	PF00082	0.732
CLV_PCSK_KEX2_1	58	60	PF00082	0.478
CLV_PCSK_KEX2_1	90	92	PF00082	0.661
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.534
CLV_PCSK_SKI1_1	433	437	PF00082	0.564
CLV_PCSK_SKI1_1	8	12	PF00082	0.538
DEG_APCC_DBOX_1	67	75	PF00400	0.497
DEG_Nend_UBRbox_4	1	3	PF02207	0.562
DEG_SPOP_SBC_1	186	190	PF00917	0.783
DEG_SPOP_SBC_1	277	281	PF00917	0.700
DOC_CKS1_1	351	356	PF01111	0.722
DOC_MAPK_gen_1	58	65	PF00069	0.507
DOC_MAPK_MEF2A_6	58	65	PF00069	0.507
DOC_PP1_RVXF_1	236	242	PF00149	0.672
DOC_PP1_RVXF_1	431	437	PF00149	0.457
DOC_PP1_RVXF_1	506	512	PF00149	0.549
DOC_PP2B_LxvP_1	579	582	PF13499	0.789
DOC_PP4_FxxP_1	115	118	PF00568	0.667
DOC_PP4_FxxP_1	351	354	PF00568	0.705
DOC_USP7_MATH_1	184	188	PF00917	0.732
DOC_USP7_MATH_1	209	213	PF00917	0.765
DOC_USP7_MATH_1	277	281	PF00917	0.752
DOC_USP7_MATH_1	299	303	PF00917	0.654
DOC_USP7_MATH_1	385	389	PF00917	0.706
DOC_USP7_MATH_1	485	489	PF00917	0.756
DOC_USP7_MATH_1	559	563	PF00917	0.630
DOC_USP7_MATH_2	446	452	PF00917	0.515
DOC_WW_Pin1_4	119	124	PF00397	0.694
DOC_WW_Pin1_4	201	206	PF00397	0.785
DOC_WW_Pin1_4	225	230	PF00397	0.601
DOC_WW_Pin1_4	266	271	PF00397	0.727
DOC_WW_Pin1_4	295	300	PF00397	0.751
DOC_WW_Pin1_4	308	313	PF00397	0.605
DOC_WW_Pin1_4	324	329	PF00397	0.736
DOC_WW_Pin1_4	339	344	PF00397	0.793
DOC_WW_Pin1_4	350	355	PF00397	0.768
DOC_WW_Pin1_4	383	388	PF00397	0.811
DOC_WW_Pin1_4	569	574	PF00397	0.749
DOC_WW_Pin1_4	588	593	PF00397	0.485
LIG_14-3-3_CanoR_1	142	150	PF00244	0.637
LIG_14-3-3_CanoR_1	179	186	PF00244	0.746
LIG_14-3-3_CanoR_1	278	287	PF00244	0.817
LIG_14-3-3_CanoR_1	294	299	PF00244	0.511
LIG_14-3-3_CanoR_1	305	311	PF00244	0.577
LIG_14-3-3_CanoR_1	339	343	PF00244	0.604
LIG_14-3-3_CanoR_1	389	395	PF00244	0.670
LIG_14-3-3_CanoR_1	508	514	PF00244	0.545
LIG_14-3-3_CanoR_1	549	555	PF00244	0.419
LIG_14-3-3_CanoR_1	6	11	PF00244	0.467
LIG_14-3-3_CanoR_1	600	609	PF00244	0.700
LIG_14-3-3_CanoR_1	662	671	PF00244	0.682
LIG_Actin_WH2_2	544	559	PF00022	0.516
LIG_APCC_ABBA_1	440	445	PF00400	0.633
LIG_BIR_III_2	120	124	PF00653	0.715
LIG_BRCT_BRCA1_1	188	192	PF00533	0.793
LIG_BRCT_BRCA1_1	296	300	PF00533	0.678
LIG_BRCT_BRCA1_1	341	345	PF00533	0.717
LIG_BRCT_BRCA1_1	42	46	PF00533	0.554
LIG_Clathr_ClatBox_1	441	445	PF01394	0.534
LIG_deltaCOP1_diTrp_1	532	536	PF00928	0.583
LIG_EH1_1	131	139	PF00400	0.614
LIG_eIF4E_1	132	138	PF01652	0.608
LIG_FHA_1	500	506	PF00498	0.518
LIG_FHA_1	551	557	PF00498	0.501
LIG_FHA_1	575	581	PF00498	0.790
LIG_FHA_2	368	374	PF00498	0.779
LIG_FHA_2	510	516	PF00498	0.448
LIG_FHA_2	624	630	PF00498	0.613
LIG_FHA_2	74	80	PF00498	0.465
LIG_LIR_Apic_2	114	118	PF02991	0.674
LIG_LIR_Apic_2	350	354	PF02991	0.703
LIG_LIR_Gen_1	160	168	PF02991	0.569
LIG_LIR_Gen_1	259	270	PF02991	0.696
LIG_LIR_Gen_1	297	307	PF02991	0.667
LIG_LIR_Gen_1	321	330	PF02991	0.582
LIG_LIR_Gen_1	411	417	PF02991	0.507
LIG_LIR_Gen_1	483	490	PF02991	0.772
LIG_LIR_Gen_1	512	520	PF02991	0.508
LIG_LIR_Gen_1	532	541	PF02991	0.254
LIG_LIR_Gen_1	607	613	PF02991	0.688
LIG_LIR_Nem_3	144	150	PF02991	0.474
LIG_LIR_Nem_3	160	166	PF02991	0.413
LIG_LIR_Nem_3	259	265	PF02991	0.696
LIG_LIR_Nem_3	297	303	PF02991	0.576
LIG_LIR_Nem_3	321	326	PF02991	0.804
LIG_LIR_Nem_3	411	415	PF02991	0.640
LIG_LIR_Nem_3	461	465	PF02991	0.525
LIG_LIR_Nem_3	512	516	PF02991	0.511
LIG_LIR_Nem_3	532	536	PF02991	0.252
LIG_LIR_Nem_3	607	612	PF02991	0.753
LIG_MAD2	335	343	PF02301	0.583
LIG_MYND_1	578	582	PF01753	0.711
LIG_Pex14_1	147	151	PF04695	0.522
LIG_Pex14_2	42	46	PF04695	0.554
LIG_Pex14_2	469	473	PF04695	0.559
LIG_Rb_pABgroove_1	432	440	PF01858	0.496
LIG_SH2_GRB2like	139	142	PF00017	0.522
LIG_SH2_PTP2	456	459	PF00017	0.609
LIG_SH2_STAT5	132	135	PF00017	0.511
LIG_SH2_STAT5	139	142	PF00017	0.507
LIG_SH2_STAT5	163	166	PF00017	0.481
LIG_SH2_STAT5	456	459	PF00017	0.507
LIG_SH2_STAT5	463	466	PF00017	0.511
LIG_SH2_STAT5	585	588	PF00017	0.572
LIG_SH3_1	223	229	PF00018	0.707
LIG_SH3_3	223	229	PF00018	0.784
LIG_SH3_3	293	299	PF00018	0.543
LIG_SUMO_SIM_par_1	552	558	PF11976	0.508
LIG_WRC_WIRS_1	300	305	PF05994	0.576
LIG_WW_3	353	357	PF00397	0.753
MOD_CDC14_SPxK_1	386	389	PF00782	0.811
MOD_CDK_SPK_2	119	124	PF00069	0.676
MOD_CDK_SPxK_1	350	356	PF00069	0.759
MOD_CDK_SPxK_1	383	389	PF00069	0.812
MOD_CDK_SPxxK_3	339	346	PF00069	0.682
MOD_CDK_SPxxK_3	383	390	PF00069	0.815
MOD_CDK_SPxxK_3	588	595	PF00069	0.630
MOD_CK1_1	154	160	PF00069	0.494
MOD_CK1_1	187	193	PF00069	0.740
MOD_CK1_1	276	282	PF00069	0.750
MOD_CK1_1	298	304	PF00069	0.782
MOD_CK1_1	308	314	PF00069	0.632
MOD_CK1_1	321	327	PF00069	0.623
MOD_CK1_1	341	347	PF00069	0.746
MOD_CK1_1	367	373	PF00069	0.776
MOD_CK1_1	392	398	PF00069	0.653
MOD_CK1_1	403	409	PF00069	0.598
MOD_CK1_1	471	477	PF00069	0.625
MOD_CK1_1	493	499	PF00069	0.599
MOD_CK1_1	561	567	PF00069	0.737
MOD_CK1_1	588	594	PF00069	0.724
MOD_CK1_1	666	672	PF00069	0.639
MOD_CK2_1	601	607	PF00069	0.728
MOD_CK2_1	73	79	PF00069	0.464
MOD_Cter_Amidation	88	91	PF01082	0.655
MOD_DYRK1A_RPxSP_1	295	299	PF00069	0.635
MOD_DYRK1A_RPxSP_1	339	343	PF00069	0.717
MOD_GlcNHglycan	151	154	PF01048	0.515
MOD_GlcNHglycan	157	160	PF01048	0.493
MOD_GlcNHglycan	189	192	PF01048	0.677
MOD_GlcNHglycan	244	247	PF01048	0.788
MOD_GlcNHglycan	266	269	PF01048	0.717
MOD_GlcNHglycan	275	278	PF01048	0.682
MOD_GlcNHglycan	313	316	PF01048	0.748
MOD_GlcNHglycan	320	323	PF01048	0.813
MOD_GlcNHglycan	346	349	PF01048	0.769
MOD_GlcNHglycan	364	367	PF01048	0.668
MOD_GlcNHglycan	373	377	PF01048	0.655
MOD_GlcNHglycan	411	415	PF01048	0.574
MOD_GlcNHglycan	417	420	PF01048	0.592
MOD_GlcNHglycan	448	453	PF01048	0.634
MOD_GlcNHglycan	561	564	PF01048	0.658
MOD_GlcNHglycan	582	585	PF01048	0.649
MOD_GlcNHglycan	665	668	PF01048	0.716
MOD_GlcNHglycan	86	90	PF01048	0.646
MOD_GSK3_1	107	114	PF00069	0.701
MOD_GSK3_1	151	158	PF00069	0.458
MOD_GSK3_1	180	187	PF00069	0.707
MOD_GSK3_1	260	267	PF00069	0.761
MOD_GSK3_1	273	280	PF00069	0.614
MOD_GSK3_1	294	301	PF00069	0.682
MOD_GSK3_1	306	313	PF00069	0.602
MOD_GSK3_1	318	325	PF00069	0.771
MOD_GSK3_1	385	392	PF00069	0.748
MOD_GSK3_1	467	474	PF00069	0.490
MOD_GSK3_1	485	492	PF00069	0.769
MOD_GSK3_1	63	70	PF00069	0.503
MOD_N-GLC_1	499	504	PF02516	0.517
MOD_NEK2_1	22	27	PF00069	0.562
MOD_NEK2_1	273	278	PF00069	0.805
MOD_NEK2_1	318	323	PF00069	0.762
MOD_NEK2_1	362	367	PF00069	0.746
MOD_NEK2_1	469	474	PF00069	0.641
MOD_NEK2_1	587	592	PF00069	0.752
MOD_NEK2_1	608	613	PF00069	0.685
MOD_NEK2_1	92	97	PF00069	0.636
MOD_NEK2_2	485	490	PF00069	0.603
MOD_PIKK_1	151	157	PF00454	0.552
MOD_PIKK_1	30	36	PF00454	0.587
MOD_PIKK_1	98	104	PF00454	0.793
MOD_PKA_1	294	300	PF00069	0.697
MOD_PKA_1	305	311	PF00069	0.596
MOD_PKA_1	389	395	PF00069	0.787
MOD_PKA_2	141	147	PF00069	0.644
MOD_PKA_2	178	184	PF00069	0.793
MOD_PKA_2	277	283	PF00069	0.737
MOD_PKA_2	294	300	PF00069	0.478
MOD_PKA_2	305	311	PF00069	0.596
MOD_PKA_2	338	344	PF00069	0.604
MOD_PKA_2	389	395	PF00069	0.685
MOD_PKA_2	480	486	PF00069	0.622
MOD_PKA_2	601	607	PF00069	0.714
MOD_PKA_2	663	669	PF00069	0.677
MOD_PKA_2	67	73	PF00069	0.504
MOD_PKA_2	93	99	PF00069	0.655
MOD_PKB_1	292	300	PF00069	0.699
MOD_Plk_1	410	416	PF00069	0.598
MOD_Plk_1	61	67	PF00069	0.506
MOD_Plk_4	133	139	PF00069	0.602
MOD_Plk_4	400	406	PF00069	0.594
MOD_Plk_4	485	491	PF00069	0.736
MOD_Plk_4	494	500	PF00069	0.632
MOD_Plk_4	550	556	PF00069	0.405
MOD_Plk_4	608	614	PF00069	0.686
MOD_ProDKin_1	119	125	PF00069	0.693
MOD_ProDKin_1	201	207	PF00069	0.786
MOD_ProDKin_1	225	231	PF00069	0.598
MOD_ProDKin_1	266	272	PF00069	0.728
MOD_ProDKin_1	295	301	PF00069	0.750
MOD_ProDKin_1	308	314	PF00069	0.606
MOD_ProDKin_1	324	330	PF00069	0.735
MOD_ProDKin_1	339	345	PF00069	0.796
MOD_ProDKin_1	350	356	PF00069	0.797
MOD_ProDKin_1	383	389	PF00069	0.812
MOD_ProDKin_1	569	575	PF00069	0.745
MOD_ProDKin_1	588	594	PF00069	0.487
TRG_DiLeu_BaEn_1	542	547	PF01217	0.468
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.712
TRG_ENDOCYTIC_2	163	166	PF00928	0.544
TRG_ENDOCYTIC_2	427	430	PF00928	0.517
TRG_ENDOCYTIC_2	456	459	PF00928	0.448
TRG_ENDOCYTIC_2	484	487	PF00928	0.778
TRG_ER_diArg_1	171	173	PF00400	0.712
TRG_ER_diArg_1	252	255	PF00400	0.758
TRG_ER_diArg_1	291	294	PF00400	0.731
TRG_ER_diArg_1	305	307	PF00400	0.535
TRG_ER_diArg_1	662	665	PF00400	0.654
TRG_ER_diArg_1	90	92	PF00400	0.594
TRG_NES_CRM1_1	432	448	PF08389	0.526
TRG_NES_CRM1_1	545	558	PF08389	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8H2	Leptomonas seymouri	37%	100%
A0A3S5H6X8	Leishmania donovani	99%	100%
A4H8K6	Leishmania braziliensis	63%	100%
E9AQP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QET7	Leishmania major	87%	100%