Polysacc_synt_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWX8_LEIIN

TriTrypDb:

LINF_160013600

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.555
CLV_C14_Caspase3-7	411	415	PF00656	0.324
CLV_MEL_PAP_1	312	318	PF00089	0.698
CLV_NRD_NRD_1	127	129	PF00675	0.616
CLV_NRD_NRD_1	15	17	PF00675	0.438
CLV_NRD_NRD_1	291	293	PF00675	0.522
CLV_NRD_NRD_1	314	316	PF00675	0.705
CLV_NRD_NRD_1	386	388	PF00675	0.576
CLV_NRD_NRD_1	433	435	PF00675	0.624
CLV_NRD_NRD_1	570	572	PF00675	0.418
CLV_NRD_NRD_1	583	585	PF00675	0.385
CLV_NRD_NRD_1	69	71	PF00675	0.661
CLV_PCSK_FUR_1	13	17	PF00082	0.464
CLV_PCSK_KEX2_1	127	129	PF00082	0.603
CLV_PCSK_KEX2_1	15	17	PF00082	0.415
CLV_PCSK_KEX2_1	314	316	PF00082	0.700
CLV_PCSK_KEX2_1	363	365	PF00082	0.530
CLV_PCSK_KEX2_1	386	388	PF00082	0.597
CLV_PCSK_KEX2_1	433	435	PF00082	0.633
CLV_PCSK_KEX2_1	583	585	PF00082	0.446
CLV_PCSK_KEX2_1	68	70	PF00082	0.659
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.600
CLV_PCSK_SKI1_1	271	275	PF00082	0.577
CLV_PCSK_SKI1_1	293	297	PF00082	0.513
CLV_PCSK_SKI1_1	305	309	PF00082	0.675
CLV_PCSK_SKI1_1	363	367	PF00082	0.550
CLV_PCSK_SKI1_1	462	466	PF00082	0.521
CLV_PCSK_SKI1_1	583	587	PF00082	0.489
CLV_Separin_Metazoa	335	339	PF03568	0.340
DEG_SPOP_SBC_1	186	190	PF00917	0.579
DEG_SPOP_SBC_1	203	207	PF00917	0.596
DOC_CYCLIN_RxL_1	289	297	PF00134	0.423
DOC_CYCLIN_RxL_1	360	372	PF00134	0.356
DOC_MAPK_DCC_7	293	303	PF00069	0.335
DOC_MAPK_gen_1	127	133	PF00069	0.468
DOC_MAPK_gen_1	292	298	PF00069	0.317
DOC_MAPK_gen_1	360	368	PF00069	0.314
DOC_MAPK_gen_1	68	77	PF00069	0.447
DOC_MAPK_JIP1_4	403	409	PF00069	0.429
DOC_MAPK_MEF2A_6	32	41	PF00069	0.496
DOC_PP1_RVXF_1	362	369	PF00149	0.349
DOC_PP1_RVXF_1	423	429	PF00149	0.338
DOC_PP1_RVXF_1	519	525	PF00149	0.618
DOC_PP2B_LxvP_1	112	115	PF13499	0.528
DOC_PP4_FxxP_1	34	37	PF00568	0.447
DOC_PP4_MxPP_1	1	4	PF00568	0.698
DOC_USP7_MATH_1	146	150	PF00917	0.447
DOC_USP7_MATH_1	180	184	PF00917	0.509
DOC_USP7_MATH_1	185	189	PF00917	0.553
DOC_USP7_MATH_1	197	201	PF00917	0.548
DOC_USP7_MATH_1	222	226	PF00917	0.544
DOC_USP7_MATH_1	229	233	PF00917	0.554
DOC_USP7_MATH_1	76	80	PF00917	0.462
DOC_USP7_MATH_1	93	97	PF00917	0.534
DOC_WW_Pin1_4	160	165	PF00397	0.443
DOC_WW_Pin1_4	244	249	PF00397	0.523
DOC_WW_Pin1_4	33	38	PF00397	0.378
DOC_WW_Pin1_4	475	480	PF00397	0.335
LIG_14-3-3_CanoR_1	314	319	PF00244	0.454
LIG_14-3-3_CanoR_1	338	347	PF00244	0.354
LIG_14-3-3_CanoR_1	418	426	PF00244	0.381
LIG_14-3-3_CanoR_1	571	581	PF00244	0.645
LIG_Actin_WH2_2	291	307	PF00022	0.351
LIG_APCC_ABBA_1	374	379	PF00400	0.365
LIG_BRCT_BRCA1_1	109	113	PF00533	0.559
LIG_BRCT_BRCA1_1	22	26	PF00533	0.596
LIG_BRCT_BRCA1_1	4	8	PF00533	0.741
LIG_BRCT_BRCA1_1	42	46	PF00533	0.150
LIG_Clathr_ClatBox_1	407	411	PF01394	0.305
LIG_FHA_1	232	238	PF00498	0.555
LIG_FHA_1	248	254	PF00498	0.456
LIG_FHA_1	306	312	PF00498	0.432
LIG_FHA_1	324	330	PF00498	0.389
LIG_FHA_1	373	379	PF00498	0.360
LIG_FHA_1	525	531	PF00498	0.596
LIG_FHA_1	541	547	PF00498	0.644
LIG_FHA_2	163	169	PF00498	0.476
LIG_FHA_2	237	243	PF00498	0.543
LIG_FHA_2	396	402	PF00498	0.441
LIG_FHA_2	483	489	PF00498	0.403
LIG_HP1_1	37	41	PF01393	0.402
LIG_LIR_Apic_2	31	37	PF02991	0.562
LIG_LIR_Apic_2	55	61	PF02991	0.416
LIG_LIR_Gen_1	250	257	PF02991	0.493
LIG_LIR_Gen_1	36	46	PF02991	0.377
LIG_LIR_Gen_1	504	514	PF02991	0.619
LIG_LIR_Gen_1	533	540	PF02991	0.611
LIG_LIR_Nem_3	169	175	PF02991	0.338
LIG_LIR_Nem_3	250	255	PF02991	0.513
LIG_LIR_Nem_3	341	347	PF02991	0.328
LIG_LIR_Nem_3	36	41	PF02991	0.377
LIG_LIR_Nem_3	420	426	PF02991	0.344
LIG_LIR_Nem_3	43	49	PF02991	0.408
LIG_LIR_Nem_3	504	509	PF02991	0.552
LIG_LIR_Nem_3	533	538	PF02991	0.547
LIG_MLH1_MIPbox_1	22	26	PF16413	0.592
LIG_PCNA_yPIPBox_3	314	328	PF02747	0.472
LIG_Pex14_1	461	465	PF04695	0.323
LIG_SH2_CRK	172	176	PF00017	0.341
LIG_SH2_PTP2	38	41	PF00017	0.447
LIG_SH2_PTP2	58	61	PF00017	0.404
LIG_SH2_SRC	177	180	PF00017	0.408
LIG_SH2_SRC	549	552	PF00017	0.544
LIG_SH2_STAP1	290	294	PF00017	0.335
LIG_SH2_STAP1	405	409	PF00017	0.312
LIG_SH2_STAT5	177	180	PF00017	0.369
LIG_SH2_STAT5	252	255	PF00017	0.422
LIG_SH2_STAT5	38	41	PF00017	0.378
LIG_SH2_STAT5	384	387	PF00017	0.399
LIG_SH2_STAT5	49	52	PF00017	0.378
LIG_SH2_STAT5	549	552	PF00017	0.530
LIG_SH2_STAT5	58	61	PF00017	0.387
LIG_SH3_3	375	381	PF00018	0.404
LIG_SH3_3	441	447	PF00018	0.383
LIG_SH3_3	473	479	PF00018	0.378
LIG_SH3_3	534	540	PF00018	0.564
LIG_SH3_5	248	252	PF00018	0.469
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.424
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.361
LIG_SUMO_SIM_par_1	406	411	PF11976	0.309
LIG_TRAF2_1	61	64	PF00917	0.455
LIG_TYR_ITIM	170	175	PF00017	0.424
LIG_WRC_WIRS_1	483	488	PF05994	0.408
MOD_CDK_SPxxK_3	160	167	PF00069	0.604
MOD_CK1_1	134	140	PF00069	0.475
MOD_CK1_1	160	166	PF00069	0.562
MOD_CK1_1	204	210	PF00069	0.719
MOD_CK1_1	213	219	PF00069	0.728
MOD_CK1_1	225	231	PF00069	0.650
MOD_CK1_1	236	242	PF00069	0.671
MOD_CK1_1	372	378	PF00069	0.521
MOD_CK1_1	478	484	PF00069	0.355
MOD_CK1_1	533	539	PF00069	0.517
MOD_CK1_1	593	599	PF00069	0.659
MOD_CK2_1	185	191	PF00069	0.626
MOD_CK2_1	213	219	PF00069	0.712
MOD_CK2_1	236	242	PF00069	0.692
MOD_CK2_1	395	401	PF00069	0.565
MOD_CMANNOS	578	581	PF00535	0.483
MOD_GlcNHglycan	143	146	PF01048	0.586
MOD_GlcNHglycan	148	151	PF01048	0.531
MOD_GlcNHglycan	183	186	PF01048	0.730
MOD_GlcNHglycan	22	25	PF01048	0.352
MOD_GlcNHglycan	224	227	PF01048	0.706
MOD_GlcNHglycan	231	234	PF01048	0.680
MOD_GlcNHglycan	332	335	PF01048	0.378
MOD_GlcNHglycan	42	45	PF01048	0.424
MOD_GlcNHglycan	529	533	PF01048	0.534
MOD_GlcNHglycan	590	593	PF01048	0.497
MOD_GlcNHglycan	95	98	PF01048	0.652
MOD_GSK3_1	181	188	PF00069	0.637
MOD_GSK3_1	197	204	PF00069	0.424
MOD_GSK3_1	206	213	PF00069	0.564
MOD_GSK3_1	225	232	PF00069	0.490
MOD_GSK3_1	233	240	PF00069	0.693
MOD_GSK3_1	368	375	PF00069	0.502
MOD_GSK3_1	474	481	PF00069	0.342
MOD_GSK3_1	482	489	PF00069	0.387
MOD_GSK3_1	524	531	PF00069	0.466
MOD_N-GLC_1	372	377	PF02516	0.501
MOD_N-GLC_1	395	400	PF02516	0.645
MOD_N-GLC_1	533	538	PF02516	0.522
MOD_N-GLC_2	277	279	PF02516	0.411
MOD_N-GLC_2	439	441	PF02516	0.505
MOD_NEK2_1	294	299	PF00069	0.472
MOD_NEK2_1	368	373	PF00069	0.416
MOD_NEK2_1	40	45	PF00069	0.381
MOD_NEK2_1	486	491	PF00069	0.513
MOD_NEK2_1	570	575	PF00069	0.595
MOD_NEK2_1	590	595	PF00069	0.446
MOD_NEK2_1	77	82	PF00069	0.533
MOD_NEK2_2	171	176	PF00069	0.479
MOD_NEK2_2	339	344	PF00069	0.502
MOD_PIKK_1	272	278	PF00454	0.497
MOD_PIKK_1	305	311	PF00454	0.637
MOD_PIKK_1	418	424	PF00454	0.437
MOD_PIKK_1	572	578	PF00454	0.622
MOD_PIKK_1	590	596	PF00454	0.385
MOD_PKA_1	314	320	PF00069	0.637
MOD_PKA_1	583	589	PF00069	0.621
MOD_PKA_2	141	147	PF00069	0.629
MOD_PKA_2	20	26	PF00069	0.539
MOD_PKA_2	314	320	PF00069	0.531
MOD_PKA_2	417	423	PF00069	0.482
MOD_PKA_2	570	576	PF00069	0.588
MOD_PKA_2	583	589	PF00069	0.585
MOD_Plk_1	210	216	PF00069	0.633
MOD_Plk_1	372	378	PF00069	0.482
MOD_Plk_1	533	539	PF00069	0.471
MOD_Plk_1	540	546	PF00069	0.482
MOD_Plk_4	210	216	PF00069	0.686
MOD_Plk_4	307	313	PF00069	0.585
MOD_Plk_4	323	329	PF00069	0.415
MOD_Plk_4	354	360	PF00069	0.483
MOD_Plk_4	478	484	PF00069	0.378
MOD_ProDKin_1	160	166	PF00069	0.562
MOD_ProDKin_1	244	250	PF00069	0.668
MOD_ProDKin_1	33	39	PF00069	0.378
MOD_ProDKin_1	475	481	PF00069	0.335
MOD_SUMO_for_1	501	504	PF00179	0.586
MOD_SUMO_rev_2	399	404	PF00179	0.561
TRG_ENDOCYTIC_2	172	175	PF00928	0.415
TRG_ENDOCYTIC_2	252	255	PF00928	0.656
TRG_ENDOCYTIC_2	344	347	PF00928	0.506
TRG_ENDOCYTIC_2	38	41	PF00928	0.378
TRG_ENDOCYTIC_2	405	408	PF00928	0.380
TRG_ENDOCYTIC_2	423	426	PF00928	0.338
TRG_ER_diArg_1	126	128	PF00400	0.543
TRG_ER_diArg_1	13	16	PF00400	0.569
TRG_ER_diArg_1	313	315	PF00400	0.640
TRG_ER_diArg_1	385	387	PF00400	0.482
TRG_ER_diArg_1	432	434	PF00400	0.545
TRG_ER_diArg_1	582	584	PF00400	0.543
TRG_ER_diArg_1	59	62	PF00400	0.521
TRG_ER_diArg_1	68	70	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R7	Leptomonas seymouri	65%	100%
A0A0S4IJV1	Bodo saltans	37%	100%
A0A1X0NZ16	Trypanosomatidae	45%	100%
A0A3Q8IJ17	Leishmania donovani	100%	100%
A4H8K5	Leishmania braziliensis	82%	100%
C9ZW26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AQP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QET8	Leishmania major	96%	100%
V5D930	Trypanosoma cruzi	46%	100%