Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeat - putative

Species:

Leishmania infantum

UniProt:

A4HWW9_LEIIN

TriTrypDb:

LINF_160012600

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4HWW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	276	278	PF00675	0.538
CLV_NRD_NRD_1	334	336	PF00675	0.418
CLV_NRD_NRD_1	504	506	PF00675	0.629
CLV_PCSK_KEX2_1	109	111	PF00082	0.741
CLV_PCSK_KEX2_1	276	278	PF00082	0.580
CLV_PCSK_KEX2_1	334	336	PF00082	0.418
CLV_PCSK_KEX2_1	504	506	PF00082	0.629
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.651
CLV_PCSK_SKI1_1	450	454	PF00082	0.536
DEG_APCC_DBOX_1	457	465	PF00400	0.557
DEG_Nend_UBRbox_2	1	3	PF02207	0.564
DEG_SCF_FBW7_2	482	489	PF00400	0.563
DEG_SPOP_SBC_1	444	448	PF00917	0.455
DEG_SPOP_SBC_1	75	79	PF00917	0.595
DOC_CYCLIN_RxL_1	212	220	PF00134	0.435
DOC_CYCLIN_RxL_1	331	339	PF00134	0.375
DOC_MAPK_gen_1	109	119	PF00069	0.537
DOC_MAPK_MEF2A_6	112	121	PF00069	0.527
DOC_MAPK_MEF2A_6	406	414	PF00069	0.336
DOC_MAPK_RevD_3	262	277	PF00069	0.446
DOC_PP1_RVXF_1	375	382	PF00149	0.467
DOC_PP2B_LxvP_1	124	127	PF13499	0.428
DOC_PP2B_LxvP_1	195	198	PF13499	0.654
DOC_PP2B_LxvP_1	99	102	PF13499	0.582
DOC_USP7_MATH_1	143	147	PF00917	0.308
DOC_USP7_MATH_1	229	233	PF00917	0.406
DOC_USP7_MATH_1	360	364	PF00917	0.592
DOC_USP7_MATH_1	384	388	PF00917	0.392
DOC_USP7_MATH_1	469	473	PF00917	0.577
DOC_USP7_MATH_1	491	495	PF00917	0.664
DOC_USP7_MATH_1	59	63	PF00917	0.525
DOC_USP7_MATH_1	82	86	PF00917	0.594
DOC_USP7_MATH_1	95	99	PF00917	0.546
DOC_WW_Pin1_4	482	487	PF00397	0.650
LIG_14-3-3_CanoR_1	28	34	PF00244	0.462
LIG_14-3-3_CanoR_1	319	328	PF00244	0.581
LIG_14-3-3_CanoR_1	456	462	PF00244	0.548
LIG_14-3-3_CanoR_1	504	511	PF00244	0.660
LIG_14-3-3_CanoR_1	520	529	PF00244	0.497
LIG_14-3-3_CanoR_1	96	102	PF00244	0.580
LIG_Actin_WH2_2	135	152	PF00022	0.408
LIG_Actin_WH2_2	445	460	PF00022	0.484
LIG_BRCT_BRCA1_1	117	121	PF00533	0.490
LIG_BRCT_BRCA1_1	372	376	PF00533	0.496
LIG_CSL_BTD_1	124	127	PF09270	0.428
LIG_eIF4E_1	395	401	PF01652	0.405
LIG_FHA_1	192	198	PF00498	0.780
LIG_FHA_1	211	217	PF00498	0.353
LIG_FHA_1	343	349	PF00498	0.416
LIG_FHA_1	506	512	PF00498	0.612
LIG_FHA_2	37	43	PF00498	0.493
LIG_FHA_2	397	403	PF00498	0.538
LIG_FHA_2	476	482	PF00498	0.680
LIG_FHA_2	505	511	PF00498	0.613
LIG_LIR_Gen_1	29	34	PF02991	0.458
LIG_LIR_Nem_3	118	124	PF02991	0.483
LIG_LIR_Nem_3	29	33	PF02991	0.438
LIG_LIR_Nem_3	345	349	PF02991	0.440
LIG_LIR_Nem_3	373	379	PF02991	0.574
LIG_LIR_Nem_3	387	391	PF02991	0.312
LIG_PDZ_Class_1	524	529	PF00595	0.569
LIG_Pex14_1	30	34	PF04695	0.453
LIG_Pex14_2	121	125	PF04695	0.486
LIG_SH2_GRB2like	395	398	PF00017	0.370
LIG_SH2_NCK_1	369	373	PF00017	0.646
LIG_SH2_SRC	417	420	PF00017	0.409
LIG_SH2_STAT5	346	349	PF00017	0.504
LIG_SH2_STAT5	395	398	PF00017	0.370
LIG_SH2_STAT5	417	420	PF00017	0.409
LIG_SH3_3	16	22	PF00018	0.611
LIG_SH3_3	196	202	PF00018	0.574
LIG_SH3_3	298	304	PF00018	0.460
LIG_SUMO_SIM_anti_2	17	22	PF11976	0.495
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.450
LIG_SUMO_SIM_par_1	215	220	PF11976	0.366
LIG_SUMO_SIM_par_1	410	416	PF11976	0.335
LIG_SUMO_SIM_par_1	46	51	PF11976	0.538
LIG_SUMO_SIM_par_1	8	14	PF11976	0.660
LIG_TRAF2_1	39	42	PF00917	0.543
LIG_WW_1	198	201	PF00397	0.517
MOD_CK1_1	108	114	PF00069	0.584
MOD_CK1_1	167	173	PF00069	0.482
MOD_CK1_1	494	500	PF00069	0.697
MOD_CK1_1	5	11	PF00069	0.703
MOD_CK1_1	67	73	PF00069	0.727
MOD_CK2_1	108	114	PF00069	0.675
MOD_CK2_1	177	183	PF00069	0.681
MOD_CK2_1	36	42	PF00069	0.464
MOD_CK2_1	396	402	PF00069	0.451
MOD_CK2_1	475	481	PF00069	0.682
MOD_CK2_1	504	510	PF00069	0.529
MOD_GlcNHglycan	166	169	PF01048	0.470
MOD_GlcNHglycan	218	222	PF01048	0.546
MOD_GlcNHglycan	280	283	PF01048	0.575
MOD_GlcNHglycan	314	317	PF01048	0.705
MOD_GlcNHglycan	373	376	PF01048	0.633
MOD_GlcNHglycan	439	442	PF01048	0.523
MOD_GlcNHglycan	471	474	PF01048	0.603
MOD_GlcNHglycan	67	70	PF01048	0.709
MOD_GlcNHglycan	7	10	PF01048	0.719
MOD_GlcNHglycan	84	87	PF01048	0.781
MOD_GSK3_1	145	152	PF00069	0.368
MOD_GSK3_1	197	204	PF00069	0.593
MOD_GSK3_1	229	236	PF00069	0.418
MOD_GSK3_1	239	246	PF00069	0.306
MOD_GSK3_1	29	36	PF00069	0.463
MOD_GSK3_1	320	327	PF00069	0.629
MOD_GSK3_1	433	440	PF00069	0.556
MOD_GSK3_1	465	472	PF00069	0.523
MOD_GSK3_1	505	512	PF00069	0.619
MOD_GSK3_1	91	98	PF00069	0.647
MOD_N-GLC_1	243	248	PF02516	0.445
MOD_N-GLC_1	396	401	PF02516	0.409
MOD_N-GLC_1	469	474	PF02516	0.635
MOD_NEK2_1	149	154	PF00069	0.298
MOD_NEK2_1	217	222	PF00069	0.352
MOD_NEK2_1	233	238	PF00069	0.346
MOD_NEK2_1	33	38	PF00069	0.472
MOD_NEK2_1	336	341	PF00069	0.312
MOD_NEK2_1	342	347	PF00069	0.392
MOD_NEK2_1	371	376	PF00069	0.590
MOD_NEK2_1	396	401	PF00069	0.371
MOD_NEK2_1	435	440	PF00069	0.556
MOD_NEK2_1	465	470	PF00069	0.581
MOD_NEK2_1	74	79	PF00069	0.543
MOD_NEK2_2	131	136	PF00069	0.403
MOD_NEK2_2	210	215	PF00069	0.438
MOD_NEK2_2	445	450	PF00069	0.570
MOD_PIKK_1	491	497	PF00454	0.651
MOD_PKA_1	504	510	PF00069	0.612
MOD_PKA_2	149	155	PF00069	0.345
MOD_PKA_2	312	318	PF00069	0.648
MOD_PKA_2	426	432	PF00069	0.484
MOD_PKA_2	457	463	PF00069	0.554
MOD_PKA_2	504	510	PF00069	0.660
MOD_PKA_2	64	70	PF00069	0.607
MOD_PKA_2	95	101	PF00069	0.580
MOD_PKB_1	63	71	PF00069	0.604
MOD_Plk_1	396	402	PF00069	0.375
MOD_Plk_4	229	235	PF00069	0.411
MOD_Plk_4	29	35	PF00069	0.468
MOD_Plk_4	342	348	PF00069	0.404
MOD_Plk_4	396	402	PF00069	0.451
MOD_Plk_4	494	500	PF00069	0.718
MOD_ProDKin_1	482	488	PF00069	0.651
MOD_SUMO_rev_2	416	422	PF00179	0.402
TRG_DiLeu_BaEn_1	510	515	PF01217	0.497
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.476
TRG_ENDOCYTIC_2	346	349	PF00928	0.509
TRG_ER_diArg_1	275	277	PF00400	0.585
TRG_ER_diArg_1	333	335	PF00400	0.434
TRG_ER_diArg_1	504	506	PF00400	0.629
TRG_ER_diArg_1	63	66	PF00400	0.583
TRG_NLS_MonoExtC_3	108	114	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG7	Leptomonas seymouri	36%	100%
A0A3S5H6X5	Leishmania donovani	99%	100%
A4H8J4	Leishmania braziliensis	70%	100%
E9AQN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QEU7	Leishmania major	86%	100%