LeishMANIAdb
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eIF2A domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
eIF2A domain-containing protein
Gene product:
Eukaryotic translation initiation factor eIF2A - putative
Species:
Leishmania infantum
UniProt:
A4HWW6_LEIIN
TriTrypDb:
LINF_160012300
Length:
551

Annotations

Annotations by Jardim et al.

Translation, eukaryotic translation initiation factor eIF2A

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0015935 small ribosomal subunit 4 1
GO:0022627 cytosolic small ribosomal subunit 5 1
GO:0032991 protein-containing complex 1 1
GO:0044391 ribosomal subunit 3 1
GO:1990904 ribonucleoprotein complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HWW6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWW6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003743 translation initiation factor activity 4 11
GO:0005488 binding 1 11
GO:0008135 translation factor activity, RNA binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0000049 tRNA binding 5 1
GO:0003723 RNA binding 4 1
GO:0003729 mRNA binding 5 1
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0043022 ribosome binding 4 1
GO:0044877 protein-containing complex binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 362 366 PF00656 0.509
CLV_NRD_NRD_1 10 12 PF00675 0.288
CLV_NRD_NRD_1 138 140 PF00675 0.327
CLV_NRD_NRD_1 523 525 PF00675 0.562
CLV_NRD_NRD_1 549 551 PF00675 0.694
CLV_PCSK_KEX2_1 119 121 PF00082 0.387
CLV_PCSK_KEX2_1 138 140 PF00082 0.346
CLV_PCSK_KEX2_1 523 525 PF00082 0.562
CLV_PCSK_KEX2_1 548 550 PF00082 0.650
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.383
CLV_PCSK_PC1ET2_1 548 550 PF00082 0.650
CLV_PCSK_SKI1_1 231 235 PF00082 0.427
CLV_PCSK_SKI1_1 244 248 PF00082 0.423
CLV_PCSK_SKI1_1 466 470 PF00082 0.235
CLV_PCSK_SKI1_1 87 91 PF00082 0.261
DEG_SPOP_SBC_1 60 64 PF00917 0.449
DOC_MAPK_gen_1 11 18 PF00069 0.299
DOC_MAPK_gen_1 450 459 PF00069 0.419
DOC_MAPK_MEF2A_6 11 20 PF00069 0.362
DOC_MAPK_MEF2A_6 312 319 PF00069 0.305
DOC_PP4_FxxP_1 275 278 PF00568 0.513
DOC_USP7_MATH_1 176 180 PF00917 0.651
DOC_USP7_MATH_1 415 419 PF00917 0.452
DOC_USP7_UBL2_3 238 242 PF12436 0.324
DOC_WW_Pin1_4 101 106 PF00397 0.428
DOC_WW_Pin1_4 118 123 PF00397 0.514
DOC_WW_Pin1_4 274 279 PF00397 0.489
DOC_WW_Pin1_4 329 334 PF00397 0.423
DOC_WW_Pin1_4 492 497 PF00397 0.462
LIG_14-3-3_CanoR_1 244 249 PF00244 0.410
LIG_14-3-3_CanoR_1 347 353 PF00244 0.423
LIG_14-3-3_CanoR_1 466 475 PF00244 0.480
LIG_14-3-3_CanoR_1 83 87 PF00244 0.392
LIG_APCC_ABBA_1 18 23 PF00400 0.367
LIG_BIR_II_1 1 5 PF00653 0.499
LIG_BRCT_BRCA1_1 438 442 PF00533 0.430
LIG_BRCT_BRCA1_1 444 448 PF00533 0.433
LIG_BRCT_BRCA1_1 99 103 PF00533 0.463
LIG_CSL_BTD_1 275 278 PF09270 0.513
LIG_FHA_1 106 112 PF00498 0.346
LIG_FHA_1 245 251 PF00498 0.285
LIG_FHA_1 299 305 PF00498 0.462
LIG_FHA_1 411 417 PF00498 0.465
LIG_FHA_1 533 539 PF00498 0.610
LIG_FHA_1 60 66 PF00498 0.346
LIG_FHA_2 149 155 PF00498 0.353
LIG_FHA_2 183 189 PF00498 0.599
LIG_FHA_2 323 329 PF00498 0.476
LIG_FHA_2 332 338 PF00498 0.420
LIG_FHA_2 360 366 PF00498 0.410
LIG_FHA_2 64 70 PF00498 0.414
LIG_LIR_Apic_2 273 278 PF02991 0.457
LIG_LIR_Gen_1 112 117 PF02991 0.373
LIG_LIR_Gen_1 279 287 PF02991 0.489
LIG_LIR_Gen_1 438 448 PF02991 0.457
LIG_LIR_Gen_1 64 75 PF02991 0.451
LIG_LIR_Nem_3 247 251 PF02991 0.408
LIG_LIR_Nem_3 279 285 PF02991 0.477
LIG_LIR_Nem_3 297 302 PF02991 0.307
LIG_LIR_Nem_3 391 395 PF02991 0.410
LIG_LIR_Nem_3 438 443 PF02991 0.457
LIG_LIR_Nem_3 445 451 PF02991 0.424
LIG_LIR_Nem_3 469 475 PF02991 0.423
LIG_LIR_Nem_3 64 70 PF02991 0.412
LIG_LIR_Nem_3 85 89 PF02991 0.471
LIG_LYPXL_yS_3 472 475 PF13949 0.423
LIG_NRBOX 334 340 PF00104 0.457
LIG_Pex14_2 86 90 PF04695 0.466
LIG_SH2_CRK 251 255 PF00017 0.309
LIG_SH2_CRK 299 303 PF00017 0.410
LIG_SH2_CRK 440 444 PF00017 0.489
LIG_SH2_CRK 509 513 PF00017 0.542
LIG_SH2_NCK_1 223 227 PF00017 0.449
LIG_SH2_PTP2 282 285 PF00017 0.489
LIG_SH2_PTP2 395 398 PF00017 0.416
LIG_SH2_STAP1 67 71 PF00017 0.323
LIG_SH2_STAT5 109 112 PF00017 0.410
LIG_SH2_STAT5 156 159 PF00017 0.287
LIG_SH2_STAT5 282 285 PF00017 0.489
LIG_SH2_STAT5 38 41 PF00017 0.486
LIG_SH2_STAT5 395 398 PF00017 0.461
LIG_SH2_STAT5 67 70 PF00017 0.422
LIG_SH3_1 531 537 PF00018 0.641
LIG_SH3_3 154 160 PF00018 0.421
LIG_SH3_3 48 54 PF00018 0.451
LIG_SH3_3 531 537 PF00018 0.599
LIG_SH3_3 89 95 PF00018 0.439
LIG_SH3_4 238 245 PF00018 0.337
LIG_SUMO_SIM_anti_2 2 7 PF11976 0.403
LIG_SUMO_SIM_anti_2 209 215 PF11976 0.487
LIG_SUMO_SIM_anti_2 336 342 PF11976 0.411
LIG_TRAF2_1 499 502 PF00917 0.653
LIG_TYR_ITIM 65 70 PF00017 0.309
LIG_UBA3_1 233 238 PF00899 0.301
LIG_UBA3_1 338 344 PF00899 0.374
LIG_UBA3_1 5 12 PF00899 0.355
LIG_WRPW_2 237 240 PF00400 0.309
MOD_CDK_SPK_2 101 106 PF00069 0.461
MOD_CDK_SPK_2 492 497 PF00069 0.485
MOD_CK1_1 174 180 PF00069 0.625
MOD_CK1_1 294 300 PF00069 0.271
MOD_CK1_1 410 416 PF00069 0.387
MOD_CK1_1 85 91 PF00069 0.435
MOD_CK2_1 124 130 PF00069 0.401
MOD_CK2_1 148 154 PF00069 0.349
MOD_CK2_1 24 30 PF00069 0.401
MOD_CK2_1 331 337 PF00069 0.374
MOD_CK2_1 63 69 PF00069 0.401
MOD_DYRK1A_RPxSP_1 492 496 PF00069 0.456
MOD_GlcNHglycan 278 281 PF01048 0.296
MOD_GlcNHglycan 292 296 PF01048 0.282
MOD_GlcNHglycan 384 387 PF01048 0.368
MOD_GlcNHglycan 418 421 PF01048 0.338
MOD_GSK3_1 105 112 PF00069 0.243
MOD_GSK3_1 124 131 PF00069 0.445
MOD_GSK3_1 170 177 PF00069 0.532
MOD_GSK3_1 187 194 PF00069 0.676
MOD_GSK3_1 270 277 PF00069 0.241
MOD_GSK3_1 294 301 PF00069 0.263
MOD_GSK3_1 416 423 PF00069 0.337
MOD_GSK3_1 442 449 PF00069 0.348
MOD_GSK3_1 59 66 PF00069 0.416
MOD_GSK3_1 97 104 PF00069 0.362
MOD_N-GLC_1 124 129 PF02516 0.403
MOD_N-GLC_1 204 209 PF02516 0.520
MOD_N-GLC_1 310 315 PF02516 0.331
MOD_N-GLC_1 410 415 PF02516 0.339
MOD_N-GLC_2 348 350 PF02516 0.374
MOD_NEK2_1 172 177 PF00069 0.553
MOD_NEK2_1 310 315 PF00069 0.316
MOD_NEK2_1 382 387 PF00069 0.259
MOD_NEK2_1 442 447 PF00069 0.307
MOD_NEK2_1 90 95 PF00069 0.411
MOD_NEK2_2 124 129 PF00069 0.403
MOD_NEK2_2 82 87 PF00069 0.250
MOD_PKA_2 36 42 PF00069 0.390
MOD_PKA_2 52 58 PF00069 0.313
MOD_PKA_2 82 88 PF00069 0.406
MOD_Plk_1 12 18 PF00069 0.365
MOD_Plk_1 124 130 PF00069 0.407
MOD_Plk_1 310 316 PF00069 0.277
MOD_Plk_1 410 416 PF00069 0.374
MOD_Plk_2-3 191 197 PF00069 0.660
MOD_Plk_2-3 322 328 PF00069 0.374
MOD_Plk_4 105 111 PF00069 0.317
MOD_Plk_4 12 18 PF00069 0.353
MOD_Plk_4 124 130 PF00069 0.407
MOD_Plk_4 176 182 PF00069 0.659
MOD_Plk_4 270 276 PF00069 0.259
MOD_Plk_4 294 300 PF00069 0.282
MOD_Plk_4 348 354 PF00069 0.263
MOD_Plk_4 443 449 PF00069 0.305
MOD_Plk_4 538 544 PF00069 0.558
MOD_Plk_4 85 91 PF00069 0.468
MOD_ProDKin_1 101 107 PF00069 0.423
MOD_ProDKin_1 118 124 PF00069 0.505
MOD_ProDKin_1 274 280 PF00069 0.374
MOD_ProDKin_1 329 335 PF00069 0.282
MOD_ProDKin_1 492 498 PF00069 0.470
MOD_SUMO_for_1 287 290 PF00179 0.263
MOD_SUMO_for_1 319 322 PF00179 0.374
MOD_SUMO_rev_2 313 319 PF00179 0.268
TRG_DiLeu_BaLyEn_6 132 137 PF01217 0.466
TRG_ENDOCYTIC_2 113 116 PF00928 0.361
TRG_ENDOCYTIC_2 282 285 PF00928 0.350
TRG_ENDOCYTIC_2 299 302 PF00928 0.136
TRG_ENDOCYTIC_2 440 443 PF00928 0.374
TRG_ENDOCYTIC_2 472 475 PF00928 0.282
TRG_ENDOCYTIC_2 67 70 PF00928 0.313
TRG_ER_diArg_1 137 139 PF00400 0.359
TRG_ER_diArg_1 450 453 PF00400 0.282
TRG_ER_diArg_1 522 524 PF00400 0.532
TRG_ER_diLys_1 546 551 PF00400 0.600
TRG_NES_CRM1_1 308 322 PF08389 0.374
TRG_NLS_MonoCore_2 545 550 PF00514 0.595
TRG_NLS_MonoExtC_3 545 550 PF00514 0.595
TRG_NLS_MonoExtN_4 546 551 PF00514 0.692
TRG_Pf-PMV_PEXEL_1 312 316 PF00026 0.263

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCC7 Leptomonas seymouri 76% 100%
A0A1X0NNW1 Trypanosomatidae 50% 99%
A0A3S5H6X4 Leishmania donovani 100% 100%
A0A422N2R4 Trypanosoma rangeli 51% 100%
A4H8J1 Leishmania braziliensis 87% 100%
C9ZPL6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9AQM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O74965 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 96%
Q4QEV0 Leishmania major 95% 100%
Q4QRJ7 Danio rerio 25% 95%
Q54PV7 Dictyostelium discoideum 27% 91%
Q5ZKC1 Gallus gallus 24% 94%
Q7ZY11 Xenopus laevis 27% 95%
Q8BJW6 Mus musculus 25% 95%
Q9BY44 Homo sapiens 25% 94%
Q9VNX8 Drosophila melanogaster 26% 86%
V5BCM0 Trypanosoma cruzi 53% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS