Peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif (a.k.a. RRM - RBD - or RNP domain)/RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain) - putative

Species:

Leishmania infantum

UniProt:

A4HWW3_LEIIN

TriTrypDb:

LINF_160011700

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HWW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWW3

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901407	obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain	8	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016853	isomerase activity	2	7
GO:0016859	cis-trans isomerase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.589
CLV_C14_Caspase3-7	489	493	PF00656	0.600
CLV_NRD_NRD_1	207	209	PF00675	0.620
CLV_NRD_NRD_1	220	222	PF00675	0.558
CLV_NRD_NRD_1	320	322	PF00675	0.605
CLV_NRD_NRD_1	323	325	PF00675	0.600
CLV_NRD_NRD_1	548	550	PF00675	0.499
CLV_NRD_NRD_1	58	60	PF00675	0.571
CLV_NRD_NRD_1	676	678	PF00675	0.482
CLV_NRD_NRD_1	690	692	PF00675	0.468
CLV_PCSK_FUR_1	321	325	PF00082	0.621
CLV_PCSK_FUR_1	366	370	PF00082	0.572
CLV_PCSK_KEX2_1	207	209	PF00082	0.605
CLV_PCSK_KEX2_1	218	220	PF00082	0.547
CLV_PCSK_KEX2_1	320	322	PF00082	0.543
CLV_PCSK_KEX2_1	323	325	PF00082	0.566
CLV_PCSK_KEX2_1	368	370	PF00082	0.567
CLV_PCSK_KEX2_1	548	550	PF00082	0.509
CLV_PCSK_KEX2_1	58	60	PF00082	0.507
CLV_PCSK_KEX2_1	678	680	PF00082	0.485
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.567
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.545
CLV_PCSK_PC1ET2_1	678	680	PF00082	0.542
CLV_PCSK_PC7_1	215	221	PF00082	0.558
CLV_PCSK_PC7_1	674	680	PF00082	0.474
CLV_PCSK_SKI1_1	134	138	PF00082	0.555
CLV_PCSK_SKI1_1	353	357	PF00082	0.647
CLV_PCSK_SKI1_1	368	372	PF00082	0.518
CLV_PCSK_SKI1_1	380	384	PF00082	0.556
CLV_PCSK_SKI1_1	681	685	PF00082	0.545
CLV_Separin_Metazoa	42	46	PF03568	0.385
CLV_Separin_Metazoa	437	441	PF03568	0.437
DEG_APCC_DBOX_1	680	688	PF00400	0.420
DOC_CYCLIN_RxL_1	131	138	PF00134	0.573
DOC_MAPK_gen_1	215	225	PF00069	0.550
DOC_MAPK_gen_1	674	684	PF00069	0.539
DOC_MAPK_MEF2A_6	304	311	PF00069	0.587
DOC_MAPK_MEF2A_6	473	482	PF00069	0.644
DOC_MAPK_MEF2A_6	559	568	PF00069	0.507
DOC_MAPK_RevD_3	354	369	PF00069	0.629
DOC_PP2B_PxIxI_1	477	483	PF00149	0.640
DOC_USP7_MATH_1	15	19	PF00917	0.470
DOC_USP7_MATH_1	175	179	PF00917	0.615
DOC_USP7_MATH_1	180	184	PF00917	0.624
DOC_USP7_MATH_1	188	192	PF00917	0.594
DOC_USP7_MATH_1	246	250	PF00917	0.525
DOC_USP7_MATH_1	259	263	PF00917	0.639
DOC_USP7_MATH_1	265	269	PF00917	0.734
DOC_USP7_MATH_1	458	462	PF00917	0.589
DOC_USP7_MATH_1	467	471	PF00917	0.560
DOC_USP7_MATH_1	532	536	PF00917	0.579
DOC_USP7_MATH_1	91	95	PF00917	0.526
DOC_USP7_UBL2_3	236	240	PF12436	0.552
DOC_WW_Pin1_4	171	176	PF00397	0.637
DOC_WW_Pin1_4	261	266	PF00397	0.621
DOC_WW_Pin1_4	495	500	PF00397	0.597
DOC_WW_Pin1_4	6	11	PF00397	0.645
LIG_14-3-3_CanoR_1	142	151	PF00244	0.760
LIG_14-3-3_CanoR_1	24	31	PF00244	0.467
LIG_14-3-3_CanoR_1	289	295	PF00244	0.538
LIG_14-3-3_CanoR_1	353	359	PF00244	0.553
LIG_14-3-3_CanoR_1	369	373	PF00244	0.576
LIG_14-3-3_CanoR_1	406	413	PF00244	0.536
LIG_14-3-3_CanoR_1	440	444	PF00244	0.565
LIG_14-3-3_CanoR_1	45	49	PF00244	0.378
LIG_14-3-3_CanoR_1	453	458	PF00244	0.494
LIG_14-3-3_CanoR_1	548	553	PF00244	0.708
LIG_14-3-3_CanoR_1	611	619	PF00244	0.468
LIG_Actin_WH2_2	304	322	PF00022	0.588
LIG_BIR_II_1	1	5	PF00653	0.497
LIG_BIR_III_2	172	176	PF00653	0.613
LIG_FHA_1	113	119	PF00498	0.501
LIG_FHA_1	177	183	PF00498	0.590
LIG_FHA_1	306	312	PF00498	0.537
LIG_FHA_1	535	541	PF00498	0.601
LIG_FHA_1	561	567	PF00498	0.509
LIG_FHA_1	70	76	PF00498	0.473
LIG_FHA_2	291	297	PF00498	0.587
LIG_FHA_2	454	460	PF00498	0.510
LIG_FHA_2	487	493	PF00498	0.777
LIG_FHA_2	595	601	PF00498	0.468
LIG_FHA_2	611	617	PF00498	0.480
LIG_Integrin_RGD_1	578	580	PF01839	0.551
LIG_IRF3_LxIS_1	40	47	PF10401	0.394
LIG_LIR_Apic_2	357	361	PF02991	0.563
LIG_LIR_Gen_1	303	312	PF02991	0.525
LIG_LIR_Gen_1	378	388	PF02991	0.566
LIG_LIR_Gen_1	39	48	PF02991	0.453
LIG_LIR_Gen_1	633	641	PF02991	0.468
LIG_LIR_Gen_1	97	108	PF02991	0.472
LIG_LIR_Nem_3	130	136	PF02991	0.546
LIG_LIR_Nem_3	303	309	PF02991	0.538
LIG_LIR_Nem_3	378	384	PF02991	0.612
LIG_LIR_Nem_3	387	392	PF02991	0.540
LIG_LIR_Nem_3	39	43	PF02991	0.458
LIG_LIR_Nem_3	607	612	PF02991	0.611
LIG_LIR_Nem_3	626	632	PF02991	0.468
LIG_LIR_Nem_3	633	637	PF02991	0.468
LIG_LIR_Nem_3	638	644	PF02991	0.579
LIG_LIR_Nem_3	97	103	PF02991	0.457
LIG_NRBOX	136	142	PF00104	0.538
LIG_NRP_CendR_1	698	700	PF00754	0.490
LIG_PTB_Apo_2	504	511	PF02174	0.569
LIG_PTB_Phospho_1	504	510	PF10480	0.634
LIG_SH2_CRK	239	243	PF00017	0.614
LIG_SH2_PTP2	306	309	PF00017	0.518
LIG_SH2_PTP2	381	384	PF00017	0.611
LIG_SH2_PTP2	448	451	PF00017	0.550
LIG_SH2_SRC	243	246	PF00017	0.613
LIG_SH2_STAT5	243	246	PF00017	0.664
LIG_SH2_STAT5	306	309	PF00017	0.518
LIG_SH2_STAT5	381	384	PF00017	0.611
LIG_SH2_STAT5	448	451	PF00017	0.550
LIG_SH2_STAT5	463	466	PF00017	0.627
LIG_SH2_STAT5	514	517	PF00017	0.582
LIG_SH3_3	148	154	PF00018	0.580
LIG_SH3_3	379	385	PF00018	0.614
LIG_SH3_3	502	508	PF00018	0.567
LIG_SH3_3	9	15	PF00018	0.488
LIG_SUMO_SIM_anti_2	434	442	PF11976	0.440
LIG_SUMO_SIM_anti_2	501	506	PF11976	0.650
LIG_SUMO_SIM_anti_2	562	568	PF11976	0.524
LIG_SUMO_SIM_par_1	178	186	PF11976	0.579
LIG_SUMO_SIM_par_1	82	87	PF11976	0.473
LIG_TYR_ITIM	627	632	PF00017	0.302
MOD_CK1_1	178	184	PF00069	0.667
MOD_CK1_1	191	197	PF00069	0.502
MOD_CK1_1	247	253	PF00069	0.573
MOD_CK1_1	266	272	PF00069	0.475
MOD_CK1_1	284	290	PF00069	0.427
MOD_CK1_1	295	301	PF00069	0.503
MOD_CK1_1	6	12	PF00069	0.542
MOD_CK1_1	94	100	PF00069	0.556
MOD_CK2_1	36	42	PF00069	0.449
MOD_CK2_1	488	494	PF00069	0.646
MOD_CK2_1	495	501	PF00069	0.581
MOD_CK2_1	594	600	PF00069	0.302
MOD_GlcNHglycan	144	147	PF01048	0.643
MOD_GlcNHglycan	246	249	PF01048	0.573
MOD_GlcNHglycan	261	264	PF01048	0.635
MOD_GlcNHglycan	265	268	PF01048	0.479
MOD_GlcNHglycan	282	286	PF01048	0.609
MOD_GlcNHglycan	386	389	PF01048	0.611
MOD_GlcNHglycan	397	400	PF01048	0.571
MOD_GlcNHglycan	50	53	PF01048	0.541
MOD_GlcNHglycan	540	543	PF01048	0.519
MOD_GlcNHglycan	613	616	PF01048	0.302
MOD_GlcNHglycan	62	65	PF01048	0.574
MOD_GlcNHglycan	92	96	PF01048	0.485
MOD_GSK3_1	171	178	PF00069	0.611
MOD_GSK3_1	188	195	PF00069	0.616
MOD_GSK3_1	20	27	PF00069	0.482
MOD_GSK3_1	259	266	PF00069	0.766
MOD_GSK3_1	368	375	PF00069	0.667
MOD_GSK3_1	380	387	PF00069	0.631
MOD_GSK3_1	391	398	PF00069	0.699
MOD_GSK3_1	44	51	PF00069	0.402
MOD_GSK3_1	449	456	PF00069	0.580
MOD_GSK3_1	463	470	PF00069	0.513
MOD_GSK3_1	534	541	PF00069	0.626
MOD_GSK3_1	659	666	PF00069	0.401
MOD_N-GLC_1	560	565	PF02516	0.510
MOD_N-GLC_2	102	104	PF02516	0.460
MOD_NEK2_1	140	145	PF00069	0.608
MOD_NEK2_1	20	25	PF00069	0.576
MOD_NEK2_1	290	295	PF00069	0.577
MOD_NEK2_1	36	41	PF00069	0.564
MOD_NEK2_1	438	443	PF00069	0.622
MOD_NEK2_1	44	49	PF00069	0.462
MOD_NEK2_1	604	609	PF00069	0.363
MOD_NEK2_1	661	666	PF00069	0.422
MOD_NEK2_1	76	81	PF00069	0.435
MOD_NEK2_2	15	20	PF00069	0.469
MOD_NEK2_2	180	185	PF00069	0.602
MOD_NEK2_2	458	463	PF00069	0.593
MOD_PIKK_1	604	610	PF00454	0.363
MOD_PIKK_1	659	665	PF00454	0.389
MOD_PKA_1	368	374	PF00069	0.632
MOD_PKA_1	548	554	PF00069	0.573
MOD_PKA_2	20	26	PF00069	0.476
MOD_PKA_2	232	238	PF00069	0.506
MOD_PKA_2	368	374	PF00069	0.632
MOD_PKA_2	439	445	PF00069	0.595
MOD_PKA_2	44	50	PF00069	0.382
MOD_PKA_2	548	554	PF00069	0.539
MOD_PKA_2	610	616	PF00069	0.334
MOD_Plk_1	295	301	PF00069	0.521
MOD_Plk_1	458	464	PF00069	0.560
MOD_Plk_1	560	566	PF00069	0.507
MOD_Plk_1	77	83	PF00069	0.445
MOD_Plk_1	91	97	PF00069	0.457
MOD_Plk_2-3	633	639	PF00069	0.318
MOD_Plk_4	15	21	PF00069	0.472
MOD_Plk_4	26	32	PF00069	0.522
MOD_Plk_4	275	281	PF00069	0.560
MOD_Plk_4	368	374	PF00069	0.632
MOD_Plk_4	439	445	PF00069	0.493
MOD_Plk_4	458	464	PF00069	0.648
MOD_Plk_4	548	554	PF00069	0.614
MOD_Plk_4	562	568	PF00069	0.435
MOD_ProDKin_1	171	177	PF00069	0.637
MOD_ProDKin_1	261	267	PF00069	0.621
MOD_ProDKin_1	495	501	PF00069	0.592
MOD_ProDKin_1	6	12	PF00069	0.643
MOD_SUMO_rev_2	576	584	PF00179	0.514
MOD_SUMO_rev_2	614	623	PF00179	0.302
TRG_DiLeu_BaEn_1	434	439	PF01217	0.447
TRG_DiLeu_BaEn_1	562	567	PF01217	0.509
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.598
TRG_ENDOCYTIC_2	133	136	PF00928	0.507
TRG_ENDOCYTIC_2	239	242	PF00928	0.615
TRG_ENDOCYTIC_2	306	309	PF00928	0.530
TRG_ENDOCYTIC_2	381	384	PF00928	0.611
TRG_ENDOCYTIC_2	448	451	PF00928	0.741
TRG_ENDOCYTIC_2	629	632	PF00928	0.302
TRG_ER_diArg_1	206	208	PF00400	0.616
TRG_ER_diArg_1	219	221	PF00400	0.551
TRG_ER_diArg_1	319	321	PF00400	0.602
TRG_ER_diArg_1	322	324	PF00400	0.597
TRG_ER_diArg_1	57	59	PF00400	0.512
TRG_ER_diArg_1	676	679	PF00400	0.477
TRG_NLS_Bipartite_1	207	222	PF00514	0.515
TRG_NLS_MonoCore_2	217	222	PF00514	0.571
TRG_NLS_MonoExtN_4	215	222	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	649	653	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB00	Leptomonas seymouri	57%	100%
A0A3Q8ICH7	Leishmania donovani	99%	100%
A4H8I6	Leishmania braziliensis	80%	100%
E9AQM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEV5	Leishmania major	87%	100%