Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

meiotic recombination protein SPO11 - putative

Species:

Leishmania infantum

UniProt:

A4HWW2_LEIIN

TriTrypDb:

LINF_160011600

Length:

263

Annotations

Annotations by Jardim et al.

DNA replication, meiotic recombination SPO11, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HWW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWW2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0003916	DNA topoisomerase activity	3	2
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	2
GO:0005488	binding	1	2
GO:0008094	ATP-dependent activity, acting on DNA	2	2
GO:0016853	isomerase activity	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.447
CLV_NRD_NRD_1	111	113	PF00675	0.399
CLV_NRD_NRD_1	239	241	PF00675	0.483
CLV_NRD_NRD_1	259	261	PF00675	0.407
CLV_PCSK_FUR_1	236	240	PF00082	0.482
CLV_PCSK_KEX2_1	111	113	PF00082	0.399
CLV_PCSK_KEX2_1	238	240	PF00082	0.489
CLV_PCSK_KEX2_1	259	261	PF00082	0.407
DEG_Nend_UBRbox_2	1	3	PF02207	0.461
DEG_SCF_TRCP1_1	29	34	PF00400	0.460
DEG_SPOP_SBC_1	130	134	PF00917	0.471
DOC_CDC14_PxL_1	5	13	PF14671	0.411
DOC_PP4_FxxP_1	226	229	PF00568	0.415
DOC_USP7_MATH_1	130	134	PF00917	0.471
DOC_USP7_MATH_1	70	74	PF00917	0.494
DOC_USP7_MATH_1	76	80	PF00917	0.501
DOC_USP7_MATH_1	99	103	PF00917	0.447
DOC_WW_Pin1_4	131	136	PF00397	0.484
DOC_WW_Pin1_4	241	246	PF00397	0.458
DOC_WW_Pin1_4	47	52	PF00397	0.502
DOC_WW_Pin1_4	95	100	PF00397	0.470
LIG_14-3-3_CanoR_1	180	184	PF00244	0.427
LIG_14-3-3_CanoR_1	192	196	PF00244	0.358
LIG_14-3-3_CanoR_1	69	78	PF00244	0.497
LIG_EVH1_2	245	249	PF00568	0.426
LIG_FHA_1	16	22	PF00498	0.393
LIG_FHA_2	108	114	PF00498	0.384
LIG_LIR_Apic_2	215	221	PF02991	0.420
LIG_LIR_Apic_2	3	9	PF02991	0.427
LIG_LIR_Nem_3	10	16	PF02991	0.402
LIG_LIR_Nem_3	2	8	PF02991	0.438
LIG_NRBOX	123	129	PF00104	0.370
LIG_SH2_CRK	218	222	PF00017	0.412
LIG_SH2_CRK	6	10	PF00017	0.410
LIG_SH2_GRB2like	222	225	PF00017	0.404
LIG_SH2_NCK_1	218	222	PF00017	0.412
LIG_SH2_NCK_1	6	10	PF00017	0.410
LIG_SH2_STAP1	222	226	PF00017	0.403
LIG_SH2_STAT5	160	163	PF00017	0.440
LIG_SH2_STAT5	218	221	PF00017	0.418
LIG_SH3_3	38	44	PF00018	0.489
MOD_CDK_SPxxK_3	131	138	PF00069	0.483
MOD_CK1_1	179	185	PF00069	0.429
MOD_CK1_1	244	250	PF00069	0.427
MOD_CK1_1	72	78	PF00069	0.495
MOD_CK1_1	79	85	PF00069	0.502
MOD_CK1_1	98	104	PF00069	0.436
MOD_CK2_1	156	162	PF00069	0.448
MOD_GlcNHglycan	167	170	PF01048	0.452
MOD_GlcNHglycan	171	174	PF01048	0.468
MOD_GlcNHglycan	29	32	PF01048	0.454
MOD_GlcNHglycan	33	36	PF01048	0.478
MOD_GlcNHglycan	38	41	PF01048	0.484
MOD_GlcNHglycan	56	59	PF01048	0.514
MOD_GlcNHglycan	74	77	PF01048	0.496
MOD_GlcNHglycan	78	81	PF01048	0.502
MOD_GlcNHglycan	85	88	PF01048	0.490
MOD_GSK3_1	107	114	PF00069	0.383
MOD_GSK3_1	165	172	PF00069	0.457
MOD_GSK3_1	27	34	PF00069	0.456
MOD_GSK3_1	50	57	PF00069	0.510
MOD_GSK3_1	61	68	PF00069	0.513
MOD_GSK3_1	72	79	PF00069	0.496
MOD_GSK3_1	83	90	PF00069	0.493
MOD_GSK3_1	95	102	PF00069	0.468
MOD_NEK2_1	54	59	PF00069	0.516
MOD_PIKK_1	244	250	PF00454	0.427
MOD_PKA_1	111	117	PF00069	0.389
MOD_PKA_2	111	117	PF00069	0.389
MOD_PKA_2	165	171	PF00069	0.455
MOD_PKA_2	179	185	PF00069	0.429
MOD_PKA_2	191	197	PF00069	0.363
MOD_Plk_4	111	117	PF00069	0.389
MOD_Plk_4	156	162	PF00069	0.448
MOD_Plk_4	191	197	PF00069	0.363
MOD_Plk_4	228	234	PF00069	0.433
MOD_ProDKin_1	131	137	PF00069	0.482
MOD_ProDKin_1	241	247	PF00069	0.452
MOD_ProDKin_1	47	53	PF00069	0.502
MOD_ProDKin_1	95	101	PF00069	0.469
MOD_SUMO_for_1	210	213	PF00179	0.352
TRG_ENDOCYTIC_2	5	8	PF00928	0.425
TRG_ER_diArg_1	235	238	PF00400	0.470
TRG_ER_diArg_1	258	260	PF00400	0.406