Putative histone H3

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative histone H3

Gene product:

Core histone H2A/H2B/H3/H4/Histone-like transcription factor (CBF/NF-Y) and archaeal histone - putative

Species:

Leishmania infantum

UniProt:

A4HWV9_LEIIN

TriTrypDb:

LINF_160011400

Length:

130

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, histone H3

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 50

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	15
GO:0005634	nucleus	5	2
GO:0032991	protein-containing complex	1	15
GO:0032993	protein-DNA complex	2	15
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0044815	DNA packaging complex	2	15
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4HWV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWV9

PDB structure(s): 6kxv_A , 6kxv_E

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003677	DNA binding	4	15
GO:0005198	structural molecule activity	1	15
GO:0005488	binding	1	15
GO:0005515	protein binding	2	15
GO:0030527	structural constituent of chromatin	2	15
GO:0046982	protein heterodimerization activity	4	15
GO:0046983	protein dimerization activity	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	34	36	PF00675	0.265
CLV_NRD_NRD_1	46	48	PF00675	0.371
CLV_PCSK_FUR_1	9	13	PF00082	0.283
CLV_PCSK_KEX2_1	11	13	PF00082	0.283
CLV_PCSK_KEX2_1	110	112	PF00082	0.360
CLV_PCSK_KEX2_1	34	36	PF00082	0.265
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.283
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.341
CLV_PCSK_SKI1_1	110	114	PF00082	0.358
CLV_PCSK_SKI1_1	12	16	PF00082	0.267

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE44	Leptomonas seymouri	56%	90%
A0A0S4IWA8	Bodo saltans	52%	90%
A0A0S4J721	Bodo saltans	67%	99%
A0A1X0P6L2	Trypanosomatidae	53%	84%
A0A3Q8IC67	Leishmania donovani	98%	100%
A0A3R7KFK4	Trypanosoma rangeli	55%	86%
A0A3S7WVC7	Leishmania donovani	56%	90%
A0A422MY47	Trypanosoma rangeli	77%	98%
A0A422MY58	Trypanosoma rangeli	76%	100%
A1CP80	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	62%	96%

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