LeishMANIAdb
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Argininosuccinate synthase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Argininosuccinate synthase
Gene product:
carbamoyl-phosphate synthase - putative
Species:
Leishmania infantum
UniProt:
A4HWV8_LEIIN
TriTrypDb:
LINF_160011200
Length:
1842

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, carbamoyl-phosphate synthase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HWV8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWV8

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 10
GO:0006139 nucleobase-containing compound metabolic process 3 10
GO:0006206 pyrimidine nucleobase metabolic process 5 10
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process 7 10
GO:0006520 amino acid metabolic process 3 10
GO:0006525 arginine metabolic process 6 10
GO:0006526 arginine biosynthetic process 7 10
GO:0006541 glutamine metabolic process 6 10
GO:0006725 cellular aromatic compound metabolic process 3 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0008652 amino acid biosynthetic process 4 10
GO:0009058 biosynthetic process 2 10
GO:0009064 glutamine family amino acid metabolic process 5 10
GO:0009084 glutamine family amino acid biosynthetic process 6 10
GO:0009112 nucleobase metabolic process 4 10
GO:0009987 cellular process 1 10
GO:0016053 organic acid biosynthetic process 4 10
GO:0018130 heterocycle biosynthetic process 4 10
GO:0019752 carboxylic acid metabolic process 5 10
GO:0019856 pyrimidine nucleobase biosynthetic process 6 10
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0043436 oxoacid metabolic process 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044249 cellular biosynthetic process 3 10
GO:0044271 cellular nitrogen compound biosynthetic process 4 10
GO:0044281 small molecule metabolic process 2 10
GO:0044283 small molecule biosynthetic process 3 10
GO:0046112 nucleobase biosynthetic process 5 10
GO:0046394 carboxylic acid biosynthetic process 5 10
GO:0046483 heterocycle metabolic process 3 10
GO:0055086 nucleobase-containing small molecule metabolic process 3 10
GO:0071704 organic substance metabolic process 2 10
GO:0072527 pyrimidine-containing compound metabolic process 4 10
GO:0072528 pyrimidine-containing compound biosynthetic process 5 10
GO:1901360 organic cyclic compound metabolic process 3 10
GO:1901362 organic cyclic compound biosynthetic process 4 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901566 organonitrogen compound biosynthetic process 4 10
GO:1901576 organic substance biosynthetic process 3 10
GO:1901605 alpha-amino acid metabolic process 4 10
GO:1901607 alpha-amino acid biosynthetic process 5 10
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0004055 argininosuccinate synthase activity 4 10
GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity 5 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0016874 ligase activity 2 10
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 10
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 4 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1311 1315 PF00656 0.385
CLV_C14_Caspase3-7 446 450 PF00656 0.315
CLV_C14_Caspase3-7 82 86 PF00656 0.445
CLV_NRD_NRD_1 115 117 PF00675 0.241
CLV_NRD_NRD_1 1234 1236 PF00675 0.441
CLV_NRD_NRD_1 1329 1331 PF00675 0.300
CLV_NRD_NRD_1 1394 1396 PF00675 0.223
CLV_NRD_NRD_1 1400 1402 PF00675 0.199
CLV_NRD_NRD_1 1414 1416 PF00675 0.101
CLV_NRD_NRD_1 1573 1575 PF00675 0.246
CLV_NRD_NRD_1 1627 1629 PF00675 0.218
CLV_NRD_NRD_1 1814 1816 PF00675 0.638
CLV_NRD_NRD_1 372 374 PF00675 0.322
CLV_NRD_NRD_1 878 880 PF00675 0.313
CLV_NRD_NRD_1 952 954 PF00675 0.346
CLV_PCSK_FUR_1 1391 1395 PF00082 0.201
CLV_PCSK_FUR_1 1571 1575 PF00082 0.245
CLV_PCSK_FUR_1 876 880 PF00082 0.319
CLV_PCSK_KEX2_1 1169 1171 PF00082 0.217
CLV_PCSK_KEX2_1 1244 1246 PF00082 0.434
CLV_PCSK_KEX2_1 1329 1331 PF00082 0.300
CLV_PCSK_KEX2_1 1393 1395 PF00082 0.220
CLV_PCSK_KEX2_1 1400 1402 PF00082 0.237
CLV_PCSK_KEX2_1 1414 1416 PF00082 0.165
CLV_PCSK_KEX2_1 1573 1575 PF00082 0.264
CLV_PCSK_KEX2_1 1814 1816 PF00082 0.553
CLV_PCSK_KEX2_1 878 880 PF00082 0.307
CLV_PCSK_KEX2_1 952 954 PF00082 0.346
CLV_PCSK_PC1ET2_1 1169 1171 PF00082 0.217
CLV_PCSK_PC1ET2_1 1244 1246 PF00082 0.458
CLV_PCSK_PC1ET2_1 1393 1395 PF00082 0.210
CLV_PCSK_SKI1_1 1098 1102 PF00082 0.217
CLV_PCSK_SKI1_1 1244 1248 PF00082 0.416
CLV_PCSK_SKI1_1 1293 1297 PF00082 0.292
CLV_PCSK_SKI1_1 1305 1309 PF00082 0.329
CLV_PCSK_SKI1_1 1330 1334 PF00082 0.294
CLV_PCSK_SKI1_1 1781 1785 PF00082 0.217
CLV_PCSK_SKI1_1 194 198 PF00082 0.199
CLV_PCSK_SKI1_1 240 244 PF00082 0.199
CLV_PCSK_SKI1_1 247 251 PF00082 0.199
CLV_PCSK_SKI1_1 373 377 PF00082 0.314
CLV_PCSK_SKI1_1 494 498 PF00082 0.199
CLV_PCSK_SKI1_1 687 691 PF00082 0.199
CLV_PCSK_SKI1_1 692 696 PF00082 0.199
CLV_PCSK_SKI1_1 800 804 PF00082 0.269
CLV_PCSK_SKI1_1 819 823 PF00082 0.110
CLV_PCSK_SKI1_1 957 961 PF00082 0.290
CLV_Separin_Metazoa 582 586 PF03568 0.399
CLV_Separin_Metazoa 845 849 PF03568 0.500
DEG_APCC_DBOX_1 497 505 PF00400 0.399
DEG_APCC_DBOX_1 818 826 PF00400 0.470
DEG_APCC_DBOX_1 847 855 PF00400 0.451
DEG_APCC_DBOX_1 878 886 PF00400 0.456
DEG_Nend_UBRbox_2 1 3 PF02207 0.474
DOC_AGCK_PIF_1 17 22 PF00069 0.417
DOC_CKS1_1 1724 1729 PF01111 0.452
DOC_CKS1_1 481 486 PF01111 0.346
DOC_CYCLIN_RxL_1 189 200 PF00134 0.440
DOC_CYCLIN_RxL_1 687 698 PF00134 0.399
DOC_CYCLIN_RxL_1 794 807 PF00134 0.500
DOC_CYCLIN_yCln2_LP_2 1520 1526 PF00134 0.440
DOC_CYCLIN_yCln2_LP_2 481 487 PF00134 0.420
DOC_MAPK_gen_1 1017 1023 PF00069 0.331
DOC_MAPK_gen_1 1039 1049 PF00069 0.399
DOC_MAPK_gen_1 116 126 PF00069 0.400
DOC_MAPK_gen_1 1235 1243 PF00069 0.494
DOC_MAPK_gen_1 1285 1292 PF00069 0.326
DOC_MAPK_gen_1 1380 1390 PF00069 0.420
DOC_MAPK_gen_1 1470 1478 PF00069 0.333
DOC_MAPK_gen_1 328 337 PF00069 0.399
DOC_MAPK_gen_1 369 378 PF00069 0.398
DOC_MAPK_gen_1 445 453 PF00069 0.312
DOC_MAPK_gen_1 474 480 PF00069 0.328
DOC_MAPK_gen_1 554 561 PF00069 0.417
DOC_MAPK_gen_1 876 884 PF00069 0.321
DOC_MAPK_gen_1 952 960 PF00069 0.323
DOC_MAPK_gen_1 994 1002 PF00069 0.282
DOC_MAPK_HePTP_8 1378 1390 PF00069 0.417
DOC_MAPK_MEF2A_6 1381 1390 PF00069 0.400
DOC_MAPK_MEF2A_6 1470 1478 PF00069 0.333
DOC_MAPK_MEF2A_6 198 205 PF00069 0.399
DOC_MAPK_MEF2A_6 554 561 PF00069 0.401
DOC_MAPK_MEF2A_6 876 884 PF00069 0.351
DOC_MAPK_MEF2A_6 996 1004 PF00069 0.278
DOC_PP1_RVXF_1 1303 1310 PF00149 0.406
DOC_PP1_RVXF_1 1554 1560 PF00149 0.470
DOC_PP1_RVXF_1 235 242 PF00149 0.470
DOC_PP1_RVXF_1 523 530 PF00149 0.470
DOC_PP1_RVXF_1 975 981 PF00149 0.303
DOC_PP2B_LxvP_1 1047 1050 PF13499 0.378
DOC_PP2B_LxvP_1 1520 1523 PF13499 0.440
DOC_PP2B_LxvP_1 1659 1662 PF13499 0.470
DOC_PP4_FxxP_1 1157 1160 PF00568 0.417
DOC_PP4_FxxP_1 1300 1303 PF00568 0.317
DOC_PP4_FxxP_1 154 157 PF00568 0.352
DOC_PP4_FxxP_1 770 773 PF00568 0.303
DOC_USP7_MATH_1 1214 1218 PF00917 0.399
DOC_USP7_MATH_1 1365 1369 PF00917 0.431
DOC_USP7_MATH_1 1441 1445 PF00917 0.420
DOC_USP7_MATH_1 1516 1520 PF00917 0.500
DOC_USP7_MATH_1 1579 1583 PF00917 0.399
DOC_USP7_MATH_1 164 168 PF00917 0.378
DOC_USP7_MATH_1 1660 1664 PF00917 0.500
DOC_USP7_MATH_1 331 335 PF00917 0.440
DOC_USP7_MATH_1 513 517 PF00917 0.399
DOC_USP7_MATH_1 671 675 PF00917 0.399
DOC_USP7_UBL2_3 1165 1169 PF12436 0.399
DOC_USP7_UBL2_3 1301 1305 PF12436 0.444
DOC_USP7_UBL2_3 1456 1460 PF12436 0.594
DOC_USP7_UBL2_3 1583 1587 PF12436 0.470
DOC_USP7_UBL2_3 1629 1633 PF12436 0.440
DOC_WW_Pin1_4 1671 1676 PF00397 0.419
DOC_WW_Pin1_4 1693 1698 PF00397 0.417
DOC_WW_Pin1_4 1723 1728 PF00397 0.452
DOC_WW_Pin1_4 480 485 PF00397 0.333
DOC_WW_Pin1_4 56 61 PF00397 0.440
DOC_WW_Pin1_4 561 566 PF00397 0.417
DOC_WW_Pin1_4 788 793 PF00397 0.399
LIG_14-3-3_CanoR_1 1208 1214 PF00244 0.399
LIG_14-3-3_CanoR_1 1490 1498 PF00244 0.429
LIG_14-3-3_CanoR_1 1573 1578 PF00244 0.418
LIG_14-3-3_CanoR_1 171 179 PF00244 0.396
LIG_14-3-3_CanoR_1 1781 1791 PF00244 0.440
LIG_14-3-3_CanoR_1 288 298 PF00244 0.440
LIG_14-3-3_CanoR_1 933 939 PF00244 0.293
LIG_Actin_WH2_2 1001 1019 PF00022 0.413
LIG_Actin_WH2_2 1186 1203 PF00022 0.399
LIG_Actin_WH2_2 1788 1806 PF00022 0.417
LIG_AP2alpha_2 651 653 PF02296 0.500
LIG_APCC_ABBA_1 1371 1376 PF00400 0.500
LIG_APCC_ABBA_1 1431 1436 PF00400 0.294
LIG_APCC_ABBAyCdc20_2 1370 1376 PF00400 0.445
LIG_BRCT_BRCA1_1 1211 1215 PF00533 0.399
LIG_BRCT_BRCA1_1 1678 1682 PF00533 0.422
LIG_BRCT_BRCA1_1 333 337 PF00533 0.440
LIG_BRCT_BRCA1_1 936 940 PF00533 0.280
LIG_CtBP_PxDLS_1 42 46 PF00389 0.417
LIG_deltaCOP1_diTrp_1 309 314 PF00928 0.401
LIG_deltaCOP1_diTrp_1 323 332 PF00928 0.404
LIG_EH1_1 1471 1479 PF00400 0.425
LIG_EH1_1 198 206 PF00400 0.500
LIG_eIF4E_1 4 10 PF01652 0.384
LIG_eIF4E_1 50 56 PF01652 0.417
LIG_eIF4E_1 823 829 PF01652 0.500
LIG_FHA_1 1095 1101 PF00498 0.457
LIG_FHA_1 1153 1159 PF00498 0.399
LIG_FHA_1 1217 1223 PF00498 0.399
LIG_FHA_1 126 132 PF00498 0.399
LIG_FHA_1 1275 1281 PF00498 0.297
LIG_FHA_1 1315 1321 PF00498 0.370
LIG_FHA_1 1338 1344 PF00498 0.408
LIG_FHA_1 157 163 PF00498 0.346
LIG_FHA_1 1694 1700 PF00498 0.470
LIG_FHA_1 176 182 PF00498 0.354
LIG_FHA_1 1782 1788 PF00498 0.417
LIG_FHA_1 200 206 PF00498 0.399
LIG_FHA_1 211 217 PF00498 0.399
LIG_FHA_1 231 237 PF00498 0.264
LIG_FHA_1 34 40 PF00498 0.399
LIG_FHA_1 346 352 PF00498 0.399
LIG_FHA_1 407 413 PF00498 0.338
LIG_FHA_1 696 702 PF00498 0.402
LIG_FHA_1 833 839 PF00498 0.503
LIG_FHA_2 1056 1062 PF00498 0.403
LIG_FHA_2 1120 1126 PF00498 0.445
LIG_FHA_2 1161 1167 PF00498 0.385
LIG_FHA_2 1617 1623 PF00498 0.449
LIG_FHA_2 1820 1826 PF00498 0.516
LIG_FHA_2 419 425 PF00498 0.326
LIG_FHA_2 749 755 PF00498 0.283
LIG_FHA_2 869 875 PF00498 0.362
LIG_FHA_2 968 974 PF00498 0.309
LIG_FHA_2 985 991 PF00498 0.297
LIG_HCF-1_HBM_1 427 430 PF13415 0.373
LIG_IRF3_LxIS_1 1216 1223 PF10401 0.399
LIG_LIR_Apic_2 1155 1160 PF02991 0.417
LIG_LIR_Apic_2 1419 1423 PF02991 0.470
LIG_LIR_Apic_2 151 157 PF02991 0.356
LIG_LIR_Apic_2 427 433 PF02991 0.305
LIG_LIR_Apic_2 768 773 PF02991 0.398
LIG_LIR_Gen_1 106 115 PF02991 0.445
LIG_LIR_Gen_1 1259 1268 PF02991 0.304
LIG_LIR_Gen_1 1382 1390 PF02991 0.396
LIG_LIR_Gen_1 1514 1524 PF02991 0.470
LIG_LIR_Gen_1 1536 1546 PF02991 0.402
LIG_LIR_Gen_1 1615 1624 PF02991 0.500
LIG_LIR_Gen_1 1674 1685 PF02991 0.417
LIG_LIR_Gen_1 1799 1808 PF02991 0.484
LIG_LIR_Gen_1 329 339 PF02991 0.399
LIG_LIR_Gen_1 578 588 PF02991 0.399
LIG_LIR_Gen_1 622 632 PF02991 0.399
LIG_LIR_Gen_1 654 664 PF02991 0.399
LIG_LIR_Gen_1 712 721 PF02991 0.276
LIG_LIR_Gen_1 780 787 PF02991 0.356
LIG_LIR_Gen_1 921 932 PF02991 0.283
LIG_LIR_Nem_3 103 108 PF02991 0.401
LIG_LIR_Nem_3 1069 1075 PF02991 0.472
LIG_LIR_Nem_3 1223 1227 PF02991 0.429
LIG_LIR_Nem_3 1259 1263 PF02991 0.299
LIG_LIR_Nem_3 1382 1387 PF02991 0.396
LIG_LIR_Nem_3 1448 1453 PF02991 0.321
LIG_LIR_Nem_3 1499 1504 PF02991 0.463
LIG_LIR_Nem_3 15 20 PF02991 0.399
LIG_LIR_Nem_3 1514 1520 PF02991 0.328
LIG_LIR_Nem_3 1536 1541 PF02991 0.402
LIG_LIR_Nem_3 1558 1562 PF02991 0.454
LIG_LIR_Nem_3 1588 1594 PF02991 0.401
LIG_LIR_Nem_3 1615 1620 PF02991 0.500
LIG_LIR_Nem_3 1674 1680 PF02991 0.417
LIG_LIR_Nem_3 1750 1755 PF02991 0.418
LIG_LIR_Nem_3 1799 1805 PF02991 0.470
LIG_LIR_Nem_3 1836 1840 PF02991 0.515
LIG_LIR_Nem_3 214 220 PF02991 0.402
LIG_LIR_Nem_3 301 305 PF02991 0.405
LIG_LIR_Nem_3 309 313 PF02991 0.391
LIG_LIR_Nem_3 329 335 PF02991 0.409
LIG_LIR_Nem_3 349 355 PF02991 0.264
LIG_LIR_Nem_3 578 584 PF02991 0.399
LIG_LIR_Nem_3 622 627 PF02991 0.399
LIG_LIR_Nem_3 654 660 PF02991 0.399
LIG_LIR_Nem_3 712 718 PF02991 0.279
LIG_LIR_Nem_3 764 770 PF02991 0.413
LIG_LIR_Nem_3 774 779 PF02991 0.371
LIG_LIR_Nem_3 791 796 PF02991 0.445
LIG_LIR_Nem_3 818 823 PF02991 0.470
LIG_LIR_Nem_3 921 927 PF02991 0.291
LIG_LIR_Nem_3 939 945 PF02991 0.188
LIG_LYPXL_yS_3 1072 1075 PF13949 0.470
LIG_NRBOX 192 198 PF00104 0.399
LIG_NRBOX 863 869 PF00104 0.445
LIG_PCNA_PIPBox_1 814 823 PF02747 0.499
LIG_Pex14_1 310 314 PF04695 0.399
LIG_Pex14_2 1513 1517 PF04695 0.440
LIG_Pex14_2 298 302 PF04695 0.399
LIG_PTB_Apo_2 1532 1539 PF02174 0.431
LIG_PTB_Apo_2 618 625 PF02174 0.399
LIG_Rb_pABgroove_1 1734 1742 PF01858 0.417
LIG_REV1ctd_RIR_1 818 828 PF16727 0.399
LIG_SH2_CRK 1172 1176 PF00017 0.500
LIG_SH2_CRK 1420 1424 PF00017 0.442
LIG_SH2_CRK 217 221 PF00017 0.399
LIG_SH2_CRK 65 69 PF00017 0.399
LIG_SH2_CRK 924 928 PF00017 0.273
LIG_SH2_CRK 942 946 PF00017 0.282
LIG_SH2_GRB2like 588 591 PF00017 0.417
LIG_SH2_GRB2like 839 842 PF00017 0.500
LIG_SH2_NCK_1 1118 1122 PF00017 0.445
LIG_SH2_NCK_1 1172 1176 PF00017 0.417
LIG_SH2_NCK_1 1724 1728 PF00017 0.425
LIG_SH2_NCK_1 4 8 PF00017 0.397
LIG_SH2_PTP2 657 660 PF00017 0.399
LIG_SH2_PTP2 715 718 PF00017 0.271
LIG_SH2_SRC 1565 1568 PF00017 0.500
LIG_SH2_SRC 24 27 PF00017 0.440
LIG_SH2_SRC 905 908 PF00017 0.424
LIG_SH2_STAP1 1124 1128 PF00017 0.409
LIG_SH2_STAP1 1374 1378 PF00017 0.418
LIG_SH2_STAP1 1740 1744 PF00017 0.417
LIG_SH2_STAP1 1755 1759 PF00017 0.417
LIG_SH2_STAP1 24 28 PF00017 0.399
LIG_SH2_STAP1 588 592 PF00017 0.417
LIG_SH2_STAP1 839 843 PF00017 0.463
LIG_SH2_STAT3 1347 1350 PF00017 0.417
LIG_SH2_STAT3 476 479 PF00017 0.343
LIG_SH2_STAT3 50 53 PF00017 0.417
LIG_SH2_STAT3 910 913 PF00017 0.340
LIG_SH2_STAT3 98 101 PF00017 0.470
LIG_SH2_STAT5 1080 1083 PF00017 0.399
LIG_SH2_STAT5 1099 1102 PF00017 0.305
LIG_SH2_STAT5 1323 1326 PF00017 0.417
LIG_SH2_STAT5 1453 1456 PF00017 0.359
LIG_SH2_STAT5 1504 1507 PF00017 0.470
LIG_SH2_STAT5 1560 1563 PF00017 0.480
LIG_SH2_STAT5 1565 1568 PF00017 0.459
LIG_SH2_STAT5 1594 1597 PF00017 0.401
LIG_SH2_STAT5 313 316 PF00017 0.417
LIG_SH2_STAT5 350 353 PF00017 0.403
LIG_SH2_STAT5 355 358 PF00017 0.304
LIG_SH2_STAT5 430 433 PF00017 0.287
LIG_SH2_STAT5 537 540 PF00017 0.417
LIG_SH2_STAT5 657 660 PF00017 0.399
LIG_SH2_STAT5 715 718 PF00017 0.271
LIG_SH2_STAT5 767 770 PF00017 0.390
LIG_SH2_STAT5 80 83 PF00017 0.435
LIG_SH2_STAT5 905 908 PF00017 0.283
LIG_SH2_STAT5 979 982 PF00017 0.286
LIG_SH2_STAT5 98 101 PF00017 0.308
LIG_SH3_3 1046 1052 PF00018 0.399
LIG_SH3_3 1067 1073 PF00018 0.399
LIG_SH3_3 1181 1187 PF00018 0.399
LIG_SH3_3 1805 1811 PF00018 0.391
LIG_SH3_3 1826 1832 PF00018 0.532
LIG_SH3_3 223 229 PF00018 0.399
LIG_SH3_3 36 42 PF00018 0.399
LIG_SH3_3 609 615 PF00018 0.399
LIG_SH3_3 715 721 PF00018 0.271
LIG_SH3_5 711 715 PF00018 0.292
LIG_SUMO_SIM_anti_2 1125 1130 PF11976 0.399
LIG_SUMO_SIM_anti_2 1180 1186 PF11976 0.393
LIG_SUMO_SIM_anti_2 200 205 PF11976 0.401
LIG_SUMO_SIM_anti_2 483 489 PF11976 0.430
LIG_SUMO_SIM_anti_2 984 993 PF11976 0.327
LIG_SUMO_SIM_par_1 1109 1115 PF11976 0.399
LIG_SUMO_SIM_par_1 1522 1528 PF11976 0.399
LIG_SUMO_SIM_par_1 1788 1794 PF11976 0.406
LIG_SUMO_SIM_par_1 180 185 PF11976 0.297
LIG_SUMO_SIM_par_1 432 437 PF11976 0.412
LIG_SUMO_SIM_par_1 486 493 PF11976 0.332
LIG_SUMO_SIM_par_1 53 59 PF11976 0.417
LIG_SUMO_SIM_par_1 984 993 PF11976 0.444
LIG_TRAF2_1 1822 1825 PF00917 0.542
LIG_TRAF2_1 516 519 PF00917 0.440
LIG_TRAF2_1 751 754 PF00917 0.267
LIG_TRAF2_1 807 810 PF00917 0.448
LIG_TRAF2_2 1159 1164 PF00917 0.417
LIG_TRFH_1 648 652 PF08558 0.399
LIG_TYR_ITIM 1070 1075 PF00017 0.470
LIG_TYR_ITIM 579 584 PF00017 0.399
LIG_UBA3_1 1800 1804 PF00899 0.440
LIG_UBA3_1 181 189 PF00899 0.255
LIG_UBA3_1 851 855 PF00899 0.414
LIG_WRC_WIRS_1 1257 1262 PF05994 0.303
LIG_WW_1 1408 1411 PF00397 0.425
MOD_CDK_SPxK_1 788 794 PF00069 0.399
MOD_CK1_1 1056 1062 PF00069 0.461
MOD_CK1_1 1104 1110 PF00069 0.387
MOD_CK1_1 1209 1215 PF00069 0.399
MOD_CK1_1 1223 1229 PF00069 0.425
MOD_CK1_1 1256 1262 PF00069 0.325
MOD_CK1_1 1555 1561 PF00069 0.470
MOD_CK1_1 167 173 PF00069 0.386
MOD_CK1_1 1785 1791 PF00069 0.500
MOD_CK1_1 46 52 PF00069 0.445
MOD_CK1_1 667 673 PF00069 0.399
MOD_CK1_1 674 680 PF00069 0.399
MOD_CK1_1 832 838 PF00069 0.472
MOD_CK1_1 984 990 PF00069 0.299
MOD_CK2_1 1055 1061 PF00069 0.425
MOD_CK2_1 1273 1279 PF00069 0.305
MOD_CK2_1 1312 1318 PF00069 0.439
MOD_CK2_1 1440 1446 PF00069 0.448
MOD_CK2_1 1542 1548 PF00069 0.470
MOD_CK2_1 1772 1778 PF00069 0.425
MOD_CK2_1 1819 1825 PF00069 0.522
MOD_CK2_1 398 404 PF00069 0.463
MOD_CK2_1 418 424 PF00069 0.138
MOD_CK2_1 513 519 PF00069 0.400
MOD_CK2_1 617 623 PF00069 0.399
MOD_CK2_1 738 744 PF00069 0.314
MOD_CK2_1 748 754 PF00069 0.264
MOD_CK2_1 804 810 PF00069 0.417
MOD_GlcNHglycan 1018 1021 PF01048 0.457
MOD_GlcNHglycan 1055 1058 PF01048 0.270
MOD_GlcNHglycan 1082 1085 PF01048 0.189
MOD_GlcNHglycan 1106 1109 PF01048 0.212
MOD_GlcNHglycan 1150 1153 PF01048 0.199
MOD_GlcNHglycan 1229 1232 PF01048 0.298
MOD_GlcNHglycan 1361 1364 PF01048 0.231
MOD_GlcNHglycan 1535 1538 PF01048 0.288
MOD_GlcNHglycan 1544 1547 PF01048 0.245
MOD_GlcNHglycan 1774 1777 PF01048 0.233
MOD_GlcNHglycan 1786 1790 PF01048 0.217
MOD_GlcNHglycan 392 396 PF01048 0.293
MOD_GlcNHglycan 510 513 PF01048 0.225
MOD_GlcNHglycan 543 546 PF01048 0.199
MOD_GlcNHglycan 628 631 PF01048 0.217
MOD_GlcNHglycan 669 672 PF01048 0.199
MOD_GlcNHglycan 806 809 PF01048 0.300
MOD_GlcNHglycan 90 93 PF01048 0.199
MOD_GSK3_1 1012 1019 PF00069 0.468
MOD_GSK3_1 1076 1083 PF00069 0.398
MOD_GSK3_1 1148 1155 PF00069 0.393
MOD_GSK3_1 1160 1167 PF00069 0.369
MOD_GSK3_1 1216 1223 PF00069 0.399
MOD_GSK3_1 1308 1315 PF00069 0.412
MOD_GSK3_1 1355 1362 PF00069 0.420
MOD_GSK3_1 1642 1649 PF00069 0.445
MOD_GSK3_1 1753 1760 PF00069 0.427
MOD_GSK3_1 1766 1773 PF00069 0.436
MOD_GSK3_1 1781 1788 PF00069 0.399
MOD_GSK3_1 231 238 PF00069 0.470
MOD_GSK3_1 314 321 PF00069 0.494
MOD_GSK3_1 613 620 PF00069 0.399
MOD_GSK3_1 667 674 PF00069 0.399
MOD_GSK3_1 695 702 PF00069 0.403
MOD_GSK3_1 734 741 PF00069 0.328
MOD_GSK3_1 744 751 PF00069 0.266
MOD_GSK3_1 829 836 PF00069 0.506
MOD_N-GLC_1 1481 1486 PF02516 0.361
MOD_N-GLC_1 1496 1501 PF02516 0.217
MOD_N-GLC_1 1833 1838 PF02516 0.518
MOD_N-GLC_1 868 873 PF02516 0.448
MOD_N-GLC_2 1464 1466 PF02516 0.467
MOD_NEK2_1 1012 1017 PF00069 0.454
MOD_NEK2_1 1066 1071 PF00069 0.446
MOD_NEK2_1 107 112 PF00069 0.385
MOD_NEK2_1 1082 1087 PF00069 0.328
MOD_NEK2_1 1220 1225 PF00069 0.399
MOD_NEK2_1 125 130 PF00069 0.461
MOD_NEK2_1 1476 1481 PF00069 0.344
MOD_NEK2_1 1496 1501 PF00069 0.264
MOD_NEK2_1 1803 1808 PF00069 0.375
MOD_NEK2_1 220 225 PF00069 0.399
MOD_NEK2_1 231 236 PF00069 0.399
MOD_NEK2_1 391 396 PF00069 0.293
MOD_NEK2_1 497 502 PF00069 0.500
MOD_NEK2_1 55 60 PF00069 0.399
MOD_NEK2_1 569 574 PF00069 0.399
MOD_NEK2_1 626 631 PF00069 0.399
MOD_NEK2_1 666 671 PF00069 0.399
MOD_NEK2_1 695 700 PF00069 0.441
MOD_NEK2_1 738 743 PF00069 0.329
MOD_NEK2_1 75 80 PF00069 0.264
MOD_NEK2_1 867 872 PF00069 0.471
MOD_NEK2_1 906 911 PF00069 0.286
MOD_NEK2_2 1152 1157 PF00069 0.417
MOD_NEK2_2 1253 1258 PF00069 0.311
MOD_NEK2_2 175 180 PF00069 0.436
MOD_NEK2_2 232 237 PF00069 0.470
MOD_NEK2_2 398 403 PF00069 0.412
MOD_NEK2_2 834 839 PF00069 0.500
MOD_PIKK_1 1312 1318 PF00454 0.481
MOD_PIKK_1 1489 1495 PF00454 0.433
MOD_PIKK_1 1757 1763 PF00454 0.449
MOD_PIKK_1 1770 1776 PF00454 0.366
MOD_PIKK_1 290 296 PF00454 0.399
MOD_PIKK_1 393 399 PF00454 0.297
MOD_PIKK_1 613 619 PF00454 0.399
MOD_PK_1 1573 1579 PF00069 0.500
MOD_PK_1 1669 1675 PF00069 0.375
MOD_PK_1 628 634 PF00069 0.417
MOD_PKA_1 1400 1406 PF00069 0.417
MOD_PKA_1 1573 1579 PF00069 0.445
MOD_PKA_2 1076 1082 PF00069 0.399
MOD_PKA_2 1207 1213 PF00069 0.399
MOD_PKA_2 1400 1406 PF00069 0.417
MOD_PKA_2 1489 1495 PF00069 0.433
MOD_PKA_2 1573 1579 PF00069 0.484
MOD_PKA_2 170 176 PF00069 0.397
MOD_PKA_2 497 503 PF00069 0.500
MOD_PKA_2 664 670 PF00069 0.399
MOD_PKA_2 829 835 PF00069 0.504
MOD_PKB_1 1571 1579 PF00069 0.440
MOD_Plk_1 1094 1100 PF00069 0.432
MOD_Plk_1 1101 1107 PF00069 0.398
MOD_Plk_1 1152 1158 PF00069 0.399
MOD_Plk_1 1496 1502 PF00069 0.440
MOD_Plk_1 1669 1675 PF00069 0.375
MOD_Plk_1 1740 1746 PF00069 0.470
MOD_Plk_1 199 205 PF00069 0.399
MOD_Plk_1 24 30 PF00069 0.399
MOD_Plk_1 569 575 PF00069 0.399
MOD_Plk_1 984 990 PF00069 0.299
MOD_Plk_2-3 1119 1125 PF00069 0.445
MOD_Plk_2-3 1616 1622 PF00069 0.470
MOD_Plk_2-3 981 987 PF00069 0.297
MOD_Plk_4 1076 1082 PF00069 0.410
MOD_Plk_4 110 116 PF00069 0.417
MOD_Plk_4 1101 1107 PF00069 0.389
MOD_Plk_4 1152 1158 PF00069 0.399
MOD_Plk_4 1223 1229 PF00069 0.470
MOD_Plk_4 1253 1259 PF00069 0.311
MOD_Plk_4 1426 1432 PF00069 0.408
MOD_Plk_4 1555 1561 PF00069 0.470
MOD_Plk_4 1573 1579 PF00069 0.294
MOD_Plk_4 1647 1653 PF00069 0.470
MOD_Plk_4 1660 1666 PF00069 0.470
MOD_Plk_4 199 205 PF00069 0.401
MOD_Plk_4 406 412 PF00069 0.325
MOD_Plk_4 483 489 PF00069 0.430
MOD_Plk_4 497 503 PF00069 0.470
MOD_Plk_4 607 613 PF00069 0.399
MOD_Plk_4 734 740 PF00069 0.320
MOD_Plk_4 834 840 PF00069 0.451
MOD_Plk_4 984 990 PF00069 0.299
MOD_ProDKin_1 1671 1677 PF00069 0.419
MOD_ProDKin_1 1693 1699 PF00069 0.417
MOD_ProDKin_1 1723 1729 PF00069 0.452
MOD_ProDKin_1 480 486 PF00069 0.343
MOD_ProDKin_1 56 62 PF00069 0.440
MOD_ProDKin_1 561 567 PF00069 0.417
MOD_ProDKin_1 788 794 PF00069 0.399
MOD_SUMO_for_1 1379 1382 PF00179 0.456
MOD_SUMO_for_1 5 8 PF00179 0.430
TRG_DiLeu_BaEn_1 1382 1387 PF01217 0.420
TRG_DiLeu_BaEn_2 1777 1783 PF01217 0.441
TRG_DiLeu_BaEn_3 733 739 PF01217 0.388
TRG_DiLeu_BaLyEn_6 1420 1425 PF01217 0.470
TRG_DiLeu_BaLyEn_6 1694 1699 PF01217 0.470
TRG_DiLeu_BaLyEn_6 883 888 PF01217 0.405
TRG_ENDOCYTIC_2 1072 1075 PF00928 0.470
TRG_ENDOCYTIC_2 108 111 PF00928 0.401
TRG_ENDOCYTIC_2 1172 1175 PF00928 0.500
TRG_ENDOCYTIC_2 1458 1461 PF00928 0.458
TRG_ENDOCYTIC_2 217 220 PF00928 0.399
TRG_ENDOCYTIC_2 581 584 PF00928 0.399
TRG_ENDOCYTIC_2 657 660 PF00928 0.399
TRG_ENDOCYTIC_2 715 718 PF00928 0.271
TRG_ENDOCYTIC_2 767 770 PF00928 0.390
TRG_ENDOCYTIC_2 793 796 PF00928 0.449
TRG_ENDOCYTIC_2 924 927 PF00928 0.271
TRG_ENDOCYTIC_2 942 945 PF00928 0.280
TRG_ER_diArg_1 1328 1330 PF00400 0.500
TRG_ER_diArg_1 1399 1401 PF00400 0.414
TRG_ER_diArg_1 1413 1415 PF00400 0.371
TRG_ER_diArg_1 1570 1573 PF00400 0.470
TRG_ER_diArg_1 1814 1816 PF00400 0.560
TRG_ER_diArg_1 875 878 PF00400 0.310
TRG_ER_diArg_1 951 953 PF00400 0.320
TRG_NES_CRM1_1 137 151 PF08389 0.440
TRG_NES_CRM1_1 1518 1532 PF08389 0.499
TRG_NES_CRM1_1 423 437 PF08389 0.320
TRG_NES_CRM1_1 813 826 PF08389 0.445
TRG_NLS_MonoExtN_4 1242 1248 PF00514 0.431
TRG_Pf-PMV_PEXEL_1 1098 1102 PF00026 0.217
TRG_Pf-PMV_PEXEL_1 1414 1419 PF00026 0.199
TRG_Pf-PMV_PEXEL_1 160 165 PF00026 0.351
TRG_Pf-PMV_PEXEL_1 1781 1786 PF00026 0.217
TRG_Pf-PMV_PEXEL_1 180 185 PF00026 0.103
TRG_Pf-PMV_PEXEL_1 400 404 PF00026 0.356
TRG_Pf-PMV_PEXEL_1 494 499 PF00026 0.270
TRG_Pf-PMV_PEXEL_1 585 589 PF00026 0.199
TRG_Pf-PMV_PEXEL_1 692 696 PF00026 0.199
TRG_Pf-PMV_PEXEL_1 800 804 PF00026 0.240
TRG_Pf-PMV_PEXEL_1 862 866 PF00026 0.270

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I157 Leptomonas seymouri 87% 100%
A0A1X0NNV1 Trypanosomatidae 76% 100%
A0A3S5H6X3 Leishmania donovani 100% 100%
A0A422MVX7 Trypanosoma rangeli 75% 100%
A4H8I3 Leishmania braziliensis 94% 100%
B2RQC6 Mus musculus 50% 83%
C9ZPQ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
E9AQL8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O93937 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 49% 81%
P05990 Drosophila melanogaster 50% 83%
P07259 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 48% 83%
P07756 Rattus norvegicus 48% 100%
P08955 Mesocricetus auratus 49% 83%
P20054 Dictyostelium discoideum 49% 83%
P27708 Homo sapiens 50% 83%
P31327 Homo sapiens 48% 100%
Q09794 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 82%
Q18990 Caenorhabditis elegans 49% 84%
Q4QEW0 Leishmania major 99% 100%
Q8C196 Mus musculus 48% 100%
Q91293 Lithobates catesbeianus 48% 100%
Q91437 Squalus acanthias 49% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS