Uridine/cytidine kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HWV3_LEIIN

TriTrypDb:

LINF_160010800

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.831
CLV_C14_Caspase3-7	36	40	PF00656	0.557
CLV_C14_Caspase3-7	394	398	PF00656	0.626
CLV_NRD_NRD_1	145	147	PF00675	0.681
CLV_NRD_NRD_1	214	216	PF00675	0.674
CLV_NRD_NRD_1	223	225	PF00675	0.669
CLV_NRD_NRD_1	293	295	PF00675	0.542
CLV_NRD_NRD_1	300	302	PF00675	0.583
CLV_NRD_NRD_1	415	417	PF00675	0.786
CLV_NRD_NRD_1	466	468	PF00675	0.578
CLV_NRD_NRD_1	545	547	PF00675	0.630
CLV_NRD_NRD_1	700	702	PF00675	0.492
CLV_PCSK_FUR_1	212	216	PF00082	0.743
CLV_PCSK_FUR_1	413	417	PF00082	0.699
CLV_PCSK_KEX2_1	145	147	PF00082	0.681
CLV_PCSK_KEX2_1	212	214	PF00082	0.626
CLV_PCSK_KEX2_1	223	225	PF00082	0.652
CLV_PCSK_KEX2_1	293	295	PF00082	0.503
CLV_PCSK_KEX2_1	300	302	PF00082	0.556
CLV_PCSK_KEX2_1	415	417	PF00082	0.709
CLV_PCSK_KEX2_1	466	468	PF00082	0.578
CLV_PCSK_KEX2_1	545	547	PF00082	0.630
CLV_PCSK_KEX2_1	700	702	PF00082	0.492
CLV_PCSK_PC7_1	411	417	PF00082	0.690
CLV_PCSK_SKI1_1	293	297	PF00082	0.525
CLV_PCSK_SKI1_1	396	400	PF00082	0.665
CLV_PCSK_SKI1_1	573	577	PF00082	0.724
DEG_APCC_DBOX_1	395	403	PF00400	0.665
DEG_APCC_DBOX_1	570	578	PF00400	0.631
DEG_SCF_FBW7_2	550	557	PF00400	0.745
DEG_SPOP_SBC_1	173	177	PF00917	0.612
DEG_SPOP_SBC_1	495	499	PF00917	0.527
DEG_SPOP_SBC_1	618	622	PF00917	0.586
DOC_CDC14_PxL_1	135	143	PF14671	0.545
DOC_CKS1_1	296	301	PF01111	0.679
DOC_CYCLIN_RxL_1	300	311	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.466
DOC_MAPK_MEF2A_6	9	16	PF00069	0.451
DOC_PP1_RVXF_1	660	666	PF00149	0.610
DOC_PP2B_LxvP_1	136	139	PF13499	0.622
DOC_PP4_FxxP_1	252	255	PF00568	0.468
DOC_PP4_FxxP_1	296	299	PF00568	0.577
DOC_PP4_FxxP_1	407	410	PF00568	0.797
DOC_USP7_MATH_1	173	177	PF00917	0.745
DOC_USP7_MATH_1	308	312	PF00917	0.671
DOC_USP7_MATH_1	418	422	PF00917	0.698
DOC_USP7_MATH_1	445	449	PF00917	0.775
DOC_USP7_MATH_1	453	457	PF00917	0.692
DOC_USP7_MATH_1	495	499	PF00917	0.548
DOC_USP7_MATH_1	513	517	PF00917	0.630
DOC_WW_Pin1_4	167	172	PF00397	0.725
DOC_WW_Pin1_4	180	185	PF00397	0.660
DOC_WW_Pin1_4	295	300	PF00397	0.576
DOC_WW_Pin1_4	37	42	PF00397	0.480
DOC_WW_Pin1_4	380	385	PF00397	0.707
DOC_WW_Pin1_4	400	405	PF00397	0.677
DOC_WW_Pin1_4	449	454	PF00397	0.756
DOC_WW_Pin1_4	497	502	PF00397	0.573
DOC_WW_Pin1_4	545	550	PF00397	0.836
DOC_WW_Pin1_4	588	593	PF00397	0.787
DOC_WW_Pin1_4	87	92	PF00397	0.542
DOC_WW_Pin1_4	98	103	PF00397	0.690
LIG_14-3-3_CanoR_1	212	218	PF00244	0.673
LIG_14-3-3_CanoR_1	271	277	PF00244	0.561
LIG_14-3-3_CanoR_1	496	501	PF00244	0.566
LIG_14-3-3_CanoR_1	545	549	PF00244	0.765
LIG_14-3-3_CanoR_1	664	669	PF00244	0.636
LIG_14-3-3_CanoR_1	75	80	PF00244	0.470
LIG_APCC_ABBA_1	482	487	PF00400	0.576
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_BIR_III_1	1	5	PF00653	0.511
LIG_BIR_III_3	1	5	PF00653	0.511
LIG_BRCT_BRCA1_1	48	52	PF00533	0.371
LIG_CSL_BTD_1	252	255	PF09270	0.468
LIG_FHA_1	287	293	PF00498	0.525
LIG_FHA_1	361	367	PF00498	0.670
LIG_FHA_1	619	625	PF00498	0.644
LIG_FHA_1	84	90	PF00498	0.532
LIG_FHA_2	176	182	PF00498	0.789
LIG_FHA_2	392	398	PF00498	0.716
LIG_FHA_2	59	65	PF00498	0.501
LIG_FHA_2	675	681	PF00498	0.683
LIG_FHA_2	719	725	PF00498	0.604
LIG_GBD_Chelix_1	30	38	PF00786	0.509
LIG_Integrin_isoDGR_2	707	709	PF01839	0.564
LIG_LIR_Apic_2	405	410	PF02991	0.688
LIG_LIR_Gen_1	479	490	PF02991	0.561
LIG_LIR_Gen_1	49	59	PF02991	0.405
LIG_LIR_Nem_3	263	268	PF02991	0.436
LIG_LIR_Nem_3	275	279	PF02991	0.365
LIG_LIR_Nem_3	479	485	PF02991	0.562
LIG_LIR_Nem_3	49	55	PF02991	0.537
LIG_LIR_Nem_3	61	65	PF02991	0.469
LIG_LIR_Nem_3	639	645	PF02991	0.518
LIG_LIR_Nem_3	652	658	PF02991	0.498
LIG_LIR_Nem_3	69	73	PF02991	0.420
LIG_MLH1_MIPbox_1	48	52	PF16413	0.371
LIG_NRP_CendR_1	731	734	PF00754	0.588
LIG_PCNA_yPIPBox_3	270	284	PF02747	0.340
LIG_Pex14_1	486	490	PF04695	0.560
LIG_Pex14_2	482	486	PF04695	0.551
LIG_Pex14_2	636	640	PF04695	0.538
LIG_Rb_LxCxE_1	579	596	PF01857	0.662
LIG_REV1ctd_RIR_1	293	298	PF16727	0.560
LIG_SH2_CRK	651	655	PF00017	0.459
LIG_SH2_CRK	70	74	PF00017	0.450
LIG_SH2_GRB2like	563	566	PF00017	0.710
LIG_SH2_NCK_1	651	655	PF00017	0.512
LIG_SH2_STAP1	279	283	PF00017	0.405
LIG_SH2_STAP1	638	642	PF00017	0.538
LIG_SH2_STAP1	651	655	PF00017	0.488
LIG_SH2_STAT5	259	262	PF00017	0.398
LIG_SH2_STAT5	276	279	PF00017	0.507
LIG_SH2_STAT5	306	309	PF00017	0.684
LIG_SH2_STAT5	563	566	PF00017	0.608
LIG_SH2_STAT5	644	647	PF00017	0.527
LIG_SH3_3	338	344	PF00018	0.719
LIG_SH3_3	38	44	PF00018	0.466
LIG_SH3_3	406	412	PF00018	0.699
LIG_SH3_3	586	592	PF00018	0.674
LIG_SH3_CIN85_PxpxPR_1	695	700	PF14604	0.655
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.643
LIG_SUMO_SIM_par_1	85	90	PF11976	0.539
LIG_TRAF2_1	207	210	PF00917	0.737
LIG_TRAF2_1	460	463	PF00917	0.535
LIG_TRAF2_1	555	558	PF00917	0.780
LIG_TRAF2_1	91	94	PF00917	0.513
LIG_TYR_ITIM	649	654	PF00017	0.489
LIG_TYR_ITIM	68	73	PF00017	0.455
LIG_UBA3_1	135	143	PF00899	0.545
LIG_WW_3	408	412	PF00397	0.692
LIG_WW_3	548	552	PF00397	0.725
MOD_CDC14_SPxK_1	548	551	PF00782	0.727
MOD_CDK_SPK_2	295	300	PF00069	0.576
MOD_CDK_SPxK_1	295	301	PF00069	0.578
MOD_CDK_SPxK_1	545	551	PF00069	0.727
MOD_CDK_SPxxK_3	98	105	PF00069	0.773
MOD_CK1_1	153	159	PF00069	0.800
MOD_CK1_1	175	181	PF00069	0.766
MOD_CK1_1	25	31	PF00069	0.448
MOD_CK1_1	388	394	PF00069	0.733
MOD_CK1_1	448	454	PF00069	0.783
MOD_CK1_1	497	503	PF00069	0.663
MOD_CK1_1	620	626	PF00069	0.666
MOD_CK1_1	673	679	PF00069	0.676
MOD_CK1_1	85	91	PF00069	0.426
MOD_CK2_1	175	181	PF00069	0.836
MOD_CK2_1	230	236	PF00069	0.682
MOD_CK2_1	552	558	PF00069	0.666
MOD_CK2_1	578	584	PF00069	0.675
MOD_CK2_1	587	593	PF00069	0.596
MOD_CK2_1	674	680	PF00069	0.758
MOD_CK2_1	87	93	PF00069	0.548
MOD_Cter_Amidation	210	213	PF01082	0.579
MOD_Cter_Amidation	464	467	PF01082	0.569
MOD_GlcNHglycan	107	110	PF01048	0.784
MOD_GlcNHglycan	152	155	PF01048	0.765
MOD_GlcNHglycan	22	25	PF01048	0.476
MOD_GlcNHglycan	238	241	PF01048	0.740
MOD_GlcNHglycan	310	313	PF01048	0.718
MOD_GlcNHglycan	421	424	PF01048	0.688
MOD_GlcNHglycan	431	434	PF01048	0.672
MOD_GlcNHglycan	453	456	PF01048	0.789
MOD_GlcNHglycan	468	471	PF01048	0.465
MOD_GlcNHglycan	472	475	PF01048	0.370
MOD_GlcNHglycan	501	504	PF01048	0.691
MOD_GlcNHglycan	603	606	PF01048	0.704
MOD_GlcNHglycan	630	633	PF01048	0.596
MOD_GlcNHglycan	671	675	PF01048	0.733
MOD_GlcNHglycan	682	685	PF01048	0.665
MOD_GlcNHglycan	726	729	PF01048	0.430
MOD_GSK3_1	149	156	PF00069	0.713
MOD_GSK3_1	22	29	PF00069	0.455
MOD_GSK3_1	33	40	PF00069	0.500
MOD_GSK3_1	380	387	PF00069	0.785
MOD_GSK3_1	445	452	PF00069	0.627
MOD_GSK3_1	466	473	PF00069	0.714
MOD_GSK3_1	495	502	PF00069	0.646
MOD_GSK3_1	540	547	PF00069	0.798
MOD_GSK3_1	618	625	PF00069	0.674
MOD_GSK3_1	669	676	PF00069	0.766
MOD_GSK3_1	83	90	PF00069	0.539
MOD_N-GLC_1	149	154	PF02516	0.508
MOD_N-GLC_1	540	545	PF02516	0.792
MOD_NEK2_1	272	277	PF00069	0.553
MOD_NEK2_1	494	499	PF00069	0.657
MOD_NEK2_1	544	549	PF00069	0.724
MOD_NEK2_1	576	581	PF00069	0.728
MOD_NEK2_2	46	51	PF00069	0.353
MOD_NEK2_2	513	518	PF00069	0.658
MOD_PIKK_1	218	224	PF00454	0.644
MOD_PIKK_1	319	325	PF00454	0.676
MOD_PIKK_1	718	724	PF00454	0.517
MOD_PK_1	213	219	PF00069	0.682
MOD_PK_1	664	670	PF00069	0.649
MOD_PK_1	75	81	PF00069	0.561
MOD_PKA_1	213	219	PF00069	0.682
MOD_PKA_1	466	472	PF00069	0.545
MOD_PKA_2	213	219	PF00069	0.694
MOD_PKA_2	466	472	PF00069	0.552
MOD_PKA_2	495	501	PF00069	0.661
MOD_PKA_2	544	550	PF00069	0.763
MOD_PKB_1	662	670	PF00069	0.634
MOD_Plk_1	198	204	PF00069	0.693
MOD_Plk_1	319	325	PF00069	0.676
MOD_Plk_2-3	191	197	PF00069	0.756
MOD_Plk_4	157	163	PF00069	0.801
MOD_Plk_4	272	278	PF00069	0.554
MOD_Plk_4	46	52	PF00069	0.361
MOD_Plk_4	75	81	PF00069	0.561
MOD_ProDKin_1	167	173	PF00069	0.725
MOD_ProDKin_1	180	186	PF00069	0.661
MOD_ProDKin_1	295	301	PF00069	0.578
MOD_ProDKin_1	37	43	PF00069	0.478
MOD_ProDKin_1	380	386	PF00069	0.706
MOD_ProDKin_1	400	406	PF00069	0.678
MOD_ProDKin_1	449	455	PF00069	0.755
MOD_ProDKin_1	497	503	PF00069	0.566
MOD_ProDKin_1	545	551	PF00069	0.838
MOD_ProDKin_1	588	594	PF00069	0.786
MOD_ProDKin_1	87	93	PF00069	0.558
MOD_ProDKin_1	98	104	PF00069	0.688
MOD_SUMO_rev_2	676	683	PF00179	0.580
TRG_DiLeu_LyEn_5	263	268	PF01217	0.369
TRG_ENDOCYTIC_2	306	309	PF00928	0.518
TRG_ENDOCYTIC_2	637	640	PF00928	0.537
TRG_ENDOCYTIC_2	642	645	PF00928	0.515
TRG_ENDOCYTIC_2	65	68	PF00928	0.469
TRG_ENDOCYTIC_2	651	654	PF00928	0.492
TRG_ENDOCYTIC_2	70	73	PF00928	0.453
TRG_ER_diArg_1	144	146	PF00400	0.590
TRG_ER_diArg_1	212	215	PF00400	0.636
TRG_ER_diArg_1	292	294	PF00400	0.529
TRG_ER_diArg_1	299	301	PF00400	0.577
TRG_ER_diArg_1	342	345	PF00400	0.651
TRG_ER_diArg_1	350	353	PF00400	0.586
TRG_ER_diArg_1	410	413	PF00400	0.686
TRG_ER_diArg_1	544	546	PF00400	0.626
TRG_ER_diArg_1	571	574	PF00400	0.597
TRG_ER_diArg_1	662	665	PF00400	0.504
TRG_ER_diArg_1	699	701	PF00400	0.511
TRG_NES_CRM1_1	361	373	PF08389	0.713
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVQ0	Leptomonas seymouri	34%	100%
A0A3S7WTV2	Leishmania donovani	99%	100%
A4H8I1	Leishmania braziliensis	64%	100%
E9AQL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
Q4QEW4	Leishmania major	88%	100%