LeishMANIAdb
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Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase
Gene product:
orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4HWV2_LEIIN
TriTrypDb:
LINF_160010700
Length:
457

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase PE=1 SV=1 - [A4HWV2_LEIIN]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 11
GO:0110165 cellular anatomical entity 1 11

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HWV2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWV2

PDB structure(s): 3qw3_A , 3qw3_B

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006206 pyrimidine nucleobase metabolic process 5 11
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process 7 11
GO:0006220 pyrimidine nucleotide metabolic process 5 11
GO:0006221 pyrimidine nucleotide biosynthetic process 6 11
GO:0006222 UMP biosynthetic process 8 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006753 nucleoside phosphate metabolic process 4 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009112 nucleobase metabolic process 4 11
GO:0009117 nucleotide metabolic process 5 11
GO:0009123 nucleoside monophosphate metabolic process 5 11
GO:0009124 nucleoside monophosphate biosynthetic process 6 11
GO:0009129 pyrimidine nucleoside monophosphate metabolic process 6 11
GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process 7 11
GO:0009156 ribonucleoside monophosphate biosynthetic process 7 11
GO:0009161 ribonucleoside monophosphate metabolic process 6 11
GO:0009165 nucleotide biosynthetic process 6 11
GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process 7 11
GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process 8 11
GO:0009218 pyrimidine ribonucleotide metabolic process 6 11
GO:0009220 pyrimidine ribonucleotide biosynthetic process 7 11
GO:0009259 ribonucleotide metabolic process 5 11
GO:0009260 ribonucleotide biosynthetic process 6 11
GO:0009987 cellular process 1 11
GO:0018130 heterocycle biosynthetic process 4 11
GO:0019438 aromatic compound biosynthetic process 4 11
GO:0019637 organophosphate metabolic process 3 11
GO:0019693 ribose phosphate metabolic process 4 11
GO:0019856 pyrimidine nucleobase biosynthetic process 6 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034654 nucleobase-containing compound biosynthetic process 4 11
GO:0044205 'de novo' UMP biosynthetic process 9 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0044281 small molecule metabolic process 2 11
GO:0046049 UMP metabolic process 7 11
GO:0046112 nucleobase biosynthetic process 5 11
GO:0046390 ribose phosphate biosynthetic process 5 11
GO:0046483 heterocycle metabolic process 3 11
GO:0055086 nucleobase-containing small molecule metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0072527 pyrimidine-containing compound metabolic process 4 11
GO:0072528 pyrimidine-containing compound biosynthetic process 5 11
GO:0090407 organophosphate biosynthetic process 4 11
GO:1901135 carbohydrate derivative metabolic process 3 11
GO:1901137 carbohydrate derivative biosynthetic process 4 11
GO:1901293 nucleoside phosphate biosynthetic process 5 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901362 organic cyclic compound biosynthetic process 4 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901566 organonitrogen compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004588 orotate phosphoribosyltransferase activity 5 11
GO:0004590 orotidine-5'-phosphate decarboxylase activity 5 11
GO:0016740 transferase activity 2 11
GO:0016757 glycosyltransferase activity 3 11
GO:0016763 pentosyltransferase activity 4 11
GO:0016829 lyase activity 2 11
GO:0016830 carbon-carbon lyase activity 3 11
GO:0016831 carboxy-lyase activity 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 90 94 PF00656 0.270
CLV_NRD_NRD_1 291 293 PF00675 0.243
CLV_NRD_NRD_1 345 347 PF00675 0.157
CLV_NRD_NRD_1 431 433 PF00675 0.388
CLV_PCSK_FUR_1 10 14 PF00082 0.262
CLV_PCSK_KEX2_1 12 14 PF00082 0.388
CLV_PCSK_KEX2_1 291 293 PF00082 0.243
CLV_PCSK_KEX2_1 345 347 PF00082 0.157
CLV_PCSK_KEX2_1 35 37 PF00082 0.232
CLV_PCSK_KEX2_1 84 86 PF00082 0.192
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.388
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.232
CLV_PCSK_PC1ET2_1 84 86 PF00082 0.192
CLV_PCSK_SKI1_1 128 132 PF00082 0.213
CLV_PCSK_SKI1_1 13 17 PF00082 0.290
CLV_PCSK_SKI1_1 252 256 PF00082 0.490
CLV_PCSK_SKI1_1 292 296 PF00082 0.271
CLV_PCSK_SKI1_1 346 350 PF00082 0.170
CLV_PCSK_SKI1_1 408 412 PF00082 0.283
CLV_PCSK_SKI1_1 446 450 PF00082 0.327
DOC_MAPK_gen_1 10 20 PF00069 0.193
DOC_MAPK_gen_1 188 196 PF00069 0.235
DOC_MAPK_gen_1 252 261 PF00069 0.350
DOC_MAPK_gen_1 279 288 PF00069 0.275
DOC_MAPK_gen_1 362 370 PF00069 0.413
DOC_MAPK_gen_1 386 394 PF00069 0.360
DOC_MAPK_MEF2A_6 12 20 PF00069 0.192
DOC_MAPK_MEF2A_6 188 196 PF00069 0.192
DOC_MAPK_MEF2A_6 282 290 PF00069 0.243
DOC_PP4_FxxP_1 196 199 PF00568 0.210
DOC_USP7_MATH_1 11 15 PF00917 0.307
DOC_USP7_MATH_1 218 222 PF00917 0.235
DOC_USP7_MATH_1 328 332 PF00917 0.452
DOC_USP7_MATH_1 436 440 PF00917 0.346
DOC_USP7_UBL2_3 135 139 PF12436 0.201
DOC_WW_Pin1_4 108 113 PF00397 0.210
DOC_WW_Pin1_4 281 286 PF00397 0.263
LIG_14-3-3_CanoR_1 10 16 PF00244 0.233
LIG_14-3-3_CanoR_1 23 31 PF00244 0.192
LIG_14-3-3_CanoR_1 291 297 PF00244 0.259
LIG_BIR_II_1 1 5 PF00653 0.300
LIG_FHA_1 177 183 PF00498 0.247
LIG_FHA_2 377 383 PF00498 0.365
LIG_GBD_Chelix_1 329 337 PF00786 0.170
LIG_Integrin_RGD_1 85 87 PF01839 0.192
LIG_LIR_Apic_2 193 199 PF02991 0.210
LIG_LIR_Gen_1 2 11 PF02991 0.231
LIG_LIR_Gen_1 284 294 PF02991 0.238
LIG_LIR_Gen_1 306 314 PF02991 0.367
LIG_LIR_Gen_1 417 424 PF02991 0.301
LIG_LIR_Gen_1 61 70 PF02991 0.235
LIG_LIR_Nem_3 193 198 PF02991 0.192
LIG_LIR_Nem_3 2 7 PF02991 0.226
LIG_LIR_Nem_3 284 290 PF02991 0.229
LIG_LIR_Nem_3 295 299 PF02991 0.357
LIG_LIR_Nem_3 306 310 PF02991 0.332
LIG_LIR_Nem_3 417 421 PF02991 0.307
LIG_LIR_Nem_3 61 66 PF02991 0.211
LIG_LIR_Nem_3 97 103 PF02991 0.194
LIG_LYPXL_yS_3 296 299 PF13949 0.452
LIG_PDZ_Class_1 452 457 PF00595 0.366
LIG_Pex14_2 448 452 PF04695 0.418
LIG_Pex14_2 54 58 PF04695 0.192
LIG_SH2_CRK 307 311 PF00017 0.357
LIG_SH2_CRK 324 328 PF00017 0.357
LIG_SH2_NCK_1 155 159 PF00017 0.210
LIG_SH2_NCK_1 44 48 PF00017 0.192
LIG_SH2_PTP2 287 290 PF00017 0.275
LIG_SH2_STAP1 155 159 PF00017 0.225
LIG_SH2_STAP1 307 311 PF00017 0.357
LIG_SH2_STAP1 416 420 PF00017 0.278
LIG_SH2_STAP1 44 48 PF00017 0.192
LIG_SH2_STAP1 95 99 PF00017 0.192
LIG_SH2_STAT5 153 156 PF00017 0.257
LIG_SH2_STAT5 287 290 PF00017 0.232
LIG_SH3_3 291 297 PF00018 0.290
LIG_SUMO_SIM_anti_2 365 372 PF11976 0.357
LIG_SUMO_SIM_anti_2 393 399 PF11976 0.394
LIG_SUMO_SIM_par_1 365 372 PF11976 0.357
LIG_SUMO_SIM_par_1 396 402 PF11976 0.357
LIG_SUMO_SIM_par_1 77 82 PF11976 0.193
LIG_TRAF2_1 30 33 PF00917 0.198
LIG_TRAF2_1 439 442 PF00917 0.414
LIG_TYR_ITIM 294 299 PF00017 0.325
LIG_TYR_ITIM 322 327 PF00017 0.192
LIG_UBA3_1 427 433 PF00899 0.467
MOD_CK1_1 280 286 PF00069 0.376
MOD_CK1_1 331 337 PF00069 0.325
MOD_CK2_1 372 378 PF00069 0.192
MOD_CK2_1 436 442 PF00069 0.340
MOD_GlcNHglycan 219 223 PF01048 0.219
MOD_GlcNHglycan 279 282 PF01048 0.364
MOD_GlcNHglycan 330 333 PF01048 0.267
MOD_GlcNHglycan 388 391 PF01048 0.235
MOD_GlcNHglycan 97 100 PF01048 0.192
MOD_GSK3_1 134 141 PF00069 0.218
MOD_GSK3_1 204 211 PF00069 0.325
MOD_GSK3_1 277 284 PF00069 0.315
MOD_GSK3_1 372 379 PF00069 0.192
MOD_GSK3_1 431 438 PF00069 0.357
MOD_N-GLC_1 225 230 PF02516 0.203
MOD_N-GLC_1 274 279 PF02516 0.409
MOD_NEK2_1 133 138 PF00069 0.228
MOD_NEK2_1 265 270 PF00069 0.259
MOD_NEK2_2 274 279 PF00069 0.300
MOD_PIKK_1 436 442 PF00454 0.439
MOD_PK_1 255 261 PF00069 0.353
MOD_PKA_2 431 437 PF00069 0.354
MOD_PKB_1 188 196 PF00069 0.235
MOD_Plk_1 274 280 PF00069 0.420
MOD_Plk_4 190 196 PF00069 0.238
MOD_Plk_4 393 399 PF00069 0.235
MOD_ProDKin_1 108 114 PF00069 0.210
MOD_ProDKin_1 281 287 PF00069 0.263
MOD_SUMO_rev_2 32 37 PF00179 0.305
MOD_SUMO_rev_2 372 381 PF00179 0.192
TRG_DiLeu_BaEn_1 33 38 PF01217 0.210
TRG_DiLeu_BaLyEn_6 337 342 PF01217 0.210
TRG_DiLeu_LyEn_5 33 38 PF01217 0.198
TRG_ENDOCYTIC_2 155 158 PF00928 0.225
TRG_ENDOCYTIC_2 287 290 PF00928 0.232
TRG_ENDOCYTIC_2 296 299 PF00928 0.192
TRG_ENDOCYTIC_2 307 310 PF00928 0.071
TRG_ENDOCYTIC_2 324 327 PF00928 0.192
TRG_ER_diArg_1 187 190 PF00400 0.236
TRG_ER_diArg_1 290 292 PF00400 0.245
TRG_ER_diArg_1 344 346 PF00400 0.192
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.235
TRG_Pf-PMV_PEXEL_1 242 246 PF00026 0.343
TRG_Pf-PMV_PEXEL_1 35 39 PF00026 0.325
TRG_PTS1 454 457 PF00515 0.384

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2D6 Leptomonas seymouri 86% 100%
A0A0S4KG32 Bodo saltans 68% 100%
A0A1X0NZ36 Trypanosomatidae 79% 100%
A0A3Q8IAC7 Leishmania donovani 100% 100%
A0A3R7RG15 Trypanosoma rangeli 76% 100%
A4H8I0 Leishmania braziliensis 93% 100%
C9ZPR2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 100%
E9AQL3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QEW5 Leishmania major 98% 100%
Q8YSY4 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 35% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS