Amastin surface glycofamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWU5_LEIIN

TriTrypDb:

LINF_160009800

Length:

184

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 18
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4HWU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.445
CLV_NRD_NRD_1	28	30	PF00675	0.581
DEG_Nend_Nbox_1	1	3	PF02207	0.667
DOC_MAPK_gen_1	29	35	PF00069	0.440
LIG_APCC_ABBA_1	176	181	PF00400	0.309
LIG_FHA_1	146	152	PF00498	0.488
LIG_FHA_1	2	8	PF00498	0.626
LIG_FHA_1	74	80	PF00498	0.456
LIG_LIR_Gen_1	162	172	PF02991	0.307
LIG_LIR_Nem_3	162	167	PF02991	0.355
LIG_LIR_Nem_3	170	175	PF02991	0.384
LIG_Pex14_2	160	164	PF04695	0.301
LIG_SH2_PTP2	158	161	PF00017	0.381
LIG_SH2_SRC	48	51	PF00017	0.340
LIG_SH2_STAT5	158	161	PF00017	0.397
LIG_SH2_STAT5	45	48	PF00017	0.420
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.474
LIG_TYR_ITIM	46	51	PF00017	0.343
LIG_UBA3_1	24	31	PF00899	0.520
MOD_CK1_1	129	135	PF00069	0.423
MOD_GlcNHglycan	169	172	PF01048	0.408
MOD_GSK3_1	73	80	PF00069	0.449
MOD_N-GLC_1	145	150	PF02516	0.643
MOD_N-GLC_2	110	112	PF02516	0.250
MOD_NEK2_1	1	6	PF00069	0.611
MOD_NEK2_1	126	131	PF00069	0.387
MOD_NEK2_1	167	172	PF00069	0.367
MOD_PKA_2	66	72	PF00069	0.417
MOD_Plk_1	145	151	PF00069	0.431
MOD_Plk_4	111	117	PF00069	0.492
MOD_Plk_4	129	135	PF00069	0.455
MOD_SUMO_rev_2	36	44	PF00179	0.352
TRG_DiLeu_BaEn_1	162	167	PF01217	0.341
TRG_ENDOCYTIC_2	158	161	PF00928	0.347
TRG_ENDOCYTIC_2	48	51	PF00928	0.304
TRG_NLS_MonoExtN_4	26	33	PF00514	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	41%	100%
A0A0N0P3Z6	Leptomonas seymouri	30%	81%
A0A0N0P4D5	Leptomonas seymouri	32%	88%
A0A1X0P9D7	Trypanosomatidae	29%	86%
A0A3Q8IIZ2	Leishmania donovani	30%	83%
A0A3R7KFR8	Trypanosoma rangeli	28%	100%
A0A3S5H6X1	Leishmania donovani	28%	92%
A0A3S7WTU4	Leishmania donovani	99%	100%
A4H8H3	Leishmania braziliensis	67%	100%
A4H8H5	Leishmania braziliensis	28%	100%
A4H8H6	Leishmania braziliensis	31%	100%
A4HWU7	Leishmania infantum	28%	92%
A4HWU8	Leishmania infantum	30%	83%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4QEX0	Leishmania major	28%	100%
Q4QEX1	Leishmania major	28%	100%
Q4QEX3	Leishmania major	91%	100%