Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWU3_LEIIN

TriTrypDb:

LINF_160009600

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HWU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.320
CLV_PCSK_KEX2_1	122	124	PF00082	0.392
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.392
CLV_PCSK_SKI1_1	99	103	PF00082	0.350
DEG_SCF_FBW7_1	1	6	PF00400	0.602
DEG_SCF_FBW7_1	71	78	PF00400	0.485
DEG_SPOP_SBC_1	5	9	PF00917	0.607
DOC_MAPK_MEF2A_6	132	140	PF00069	0.440
DOC_USP7_MATH_1	177	181	PF00917	0.413
DOC_USP7_MATH_1	3	7	PF00917	0.722
DOC_WW_Pin1_4	71	76	PF00397	0.464
LIG_14-3-3_CanoR_1	106	115	PF00244	0.468
LIG_14-3-3_CanoR_1	11	21	PF00244	0.681
LIG_14-3-3_CanoR_1	63	68	PF00244	0.475
LIG_DLG_GKlike_1	63	71	PF00625	0.474
LIG_FHA_1	135	141	PF00498	0.305
LIG_FHA_2	204	210	PF00498	0.399
LIG_FHA_2	53	59	PF00498	0.551
LIG_LIR_Apic_2	19	24	PF02991	0.685
LIG_LIR_Gen_1	170	177	PF02991	0.365
LIG_LIR_Gen_1	55	65	PF02991	0.536
LIG_LIR_Nem_3	170	175	PF02991	0.349
LIG_LIR_Nem_3	55	60	PF02991	0.555
LIG_LIR_Nem_3	86	91	PF02991	0.478
LIG_PDZ_Class_2	229	234	PF00595	0.405
LIG_SH2_CRK	172	176	PF00017	0.311
LIG_SH2_STAP1	77	81	PF00017	0.551
LIG_SH2_STAT5	77	80	PF00017	0.464
LIG_SH2_STAT5	84	87	PF00017	0.440
LIG_SH3_3	138	144	PF00018	0.317
LIG_SH3_3	210	216	PF00018	0.373
LIG_SH3_3	94	100	PF00018	0.560
LIG_TYR_ITIM	82	87	PF00017	0.555
LIG_UBA3_1	101	108	PF00899	0.461
LIG_UBA3_1	116	122	PF00899	0.486
MOD_CK1_1	181	187	PF00069	0.458
MOD_CK1_1	6	12	PF00069	0.693
MOD_CK2_1	203	209	PF00069	0.374
MOD_CK2_1	63	69	PF00069	0.509
MOD_GlcNHglycan	150	153	PF01048	0.509
MOD_GlcNHglycan	18	21	PF01048	0.501
MOD_GlcNHglycan	180	183	PF01048	0.654
MOD_GlcNHglycan	8	11	PF01048	0.559
MOD_GSK3_1	157	164	PF00069	0.280
MOD_GSK3_1	177	184	PF00069	0.249
MOD_GSK3_1	6	13	PF00069	0.693
MOD_GSK3_1	71	78	PF00069	0.477
MOD_LATS_1	61	67	PF00433	0.479
MOD_NEK2_1	147	152	PF00069	0.341
MOD_NEK2_1	39	44	PF00069	0.511
MOD_NEK2_2	203	208	PF00069	0.311
MOD_PKA_2	10	16	PF00069	0.683
MOD_PKA_2	177	183	PF00069	0.258
MOD_PKA_2	3	9	PF00069	0.769
MOD_Plk_4	26	32	PF00069	0.658
MOD_ProDKin_1	71	77	PF00069	0.469
TRG_ENDOCYTIC_2	172	175	PF00928	0.316
TRG_ENDOCYTIC_2	84	87	PF00928	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I779	Leptomonas seymouri	59%	98%
A0A0S4JEF8	Bodo saltans	40%	100%
A0A1X0NHP7	Trypanosomatidae	49%	100%
A0A3S7WTT8	Leishmania donovani	100%	100%
A0A422N958	Trypanosoma rangeli	47%	91%
A4H8G9	Leishmania braziliensis	85%	100%
C9ZW39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AQK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEX5	Leishmania major	95%	100%
V5D515	Trypanosoma cruzi	43%	100%