Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWU1_LEIIN

TriTrypDb:

LINF_160009400

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.652
CLV_C14_Caspase3-7	170	174	PF00656	0.675
CLV_NRD_NRD_1	132	134	PF00675	0.523
CLV_NRD_NRD_1	139	141	PF00675	0.515
CLV_NRD_NRD_1	15	17	PF00675	0.691
CLV_NRD_NRD_1	9	11	PF00675	0.753
CLV_PCSK_KEX2_1	132	134	PF00082	0.523
CLV_PCSK_KEX2_1	15	17	PF00082	0.693
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.693
CLV_PCSK_SKI1_1	145	149	PF00082	0.678
DEG_SPOP_SBC_1	83	87	PF00917	0.661
DOC_MAPK_gen_1	137	146	PF00069	0.641
DOC_MAPK_gen_1	14	23	PF00069	0.654
DOC_MAPK_gen_1	157	166	PF00069	0.607
DOC_USP7_MATH_1	27	31	PF00917	0.644
DOC_USP7_MATH_1	39	43	PF00917	0.504
DOC_USP7_MATH_1	59	63	PF00917	0.716
DOC_USP7_MATH_1	67	71	PF00917	0.720
DOC_USP7_MATH_1	84	88	PF00917	0.672
DOC_USP7_UBL2_3	11	15	PF12436	0.637
DOC_USP7_UBL2_3	137	141	PF12436	0.604
DOC_WW_Pin1_4	79	84	PF00397	0.711
LIG_14-3-3_CanoR_1	159	164	PF00244	0.608
LIG_14-3-3_CanoR_1	31	37	PF00244	0.556
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	29	33	PF00533	0.626
LIG_BRCT_BRCA1_1	85	89	PF00533	0.638
LIG_FHA_1	33	39	PF00498	0.582
LIG_FHA_2	117	123	PF00498	0.718
LIG_LIR_Apic_2	104	110	PF02991	0.503
LIG_LIR_Gen_1	30	39	PF02991	0.621
LIG_LIR_Gen_1	53	59	PF02991	0.629
LIG_LIR_Gen_1	95	106	PF02991	0.514
LIG_LIR_Nem_3	125	130	PF02991	0.600
LIG_LIR_Nem_3	30	36	PF02991	0.627
LIG_LIR_Nem_3	53	58	PF02991	0.639
LIG_LIR_Nem_3	86	92	PF02991	0.571
LIG_LIR_Nem_3	95	101	PF02991	0.451
LIG_RPA_C_Fungi	26	38	PF08784	0.665
LIG_SH3_3	148	154	PF00018	0.701
LIG_SH3_3	33	39	PF00018	0.530
LIG_TRAF2_1	111	114	PF00917	0.544
LIG_TRAF2_2	45	50	PF00917	0.640
LIG_UBA3_1	97	105	PF00899	0.567
MOD_CK1_1	167	173	PF00069	0.690
MOD_CK1_1	63	69	PF00069	0.679
MOD_CK1_1	70	76	PF00069	0.700
MOD_CK1_1	82	88	PF00069	0.670
MOD_CK2_1	108	114	PF00069	0.565
MOD_Cter_Amidation	12	15	PF01082	0.684
MOD_GlcNHglycan	62	65	PF01048	0.627
MOD_GlcNHglycan	72	75	PF01048	0.733
MOD_GlcNHglycan	77	80	PF01048	0.735
MOD_GlcNHglycan	86	89	PF01048	0.695
MOD_GSK3_1	164	171	PF00069	0.712
MOD_GSK3_1	27	34	PF00069	0.608
MOD_GSK3_1	59	66	PF00069	0.637
MOD_GSK3_1	68	75	PF00069	0.638
MOD_GSK3_1	79	86	PF00069	0.619
MOD_NEK2_1	166	171	PF00069	0.722
MOD_PKA_2	21	27	PF00069	0.550
MOD_PKA_2	39	45	PF00069	0.539
MOD_Plk_4	159	165	PF00069	0.637
MOD_Plk_4	50	56	PF00069	0.614
MOD_ProDKin_1	79	85	PF00069	0.708
MOD_SUMO_for_1	147	150	PF00179	0.708
MOD_SUMO_rev_2	129	139	PF00179	0.588
TRG_ENDOCYTIC_2	55	58	PF00928	0.648
TRG_ER_diArg_1	20	23	PF00400	0.565
TRG_NLS_MonoCore_2	13	18	PF00514	0.699
TRG_NLS_MonoExtN_4	11	18	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B0	Leptomonas seymouri	64%	100%
A0A0S4JAB3	Bodo saltans	43%	100%
A0A1X0P0C9	Trypanosomatidae	54%	100%
A0A3R7M9R7	Trypanosoma rangeli	58%	100%
A0A3S7WTU8	Leishmania donovani	100%	100%
A4H8G8	Leishmania braziliensis	74%	100%
C9ZW40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AQK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	97%
Q4QEX7	Leishmania major	86%	100%