Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWT9_LEIIN

TriTrypDb:

LINF_160009200

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.796
CLV_C14_Caspase3-7	483	487	PF00656	0.798
CLV_NRD_NRD_1	158	160	PF00675	0.553
CLV_NRD_NRD_1	361	363	PF00675	0.705
CLV_NRD_NRD_1	445	447	PF00675	0.663
CLV_NRD_NRD_1	545	547	PF00675	0.826
CLV_PCSK_KEX2_1	157	159	PF00082	0.580
CLV_PCSK_KEX2_1	210	212	PF00082	0.457
CLV_PCSK_KEX2_1	320	322	PF00082	0.599
CLV_PCSK_KEX2_1	374	376	PF00082	0.817
CLV_PCSK_KEX2_1	444	446	PF00082	0.663
CLV_PCSK_KEX2_1	544	546	PF00082	0.731
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.580
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.501
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.592
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.817
CLV_PCSK_SKI1_1	136	140	PF00082	0.452
CLV_PCSK_SKI1_1	284	288	PF00082	0.436
CLV_PCSK_SKI1_1	327	331	PF00082	0.463
CLV_PCSK_SKI1_1	406	410	PF00082	0.708
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DOC_CKS1_1	276	281	PF01111	0.572
DOC_CKS1_1	71	76	PF01111	0.364
DOC_CYCLIN_RxL_1	229	240	PF00134	0.565
DOC_CYCLIN_yClb5_NLxxxL_5	184	193	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.597
DOC_MAPK_gen_1	243	252	PF00069	0.531
DOC_MAPK_MEF2A_6	190	197	PF00069	0.448
DOC_MAPK_MEF2A_6	245	254	PF00069	0.529
DOC_MAPK_MEF2A_6	69	78	PF00069	0.496
DOC_PP2B_LxvP_1	145	148	PF13499	0.622
DOC_PP2B_LxvP_1	193	196	PF13499	0.399
DOC_PP2B_LxvP_1	234	237	PF13499	0.551
DOC_USP7_MATH_1	101	105	PF00917	0.758
DOC_USP7_MATH_1	291	295	PF00917	0.559
DOC_USP7_MATH_1	355	359	PF00917	0.743
DOC_USP7_MATH_1	389	393	PF00917	0.781
DOC_USP7_MATH_1	429	433	PF00917	0.660
DOC_USP7_MATH_1	456	460	PF00917	0.795
DOC_USP7_MATH_1	471	475	PF00917	0.558
DOC_USP7_MATH_1	480	484	PF00917	0.547
DOC_USP7_MATH_1	490	494	PF00917	0.608
DOC_USP7_MATH_1	526	530	PF00917	0.717
DOC_USP7_MATH_1	555	559	PF00917	0.774
DOC_USP7_UBL2_3	370	374	PF12436	0.776
DOC_WW_Pin1_4	275	280	PF00397	0.563
DOC_WW_Pin1_4	45	50	PF00397	0.626
DOC_WW_Pin1_4	469	474	PF00397	0.737
DOC_WW_Pin1_4	476	481	PF00397	0.594
DOC_WW_Pin1_4	61	66	PF00397	0.526
DOC_WW_Pin1_4	70	75	PF00397	0.357
DOC_WW_Pin1_4	97	102	PF00397	0.706
LIG_14-3-3_CanoR_1	136	145	PF00244	0.436
LIG_14-3-3_CanoR_1	211	219	PF00244	0.520
LIG_14-3-3_CanoR_1	229	235	PF00244	0.578
LIG_14-3-3_CanoR_1	303	308	PF00244	0.465
LIG_14-3-3_CanoR_1	400	408	PF00244	0.721
LIG_14-3-3_CanoR_1	418	426	PF00244	0.542
LIG_14-3-3_CanoR_1	431	441	PF00244	0.529
LIG_Actin_WH2_2	423	440	PF00022	0.700
LIG_APCC_ABBAyCdc20_2	530	536	PF00400	0.566
LIG_BRCT_BRCA1_1	247	251	PF00533	0.495
LIG_deltaCOP1_diTrp_1	168	174	PF00928	0.568
LIG_eIF4E_1	265	271	PF01652	0.397
LIG_FHA_1	116	122	PF00498	0.692
LIG_FHA_1	142	148	PF00498	0.587
LIG_FHA_1	179	185	PF00498	0.425
LIG_FHA_1	22	28	PF00498	0.643
LIG_FHA_1	239	245	PF00498	0.545
LIG_FHA_1	303	309	PF00498	0.608
LIG_FHA_1	34	40	PF00498	0.518
LIG_FHA_1	62	68	PF00498	0.507
LIG_FHA_1	71	77	PF00498	0.368
LIG_FHA_2	171	177	PF00498	0.365
LIG_FHA_2	23	29	PF00498	0.686
LIG_FHA_2	339	345	PF00498	0.698
LIG_FHA_2	418	424	PF00498	0.644
LIG_FHA_2	46	52	PF00498	0.509
LIG_Integrin_isoDGR_2	227	229	PF01839	0.468
LIG_LIR_Gen_1	168	179	PF02991	0.417
LIG_LIR_Gen_1	262	273	PF02991	0.477
LIG_LIR_Gen_1	73	83	PF02991	0.370
LIG_LIR_Nem_3	168	174	PF02991	0.465
LIG_LIR_Nem_3	191	197	PF02991	0.511
LIG_LIR_Nem_3	248	254	PF02991	0.395
LIG_LIR_Nem_3	262	268	PF02991	0.395
LIG_LIR_Nem_3	317	322	PF02991	0.443
LIG_LIR_Nem_3	402	408	PF02991	0.753
LIG_LIR_Nem_3	66	71	PF02991	0.361
LIG_LIR_Nem_3	73	78	PF02991	0.369
LIG_MAD2	57	65	PF02301	0.540
LIG_MYND_1	476	480	PF01753	0.691
LIG_NRBOX	66	72	PF00104	0.445
LIG_PCNA_yPIPBox_3	283	295	PF02747	0.427
LIG_PDZ_Class_2	570	575	PF00595	0.710
LIG_Pex14_1	315	319	PF04695	0.448
LIG_RPA_C_Fungi	154	166	PF08784	0.572
LIG_SH2_CRK	319	323	PF00017	0.444
LIG_SH2_CRK	68	72	PF00017	0.481
LIG_SH2_PTP2	194	197	PF00017	0.484
LIG_SH2_STAT5	194	197	PF00017	0.484
LIG_SH2_STAT5	265	268	PF00017	0.404
LIG_SH2_STAT5	407	410	PF00017	0.577
LIG_SH2_STAT5	63	66	PF00017	0.470
LIG_SH2_STAT5	72	75	PF00017	0.355
LIG_SH3_2	477	482	PF14604	0.639
LIG_SH3_2	540	545	PF14604	0.601
LIG_SH3_3	124	130	PF00018	0.637
LIG_SH3_3	467	473	PF00018	0.801
LIG_SH3_3	474	480	PF00018	0.597
LIG_SH3_3	537	543	PF00018	0.601
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.415
LIG_TRAF2_1	421	424	PF00917	0.621
LIG_TRAF2_1	43	46	PF00917	0.554
LIG_TRAF2_1	449	452	PF00917	0.710
LIG_TYR_ITIM	263	268	PF00017	0.415
MOD_CDC14_SPxK_1	479	482	PF00782	0.699
MOD_CDK_SPxK_1	476	482	PF00069	0.736
MOD_CK1_1	108	114	PF00069	0.790
MOD_CK1_1	432	438	PF00069	0.693
MOD_CK1_1	460	466	PF00069	0.789
MOD_CK1_1	481	487	PF00069	0.695
MOD_CK1_1	528	534	PF00069	0.716
MOD_CK1_1	61	67	PF00069	0.425
MOD_CK1_1	99	105	PF00069	0.772
MOD_CK2_1	22	28	PF00069	0.685
MOD_CK2_1	236	242	PF00069	0.529
MOD_CK2_1	291	297	PF00069	0.500
MOD_CK2_1	338	344	PF00069	0.713
MOD_CK2_1	389	395	PF00069	0.762
MOD_CK2_1	417	423	PF00069	0.535
MOD_CK2_1	446	452	PF00069	0.762
MOD_CK2_1	45	51	PF00069	0.514
MOD_CK2_1	469	475	PF00069	0.766
MOD_CK2_1	526	532	PF00069	0.739
MOD_Cter_Amidation	155	158	PF01082	0.568
MOD_Cter_Amidation	372	375	PF01082	0.806
MOD_GlcNHglycan	101	104	PF01048	0.749
MOD_GlcNHglycan	105	108	PF01048	0.754
MOD_GlcNHglycan	212	215	PF01048	0.536
MOD_GlcNHglycan	280	283	PF01048	0.585
MOD_GlcNHglycan	344	347	PF01048	0.778
MOD_GlcNHglycan	536	539	PF01048	0.699
MOD_GlcNHglycan	60	63	PF01048	0.534
MOD_GSK3_1	105	112	PF00069	0.765
MOD_GSK3_1	115	122	PF00069	0.737
MOD_GSK3_1	206	213	PF00069	0.553
MOD_GSK3_1	291	298	PF00069	0.507
MOD_GSK3_1	338	345	PF00069	0.719
MOD_GSK3_1	351	358	PF00069	0.580
MOD_GSK3_1	373	380	PF00069	0.753
MOD_GSK3_1	390	397	PF00069	0.466
MOD_GSK3_1	446	453	PF00069	0.729
MOD_GSK3_1	456	463	PF00069	0.704
MOD_GSK3_1	47	54	PF00069	0.557
MOD_GSK3_1	476	483	PF00069	0.812
MOD_GSK3_1	524	531	PF00069	0.673
MOD_GSK3_1	95	102	PF00069	0.731
MOD_N-GLC_1	342	347	PF02516	0.791
MOD_NEK2_1	22	27	PF00069	0.635
MOD_NEK2_1	302	307	PF00069	0.473
MOD_NEK2_1	308	313	PF00069	0.431
MOD_NEK2_1	96	101	PF00069	0.706
MOD_PKA_1	210	216	PF00069	0.551
MOD_PKA_1	362	368	PF00069	0.776
MOD_PKA_1	446	452	PF00069	0.708
MOD_PKA_2	210	216	PF00069	0.551
MOD_PKA_2	302	308	PF00069	0.469
MOD_PKA_2	399	405	PF00069	0.712
MOD_PKA_2	417	423	PF00069	0.539
MOD_PKA_2	432	438	PF00069	0.568
MOD_PKA_2	481	487	PF00069	0.736
MOD_PKB_1	243	251	PF00069	0.532
MOD_PKB_1	444	452	PF00069	0.726
MOD_Plk_1	390	396	PF00069	0.722
MOD_Plk_1	414	420	PF00069	0.642
MOD_Plk_1	464	470	PF00069	0.811
MOD_Plk_2-3	6	12	PF00069	0.624
MOD_Plk_4	303	309	PF00069	0.575
MOD_Plk_4	63	69	PF00069	0.468
MOD_ProDKin_1	275	281	PF00069	0.565
MOD_ProDKin_1	45	51	PF00069	0.622
MOD_ProDKin_1	469	475	PF00069	0.740
MOD_ProDKin_1	476	482	PF00069	0.597
MOD_ProDKin_1	61	67	PF00069	0.522
MOD_ProDKin_1	70	76	PF00069	0.361
MOD_ProDKin_1	97	103	PF00069	0.707
MOD_SUMO_for_1	514	517	PF00179	0.733
TRG_DiLeu_BaEn_1	242	247	PF01217	0.545
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.483
TRG_ENDOCYTIC_2	194	197	PF00928	0.469
TRG_ENDOCYTIC_2	265	268	PF00928	0.400
TRG_ENDOCYTIC_2	319	322	PF00928	0.413
TRG_ENDOCYTIC_2	405	408	PF00928	0.730
TRG_ENDOCYTIC_2	68	71	PF00928	0.378
TRG_ENDOCYTIC_2	72	75	PF00928	0.373
TRG_ER_diArg_1	14	17	PF00400	0.635
TRG_ER_diArg_1	158	160	PF00400	0.553
TRG_ER_diArg_1	243	246	PF00400	0.507
TRG_ER_diArg_1	430	433	PF00400	0.517
TRG_ER_diArg_1	444	446	PF00400	0.612
TRG_ER_diArg_1	543	546	PF00400	0.741
TRG_ER_diArg_1	55	58	PF00400	0.525
TRG_NES_CRM1_1	191	207	PF08389	0.389
TRG_NLS_Bipartite_1	362	378	PF00514	0.801
TRG_NLS_MonoExtC_3	445	450	PF00514	0.798
TRG_NLS_MonoExtN_4	444	450	PF00514	0.732
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X8	Leptomonas seymouri	62%	86%
A0A1X0NZC8	Trypanosomatidae	42%	95%
A0A3S7WTU1	Leishmania donovani	99%	100%
A0A422N971	Trypanosoma rangeli	42%	96%
A4H8G6	Leishmania braziliensis	85%	100%
C9ZPR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QEX9	Leishmania major	93%	100%
V5B948	Trypanosoma cruzi	38%	100%