LeishMANIAdb
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Putative tubulin tyrosine ligase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative tubulin tyrosine ligase
Gene product:
tubulin tyrosine ligase - putative
Species:
Leishmania infantum
UniProt:
A4HWT7_LEIIN
TriTrypDb:
LINF_160008900
Length:
817

Annotations

Annotations by Jardim et al.

Structural Proteins, tubulin tyrosine ligase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005874 microtubule 6 7
GO:0005929 cilium 4 8
GO:0042995 cell projection 2 8
GO:0043226 organelle 2 8
GO:0043227 membrane-bounded organelle 3 8
GO:0099080 supramolecular complex 2 7
GO:0099081 supramolecular polymer 3 7
GO:0099512 supramolecular fiber 4 7
GO:0099513 polymeric cytoskeletal fiber 5 7
GO:0110165 cellular anatomical entity 1 8
GO:0120025 plasma membrane bounded cell projection 3 8
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HWT7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWT7

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0018095 protein polyglutamylation 7 8
GO:0018193 peptidyl-amino acid modification 5 8
GO:0018200 peptidyl-glutamic acid modification 6 8
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0000226 microtubule cytoskeleton organization 3 2
GO:0006996 organelle organization 4 2
GO:0007010 cytoskeleton organization 5 2
GO:0007017 microtubule-based process 2 2
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0071840 cellular component organization or biogenesis 2 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 11
GO:0004835 tubulin-tyrosine ligase activity 3 8
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 7
GO:0016874 ligase activity 2 11
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 8
GO:0016881 acid-amino acid ligase activity 4 8
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140096 catalytic activity, acting on a protein 2 8
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7
GO:0005515 protein binding 2 2
GO:0008092 cytoskeletal protein binding 3 2
GO:0015631 tubulin binding 4 2
GO:0070739 protein-glutamic acid ligase activity 3 2
GO:0070740 tubulin-glutamic acid ligase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 31 35 PF00656 0.538
CLV_NRD_NRD_1 100 102 PF00675 0.706
CLV_NRD_NRD_1 103 105 PF00675 0.641
CLV_NRD_NRD_1 225 227 PF00675 0.638
CLV_NRD_NRD_1 330 332 PF00675 0.473
CLV_NRD_NRD_1 363 365 PF00675 0.420
CLV_NRD_NRD_1 392 394 PF00675 0.284
CLV_NRD_NRD_1 485 487 PF00675 0.281
CLV_NRD_NRD_1 55 57 PF00675 0.580
CLV_NRD_NRD_1 71 73 PF00675 0.676
CLV_PCSK_FUR_1 101 105 PF00082 0.559
CLV_PCSK_FUR_1 328 332 PF00082 0.453
CLV_PCSK_KEX2_1 100 102 PF00082 0.611
CLV_PCSK_KEX2_1 103 105 PF00082 0.581
CLV_PCSK_KEX2_1 196 198 PF00082 0.587
CLV_PCSK_KEX2_1 225 227 PF00082 0.641
CLV_PCSK_KEX2_1 330 332 PF00082 0.473
CLV_PCSK_KEX2_1 363 365 PF00082 0.451
CLV_PCSK_KEX2_1 402 404 PF00082 0.295
CLV_PCSK_KEX2_1 484 486 PF00082 0.281
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.601
CLV_PCSK_PC1ET2_1 103 105 PF00082 0.572
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.580
CLV_PCSK_PC1ET2_1 402 404 PF00082 0.234
CLV_PCSK_SKI1_1 14 18 PF00082 0.600
CLV_PCSK_SKI1_1 399 403 PF00082 0.256
CLV_PCSK_SKI1_1 501 505 PF00082 0.257
CLV_PCSK_SKI1_1 767 771 PF00082 0.257
CLV_PCSK_SKI1_1 779 783 PF00082 0.267
DEG_Nend_UBRbox_2 1 3 PF02207 0.600
DEG_SCF_FBW7_1 83 89 PF00400 0.637
DEG_SPOP_SBC_1 283 287 PF00917 0.576
DOC_CKS1_1 83 88 PF01111 0.638
DOC_MAPK_gen_1 196 204 PF00069 0.596
DOC_MAPK_gen_1 619 627 PF00069 0.495
DOC_MAPK_MEF2A_6 619 627 PF00069 0.499
DOC_MAPK_NFAT4_5 620 628 PF00069 0.495
DOC_MAPK_RevD_3 184 197 PF00069 0.571
DOC_PP1_RVXF_1 707 714 PF00149 0.484
DOC_PP1_RVXF_1 777 783 PF00149 0.461
DOC_USP7_MATH_1 165 169 PF00917 0.633
DOC_USP7_MATH_1 189 193 PF00917 0.617
DOC_USP7_MATH_1 208 212 PF00917 0.623
DOC_USP7_MATH_1 229 233 PF00917 0.716
DOC_USP7_MATH_1 274 278 PF00917 0.601
DOC_USP7_MATH_1 30 34 PF00917 0.568
DOC_USP7_MATH_1 303 307 PF00917 0.737
DOC_USP7_MATH_1 320 324 PF00917 0.602
DOC_USP7_MATH_1 41 45 PF00917 0.560
DOC_USP7_MATH_1 438 442 PF00917 0.496
DOC_USP7_MATH_1 584 588 PF00917 0.620
DOC_USP7_MATH_1 593 597 PF00917 0.677
DOC_USP7_MATH_1 653 657 PF00917 0.529
DOC_USP7_MATH_1 755 759 PF00917 0.463
DOC_USP7_MATH_1 91 95 PF00917 0.597
DOC_USP7_UBL2_3 59 63 PF12436 0.544
DOC_USP7_UBL2_3 8 12 PF12436 0.565
DOC_WW_Pin1_4 135 140 PF00397 0.586
DOC_WW_Pin1_4 21 26 PF00397 0.620
DOC_WW_Pin1_4 279 284 PF00397 0.635
DOC_WW_Pin1_4 44 49 PF00397 0.591
DOC_WW_Pin1_4 529 534 PF00397 0.518
DOC_WW_Pin1_4 570 575 PF00397 0.671
DOC_WW_Pin1_4 753 758 PF00397 0.457
DOC_WW_Pin1_4 82 87 PF00397 0.638
DOC_WW_Pin1_4 92 97 PF00397 0.566
LIG_14-3-3_CanoR_1 104 111 PF00244 0.581
LIG_14-3-3_CanoR_1 250 259 PF00244 0.495
LIG_14-3-3_CanoR_1 415 419 PF00244 0.461
LIG_14-3-3_CanoR_1 451 457 PF00244 0.476
LIG_14-3-3_CanoR_1 56 66 PF00244 0.545
LIG_14-3-3_CanoR_1 81 86 PF00244 0.628
LIG_Actin_WH2_2 704 722 PF00022 0.476
LIG_APCC_ABBA_1 475 480 PF00400 0.457
LIG_BIR_III_4 174 178 PF00653 0.608
LIG_BIR_III_4 433 437 PF00653 0.449
LIG_BRCT_BRCA1_1 32 36 PF00533 0.536
LIG_BRCT_BRCA1_1 370 374 PF00533 0.434
LIG_BRCT_BRCA1_1 457 461 PF00533 0.481
LIG_BRCT_BRCA1_1 575 579 PF00533 0.592
LIG_deltaCOP1_diTrp_1 354 359 PF00928 0.357
LIG_eIF4E_1 609 615 PF01652 0.457
LIG_eIF4E_1 736 742 PF01652 0.457
LIG_FHA_1 197 203 PF00498 0.588
LIG_FHA_1 420 426 PF00498 0.438
LIG_FHA_1 466 472 PF00498 0.457
LIG_FHA_1 486 492 PF00498 0.457
LIG_FHA_1 580 586 PF00498 0.564
LIG_FHA_1 65 71 PF00498 0.562
LIG_FHA_1 759 765 PF00498 0.586
LIG_FHA_1 775 781 PF00498 0.405
LIG_FHA_1 87 93 PF00498 0.737
LIG_FHA_2 251 257 PF00498 0.505
LIG_FHA_2 390 396 PF00498 0.457
LIG_FHA_2 418 424 PF00498 0.480
LIG_FHA_2 761 767 PF00498 0.457
LIG_Integrin_isoDGR_2 223 225 PF01839 0.563
LIG_LIR_Apic_2 468 472 PF02991 0.494
LIG_LIR_Gen_1 354 362 PF02991 0.355
LIG_LIR_Gen_1 411 421 PF02991 0.481
LIG_LIR_Gen_1 641 652 PF02991 0.457
LIG_LIR_Gen_1 687 695 PF02991 0.448
LIG_LIR_Nem_3 354 358 PF02991 0.358
LIG_LIR_Nem_3 395 401 PF02991 0.458
LIG_LIR_Nem_3 411 416 PF02991 0.457
LIG_LIR_Nem_3 630 635 PF02991 0.507
LIG_LIR_Nem_3 641 647 PF02991 0.501
LIG_LIR_Nem_3 687 691 PF02991 0.448
LIG_LIR_Nem_3 732 736 PF02991 0.559
LIG_LIR_Nem_3 810 815 PF02991 0.402
LIG_MAD2 779 787 PF02301 0.457
LIG_PCNA_PIPBox_1 659 668 PF02747 0.457
LIG_PDZ_Class_2 812 817 PF00595 0.376
LIG_Pex14_2 478 482 PF04695 0.481
LIG_Pex14_2 688 692 PF04695 0.444
LIG_PTB_Apo_2 707 714 PF02174 0.457
LIG_SH2_CRK 398 402 PF00017 0.459
LIG_SH2_CRK 413 417 PF00017 0.457
LIG_SH2_CRK 469 473 PF00017 0.457
LIG_SH2_CRK 632 636 PF00017 0.507
LIG_SH2_CRK 716 720 PF00017 0.461
LIG_SH2_CRK 738 742 PF00017 0.458
LIG_SH2_NCK_1 469 473 PF00017 0.457
LIG_SH2_PTP2 626 629 PF00017 0.467
LIG_SH2_SRC 604 607 PF00017 0.459
LIG_SH2_STAP1 738 742 PF00017 0.458
LIG_SH2_STAT5 404 407 PF00017 0.457
LIG_SH2_STAT5 604 607 PF00017 0.495
LIG_SH2_STAT5 609 612 PF00017 0.495
LIG_SH2_STAT5 626 629 PF00017 0.527
LIG_SH2_STAT5 638 641 PF00017 0.495
LIG_SH2_STAT5 694 697 PF00017 0.511
LIG_SH2_STAT5 702 705 PF00017 0.511
LIG_SH3_3 183 189 PF00018 0.744
LIG_SH3_3 571 577 PF00018 0.553
LIG_SH3_3 778 784 PF00018 0.465
LIG_SH3_3 85 91 PF00018 0.623
LIG_SUMO_SIM_anti_2 199 205 PF11976 0.601
LIG_SUMO_SIM_par_1 452 458 PF11976 0.459
LIG_TYR_ITAM 395 416 PF00017 0.457
LIG_TYR_ITIM 396 401 PF00017 0.457
LIG_TYR_ITIM 714 719 PF00017 0.457
LIG_WRC_WIRS_1 456 461 PF05994 0.481
LIG_WRC_WIRS_1 525 530 PF05994 0.536
LIG_WW_1 783 786 PF00397 0.481
LIG_WW_2 90 93 PF00397 0.583
MOD_CDK_SPK_2 573 578 PF00069 0.517
MOD_CDK_SPxxK_3 529 536 PF00069 0.522
MOD_CK1_1 106 112 PF00069 0.631
MOD_CK1_1 19 25 PF00069 0.565
MOD_CK1_1 234 240 PF00069 0.757
MOD_CK1_1 282 288 PF00069 0.629
MOD_CK1_1 306 312 PF00069 0.668
MOD_CK1_1 44 50 PF00069 0.566
MOD_CK1_1 455 461 PF00069 0.473
MOD_CK1_1 555 561 PF00069 0.607
MOD_CK1_1 570 576 PF00069 0.596
MOD_CK1_1 583 589 PF00069 0.535
MOD_CK1_1 664 670 PF00069 0.442
MOD_CK1_1 758 764 PF00069 0.477
MOD_CK1_1 82 88 PF00069 0.605
MOD_CK1_1 95 101 PF00069 0.607
MOD_CK2_1 551 557 PF00069 0.658
MOD_Cter_Amidation 194 197 PF01082 0.573
MOD_Cter_Amidation 223 226 PF01082 0.565
MOD_Cter_Amidation 617 620 PF01082 0.295
MOD_GlcNHglycan 105 108 PF01048 0.590
MOD_GlcNHglycan 18 21 PF01048 0.581
MOD_GlcNHglycan 182 185 PF01048 0.622
MOD_GlcNHglycan 210 213 PF01048 0.639
MOD_GlcNHglycan 218 221 PF01048 0.691
MOD_GlcNHglycan 237 240 PF01048 0.812
MOD_GlcNHglycan 276 279 PF01048 0.702
MOD_GlcNHglycan 295 298 PF01048 0.573
MOD_GlcNHglycan 322 325 PF01048 0.593
MOD_GlcNHglycan 425 428 PF01048 0.276
MOD_GlcNHglycan 43 46 PF01048 0.660
MOD_GlcNHglycan 440 443 PF01048 0.333
MOD_GlcNHglycan 557 560 PF01048 0.684
MOD_GlcNHglycan 563 566 PF01048 0.635
MOD_GlcNHglycan 582 585 PF01048 0.748
MOD_GlcNHglycan 595 598 PF01048 0.536
MOD_GlcNHglycan 8 11 PF01048 0.763
MOD_GlcNHglycan 97 100 PF01048 0.700
MOD_GSK3_1 106 113 PF00069 0.557
MOD_GSK3_1 131 138 PF00069 0.637
MOD_GSK3_1 15 22 PF00069 0.543
MOD_GSK3_1 165 172 PF00069 0.671
MOD_GSK3_1 2 9 PF00069 0.601
MOD_GSK3_1 231 238 PF00069 0.740
MOD_GSK3_1 269 276 PF00069 0.590
MOD_GSK3_1 278 285 PF00069 0.615
MOD_GSK3_1 302 309 PF00069 0.578
MOD_GSK3_1 365 372 PF00069 0.417
MOD_GSK3_1 419 426 PF00069 0.484
MOD_GSK3_1 44 51 PF00069 0.590
MOD_GSK3_1 461 468 PF00069 0.479
MOD_GSK3_1 524 531 PF00069 0.522
MOD_GSK3_1 551 558 PF00069 0.597
MOD_GSK3_1 579 586 PF00069 0.729
MOD_GSK3_1 600 607 PF00069 0.267
MOD_GSK3_1 71 78 PF00069 0.597
MOD_GSK3_1 753 760 PF00069 0.489
MOD_GSK3_1 799 806 PF00069 0.432
MOD_GSK3_1 82 89 PF00069 0.641
MOD_GSK3_1 91 98 PF00069 0.565
MOD_N-GLC_1 208 213 PF02516 0.603
MOD_N-GLC_1 579 584 PF02516 0.564
MOD_N-GLC_1 678 683 PF02516 0.264
MOD_N-GLC_1 753 758 PF02516 0.257
MOD_N-GLC_1 774 779 PF02516 0.222
MOD_N-GLC_2 567 569 PF02516 0.587
MOD_NEK2_1 284 289 PF00069 0.623
MOD_NEK2_1 461 466 PF00069 0.457
MOD_NEK2_1 528 533 PF00069 0.524
MOD_NEK2_1 579 584 PF00069 0.603
MOD_NEK2_1 600 605 PF00069 0.458
MOD_NEK2_1 628 633 PF00069 0.457
MOD_NEK2_1 647 652 PF00069 0.457
MOD_NEK2_1 759 764 PF00069 0.457
MOD_NEK2_1 774 779 PF00069 0.457
MOD_NEK2_2 245 250 PF00069 0.600
MOD_NEK2_2 370 375 PF00069 0.428
MOD_NEK2_2 414 419 PF00069 0.457
MOD_PIKK_1 322 328 PF00454 0.546
MOD_PIKK_1 485 491 PF00454 0.472
MOD_PIKK_1 495 501 PF00454 0.462
MOD_PIKK_1 584 590 PF00454 0.596
MOD_PKA_1 103 109 PF00069 0.604
MOD_PKA_1 196 202 PF00069 0.586
MOD_PKA_1 485 491 PF00069 0.481
MOD_PKA_1 519 525 PF00069 0.444
MOD_PKA_1 57 63 PF00069 0.597
MOD_PKA_2 103 109 PF00069 0.604
MOD_PKA_2 196 202 PF00069 0.586
MOD_PKA_2 306 312 PF00069 0.615
MOD_PKA_2 365 371 PF00069 0.386
MOD_PKA_2 414 420 PF00069 0.457
MOD_PKA_2 485 491 PF00069 0.457
MOD_PKA_2 71 77 PF00069 0.779
MOD_PKB_1 77 85 PF00069 0.610
MOD_Plk_1 245 251 PF00069 0.611
MOD_Plk_1 774 780 PF00069 0.422
MOD_Plk_1 79 85 PF00069 0.598
MOD_Plk_2-3 131 137 PF00069 0.613
MOD_Plk_2-3 729 735 PF00069 0.481
MOD_Plk_4 106 112 PF00069 0.552
MOD_Plk_4 524 530 PF00069 0.558
MOD_Plk_4 540 546 PF00069 0.467
MOD_Plk_4 600 606 PF00069 0.341
MOD_ProDKin_1 135 141 PF00069 0.587
MOD_ProDKin_1 21 27 PF00069 0.619
MOD_ProDKin_1 279 285 PF00069 0.633
MOD_ProDKin_1 44 50 PF00069 0.591
MOD_ProDKin_1 529 535 PF00069 0.517
MOD_ProDKin_1 570 576 PF00069 0.669
MOD_ProDKin_1 753 759 PF00069 0.457
MOD_ProDKin_1 82 88 PF00069 0.638
MOD_ProDKin_1 92 98 PF00069 0.568
MOD_SUMO_for_1 126 129 PF00179 0.598
MOD_SUMO_rev_2 344 350 PF00179 0.480
MOD_SUMO_rev_2 517 522 PF00179 0.449
TRG_AP2beta_CARGO_1 641 651 PF09066 0.457
TRG_DiLeu_BaLyEn_6 197 202 PF01217 0.539
TRG_DiLeu_BaLyEn_6 610 615 PF01217 0.457
TRG_DiLeu_BaLyEn_6 764 769 PF01217 0.457
TRG_ENDOCYTIC_2 398 401 PF00928 0.459
TRG_ENDOCYTIC_2 413 416 PF00928 0.457
TRG_ENDOCYTIC_2 626 629 PF00928 0.505
TRG_ENDOCYTIC_2 632 635 PF00928 0.519
TRG_ENDOCYTIC_2 716 719 PF00928 0.474
TRG_ENDOCYTIC_2 738 741 PF00928 0.458
TRG_ER_diArg_1 327 330 PF00400 0.478
TRG_ER_diArg_1 362 364 PF00400 0.419
TRG_ER_diArg_1 484 486 PF00400 0.481
TRG_ER_diArg_1 798 801 PF00400 0.408
TRG_NES_CRM1_1 660 675 PF08389 0.457
TRG_NLS_MonoCore_2 55 60 PF00514 0.587
TRG_NLS_MonoCore_2 99 104 PF00514 0.560
TRG_NLS_MonoExtC_3 99 104 PF00514 0.574
TRG_NLS_MonoExtN_4 100 107 PF00514 0.587
TRG_NLS_MonoExtN_4 56 61 PF00514 0.585
TRG_Pf-PMV_PEXEL_1 161 166 PF00026 0.650
TRG_Pf-PMV_PEXEL_1 403 407 PF00026 0.257
TRG_Pf-PMV_PEXEL_1 767 771 PF00026 0.257

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDX5 Leptomonas seymouri 61% 100%
A0A3Q8IDL7 Leishmania donovani 24% 100%
A0A3S5H6X0 Leishmania donovani 100% 100%
A4H8G3 Leishmania braziliensis 72% 95%
A4HYN9 Leishmania infantum 24% 100%
E9AID0 Leishmania braziliensis 24% 100%
E9AQJ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9AUL7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
Q4QCW7 Leishmania major 24% 100%
Q4QEY2 Leishmania major 90% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS