Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWT6_LEIIN

TriTrypDb:

LINF_160008800

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.392
CLV_C14_Caspase3-7	468	472	PF00656	0.463
CLV_C14_Caspase3-7	70	74	PF00656	0.646
CLV_C14_Caspase3-7	81	85	PF00656	0.570
CLV_NRD_NRD_1	290	292	PF00675	0.590
CLV_NRD_NRD_1	33	35	PF00675	0.599
CLV_NRD_NRD_1	55	57	PF00675	0.508
CLV_PCSK_KEX2_1	33	35	PF00082	0.598
CLV_PCSK_KEX2_1	8	10	PF00082	0.677
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.570
CLV_PCSK_SKI1_1	117	121	PF00082	0.547
CLV_PCSK_SKI1_1	128	132	PF00082	0.419
CLV_PCSK_SKI1_1	241	245	PF00082	0.451
CLV_PCSK_SKI1_1	294	298	PF00082	0.508
CLV_PCSK_SKI1_1	56	60	PF00082	0.591
CLV_PCSK_SKI1_1	9	13	PF00082	0.567
DEG_APCC_DBOX_1	195	203	PF00400	0.350
DEG_COP1_1	157	166	PF00400	0.625
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DOC_CYCLIN_RxL_1	125	134	PF00134	0.461
DOC_MAPK_gen_1	8	14	PF00069	0.630
DOC_MAPK_MEF2A_6	196	203	PF00069	0.342
DOC_MAPK_MEF2A_6	323	330	PF00069	0.308
DOC_MAPK_MEF2A_6	36	44	PF00069	0.554
DOC_PP4_FxxP_1	299	302	PF00568	0.467
DOC_USP7_MATH_1	149	153	PF00917	0.703
DOC_USP7_MATH_1	159	163	PF00917	0.566
DOC_USP7_MATH_1	302	306	PF00917	0.356
DOC_USP7_MATH_1	398	402	PF00917	0.691
DOC_USP7_MATH_1	83	87	PF00917	0.651
DOC_USP7_MATH_1	97	101	PF00917	0.599
DOC_WW_Pin1_4	135	140	PF00397	0.729
DOC_WW_Pin1_4	396	401	PF00397	0.714
LIG_14-3-3_CanoR_1	110	120	PF00244	0.501
LIG_14-3-3_CanoR_1	180	186	PF00244	0.477
LIG_14-3-3_CanoR_1	196	202	PF00244	0.438
LIG_14-3-3_CanoR_1	23	32	PF00244	0.662
LIG_14-3-3_CanoR_1	316	326	PF00244	0.522
LIG_14-3-3_CanoR_1	355	359	PF00244	0.364
LIG_Actin_WH2_2	246	263	PF00022	0.352
LIG_BRCT_BRCA1_1	247	251	PF00533	0.373
LIG_BRCT_BRCA1_1	411	415	PF00533	0.415
LIG_Clathr_ClatBox_1	207	211	PF01394	0.394
LIG_FHA_1	173	179	PF00498	0.400
LIG_FHA_1	198	204	PF00498	0.455
LIG_FHA_1	279	285	PF00498	0.691
LIG_FHA_1	295	301	PF00498	0.389
LIG_FHA_1	354	360	PF00498	0.420
LIG_FHA_1	392	398	PF00498	0.581
LIG_FHA_1	471	477	PF00498	0.409
LIG_FHA_1	53	59	PF00498	0.669
LIG_FHA_2	179	185	PF00498	0.379
LIG_FHA_2	68	74	PF00498	0.748
LIG_FHA_2	79	85	PF00498	0.582
LIG_FHA_2	86	92	PF00498	0.450
LIG_LIR_Apic_2	297	302	PF02991	0.471
LIG_LIR_Gen_1	249	260	PF02991	0.316
LIG_LIR_Gen_1	366	376	PF02991	0.409
LIG_LIR_Nem_3	211	216	PF02991	0.485
LIG_LIR_Nem_3	249	255	PF02991	0.314
LIG_LIR_Nem_3	366	372	PF02991	0.387
LIG_LYPXL_S_1	38	42	PF13949	0.539
LIG_LYPXL_yS_3	39	42	PF13949	0.541
LIG_NRBOX	126	132	PF00104	0.518
LIG_NRBOX	198	204	PF00104	0.323
LIG_PCNA_yPIPBox_3	117	131	PF02747	0.541
LIG_SH2_CRK	213	217	PF00017	0.571
LIG_SH2_CRK	369	373	PF00017	0.386
LIG_SH2_CRK	411	415	PF00017	0.431
LIG_SH2_NCK_1	411	415	PF00017	0.431
LIG_SH2_SRC	213	216	PF00017	0.430
LIG_SH2_STAP1	411	415	PF00017	0.431
LIG_SH2_STAP1	455	459	PF00017	0.338
LIG_SH2_STAT5	327	330	PF00017	0.396
LIG_SH3_3	209	215	PF00018	0.576
LIG_SH3_3	394	400	PF00018	0.646
LIG_SH3_3	421	427	PF00018	0.401
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.500
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.328
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.411
LIG_SUMO_SIM_par_1	10	15	PF11976	0.500
LIG_SUMO_SIM_par_1	129	134	PF11976	0.661
LIG_TRAF2_1	181	184	PF00917	0.441
LIG_TRFH_1	208	212	PF08558	0.413
LIG_TYR_ITIM	37	42	PF00017	0.542
LIG_UBA3_1	130	137	PF00899	0.438
LIG_UBA3_1	232	239	PF00899	0.387
MOD_CK1_1	100	106	PF00069	0.503
MOD_CK1_1	162	168	PF00069	0.735
MOD_CK1_1	194	200	PF00069	0.507
MOD_CK1_1	3	9	PF00069	0.585
MOD_CK1_1	332	338	PF00069	0.408
MOD_CK1_1	357	363	PF00069	0.413
MOD_CK1_1	417	423	PF00069	0.441
MOD_CK1_1	43	49	PF00069	0.665
MOD_CK1_1	67	73	PF00069	0.615
MOD_CK1_1	85	91	PF00069	0.744
MOD_CK2_1	178	184	PF00069	0.387
MOD_CK2_1	83	89	PF00069	0.739
MOD_Cter_Amidation	289	292	PF01082	0.593
MOD_GlcNHglycan	133	136	PF01048	0.570
MOD_GlcNHglycan	14	17	PF01048	0.676
MOD_GlcNHglycan	151	154	PF01048	0.699
MOD_GlcNHglycan	186	189	PF01048	0.519
MOD_GlcNHglycan	245	248	PF01048	0.381
MOD_GlcNHglycan	304	307	PF01048	0.401
MOD_GlcNHglycan	320	323	PF01048	0.501
MOD_GlcNHglycan	359	362	PF01048	0.400
MOD_GlcNHglycan	389	392	PF01048	0.565
MOD_GlcNHglycan	400	403	PF01048	0.678
MOD_GlcNHglycan	416	419	PF01048	0.289
MOD_GlcNHglycan	466	470	PF01048	0.518
MOD_GlcNHglycan	66	69	PF01048	0.605
MOD_GlcNHglycan	84	88	PF01048	0.712
MOD_GlcNHglycan	99	102	PF01048	0.428
MOD_GSK3_1	131	138	PF00069	0.584
MOD_GSK3_1	154	161	PF00069	0.678
MOD_GSK3_1	191	198	PF00069	0.555
MOD_GSK3_1	3	10	PF00069	0.587
MOD_GSK3_1	353	360	PF00069	0.425
MOD_GSK3_1	387	394	PF00069	0.580
MOD_GSK3_1	40	47	PF00069	0.629
MOD_GSK3_1	409	416	PF00069	0.468
MOD_GSK3_1	449	456	PF00069	0.435
MOD_GSK3_1	470	477	PF00069	0.414
MOD_GSK3_1	64	71	PF00069	0.652
MOD_GSK3_1	78	85	PF00069	0.633
MOD_GSK3_1	97	104	PF00069	0.421
MOD_N-GLC_1	218	223	PF02516	0.408
MOD_NEK2_1	12	17	PF00069	0.618
MOD_NEK2_1	131	136	PF00069	0.572
MOD_NEK2_1	44	49	PF00069	0.662
MOD_NEK2_1	52	57	PF00069	0.598
MOD_PIKK_1	120	126	PF00454	0.496
MOD_PIKK_1	434	440	PF00454	0.459
MOD_PKA_2	179	185	PF00069	0.437
MOD_PKA_2	195	201	PF00069	0.457
MOD_PKA_2	221	227	PF00069	0.407
MOD_PKA_2	24	30	PF00069	0.577
MOD_PKA_2	315	321	PF00069	0.528
MOD_PKA_2	354	360	PF00069	0.444
MOD_Plk_1	194	200	PF00069	0.387
MOD_Plk_1	218	224	PF00069	0.405
MOD_Plk_1	90	96	PF00069	0.583
MOD_Plk_4	197	203	PF00069	0.356
MOD_Plk_4	221	227	PF00069	0.411
MOD_Plk_4	354	360	PF00069	0.416
MOD_Plk_4	409	415	PF00069	0.458
MOD_ProDKin_1	135	141	PF00069	0.734
MOD_ProDKin_1	396	402	PF00069	0.714
MOD_SUMO_for_1	463	466	PF00179	0.457
MOD_SUMO_rev_2	114	119	PF00179	0.608
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.464
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.587
TRG_ENDOCYTIC_2	213	216	PF00928	0.478
TRG_ENDOCYTIC_2	327	330	PF00928	0.346
TRG_ENDOCYTIC_2	349	352	PF00928	0.321
TRG_ENDOCYTIC_2	369	372	PF00928	0.206
TRG_ENDOCYTIC_2	39	42	PF00928	0.646
TRG_ENDOCYTIC_2	411	414	PF00928	0.439
TRG_ER_diArg_1	220	223	PF00400	0.587
TRG_ER_diArg_1	288	291	PF00400	0.478
TRG_ER_diArg_1	32	34	PF00400	0.596
TRG_ER_diArg_1	338	341	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA0	Leptomonas seymouri	51%	100%
A0A3R7NAP5	Trypanosoma rangeli	31%	100%
A0A3S7WTT1	Leishmania donovani	100%	100%
E9AQJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QEY3	Leishmania major	86%	100%