Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWT2_LEIIN

TriTrypDb:

LINF_160008400

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.511
CLV_NRD_NRD_1	216	218	PF00675	0.341
CLV_NRD_NRD_1	313	315	PF00675	0.556
CLV_NRD_NRD_1	348	350	PF00675	0.356
CLV_NRD_NRD_1	7	9	PF00675	0.743
CLV_PCSK_KEX2_1	189	191	PF00082	0.593
CLV_PCSK_KEX2_1	216	218	PF00082	0.341
CLV_PCSK_KEX2_1	348	350	PF00082	0.355
CLV_PCSK_KEX2_1	7	9	PF00082	0.743
CLV_PCSK_KEX2_1	84	86	PF00082	0.469
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.521
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.421
CLV_PCSK_SKI1_1	182	186	PF00082	0.632
CLV_PCSK_SKI1_1	197	201	PF00082	0.518
CLV_PCSK_SKI1_1	314	318	PF00082	0.413
CLV_PCSK_SKI1_1	340	344	PF00082	0.394
CLV_PCSK_SKI1_1	349	353	PF00082	0.296
DEG_APCC_DBOX_1	216	224	PF00400	0.345
DOC_CKS1_1	178	183	PF01111	0.660
DOC_CYCLIN_RxL_1	345	353	PF00134	0.399
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.514
DOC_MAPK_gen_1	348	356	PF00069	0.386
DOC_PP1_RVXF_1	318	325	PF00149	0.322
DOC_PP1_RVXF_1	346	353	PF00149	0.396
DOC_PP2B_LxvP_1	266	269	PF13499	0.514
DOC_USP7_MATH_1	149	153	PF00917	0.724
DOC_USP7_MATH_1	156	160	PF00917	0.691
DOC_USP7_MATH_1	308	312	PF00917	0.473
DOC_USP7_MATH_1	37	41	PF00917	0.639
DOC_USP7_MATH_1	47	51	PF00917	0.588
DOC_USP7_MATH_1	53	57	PF00917	0.682
DOC_WW_Pin1_4	150	155	PF00397	0.675
DOC_WW_Pin1_4	17	22	PF00397	0.576
DOC_WW_Pin1_4	177	182	PF00397	0.650
DOC_WW_Pin1_4	240	245	PF00397	0.500
DOC_WW_Pin1_4	372	377	PF00397	0.507
LIG_14-3-3_CanoR_1	166	175	PF00244	0.733
LIG_14-3-3_CanoR_1	203	211	PF00244	0.571
LIG_14-3-3_CanoR_1	8	14	PF00244	0.515
LIG_BRCT_BRCA1_1	108	112	PF00533	0.483
LIG_Clathr_ClatBox_1	326	330	PF01394	0.437
LIG_eIF4E_1	120	126	PF01652	0.525
LIG_FAT_LD_1	220	228	PF03623	0.423
LIG_FHA_1	106	112	PF00498	0.460
LIG_FHA_1	203	209	PF00498	0.611
LIG_FHA_2	132	138	PF00498	0.622
LIG_FHA_2	284	290	PF00498	0.491
LIG_LIR_Gen_1	289	300	PF02991	0.340
LIG_LIR_Gen_1	86	95	PF02991	0.335
LIG_LIR_Nem_3	109	115	PF02991	0.497
LIG_LIR_Nem_3	194	199	PF02991	0.600
LIG_LIR_Nem_3	289	295	PF02991	0.346
LIG_LIR_Nem_3	86	90	PF02991	0.333
LIG_LYPXL_S_1	266	270	PF13949	0.420
LIG_LYPXL_yS_3	267	270	PF13949	0.413
LIG_MAD2	261	269	PF02301	0.430
LIG_MYND_1	49	53	PF01753	0.510
LIG_NRBOX	110	116	PF00104	0.380
LIG_NRBOX	219	225	PF00104	0.461
LIG_Pex14_2	192	196	PF04695	0.515
LIG_Pex14_2	352	356	PF04695	0.407
LIG_Rb_LxCxE_1	325	344	PF01857	0.407
LIG_REV1ctd_RIR_1	315	324	PF16727	0.377
LIG_SH2_CRK	292	296	PF00017	0.392
LIG_SH2_STAT5	117	120	PF00017	0.424
LIG_SH2_STAT5	198	201	PF00017	0.555
LIG_SH2_STAT5	226	229	PF00017	0.454
LIG_SH3_3	10	16	PF00018	0.737
LIG_SH3_3	159	165	PF00018	0.558
LIG_Sin3_3	112	119	PF02671	0.390
LIG_TRAF2_1	377	380	PF00917	0.474
MOD_CDK_SPK_2	177	182	PF00069	0.500
MOD_CDK_SPxxK_3	17	24	PF00069	0.417
MOD_CK1_1	150	156	PF00069	0.745
MOD_CK1_1	20	26	PF00069	0.397
MOD_CK1_1	57	63	PF00069	0.552
MOD_CK1_1	83	89	PF00069	0.493
MOD_CK2_1	131	137	PF00069	0.603
MOD_CK2_1	283	289	PF00069	0.364
MOD_CK2_1	374	380	PF00069	0.448
MOD_CK2_1	53	59	PF00069	0.630
MOD_GlcNHglycan	168	171	PF01048	0.671
MOD_GlcNHglycan	185	188	PF01048	0.453
MOD_GlcNHglycan	270	273	PF01048	0.425
MOD_GSK3_1	197	204	PF00069	0.583
MOD_GSK3_1	26	33	PF00069	0.466
MOD_GSK3_1	37	44	PF00069	0.636
MOD_GSK3_1	53	60	PF00069	0.645
MOD_GSK3_1	96	103	PF00069	0.525
MOD_N-GLC_1	276	281	PF02516	0.415
MOD_N-GLC_1	96	101	PF02516	0.605
MOD_NEK2_1	1	6	PF00069	0.661
MOD_NEK2_1	115	120	PF00069	0.469
MOD_NEK2_1	168	173	PF00069	0.537
MOD_NEK2_1	26	31	PF00069	0.450
MOD_NEK2_1	341	346	PF00069	0.440
MOD_NEK2_1	63	68	PF00069	0.612
MOD_NEK2_2	96	101	PF00069	0.407
MOD_PIKK_1	147	153	PF00454	0.579
MOD_PIKK_1	276	282	PF00454	0.380
MOD_PKA_2	202	208	PF00069	0.570
MOD_PKA_2	26	32	PF00069	0.571
MOD_Plk_1	105	111	PF00069	0.301
MOD_Plk_1	156	162	PF00069	0.501
MOD_Plk_1	96	102	PF00069	0.595
MOD_Plk_2-3	333	339	PF00069	0.424
MOD_Plk_4	1	7	PF00069	0.711
MOD_Plk_4	106	112	PF00069	0.506
MOD_Plk_4	191	197	PF00069	0.576
MOD_Plk_4	30	36	PF00069	0.544
MOD_Plk_4	47	53	PF00069	0.737
MOD_Plk_4	59	65	PF00069	0.559
MOD_ProDKin_1	150	156	PF00069	0.676
MOD_ProDKin_1	17	23	PF00069	0.567
MOD_ProDKin_1	177	183	PF00069	0.645
MOD_ProDKin_1	240	246	PF00069	0.501
MOD_ProDKin_1	372	378	PF00069	0.505
MOD_SUMO_rev_2	310	317	PF00179	0.430
MOD_SUMO_rev_2	333	342	PF00179	0.512
MOD_SUMO_rev_2	375	384	PF00179	0.434
TRG_DiLeu_BaEn_1	219	224	PF01217	0.427
TRG_DiLeu_BaEn_1	337	342	PF01217	0.410
TRG_DiLeu_BaEn_1	59	64	PF01217	0.569
TRG_DiLeu_BaEn_4	337	343	PF01217	0.409
TRG_DiLeu_BaEn_4	379	385	PF01217	0.390
TRG_ENDOCYTIC_2	267	270	PF00928	0.413
TRG_ENDOCYTIC_2	292	295	PF00928	0.370
TRG_ER_diArg_1	215	217	PF00400	0.393
TRG_ER_diArg_1	347	349	PF00400	0.358
TRG_ER_diArg_1	6	8	PF00400	0.749
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	320	325	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y6	Leptomonas seymouri	51%	90%
A0A0S4JDY7	Bodo saltans	43%	100%
A0A1X0NZ32	Trypanosomatidae	27%	91%
A0A3Q8IAF9	Leishmania donovani	99%	100%
A0A3R7KLW2	Trypanosoma rangeli	28%	87%
A0A422N3A0	Trypanosoma rangeli	51%	100%
A4H8F9	Leishmania braziliensis	82%	100%
C9ZW42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZW43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
E9AQJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QEY7	Leishmania major	94%	100%
V5AX32	Trypanosoma cruzi	28%	73%
V5D513	Trypanosoma cruzi	30%	100%