LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HWS9_LEIIN
TriTrypDb:
LINF_160008100
Length:
611

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWS9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWS9

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 19
GO:0006793 phosphorus metabolic process 3 19
GO:0006796 phosphate-containing compound metabolic process 4 19
GO:0006807 nitrogen compound metabolic process 2 19
GO:0008152 metabolic process 1 19
GO:0009987 cellular process 1 19
GO:0016310 phosphorylation 5 19
GO:0019538 protein metabolic process 3 19
GO:0036211 protein modification process 4 19
GO:0043170 macromolecule metabolic process 3 19
GO:0043412 macromolecule modification 4 19
GO:0044237 cellular metabolic process 2 19
GO:0044238 primary metabolic process 2 19
GO:0071704 organic substance metabolic process 2 19
GO:1901564 organonitrogen compound metabolic process 3 19
GO:0007165 signal transduction 2 1
GO:0009966 regulation of signal transduction 4 1
GO:0010646 regulation of cell communication 4 1
GO:0023051 regulation of signaling 3 1
GO:0035556 intracellular signal transduction 3 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0048583 regulation of response to stimulus 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 19
GO:0003824 catalytic activity 1 19
GO:0004672 protein kinase activity 3 19
GO:0005488 binding 1 19
GO:0005524 ATP binding 5 19
GO:0016301 kinase activity 4 19
GO:0016740 transferase activity 2 19
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 19
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 19
GO:0017076 purine nucleotide binding 4 19
GO:0030554 adenyl nucleotide binding 5 19
GO:0032553 ribonucleotide binding 3 19
GO:0032555 purine ribonucleotide binding 4 19
GO:0032559 adenyl ribonucleotide binding 5 19
GO:0035639 purine ribonucleoside triphosphate binding 4 19
GO:0036094 small molecule binding 2 19
GO:0043167 ion binding 2 19
GO:0043168 anion binding 3 19
GO:0097159 organic cyclic compound binding 2 19
GO:0097367 carbohydrate derivative binding 2 19
GO:0140096 catalytic activity, acting on a protein 2 19
GO:1901265 nucleoside phosphate binding 3 19
GO:1901363 heterocyclic compound binding 2 19
GO:0004674 protein serine/threonine kinase activity 4 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 303 307 PF00656 0.645
CLV_NRD_NRD_1 113 115 PF00675 0.412
CLV_NRD_NRD_1 175 177 PF00675 0.259
CLV_NRD_NRD_1 254 256 PF00675 0.330
CLV_NRD_NRD_1 298 300 PF00675 0.524
CLV_NRD_NRD_1 304 306 PF00675 0.567
CLV_NRD_NRD_1 362 364 PF00675 0.613
CLV_PCSK_KEX2_1 113 115 PF00082 0.355
CLV_PCSK_KEX2_1 175 177 PF00082 0.245
CLV_PCSK_KEX2_1 254 256 PF00082 0.249
CLV_PCSK_KEX2_1 297 299 PF00082 0.439
CLV_PCSK_KEX2_1 304 306 PF00082 0.505
CLV_PCSK_KEX2_1 362 364 PF00082 0.619
CLV_PCSK_SKI1_1 143 147 PF00082 0.388
CLV_PCSK_SKI1_1 18 22 PF00082 0.414
CLV_PCSK_SKI1_1 226 230 PF00082 0.278
CLV_PCSK_SKI1_1 254 258 PF00082 0.309
CLV_PCSK_SKI1_1 396 400 PF00082 0.549
CLV_PCSK_SKI1_1 418 422 PF00082 0.696
CLV_PCSK_SKI1_1 563 567 PF00082 0.451
DEG_APCC_DBOX_1 125 133 PF00400 0.295
DEG_APCC_DBOX_1 395 403 PF00400 0.542
DEG_SCF_FBW7_1 502 507 PF00400 0.491
DOC_ANK_TNKS_1 454 461 PF00023 0.512
DOC_CDC14_PxL_1 397 405 PF14671 0.520
DOC_CYCLIN_RxL_1 251 260 PF00134 0.308
DOC_CYCLIN_yCln2_LP_2 116 122 PF00134 0.277
DOC_MAPK_DCC_7 396 405 PF00069 0.540
DOC_MAPK_gen_1 143 152 PF00069 0.321
DOC_MAPK_HePTP_8 393 405 PF00069 0.541
DOC_MAPK_MEF2A_6 396 405 PF00069 0.540
DOC_PP1_RVXF_1 224 231 PF00149 0.262
DOC_PP4_FxxP_1 229 232 PF00568 0.259
DOC_PP4_FxxP_1 275 278 PF00568 0.369
DOC_USP7_MATH_1 280 284 PF00917 0.577
DOC_USP7_MATH_1 426 430 PF00917 0.589
DOC_USP7_MATH_1 504 508 PF00917 0.657
DOC_WW_Pin1_4 243 248 PF00397 0.243
DOC_WW_Pin1_4 362 367 PF00397 0.522
DOC_WW_Pin1_4 500 505 PF00397 0.640
DOC_WW_Pin1_4 544 549 PF00397 0.420
LIG_14-3-3_CanoR_1 113 119 PF00244 0.334
LIG_14-3-3_CanoR_1 126 130 PF00244 0.409
LIG_14-3-3_CanoR_1 175 180 PF00244 0.274
LIG_14-3-3_CanoR_1 297 302 PF00244 0.536
LIG_14-3-3_CanoR_1 322 327 PF00244 0.529
LIG_14-3-3_CanoR_1 39 49 PF00244 0.263
LIG_Actin_WH2_2 249 266 PF00022 0.309
LIG_Actin_WH2_2 585 600 PF00022 0.555
LIG_AP2alpha_2 273 275 PF02296 0.243
LIG_APCC_ABBA_1 272 277 PF00400 0.240
LIG_APCC_ABBAyCdc20_2 138 144 PF00400 0.368
LIG_Clathr_ClatBox_1 402 406 PF01394 0.640
LIG_deltaCOP1_diTrp_1 243 252 PF00928 0.243
LIG_FHA_1 207 213 PF00498 0.431
LIG_FHA_1 321 327 PF00498 0.652
LIG_FHA_1 41 47 PF00498 0.271
LIG_FHA_1 423 429 PF00498 0.519
LIG_FHA_1 501 507 PF00498 0.489
LIG_FHA_1 554 560 PF00498 0.672
LIG_FHA_1 573 579 PF00498 0.401
LIG_FHA_2 105 111 PF00498 0.263
LIG_FHA_2 190 196 PF00498 0.230
LIG_FHA_2 206 212 PF00498 0.263
LIG_FHA_2 55 61 PF00498 0.418
LIG_FHA_2 559 565 PF00498 0.516
LIG_LIR_Apic_2 182 188 PF02991 0.321
LIG_LIR_Apic_2 273 278 PF02991 0.371
LIG_LIR_Gen_1 106 116 PF02991 0.372
LIG_LIR_Gen_1 19 29 PF02991 0.340
LIG_LIR_Gen_1 86 95 PF02991 0.308
LIG_LIR_Nem_3 106 112 PF02991 0.266
LIG_LIR_Nem_3 19 24 PF02991 0.401
LIG_LIR_Nem_3 407 413 PF02991 0.537
LIG_LIR_Nem_3 507 512 PF02991 0.548
LIG_PCNA_yPIPBox_3 284 298 PF02747 0.477
LIG_Rb_LxCxE_1 547 564 PF01857 0.416
LIG_SH2_CRK 109 113 PF00017 0.257
LIG_SH2_CRK 513 517 PF00017 0.505
LIG_SH2_STAP1 196 200 PF00017 0.243
LIG_SH2_STAP1 574 578 PF00017 0.582
LIG_SH2_STAT5 123 126 PF00017 0.308
LIG_SH2_STAT5 134 137 PF00017 0.377
LIG_SH2_STAT5 219 222 PF00017 0.231
LIG_SH2_STAT5 470 473 PF00017 0.529
LIG_SH2_STAT5 487 490 PF00017 0.472
LIG_SH2_STAT5 550 553 PF00017 0.574
LIG_SH2_STAT5 571 574 PF00017 0.525
LIG_SH2_STAT5 99 102 PF00017 0.276
LIG_SH3_3 453 459 PF00018 0.526
LIG_SH3_3 509 515 PF00018 0.532
LIG_SUMO_SIM_anti_2 68 74 PF11976 0.257
LIG_SUMO_SIM_par_1 208 214 PF11976 0.309
LIG_TRAF2_1 282 285 PF00917 0.430
LIG_TRAF2_1 333 336 PF00917 0.572
LIG_WW_1 510 513 PF00397 0.534
MOD_CK1_1 104 110 PF00069 0.366
MOD_CK1_1 266 272 PF00069 0.345
MOD_CK1_1 312 318 PF00069 0.549
MOD_CK2_1 205 211 PF00069 0.263
MOD_CK2_1 280 286 PF00069 0.608
MOD_CK2_1 297 303 PF00069 0.514
MOD_CK2_1 54 60 PF00069 0.418
MOD_CK2_1 558 564 PF00069 0.600
MOD_CK2_1 576 582 PF00069 0.400
MOD_GlcNHglycan 265 268 PF01048 0.368
MOD_GlcNHglycan 277 281 PF01048 0.569
MOD_GlcNHglycan 314 317 PF01048 0.558
MOD_GlcNHglycan 4 7 PF01048 0.533
MOD_GlcNHglycan 428 431 PF01048 0.519
MOD_GlcNHglycan 441 444 PF01048 0.663
MOD_GlcNHglycan 496 499 PF01048 0.525
MOD_GlcNHglycan 506 509 PF01048 0.507
MOD_GlcNHglycan 541 544 PF01048 0.533
MOD_GSK3_1 171 178 PF00069 0.260
MOD_GSK3_1 201 208 PF00069 0.248
MOD_GSK3_1 276 283 PF00069 0.592
MOD_GSK3_1 293 300 PF00069 0.414
MOD_GSK3_1 311 318 PF00069 0.507
MOD_GSK3_1 422 429 PF00069 0.596
MOD_GSK3_1 476 483 PF00069 0.545
MOD_GSK3_1 500 507 PF00069 0.626
MOD_GSK3_1 554 561 PF00069 0.533
MOD_GSK3_1 572 579 PF00069 0.565
MOD_GSK3_1 601 608 PF00069 0.443
MOD_N-GLC_1 312 317 PF02516 0.585
MOD_N-GLC_1 474 479 PF02516 0.547
MOD_NEK2_1 150 155 PF00069 0.355
MOD_NEK2_1 169 174 PF00069 0.276
MOD_NEK2_1 179 184 PF00069 0.264
MOD_NEK2_1 205 210 PF00069 0.289
MOD_NEK2_1 421 426 PF00069 0.665
MOD_NEK2_1 480 485 PF00069 0.521
MOD_NEK2_1 532 537 PF00069 0.404
MOD_NEK2_1 554 559 PF00069 0.528
MOD_NEK2_1 592 597 PF00069 0.416
MOD_NEK2_1 83 88 PF00069 0.400
MOD_NEK2_2 416 421 PF00069 0.523
MOD_PIKK_1 280 286 PF00454 0.449
MOD_PK_1 322 328 PF00069 0.539
MOD_PKA_1 175 181 PF00069 0.243
MOD_PKA_1 297 303 PF00069 0.513
MOD_PKA_2 125 131 PF00069 0.345
MOD_PKA_2 175 181 PF00069 0.272
MOD_PKA_2 263 269 PF00069 0.286
MOD_PKA_2 297 303 PF00069 0.534
MOD_PKA_2 321 327 PF00069 0.513
MOD_PKA_2 40 46 PF00069 0.245
MOD_Plk_1 312 318 PF00069 0.687
MOD_Plk_1 406 412 PF00069 0.582
MOD_Plk_1 554 560 PF00069 0.532
MOD_Plk_2-3 101 107 PF00069 0.263
MOD_Plk_2-3 189 195 PF00069 0.230
MOD_Plk_2-3 406 412 PF00069 0.641
MOD_Plk_4 125 131 PF00069 0.388
MOD_Plk_4 175 181 PF00069 0.243
MOD_Plk_4 266 272 PF00069 0.316
MOD_Plk_4 315 321 PF00069 0.518
MOD_Plk_4 322 328 PF00069 0.524
MOD_Plk_4 476 482 PF00069 0.535
MOD_Plk_4 592 598 PF00069 0.414
MOD_Plk_4 61 67 PF00069 0.345
MOD_ProDKin_1 243 249 PF00069 0.243
MOD_ProDKin_1 362 368 PF00069 0.529
MOD_ProDKin_1 500 506 PF00069 0.640
MOD_ProDKin_1 544 550 PF00069 0.422
MOD_SUMO_rev_2 14 20 PF00179 0.369
MOD_SUMO_rev_2 162 172 PF00179 0.289
MOD_SUMO_rev_2 579 586 PF00179 0.560
TRG_DiLeu_BaEn_1 534 539 PF01217 0.562
TRG_DiLeu_BaLyEn_6 116 121 PF01217 0.306
TRG_DiLeu_BaLyEn_6 252 257 PF01217 0.257
TRG_DiLeu_BaLyEn_6 398 403 PF01217 0.644
TRG_ENDOCYTIC_2 109 112 PF00928 0.266
TRG_ENDOCYTIC_2 219 222 PF00928 0.226
TRG_ENDOCYTIC_2 87 90 PF00928 0.357
TRG_ER_diArg_1 112 114 PF00400 0.412
TRG_ER_diArg_1 253 255 PF00400 0.284
TRG_ER_diArg_1 297 299 PF00400 0.573
TRG_NES_CRM1_1 44 58 PF08389 0.242
TRG_NES_CRM1_1 60 74 PF08389 0.413
TRG_Pf-PMV_PEXEL_1 114 118 PF00026 0.353
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.342
TRG_Pf-PMV_PEXEL_1 18 22 PF00026 0.328
TRG_Pf-PMV_PEXEL_1 255 260 PF00026 0.225

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEW4 Leptomonas seymouri 58% 100%
A0A0S4IHW4 Bodo saltans 45% 100%
A0A3Q8IHH8 Leishmania donovani 26% 100%
A0A3R7K109 Trypanosoma rangeli 49% 100%
A0A3S5H5G0 Leishmania donovani 27% 100%
A0A3S7WTT7 Leishmania donovani 100% 100%
A4H459 Leishmania braziliensis 27% 100%
A4H8F5 Leishmania braziliensis 80% 100%
A4HSE2 Leishmania infantum 27% 100%
A4I4X0 Leishmania infantum 26% 100%
C9ZW46 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AEB9 Leishmania major 25% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AQI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QEZ0 Leishmania major 91% 100%
Q4QJJ0 Leishmania major 27% 100%
V5B141 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS