Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWS6_LEIIN

TriTrypDb:

LINF_160007800

Length:

1042

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	625	629	PF00656	0.455
CLV_C14_Caspase3-7	715	719	PF00656	0.343
CLV_NRD_NRD_1	252	254	PF00675	0.500
CLV_NRD_NRD_1	268	270	PF00675	0.446
CLV_NRD_NRD_1	328	330	PF00675	0.553
CLV_NRD_NRD_1	907	909	PF00675	0.344
CLV_NRD_NRD_1	982	984	PF00675	0.516
CLV_PCSK_KEX2_1	251	253	PF00082	0.488
CLV_PCSK_KEX2_1	268	270	PF00082	0.449
CLV_PCSK_KEX2_1	328	330	PF00082	0.553
CLV_PCSK_KEX2_1	907	909	PF00082	0.344
CLV_PCSK_KEX2_1	982	984	PF00082	0.516
CLV_PCSK_SKI1_1	197	201	PF00082	0.443
CLV_PCSK_SKI1_1	296	300	PF00082	0.388
CLV_PCSK_SKI1_1	666	670	PF00082	0.337
CLV_PCSK_SKI1_1	686	690	PF00082	0.307
CLV_PCSK_SKI1_1	757	761	PF00082	0.399
CLV_PCSK_SKI1_1	926	930	PF00082	0.356
CLV_PCSK_SKI1_1	956	960	PF00082	0.494
CLV_PCSK_SKI1_1	997	1001	PF00082	0.420
DEG_APCC_DBOX_1	335	343	PF00400	0.515
DEG_APCC_DBOX_1	665	673	PF00400	0.339
DEG_Nend_Nbox_1	1	3	PF02207	0.572
DEG_SCF_FBW7_1	177	184	PF00400	0.656
DEG_SCF_FBW7_1	228	235	PF00400	0.568
DEG_SCF_FBW7_2	405	412	PF00400	0.620
DEG_SPOP_SBC_1	176	180	PF00917	0.661
DOC_CYCLIN_RxL_1	266	277	PF00134	0.439
DOC_CYCLIN_yClb1_LxF_4	924	929	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	921	927	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	986	992	PF00134	0.414
DOC_MAPK_DCC_7	748	758	PF00069	0.411
DOC_MAPK_gen_1	12	21	PF00069	0.487
DOC_MAPK_gen_1	251	259	PF00069	0.424
DOC_MAPK_gen_1	542	550	PF00069	0.531
DOC_MAPK_gen_1	782	792	PF00069	0.389
DOC_MAPK_gen_1	800	809	PF00069	0.362
DOC_MAPK_gen_1	982	990	PF00069	0.466
DOC_MAPK_MEF2A_6	15	23	PF00069	0.444
DOC_MAPK_MEF2A_6	589	598	PF00069	0.366
DOC_MAPK_MEF2A_6	702	711	PF00069	0.358
DOC_MAPK_MEF2A_6	785	792	PF00069	0.392
DOC_MAPK_MEF2A_6	982	990	PF00069	0.466
DOC_MAPK_NFAT4_5	785	793	PF00069	0.394
DOC_PP1_RVXF_1	297	304	PF00149	0.353
DOC_PP1_RVXF_1	924	930	PF00149	0.345
DOC_PP2B_LxvP_1	594	597	PF13499	0.472
DOC_PP2B_LxvP_1	921	924	PF13499	0.374
DOC_PP2B_LxvP_1	986	989	PF13499	0.419
DOC_PP4_FxxP_1	305	308	PF00568	0.451
DOC_USP7_MATH_1	176	180	PF00917	0.671
DOC_USP7_MATH_1	188	192	PF00917	0.535
DOC_USP7_MATH_1	232	236	PF00917	0.621
DOC_USP7_MATH_1	321	325	PF00917	0.581
DOC_USP7_MATH_1	331	335	PF00917	0.589
DOC_USP7_MATH_1	421	425	PF00917	0.615
DOC_USP7_MATH_1	438	442	PF00917	0.576
DOC_USP7_MATH_1	50	54	PF00917	0.595
DOC_USP7_MATH_1	519	523	PF00917	0.620
DOC_USP7_MATH_1	534	538	PF00917	0.498
DOC_USP7_MATH_1	561	565	PF00917	0.389
DOC_USP7_MATH_1	734	738	PF00917	0.429
DOC_USP7_MATH_1	780	784	PF00917	0.336
DOC_USP7_MATH_1	857	861	PF00917	0.531
DOC_USP7_MATH_1	898	902	PF00917	0.372
DOC_USP7_MATH_1	950	954	PF00917	0.484
DOC_WW_Pin1_4	172	177	PF00397	0.748
DOC_WW_Pin1_4	228	233	PF00397	0.646
DOC_WW_Pin1_4	405	410	PF00397	0.619
DOC_WW_Pin1_4	564	569	PF00397	0.339
DOC_WW_Pin1_4	612	617	PF00397	0.399
DOC_WW_Pin1_4	732	737	PF00397	0.391
DOC_WW_Pin1_4	78	83	PF00397	0.624
DOC_WW_Pin1_4	807	812	PF00397	0.404
DOC_WW_Pin1_4	944	949	PF00397	0.611
LIG_14-3-3_CanoR_1	15	19	PF00244	0.431
LIG_14-3-3_CanoR_1	4	8	PF00244	0.607
LIG_14-3-3_CanoR_1	432	440	PF00244	0.567
LIG_14-3-3_CanoR_1	471	477	PF00244	0.275
LIG_14-3-3_CanoR_1	518	528	PF00244	0.615
LIG_14-3-3_CanoR_1	542	548	PF00244	0.497
LIG_14-3-3_CanoR_1	686	695	PF00244	0.386
LIG_14-3-3_CanoR_1	782	792	PF00244	0.365
LIG_14-3-3_CanoR_1	800	809	PF00244	0.522
LIG_Actin_WH2_2	735	750	PF00022	0.346
LIG_APCC_ABBA_1	809	814	PF00400	0.357
LIG_BRCT_BRCA1_1	496	500	PF00533	0.318
LIG_Clathr_ClatBox_1	864	868	PF01394	0.444
LIG_eIF4E_1	1036	1042	PF01652	0.385
LIG_EVH1_1	144	148	PF00568	0.534
LIG_FHA_1	1018	1024	PF00498	0.558
LIG_FHA_1	1036	1042	PF00498	0.319
LIG_FHA_1	203	209	PF00498	0.459
LIG_FHA_1	222	228	PF00498	0.466
LIG_FHA_1	55	61	PF00498	0.612
LIG_FHA_1	613	619	PF00498	0.444
LIG_FHA_1	629	635	PF00498	0.413
LIG_FHA_1	680	686	PF00498	0.411
LIG_FHA_1	704	710	PF00498	0.398
LIG_FHA_1	814	820	PF00498	0.341
LIG_FHA_2	281	287	PF00498	0.561
LIG_FHA_2	365	371	PF00498	0.415
LIG_FHA_2	39	45	PF00498	0.473
LIG_FHA_2	488	494	PF00498	0.461
LIG_FHA_2	623	629	PF00498	0.508
LIG_FHA_2	687	693	PF00498	0.331
LIG_GBD_Chelix_1	602	610	PF00786	0.376
LIG_LIR_Apic_2	142	147	PF02991	0.507
LIG_LIR_Apic_2	751	755	PF02991	0.354
LIG_LIR_Gen_1	17	23	PF02991	0.425
LIG_LIR_Gen_1	497	505	PF02991	0.319
LIG_LIR_Gen_1	692	699	PF02991	0.398
LIG_LIR_Gen_1	810	820	PF02991	0.383
LIG_LIR_Nem_3	1002	1007	PF02991	0.396
LIG_LIR_Nem_3	17	21	PF02991	0.444
LIG_LIR_Nem_3	290	295	PF02991	0.403
LIG_LIR_Nem_3	467	473	PF02991	0.335
LIG_LIR_Nem_3	497	503	PF02991	0.314
LIG_LIR_Nem_3	718	723	PF02991	0.368
LIG_LIR_Nem_3	768	773	PF02991	0.337
LIG_LIR_Nem_3	810	815	PF02991	0.397
LIG_NRBOX	472	478	PF00104	0.398
LIG_NRBOX	911	917	PF00104	0.335
LIG_PCNA_PIPBox_1	66	75	PF02747	0.626
LIG_Pex14_1	716	720	PF04695	0.355
LIG_PTB_Apo_2	769	776	PF02174	0.348
LIG_PTB_Phospho_1	769	775	PF10480	0.350
LIG_REV1ctd_RIR_1	790	798	PF16727	0.411
LIG_RPA_C_Fungi	883	895	PF08784	0.317
LIG_SH2_PTP2	987	990	PF00017	0.493
LIG_SH2_SRC	483	486	PF00017	0.435
LIG_SH2_SRC	725	728	PF00017	0.488
LIG_SH2_SRC	987	990	PF00017	0.469
LIG_SH2_STAP1	556	560	PF00017	0.384
LIG_SH2_STAT5	1036	1039	PF00017	0.430
LIG_SH2_STAT5	149	152	PF00017	0.455
LIG_SH2_STAT5	483	486	PF00017	0.435
LIG_SH2_STAT5	633	636	PF00017	0.421
LIG_SH2_STAT5	725	728	PF00017	0.591
LIG_SH2_STAT5	773	776	PF00017	0.322
LIG_SH2_STAT5	987	990	PF00017	0.493
LIG_SH3_2	304	309	PF14604	0.537
LIG_SH3_3	142	148	PF00018	0.550
LIG_SH3_3	298	304	PF00018	0.363
LIG_SH3_3	476	482	PF00018	0.417
LIG_SH3_3	527	533	PF00018	0.577
LIG_SH3_3	562	568	PF00018	0.339
LIG_SH3_3	593	599	PF00018	0.360
LIG_SH3_3	611	617	PF00018	0.434
LIG_SH3_3	82	88	PF00018	0.545
LIG_SH3_3	942	948	PF00018	0.624
LIG_SH3_CIN85_PxpxPR_1	304	309	PF14604	0.455
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.405
LIG_SUMO_SIM_par_1	526	531	PF11976	0.535
LIG_SUMO_SIM_par_1	546	552	PF11976	0.409
LIG_SUMO_SIM_par_1	804	810	PF11976	0.447
LIG_SUMO_SIM_par_1	863	868	PF11976	0.585
LIG_TRFH_1	478	482	PF08558	0.433
LIG_TRFH_1	695	699	PF08558	0.392
LIG_UBA3_1	499	507	PF00899	0.398
LIG_UBA3_1	583	589	PF00899	0.450
LIG_UBA3_1	707	712	PF00899	0.318
LIG_WRC_WIRS_1	189	194	PF05994	0.590
LIG_WRC_WIRS_1	890	895	PF05994	0.385
LIG_WW_1	337	340	PF00397	0.467
LIG_WW_3	306	310	PF00397	0.488
MOD_CDK_SPK_2	78	83	PF00069	0.599
MOD_CDK_SPxK_1	177	183	PF00069	0.657
MOD_CK1_1	179	185	PF00069	0.568
MOD_CK1_1	191	197	PF00069	0.563
MOD_CK1_1	284	290	PF00069	0.567
MOD_CK1_1	397	403	PF00069	0.597
MOD_CK1_1	424	430	PF00069	0.663
MOD_CK1_1	433	439	PF00069	0.577
MOD_CK1_1	448	454	PF00069	0.493
MOD_CK1_1	5	11	PF00069	0.608
MOD_CK1_1	517	523	PF00069	0.605
MOD_CK1_1	564	570	PF00069	0.398
MOD_CK1_1	620	626	PF00069	0.511
MOD_CK1_1	76	82	PF00069	0.652
MOD_CK1_1	783	789	PF00069	0.364
MOD_CK2_1	1023	1029	PF00069	0.412
MOD_CK2_1	417	423	PF00069	0.573
MOD_CK2_1	487	493	PF00069	0.457
MOD_CK2_1	686	692	PF00069	0.327
MOD_Cter_Amidation	326	329	PF01082	0.521
MOD_GlcNHglycan	113	116	PF01048	0.459
MOD_GlcNHglycan	283	286	PF01048	0.608
MOD_GlcNHglycan	315	318	PF01048	0.690
MOD_GlcNHglycan	323	326	PF01048	0.573
MOD_GlcNHglycan	329	332	PF01048	0.475
MOD_GlcNHglycan	333	336	PF01048	0.454
MOD_GlcNHglycan	396	399	PF01048	0.556
MOD_GlcNHglycan	419	422	PF01048	0.638
MOD_GlcNHglycan	423	426	PF01048	0.642
MOD_GlcNHglycan	440	443	PF01048	0.495
MOD_GlcNHglycan	48	51	PF01048	0.581
MOD_GlcNHglycan	496	499	PF01048	0.422
MOD_GlcNHglycan	52	55	PF01048	0.565
MOD_GlcNHglycan	521	524	PF01048	0.636
MOD_GlcNHglycan	619	622	PF01048	0.677
MOD_GlcNHglycan	654	658	PF01048	0.541
MOD_GlcNHglycan	66	69	PF01048	0.531
MOD_GlcNHglycan	660	663	PF01048	0.411
MOD_GlcNHglycan	669	672	PF01048	0.271
MOD_GlcNHglycan	682	685	PF01048	0.387
MOD_GlcNHglycan	782	785	PF01048	0.382
MOD_GlcNHglycan	803	806	PF01048	0.628
MOD_GlcNHglycan	848	852	PF01048	0.539
MOD_GlcNHglycan	859	862	PF01048	0.565
MOD_GSK3_1	127	134	PF00069	0.478
MOD_GSK3_1	172	179	PF00069	0.768
MOD_GSK3_1	228	235	PF00069	0.728
MOD_GSK3_1	273	280	PF00069	0.541
MOD_GSK3_1	284	291	PF00069	0.460
MOD_GSK3_1	327	334	PF00069	0.650
MOD_GSK3_1	38	45	PF00069	0.464
MOD_GSK3_1	417	424	PF00069	0.626
MOD_GSK3_1	432	439	PF00069	0.565
MOD_GSK3_1	448	455	PF00069	0.525
MOD_GSK3_1	46	53	PF00069	0.682
MOD_GSK3_1	514	521	PF00069	0.623
MOD_GSK3_1	56	63	PF00069	0.510
MOD_GSK3_1	564	571	PF00069	0.523
MOD_GSK3_1	620	627	PF00069	0.574
MOD_GSK3_1	628	635	PF00069	0.491
MOD_GSK3_1	64	71	PF00069	0.631
MOD_GSK3_1	667	674	PF00069	0.382
MOD_GSK3_1	675	682	PF00069	0.437
MOD_GSK3_1	72	79	PF00069	0.670
MOD_GSK3_1	801	808	PF00069	0.499
MOD_LATS_1	516	522	PF00433	0.600
MOD_N-GLC_1	163	168	PF02516	0.617
MOD_NEK2_1	2	7	PF00069	0.556
MOD_NEK2_1	42	47	PF00069	0.532
MOD_NEK2_1	503	508	PF00069	0.378
MOD_NEK2_1	610	615	PF00069	0.430
MOD_NEK2_1	73	78	PF00069	0.569
MOD_NEK2_1	792	797	PF00069	0.363
MOD_PIKK_1	191	197	PF00454	0.539
MOD_PIKK_1	448	454	PF00454	0.601
MOD_PIKK_1	62	68	PF00454	0.630
MOD_PIKK_1	870	876	PF00454	0.356
MOD_PK_1	56	62	PF00069	0.580
MOD_PKA_2	132	138	PF00069	0.431
MOD_PKA_2	14	20	PF00069	0.427
MOD_PKA_2	150	156	PF00069	0.396
MOD_PKA_2	3	9	PF00069	0.630
MOD_PKA_2	327	333	PF00069	0.744
MOD_PKA_2	433	439	PF00069	0.563
MOD_PKA_2	517	523	PF00069	0.627
MOD_PKA_2	658	664	PF00069	0.383
MOD_PKA_2	801	807	PF00069	0.521
MOD_PKA_2	976	982	PF00069	0.531
MOD_Plk_1	364	370	PF00069	0.454
MOD_Plk_1	42	48	PF00069	0.462
MOD_Plk_1	653	659	PF00069	0.383
MOD_Plk_1	700	706	PF00069	0.375
MOD_Plk_1	813	819	PF00069	0.321
MOD_Plk_4	1023	1029	PF00069	0.391
MOD_Plk_4	14	20	PF00069	0.472
MOD_Plk_4	223	229	PF00069	0.618
MOD_Plk_4	445	451	PF00069	0.540
MOD_Plk_4	472	478	PF00069	0.281
MOD_Plk_4	703	709	PF00069	0.412
MOD_Plk_4	734	740	PF00069	0.426
MOD_Plk_4	748	754	PF00069	0.247
MOD_Plk_4	889	895	PF00069	0.527
MOD_Plk_4	934	940	PF00069	0.543
MOD_ProDKin_1	172	178	PF00069	0.748
MOD_ProDKin_1	228	234	PF00069	0.645
MOD_ProDKin_1	405	411	PF00069	0.618
MOD_ProDKin_1	564	570	PF00069	0.342
MOD_ProDKin_1	612	618	PF00069	0.416
MOD_ProDKin_1	732	738	PF00069	0.384
MOD_ProDKin_1	78	84	PF00069	0.622
MOD_ProDKin_1	807	813	PF00069	0.395
MOD_ProDKin_1	944	950	PF00069	0.602
MOD_SUMO_for_1	239	242	PF00179	0.464
MOD_SUMO_rev_2	504	509	PF00179	0.400
TRG_DiLeu_BaEn_1	43	48	PF01217	0.483
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.364
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.481
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.344
TRG_DiLeu_BaLyEn_6	860	865	PF01217	0.468
TRG_ENDOCYTIC_2	695	698	PF00928	0.402
TRG_ENDOCYTIC_2	812	815	PF00928	0.486
TRG_ENDOCYTIC_2	987	990	PF00928	0.493
TRG_ER_diArg_1	250	253	PF00400	0.462
TRG_ER_diArg_1	431	434	PF00400	0.585
TRG_ER_diArg_1	906	908	PF00400	0.346
TRG_ER_diArg_1	982	985	PF00400	0.497
TRG_NES_CRM1_1	814	826	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ5	Leptomonas seymouri	46%	100%
A0A3Q8IIY2	Leishmania donovani	99%	100%
A4H8F6	Leishmania braziliensis	70%	93%
E9AQI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QEZ3	Leishmania major	90%	100%