LeishMANIAdb
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AB hydrolase-1 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AB hydrolase-1 domain-containing protein
Gene product:
Ankyrin repeats (3 copies)/Ankyrin repeats (many copies)/Ankyrin repeat/Alpha/beta hydrolase family - putative
Species:
Leishmania infantum
UniProt:
A4HWS5_LEIIN
TriTrypDb:
LINF_160007700
Length:
495

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HWS5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWS5

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0019538 protein metabolic process 3 4
GO:0043170 macromolecule metabolic process 3 4
GO:0044238 primary metabolic process 2 4
GO:0071704 organic substance metabolic process 2 4
GO:1901564 organonitrogen compound metabolic process 3 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016787 hydrolase activity 2 6
GO:0008233 peptidase activity 3 4
GO:0008236 serine-type peptidase activity 4 4
GO:0017171 serine hydrolase activity 3 4
GO:0140096 catalytic activity, acting on a protein 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 135 137 PF00675 0.344
CLV_NRD_NRD_1 260 262 PF00675 0.321
CLV_NRD_NRD_1 385 387 PF00675 0.339
CLV_PCSK_FUR_1 258 262 PF00082 0.276
CLV_PCSK_KEX2_1 260 262 PF00082 0.297
CLV_PCSK_KEX2_1 29 31 PF00082 0.363
CLV_PCSK_KEX2_1 319 321 PF00082 0.358
CLV_PCSK_KEX2_1 35 37 PF00082 0.364
CLV_PCSK_KEX2_1 374 376 PF00082 0.374
CLV_PCSK_KEX2_1 385 387 PF00082 0.336
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.381
CLV_PCSK_PC1ET2_1 319 321 PF00082 0.358
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.310
CLV_PCSK_PC1ET2_1 374 376 PF00082 0.399
CLV_PCSK_SKI1_1 136 140 PF00082 0.315
CLV_PCSK_SKI1_1 293 297 PF00082 0.285
CLV_PCSK_SKI1_1 386 390 PF00082 0.361
CLV_PCSK_SKI1_1 416 420 PF00082 0.294
CLV_PCSK_SKI1_1 76 80 PF00082 0.366
CLV_PCSK_SKI1_1 91 95 PF00082 0.335
DEG_APCC_DBOX_1 135 143 PF00400 0.520
DEG_Nend_UBRbox_1 1 4 PF02207 0.744
DEG_SCF_FBW7_1 79 86 PF00400 0.525
DEG_SPOP_SBC_1 351 355 PF00917 0.579
DOC_CKS1_1 80 85 PF01111 0.581
DOC_CYCLIN_yCln2_LP_2 142 148 PF00134 0.363
DOC_MAPK_DCC_7 412 420 PF00069 0.506
DOC_MAPK_gen_1 136 144 PF00069 0.475
DOC_MAPK_gen_1 244 253 PF00069 0.544
DOC_MAPK_gen_1 374 380 PF00069 0.605
DOC_MAPK_gen_1 73 81 PF00069 0.530
DOC_MAPK_MEF2A_6 136 144 PF00069 0.479
DOC_MAPK_MEF2A_6 244 252 PF00069 0.570
DOC_MAPK_MEF2A_6 412 421 PF00069 0.506
DOC_MAPK_MEF2A_6 63 70 PF00069 0.525
DOC_MAPK_MEF2A_6 87 94 PF00069 0.588
DOC_MAPK_NFAT4_5 87 95 PF00069 0.610
DOC_MAPK_RevD_3 21 36 PF00069 0.571
DOC_PP1_RVXF_1 89 95 PF00149 0.625
DOC_PP2B_LxvP_1 142 145 PF13499 0.363
DOC_SPAK_OSR1_1 302 306 PF12202 0.476
DOC_USP7_MATH_1 191 195 PF00917 0.654
DOC_USP7_MATH_1 488 492 PF00917 0.770
DOC_USP7_MATH_1 83 87 PF00917 0.671
DOC_USP7_UBL2_3 25 29 PF12436 0.562
DOC_USP7_UBL2_3 315 319 PF12436 0.558
DOC_WW_Pin1_4 128 133 PF00397 0.658
DOC_WW_Pin1_4 411 416 PF00397 0.558
DOC_WW_Pin1_4 478 483 PF00397 0.712
DOC_WW_Pin1_4 484 489 PF00397 0.781
DOC_WW_Pin1_4 79 84 PF00397 0.562
LIG_14-3-3_CanoR_1 260 264 PF00244 0.562
LIG_14-3-3_CanoR_1 293 298 PF00244 0.487
LIG_14-3-3_CanoR_1 375 379 PF00244 0.559
LIG_14-3-3_CanoR_1 385 391 PF00244 0.537
LIG_14-3-3_CanoR_1 42 46 PF00244 0.543
LIG_14-3-3_CanoR_1 432 438 PF00244 0.537
LIG_BRCT_BRCA1_1 367 371 PF00533 0.568
LIG_deltaCOP1_diTrp_1 203 208 PF00928 0.625
LIG_FHA_1 294 300 PF00498 0.553
LIG_FHA_1 387 393 PF00498 0.570
LIG_FHA_2 355 361 PF00498 0.545
LIG_FHA_2 438 444 PF00498 0.602
LIG_FHA_2 459 465 PF00498 0.552
LIG_Integrin_RGD_1 63 65 PF01839 0.362
LIG_LIR_Gen_1 219 225 PF02991 0.565
LIG_LIR_Gen_1 301 311 PF02991 0.476
LIG_LIR_Gen_1 44 55 PF02991 0.574
LIG_LIR_Nem_3 165 171 PF02991 0.340
LIG_LIR_Nem_3 219 223 PF02991 0.576
LIG_LIR_Nem_3 301 306 PF02991 0.476
LIG_LIR_Nem_3 379 384 PF02991 0.524
LIG_MAD2 137 145 PF02301 0.515
LIG_MLH1_MIPbox_1 367 371 PF16413 0.568
LIG_PCNA_yPIPBox_3 53 63 PF02747 0.537
LIG_Pex14_2 157 161 PF04695 0.358
LIG_Pex14_2 390 394 PF04695 0.569
LIG_PTB_Apo_2 269 276 PF02174 0.562
LIG_PTB_Phospho_1 269 275 PF10480 0.562
LIG_SH2_CRK 152 156 PF00017 0.468
LIG_SH2_CRK 275 279 PF00017 0.476
LIG_SH2_CRK 318 322 PF00017 0.537
LIG_SH2_NCK_1 220 224 PF00017 0.538
LIG_SH2_PTP2 237 240 PF00017 0.550
LIG_SH2_SRC 220 223 PF00017 0.535
LIG_SH2_SRC 237 240 PF00017 0.520
LIG_SH2_STAP1 376 380 PF00017 0.547
LIG_SH2_STAP1 466 470 PF00017 0.536
LIG_SH2_STAT3 370 373 PF00017 0.627
LIG_SH2_STAT5 170 173 PF00017 0.338
LIG_SH2_STAT5 175 178 PF00017 0.342
LIG_SH2_STAT5 237 240 PF00017 0.520
LIG_SH2_STAT5 370 373 PF00017 0.548
LIG_SH2_STAT5 448 451 PF00017 0.534
LIG_SH2_STAT5 59 62 PF00017 0.523
LIG_SH3_2 239 244 PF14604 0.643
LIG_SH3_3 235 241 PF00018 0.505
LIG_SH3_3 480 486 PF00018 0.753
LIG_SUMO_SIM_par_1 362 368 PF11976 0.615
LIG_TRAF2_1 487 490 PF00917 0.725
LIG_TYR_ITIM 150 155 PF00017 0.439
LIG_TYR_ITIM 218 223 PF00017 0.409
LIG_UBA3_1 23 29 PF00899 0.437
LIG_WW_1 184 187 PF00397 0.401
MOD_CDK_SPK_2 411 416 PF00069 0.444
MOD_CK1_1 131 137 PF00069 0.562
MOD_CK1_1 15 21 PF00069 0.635
MOD_CK1_1 194 200 PF00069 0.567
MOD_CK1_1 481 487 PF00069 0.648
MOD_CK2_1 3 9 PF00069 0.718
MOD_CK2_1 437 443 PF00069 0.484
MOD_CK2_1 484 490 PF00069 0.706
MOD_CMANNOS 205 208 PF00535 0.536
MOD_CMANNOS 391 394 PF00535 0.501
MOD_GlcNHglycan 193 196 PF01048 0.572
MOD_GlcNHglycan 288 291 PF01048 0.435
MOD_GlcNHglycan 354 357 PF01048 0.477
MOD_GlcNHglycan 367 370 PF01048 0.524
MOD_GSK3_1 124 131 PF00069 0.593
MOD_GSK3_1 15 22 PF00069 0.587
MOD_GSK3_1 324 331 PF00069 0.328
MOD_GSK3_1 350 357 PF00069 0.504
MOD_GSK3_1 477 484 PF00069 0.664
MOD_GSK3_1 55 62 PF00069 0.381
MOD_GSK3_1 79 86 PF00069 0.425
MOD_NEK2_1 311 316 PF00069 0.357
MOD_NEK2_1 324 329 PF00069 0.306
MOD_NEK2_1 365 370 PF00069 0.515
MOD_NEK2_1 424 429 PF00069 0.558
MOD_NEK2_1 437 442 PF00069 0.312
MOD_NEK2_1 458 463 PF00069 0.419
MOD_NEK2_1 92 97 PF00069 0.452
MOD_NEK2_2 106 111 PF00069 0.480
MOD_NEK2_2 41 46 PF00069 0.437
MOD_PK_1 374 380 PF00069 0.474
MOD_PKA_1 374 380 PF00069 0.534
MOD_PKA_2 124 130 PF00069 0.596
MOD_PKA_2 259 265 PF00069 0.437
MOD_PKA_2 374 380 PF00069 0.474
MOD_PKA_2 41 47 PF00069 0.407
MOD_PKA_2 431 437 PF00069 0.414
MOD_PKB_1 10 18 PF00069 0.641
MOD_PKB_1 291 299 PF00069 0.339
MOD_Plk_1 12 18 PF00069 0.637
MOD_Plk_1 466 472 PF00069 0.472
MOD_Plk_2-3 259 265 PF00069 0.449
MOD_Plk_4 19 25 PF00069 0.445
MOD_Plk_4 329 335 PF00069 0.363
MOD_Plk_4 354 360 PF00069 0.515
MOD_Plk_4 386 392 PF00069 0.406
MOD_Plk_4 424 430 PF00069 0.528
MOD_Plk_4 466 472 PF00069 0.507
MOD_Plk_4 55 61 PF00069 0.358
MOD_ProDKin_1 128 134 PF00069 0.578
MOD_ProDKin_1 411 417 PF00069 0.439
MOD_ProDKin_1 478 484 PF00069 0.669
MOD_ProDKin_1 79 85 PF00069 0.449
MOD_SUMO_rev_2 439 447 PF00179 0.398
MOD_SUMO_rev_2 69 78 PF00179 0.475
TRG_DiLeu_BaLyEn_6 142 147 PF01217 0.391
TRG_DiLeu_BaLyEn_6 88 93 PF01217 0.524
TRG_ENDOCYTIC_2 152 155 PF00928 0.399
TRG_ENDOCYTIC_2 170 173 PF00928 0.227
TRG_ENDOCYTIC_2 220 223 PF00928 0.408
TRG_ENDOCYTIC_2 275 278 PF00928 0.328
TRG_ENDOCYTIC_2 318 321 PF00928 0.344
TRG_ENDOCYTIC_2 47 50 PF00928 0.449
TRG_ER_diArg_1 384 386 PF00400 0.393
TRG_ER_diLys_1 492 495 PF00400 0.744

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0G5 Leptomonas seymouri 76% 98%
A0A0S4IJD1 Bodo saltans 46% 98%
A0A1X0NHG0 Trypanosomatidae 57% 100%
A0A3S5H6W8 Leishmania donovani 100% 100%
A0A422N2H5 Trypanosoma rangeli 57% 100%
A4H8F2 Leishmania braziliensis 86% 100%
C9ZW49 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9AQI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QEZ4 Leishmania major 96% 100%
V5B955 Trypanosoma cruzi 57% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS