Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongator-like Protein 3a - putative

Species:

Leishmania infantum

UniProt:

A4HWS3_LEIIN

TriTrypDb:

LINF_160007500

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005819	spindle	5	1

Expansion

Sequence features

A4HWS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWS3

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	1
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	2
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	19
GO:0003676	nucleic acid binding	3	19
GO:0003723	RNA binding	4	19
GO:0003824	catalytic activity	1	19
GO:0005488	binding	1	19
GO:0016407	acetyltransferase activity	5	19
GO:0016740	transferase activity	2	19
GO:0016746	acyltransferase activity	3	19
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	19
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19
GO:0051536	iron-sulfur cluster binding	3	19
GO:0051539	4 iron, 4 sulfur cluster binding	4	19
GO:0051540	metal cluster binding	2	19
GO:0097159	organic cyclic compound binding	2	19
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	11
GO:1901363	heterocyclic compound binding	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.321
CLV_C14_Caspase3-7	45	49	PF00656	0.369
CLV_C14_Caspase3-7	652	656	PF00656	0.564
CLV_NRD_NRD_1	222	224	PF00675	0.266
CLV_NRD_NRD_1	291	293	PF00675	0.295
CLV_NRD_NRD_1	332	334	PF00675	0.262
CLV_NRD_NRD_1	520	522	PF00675	0.356
CLV_NRD_NRD_1	633	635	PF00675	0.313
CLV_NRD_NRD_1	682	684	PF00675	0.654
CLV_NRD_NRD_1	731	733	PF00675	0.580
CLV_NRD_NRD_1	80	82	PF00675	0.439
CLV_NRD_NRD_1	84	86	PF00675	0.441
CLV_PCSK_KEX2_1	222	224	PF00082	0.233
CLV_PCSK_KEX2_1	291	293	PF00082	0.292
CLV_PCSK_KEX2_1	332	334	PF00082	0.262
CLV_PCSK_KEX2_1	520	522	PF00082	0.373
CLV_PCSK_KEX2_1	632	634	PF00082	0.308
CLV_PCSK_KEX2_1	682	684	PF00082	0.654
CLV_PCSK_KEX2_1	733	735	PF00082	0.516
CLV_PCSK_KEX2_1	84	86	PF00082	0.590
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.359
CLV_PCSK_PC1ET2_1	733	735	PF00082	0.492
CLV_PCSK_PC7_1	628	634	PF00082	0.278
CLV_PCSK_SKI1_1	274	278	PF00082	0.233
CLV_PCSK_SKI1_1	368	372	PF00082	0.219
CLV_PCSK_SKI1_1	394	398	PF00082	0.314
CLV_PCSK_SKI1_1	480	484	PF00082	0.243
CLV_PCSK_SKI1_1	500	504	PF00082	0.250
CLV_PCSK_SKI1_1	506	510	PF00082	0.436
CLV_PCSK_SKI1_1	513	517	PF00082	0.400
CLV_PCSK_SKI1_1	84	88	PF00082	0.397
CLV_PCSK_SKI1_1	89	93	PF00082	0.333
CLV_PCSK_SKI1_1	97	101	PF00082	0.374
DEG_APCC_DBOX_1	291	299	PF00400	0.474
DOC_ANK_TNKS_1	744	751	PF00023	0.443
DOC_CDC14_PxL_1	28	36	PF14671	0.404
DOC_CKS1_1	155	160	PF01111	0.624
DOC_CKS1_1	417	422	PF01111	0.433
DOC_CKS1_1	556	561	PF01111	0.272
DOC_CKS1_1	589	594	PF01111	0.197
DOC_CYCLIN_yClb1_LxF_4	224	229	PF00134	0.433
DOC_CYCLIN_yClb5_NLxxxL_5	474	483	PF00134	0.443
DOC_MAPK_gen_1	171	181	PF00069	0.397
DOC_MAPK_gen_1	222	229	PF00069	0.466
DOC_MAPK_gen_1	238	245	PF00069	0.433
DOC_MAPK_gen_1	291	297	PF00069	0.516
DOC_MAPK_gen_1	449	458	PF00069	0.433
DOC_MAPK_gen_1	84	93	PF00069	0.395
DOC_MAPK_HePTP_8	446	458	PF00069	0.433
DOC_MAPK_MEF2A_6	449	458	PF00069	0.429
DOC_PP1_RVXF_1	164	171	PF00149	0.508
DOC_PP1_RVXF_1	224	230	PF00149	0.433
DOC_PP2B_PxIxI_1	453	459	PF00149	0.538
DOC_PP4_FxxP_1	170	173	PF00568	0.524
DOC_PP4_FxxP_1	284	287	PF00568	0.538
DOC_USP7_MATH_1	142	146	PF00917	0.693
DOC_USP7_MATH_1	151	155	PF00917	0.688
DOC_USP7_MATH_1	594	598	PF00917	0.378
DOC_USP7_MATH_1	743	747	PF00917	0.484
DOC_WW_Pin1_4	137	142	PF00397	0.702
DOC_WW_Pin1_4	14	19	PF00397	0.689
DOC_WW_Pin1_4	149	154	PF00397	0.687
DOC_WW_Pin1_4	386	391	PF00397	0.368
DOC_WW_Pin1_4	400	405	PF00397	0.352
DOC_WW_Pin1_4	416	421	PF00397	0.433
DOC_WW_Pin1_4	431	436	PF00397	0.440
DOC_WW_Pin1_4	555	560	PF00397	0.270
DOC_WW_Pin1_4	588	593	PF00397	0.246
DOC_WW_Pin1_4	690	695	PF00397	0.662
LIG_14-3-3_CanoR_1	238	243	PF00244	0.433
LIG_14-3-3_CanoR_1	688	693	PF00244	0.660
LIG_14-3-3_CanoR_1	722	726	PF00244	0.452
LIG_Actin_WH2_2	667	684	PF00022	0.477
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BIR_III_4	747	751	PF00653	0.428
LIG_eIF4E_1	436	442	PF01652	0.460
LIG_FHA_1	126	132	PF00498	0.772
LIG_FHA_1	155	161	PF00498	0.445
LIG_FHA_1	507	513	PF00498	0.575
LIG_FHA_1	687	693	PF00498	0.715
LIG_FHA_1	710	716	PF00498	0.518
LIG_FHA_2	280	286	PF00498	0.471
LIG_FHA_2	316	322	PF00498	0.438
LIG_FHA_2	357	363	PF00498	0.475
LIG_FHA_2	5	11	PF00498	0.571
LIG_FHA_2	514	520	PF00498	0.509
LIG_FHA_2	579	585	PF00498	0.313
LIG_FHA_2	68	74	PF00498	0.527
LIG_LIR_Apic_2	262	267	PF02991	0.420
LIG_LIR_Apic_2	282	287	PF02991	0.453
LIG_LIR_Gen_1	165	173	PF02991	0.523
LIG_LIR_Gen_1	20	29	PF02991	0.573
LIG_LIR_Gen_1	418	428	PF02991	0.476
LIG_LIR_Gen_1	528	537	PF02991	0.330
LIG_LIR_Gen_1	557	568	PF02991	0.266
LIG_LIR_Gen_1	613	622	PF02991	0.309
LIG_LIR_LC3C_4	177	182	PF02991	0.378
LIG_LIR_Nem_3	165	170	PF02991	0.509
LIG_LIR_Nem_3	196	202	PF02991	0.303
LIG_LIR_Nem_3	20	24	PF02991	0.581
LIG_LIR_Nem_3	228	232	PF02991	0.444
LIG_LIR_Nem_3	260	264	PF02991	0.475
LIG_LIR_Nem_3	409	414	PF02991	0.452
LIG_LIR_Nem_3	418	424	PF02991	0.476
LIG_LIR_Nem_3	430	436	PF02991	0.476
LIG_LIR_Nem_3	528	534	PF02991	0.305
LIG_LIR_Nem_3	557	563	PF02991	0.379
LIG_LIR_Nem_3	613	619	PF02991	0.281
LIG_MYND_3	31	35	PF01753	0.414
LIG_NRBOX	33	39	PF00104	0.401
LIG_NRBOX	478	484	PF00104	0.436
LIG_Pex14_1	199	203	PF04695	0.433
LIG_Pex14_1	556	560	PF04695	0.278
LIG_Pex14_2	195	199	PF04695	0.264
LIG_SH2_CRK	575	579	PF00017	0.321
LIG_SH2_CRK	616	620	PF00017	0.267
LIG_SH2_CRK	636	640	PF00017	0.455
LIG_SH2_CRK	718	722	PF00017	0.380
LIG_SH2_CRK	83	87	PF00017	0.434
LIG_SH2_NCK_1	616	620	PF00017	0.316
LIG_SH2_STAP1	616	620	PF00017	0.316
LIG_SH2_STAT3	414	417	PF00017	0.433
LIG_SH2_STAT5	167	170	PF00017	0.352
LIG_SH2_STAT5	203	206	PF00017	0.456
LIG_SH2_STAT5	214	217	PF00017	0.456
LIG_SH2_STAT5	405	408	PF00017	0.410
LIG_SH2_STAT5	433	436	PF00017	0.557
LIG_SH2_STAT5	469	472	PF00017	0.456
LIG_SH2_STAT5	582	585	PF00017	0.402
LIG_SH3_1	202	208	PF00018	0.433
LIG_SH3_2	287	292	PF14604	0.538
LIG_SH3_3	136	142	PF00018	0.684
LIG_SH3_3	156	162	PF00018	0.393
LIG_SH3_3	202	208	PF00018	0.456
LIG_SH3_3	284	290	PF00018	0.500
LIG_SH3_3	380	386	PF00018	0.481
LIG_SH3_3	531	537	PF00018	0.357
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.366
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.456
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.316
LIG_SUMO_SIM_par_1	177	183	PF11976	0.366
LIG_SxIP_EBH_1	688	701	PF03271	0.497
LIG_TRAF2_1	116	119	PF00917	0.552
LIG_TRAF2_1	516	519	PF00917	0.358
LIG_TRAF2_1	611	614	PF00917	0.246
LIG_UBA3_1	441	449	PF00899	0.326
MOD_CDK_SPxxK_3	149	156	PF00069	0.552
MOD_CK1_1	154	160	PF00069	0.628
MOD_CK1_1	2	8	PF00069	0.670
MOD_CK1_1	525	531	PF00069	0.308
MOD_CK2_1	2	8	PF00069	0.625
MOD_CK2_1	355	361	PF00069	0.299
MOD_CK2_1	419	425	PF00069	0.295
MOD_CK2_1	513	519	PF00069	0.438
MOD_CK2_1	578	584	PF00069	0.317
MOD_CK2_1	67	73	PF00069	0.566
MOD_CK2_1	743	749	PF00069	0.534
MOD_GlcNHglycan	12	15	PF01048	0.730
MOD_GlcNHglycan	123	126	PF01048	0.769
MOD_GlcNHglycan	144	147	PF01048	0.687
MOD_GlcNHglycan	176	179	PF01048	0.397
MOD_GlcNHglycan	186	189	PF01048	0.344
MOD_GlcNHglycan	305	308	PF01048	0.325
MOD_GlcNHglycan	513	516	PF01048	0.466
MOD_GlcNHglycan	596	599	PF01048	0.343
MOD_GlcNHglycan	622	625	PF01048	0.264
MOD_GlcNHglycan	729	732	PF01048	0.549
MOD_GSK3_1	10	17	PF00069	0.762
MOD_GSK3_1	121	128	PF00069	0.519
MOD_GSK3_1	142	149	PF00069	0.711
MOD_GSK3_1	180	187	PF00069	0.353
MOD_GSK3_1	315	322	PF00069	0.286
MOD_GSK3_1	356	363	PF00069	0.333
MOD_GSK3_1	415	422	PF00069	0.296
MOD_GSK3_1	535	542	PF00069	0.493
MOD_GSK3_1	655	662	PF00069	0.695
MOD_GSK3_1	686	693	PF00069	0.560
MOD_N-GLC_1	193	198	PF02516	0.341
MOD_N-GLC_1	303	308	PF02516	0.264
MOD_N-GLC_1	686	691	PF02516	0.671
MOD_NEK2_1	100	105	PF00069	0.520
MOD_NEK2_1	180	185	PF00069	0.347
MOD_NEK2_1	303	308	PF00069	0.278
MOD_NEK2_1	334	339	PF00069	0.308
MOD_NEK2_1	370	375	PF00069	0.299
MOD_NEK2_1	721	726	PF00069	0.582
MOD_NEK2_1	87	92	PF00069	0.456
MOD_NEK2_2	279	284	PF00069	0.296
MOD_PIKK_1	12	18	PF00454	0.516
MOD_PIKK_1	172	178	PF00454	0.376
MOD_PIKK_1	614	620	PF00454	0.456
MOD_PIKK_1	709	715	PF00454	0.575
MOD_PK_1	688	694	PF00069	0.463
MOD_PKA_2	100	106	PF00069	0.525
MOD_PKA_2	355	361	PF00069	0.278
MOD_PKA_2	687	693	PF00069	0.617
MOD_PKA_2	721	727	PF00069	0.456
MOD_Plk_1	52	58	PF00069	0.336
MOD_Plk_1	539	545	PF00069	0.376
MOD_Plk_1	670	676	PF00069	0.618
MOD_Plk_2-3	4	10	PF00069	0.572
MOD_Plk_2-3	535	541	PF00069	0.402
MOD_Plk_4	180	186	PF00069	0.354
MOD_Plk_4	279	285	PF00069	0.327
MOD_Plk_4	349	355	PF00069	0.366
MOD_Plk_4	539	545	PF00069	0.264
MOD_Plk_4	578	584	PF00069	0.365
MOD_Plk_4	87	93	PF00069	0.337
MOD_ProDKin_1	137	143	PF00069	0.704
MOD_ProDKin_1	14	20	PF00069	0.677
MOD_ProDKin_1	149	155	PF00069	0.682
MOD_ProDKin_1	386	392	PF00069	0.368
MOD_ProDKin_1	400	406	PF00069	0.347
MOD_ProDKin_1	416	422	PF00069	0.264
MOD_ProDKin_1	431	437	PF00069	0.274
MOD_ProDKin_1	555	561	PF00069	0.270
MOD_ProDKin_1	588	594	PF00069	0.246
MOD_ProDKin_1	690	696	PF00069	0.663
MOD_SUMO_for_1	665	668	PF00179	0.492
MOD_SUMO_rev_2	20	29	PF00179	0.592
MOD_SUMO_rev_2	425	434	PF00179	0.308
TRG_DiLeu_BaEn_3	52	58	PF01217	0.336
TRG_DiLeu_BaEn_4	584	590	PF01217	0.197
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.424
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.357
TRG_DiLeu_BaLyEn_6	634	639	PF01217	0.343
TRG_ENDOCYTIC_2	167	170	PF00928	0.499
TRG_ENDOCYTIC_2	232	235	PF00928	0.278
TRG_ENDOCYTIC_2	575	578	PF00928	0.296
TRG_ENDOCYTIC_2	616	619	PF00928	0.316
TRG_ENDOCYTIC_2	636	639	PF00928	0.299
TRG_ENDOCYTIC_2	718	721	PF00928	0.529
TRG_ENDOCYTIC_2	83	86	PF00928	0.439
TRG_ENDOCYTIC_2	96	99	PF00928	0.390
TRG_ER_diArg_1	221	223	PF00400	0.305
TRG_ER_diArg_1	290	292	PF00400	0.357
TRG_ER_diArg_1	331	333	PF00400	0.305
TRG_ER_diArg_1	497	500	PF00400	0.352
TRG_ER_diArg_1	520	522	PF00400	0.373
TRG_ER_diArg_1	547	550	PF00400	0.296
TRG_ER_diArg_1	681	683	PF00400	0.604
TRG_ER_diArg_1	83	85	PF00400	0.575
TRG_NLS_MonoExtC_3	731	736	PF00514	0.613
TRG_NLS_MonoExtC_3	80	85	PF00514	0.458
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFU7	Leptomonas seymouri	71%	100%
A0A0S4KPU1	Bodo saltans	59%	100%
A0A1X0NG94	Trypanosomatidae	61%	100%
A0A1X0NX69	Trypanosomatidae	45%	100%
A0A3Q8ICG0	Leishmania donovani	100%	100%
A0A3S7WXV4	Leishmania donovani	46%	100%
A0A422NDG5	Trypanosoma rangeli	62%	100%
A4H8F0	Leishmania braziliensis	85%	100%
A4HD08	Leishmania braziliensis	45%	100%
A4I0J4	Leishmania infantum	46%	100%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4QB17	Leishmania major	46%	100%
Q4QEZ6	Leishmania major	94%	100%
V5B5L2	Trypanosoma cruzi	60%	100%