Las1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Las1 family protein

Gene product:

Las1-like - putative

Species:

Leishmania infantum

UniProt:

A4HWR8_LEIIN

TriTrypDb:

LINF_160007000

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	10
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	10
GO:0090730	Las1 complex	4	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1902555	endoribonuclease complex	4	10
GO:1902911	protein kinase complex	5	10
GO:1905348	endonuclease complex	3	10
GO:1905354	exoribonuclease complex	3	10
GO:1990234	transferase complex	3	10
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HWR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWR8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006364	rRNA processing	8	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016072	rRNA metabolic process	7	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000470	maturation of LSU-rRNA	9	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004519	endonuclease activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.708
CLV_NRD_NRD_1	11	13	PF00675	0.510
CLV_NRD_NRD_1	118	120	PF00675	0.420
CLV_NRD_NRD_1	178	180	PF00675	0.344
CLV_NRD_NRD_1	18	20	PF00675	0.480
CLV_NRD_NRD_1	249	251	PF00675	0.760
CLV_NRD_NRD_1	26	28	PF00675	0.497
CLV_NRD_NRD_1	335	337	PF00675	0.765
CLV_NRD_NRD_1	40	42	PF00675	0.673
CLV_PCSK_FUR_1	24	28	PF00082	0.628
CLV_PCSK_KEX2_1	104	106	PF00082	0.155
CLV_PCSK_KEX2_1	11	13	PF00082	0.509
CLV_PCSK_KEX2_1	18	20	PF00082	0.500
CLV_PCSK_KEX2_1	180	182	PF00082	0.344
CLV_PCSK_KEX2_1	26	28	PF00082	0.495
CLV_PCSK_KEX2_1	335	337	PF00082	0.769
CLV_PCSK_KEX2_1	40	42	PF00082	0.622
CLV_PCSK_KEX2_1	91	93	PF00082	0.389
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.155
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.344
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.726
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.406
CLV_PCSK_SKI1_1	105	109	PF00082	0.357
CLV_PCSK_SKI1_1	12	16	PF00082	0.643
CLV_PCSK_SKI1_1	287	291	PF00082	0.555
CLV_PCSK_SKI1_1	315	319	PF00082	0.548
CLV_PCSK_SKI1_1	91	95	PF00082	0.376
DEG_APCC_DBOX_1	104	112	PF00400	0.369
DEG_APCC_DBOX_1	25	33	PF00400	0.672
DOC_CYCLIN_RxL_1	89	96	PF00134	0.342
DOC_MAPK_gen_1	179	187	PF00069	0.369
DOC_MAPK_gen_1	312	321	PF00069	0.546
DOC_MAPK_MEF2A_6	210	219	PF00069	0.369
DOC_PP1_RVXF_1	89	96	PF00149	0.358
DOC_PP2B_LxvP_1	276	279	PF13499	0.677
DOC_PP2B_LxvP_1	35	38	PF13499	0.695
DOC_USP7_MATH_1	103	107	PF00917	0.388
DOC_USP7_MATH_1	204	208	PF00917	0.408
DOC_USP7_MATH_1	258	262	PF00917	0.724
DOC_USP7_MATH_1	272	276	PF00917	0.607
DOC_WW_Pin1_4	240	245	PF00397	0.527
DOC_WW_Pin1_4	261	266	PF00397	0.750
DOC_WW_Pin1_4	319	324	PF00397	0.737
DOC_WW_Pin1_4	69	74	PF00397	0.651
LIG_14-3-3_CanoR_1	179	188	PF00244	0.449
LIG_14-3-3_CanoR_1	239	244	PF00244	0.544
LIG_14-3-3_CanoR_1	259	267	PF00244	0.623
LIG_14-3-3_CanoR_1	50	57	PF00244	0.780
LIG_14-3-3_CterR_2	351	353	PF00244	0.643
LIG_Actin_WH2_2	131	149	PF00022	0.485
LIG_BIR_III_4	296	300	PF00653	0.634
LIG_BRCT_BRCA1_1	76	80	PF00533	0.545
LIG_deltaCOP1_diTrp_1	83	87	PF00928	0.401
LIG_FHA_1	108	114	PF00498	0.429
LIG_FHA_1	129	135	PF00498	0.344
LIG_FHA_1	262	268	PF00498	0.729
LIG_FHA_1	59	65	PF00498	0.748
LIG_FHA_1	70	76	PF00498	0.597
LIG_FHA_2	280	286	PF00498	0.580
LIG_FHA_2	54	60	PF00498	0.709
LIG_LIR_Gen_1	86	95	PF02991	0.403
LIG_LIR_Nem_3	86	90	PF02991	0.348
LIG_Pex14_2	221	225	PF04695	0.344
LIG_Pex14_2	76	80	PF04695	0.464
LIG_SH2_SRC	127	130	PF00017	0.344
LIG_SH2_STAT5	127	130	PF00017	0.369
LIG_SH3_3	266	272	PF00018	0.674
LIG_SUMO_SIM_anti_2	313	320	PF11976	0.546
LIG_SUMO_SIM_par_1	317	322	PF11976	0.682
MOD_CDK_SPxxK_3	319	326	PF00069	0.551
MOD_CK1_1	169	175	PF00069	0.444
MOD_CK1_1	261	267	PF00069	0.567
MOD_CK1_1	340	346	PF00069	0.739
MOD_CK1_1	58	64	PF00069	0.685
MOD_CK2_1	103	109	PF00069	0.476
MOD_CMANNOS	84	87	PF00535	0.344
MOD_GlcNHglycan	105	108	PF01048	0.421
MOD_GlcNHglycan	171	174	PF01048	0.439
MOD_GlcNHglycan	339	342	PF01048	0.681
MOD_GSK3_1	103	110	PF00069	0.466
MOD_GSK3_1	336	343	PF00069	0.781
MOD_GSK3_1	49	56	PF00069	0.658
MOD_GSK3_1	58	65	PF00069	0.586
MOD_N-GLC_1	97	102	PF02516	0.435
MOD_NEK2_1	166	171	PF00069	0.405
MOD_NEK2_1	219	224	PF00069	0.485
MOD_NEK2_1	97	102	PF00069	0.450
MOD_NEK2_2	107	112	PF00069	0.408
MOD_PIKK_1	219	225	PF00454	0.485
MOD_PKA_1	180	186	PF00069	0.485
MOD_PKA_1	335	341	PF00069	0.674
MOD_PKA_2	180	186	PF00069	0.485
MOD_PKA_2	238	244	PF00069	0.544
MOD_PKA_2	258	264	PF00069	0.618
MOD_PKA_2	335	341	PF00069	0.713
MOD_PKA_2	49	55	PF00069	0.781
MOD_Plk_2-3	292	298	PF00069	0.688
MOD_Plk_4	75	81	PF00069	0.436
MOD_ProDKin_1	240	246	PF00069	0.533
MOD_ProDKin_1	261	267	PF00069	0.749
MOD_ProDKin_1	319	325	PF00069	0.738
MOD_ProDKin_1	69	75	PF00069	0.645
MOD_SUMO_rev_2	280	289	PF00179	0.601
MOD_SUMO_rev_2	83	93	PF00179	0.394
TRG_DiLeu_BaEn_4	30	36	PF01217	0.646
TRG_ER_diArg_1	114	117	PF00400	0.449
TRG_ER_diArg_1	178	181	PF00400	0.325
TRG_ER_diArg_1	18	20	PF00400	0.529
TRG_ER_diArg_1	194	197	PF00400	0.325
TRG_ER_diArg_1	24	27	PF00400	0.596
TRG_ER_diArg_1	252	255	PF00400	0.731
TRG_NES_CRM1_1	208	218	PF08389	0.344
TRG_NLS_MonoCore_2	249	254	PF00514	0.702
TRG_NLS_MonoExtC_3	178	184	PF00514	0.344
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAG6	Leptomonas seymouri	55%	100%
A0A0S4JJ56	Bodo saltans	35%	100%
A0A1X0NFY0	Trypanosomatidae	44%	100%
A0A3Q8IA87	Leishmania donovani	100%	100%
A0A3R7K8F7	Trypanosoma rangeli	45%	100%
A4H8E5	Leishmania braziliensis	72%	98%
E9AQH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QF01	Leishmania major	86%	100%