Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWR4_LEIIN

TriTrypDb:

LINF_160006600

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.700
CLV_PCSK_KEX2_1	126	128	PF00082	0.660
CLV_PCSK_KEX2_1	219	221	PF00082	0.432
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.447
CLV_PCSK_SKI1_1	24	28	PF00082	0.521
DEG_SCF_FBW7_1	109	116	PF00400	0.590
DOC_CDC14_PxL_1	17	25	PF14671	0.461
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.606
DOC_PP2B_LxvP_1	165	168	PF13499	0.597
DOC_USP7_MATH_1	115	119	PF00917	0.545
DOC_USP7_MATH_1	16	20	PF00917	0.527
DOC_USP7_MATH_1	179	183	PF00917	0.614
DOC_USP7_MATH_1	229	233	PF00917	0.489
DOC_WW_Pin1_4	107	112	PF00397	0.616
DOC_WW_Pin1_4	113	118	PF00397	0.671
DOC_WW_Pin1_4	127	132	PF00397	0.477
DOC_WW_Pin1_4	171	176	PF00397	0.615
DOC_WW_Pin1_4	196	201	PF00397	0.611
DOC_WW_Pin1_4	95	100	PF00397	0.630
LIG_FHA_1	222	228	PF00498	0.527
LIG_Integrin_isoDGR_2	186	188	PF01839	0.633
LIG_Integrin_RGD_1	188	190	PF01839	0.552
LIG_LIR_Gen_1	207	216	PF02991	0.434
LIG_LIR_Gen_1	74	83	PF02991	0.557
LIG_LIR_Nem_3	19	23	PF02991	0.452
LIG_LIR_Nem_3	207	212	PF02991	0.463
LIG_LIR_Nem_3	52	58	PF02991	0.493
LIG_LIR_Nem_3	74	78	PF02991	0.522
LIG_LYPXL_yS_3	20	23	PF13949	0.450
LIG_NRBOX	22	28	PF00104	0.516
LIG_Pex14_2	209	213	PF04695	0.558
LIG_SH2_CRK	75	79	PF00017	0.582
LIG_SH2_NCK_1	81	85	PF00017	0.461
LIG_SH2_STAP1	75	79	PF00017	0.582
LIG_SH3_3	105	111	PF00018	0.599
LIG_SH3_3	114	120	PF00018	0.569
LIG_SH3_3	197	203	PF00018	0.601
LIG_SH3_3	62	68	PF00018	0.588
LIG_TRAF2_1	120	123	PF00917	0.588
MOD_CDC14_SPxK_1	116	119	PF00782	0.579
MOD_CDK_SPxK_1	113	119	PF00069	0.567
MOD_CDK_SPxxK_3	95	102	PF00069	0.524
MOD_CK1_1	107	113	PF00069	0.489
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.599
MOD_GlcNHglycan	182	185	PF01048	0.612
MOD_GlcNHglycan	74	78	PF01048	0.507
MOD_GlcNHglycan	81	84	PF01048	0.487
MOD_GSK3_1	109	116	PF00069	0.586
MOD_NEK2_1	1	6	PF00069	0.533
MOD_Plk_1	73	79	PF00069	0.556
MOD_Plk_4	104	110	PF00069	0.506
MOD_ProDKin_1	107	113	PF00069	0.612
MOD_ProDKin_1	127	133	PF00069	0.478
MOD_ProDKin_1	171	177	PF00069	0.618
MOD_ProDKin_1	196	202	PF00069	0.604
MOD_ProDKin_1	95	101	PF00069	0.634
MOD_SUMO_rev_2	214	221	PF00179	0.467
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.477
TRG_ENDOCYTIC_2	20	23	PF00928	0.450
TRG_ENDOCYTIC_2	75	78	PF00928	0.580
TRG_ER_diArg_1	125	127	PF00400	0.665
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFT2	Leptomonas seymouri	44%	100%
A0A3S7WTR0	Leishmania donovani	97%	100%
A4H8E2	Leishmania braziliensis	61%	100%
E9AQH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QF05	Leishmania major	88%	100%