Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWR2_LEIIN

TriTrypDb:

LINF_160006400

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.657
CLV_NRD_NRD_1	121	123	PF00675	0.540
CLV_NRD_NRD_1	37	39	PF00675	0.557
CLV_NRD_NRD_1	68	70	PF00675	0.692
CLV_PCSK_KEX2_1	63	65	PF00082	0.651
CLV_PCSK_KEX2_1	67	69	PF00082	0.650
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.637
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.626
CLV_PCSK_PC7_1	64	70	PF00082	0.675
CLV_PCSK_SKI1_1	104	108	PF00082	0.616
CLV_PCSK_SKI1_1	122	126	PF00082	0.517
DEG_APCC_DBOX_1	114	122	PF00400	0.657
DEG_APCC_DBOX_1	68	76	PF00400	0.774
DEG_SCF_FBW7_1	161	168	PF00400	0.632
DOC_CYCLIN_RxL_1	116	130	PF00134	0.561
DOC_MAPK_gen_1	117	126	PF00069	0.556
DOC_MAPK_MEF2A_6	120	128	PF00069	0.572
DOC_USP7_MATH_1	163	167	PF00917	0.673
DOC_USP7_MATH_1	44	48	PF00917	0.708
DOC_USP7_UBL2_3	39	43	PF12436	0.693
DOC_USP7_UBL2_3	63	67	PF12436	0.547
DOC_WW_Pin1_4	140	145	PF00397	0.728
DOC_WW_Pin1_4	161	166	PF00397	0.649
LIG_14-3-3_CterR_2	204	208	PF00244	0.571
LIG_Actin_WH2_2	191	208	PF00022	0.533
LIG_deltaCOP1_diTrp_1	182	191	PF00928	0.668
LIG_FHA_1	165	171	PF00498	0.773
LIG_FHA_1	48	54	PF00498	0.689
LIG_FHA_1	94	100	PF00498	0.697
LIG_FHA_2	166	172	PF00498	0.701
LIG_FHA_2	2	8	PF00498	0.709
LIG_MYND_1	140	144	PF01753	0.754
LIG_SH2_NCK_1	30	34	PF00017	0.542
LIG_SH2_SRC	30	33	PF00017	0.593
LIG_SH3_3	76	82	PF00018	0.696
LIG_TRAF2_1	132	135	PF00917	0.699
LIG_TRAF2_1	180	183	PF00917	0.518
MOD_CK1_1	143	149	PF00069	0.766
MOD_CK1_1	47	53	PF00069	0.694
MOD_CK2_1	128	134	PF00069	0.580
MOD_CK2_1	15	21	PF00069	0.639
MOD_GlcNHglycan	130	133	PF01048	0.620
MOD_GlcNHglycan	155	159	PF01048	0.752
MOD_GSK3_1	161	168	PF00069	0.680
MOD_GSK3_1	174	181	PF00069	0.535
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	198	203	PF00069	0.580
MOD_PK_1	80	86	PF00069	0.720
MOD_PKA_1	63	69	PF00069	0.673
MOD_PKA_2	174	180	PF00069	0.727
MOD_PKA_2	63	69	PF00069	0.673
MOD_Plk_1	134	140	PF00069	0.593
MOD_Plk_4	165	171	PF00069	0.728
MOD_Plk_4	198	204	PF00069	0.639
MOD_ProDKin_1	140	146	PF00069	0.730
MOD_ProDKin_1	161	167	PF00069	0.647
TRG_ER_diArg_1	115	118	PF00400	0.660
TRG_ER_diArg_1	203	206	PF00400	0.534
TRG_NLS_MonoExtC_3	66	71	PF00514	0.564
TRG_NLS_MonoExtN_4	120	126	PF00514	0.542
TRG_NLS_MonoExtN_4	64	71	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0H3	Leptomonas seymouri	34%	100%
A0A3Q8IIW8	Leishmania donovani	97%	100%
E9AQG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QF07	Leishmania major	81%	100%